Protein: SPAG6
Sperm-associated antigen 6 (Axoneme central apparatus protein) (Protein PF16 homolog)

Gene: SPAG6
Organism: Mus musculus
Interactions: 193
UniProt ID: Q9JLI7

Gene Ontology (top 5):
GO:0001669 - acrosomal vesicle
GO:0002177 - manchette
GO:0003351 - epithelial cilium movement involved in extracellular fluid movement
GO:0003356 - regulation of cilium beat frequency
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1274455

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

6

High-throughput

0.621

High

1282053

DGKZ
Diacylglycerol kinase zeta

1

1

High-throughput

0.621

High

1440913

IKBA
NF-kappa-B inhibitor alpha

1

6

High-throughput

0.621

High

205238

MDM4
Protein Mdm4

1

3

High-throughput

0.555

High

1424031

ANKE1
Ankyrin repeat and EF-hand domain-containing protein 1

1

1

High-throughput

0.555

High

205618

CSN5
COP9 signalosome complex subunit 5

1

6

High-throughput

0.552

High

550740

DYLT2
Dynein light chain Tctex-type protein 2

1

0

High-throughput

0.529

High

1297020

ISK2
Serine protease inhibitor Kazal-type 2

1

0

High-throughput

0.529

High

1440916

SNAPN
SNARE-associated protein Snapin

1

0

High-throughput

0.529

High

1190017

TNKS2
Poly [ADP-ribose] polymerase tankyrase-2

1

0

High-throughput

0.519

High

1229329

PKP4
Plakophilin-4

1

0

High-throughput

0.519

High

1209170

SPG17
Sperm-associated antigen 17

1

0

Small-scale

0.484

High

92755

HFM1
Probable ATP-dependent DNA helicase HFM1

1

3

High-throughput

0.481

High

97767

IF140
Intraflagellar transport protein 140 homolog

1

1

High-throughput

0.481

High

205182

NPC1
NPC intracellular cholesterol transporter 1

1

2

High-throughput

0.481

High

205302

STAG2
Cohesin subunit SA-2

1

1

High-throughput

0.481

High

683953

MOES
Moesin

1

3

High-throughput

0.481

High

706388

TBP
TATA-box-binding protein

1

2

High-throughput

0.481

High

810541

DYN1
Dynamin-1

1

1

High-throughput

0.481

High

867932

PFKAM
ATP-dependent 6-phosphofructokinase, muscle type

1

1

High-throughput

0.481

High

868945

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.481

High

873446

PP2BB
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

1

5

High-throughput

0.481

High

926893

STMN1
Stathmin

1

1

High-throughput

0.481

High

947854

IF5
Eukaryotic translation initiation factor 5

1

1

High-throughput

0.481

High

958404

ARP2
Actin-related protein 2

1

6

High-throughput

0.481

High

989464

CH60
60 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.481

High

993861

UBC9
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.481

High

1010012

TCPG
T-complex protein 1 subunit gamma

1

1

High-throughput

0.481

High

1190055

Q3UH16
plus-end-directed kinesin ATPase

1

1

High-throughput

0.481

High

1223096

FXR1
RNA-binding protein FXR1

1

1

High-throughput

0.481

High

1235710

NIPBL
Nipped-B-like protein

1

6

High-throughput

0.481

High

1243507

HERC4
Probable E3 ubiquitin-protein ligase HERC4

1

6

High-throughput

0.481

High

1246339

RIGI
Antiviral innate immune response receptor RIG-I

1

5

High-throughput

0.481

High

1298016

BBS4
BBSome complex member BBS4

1

6

High-throughput

0.481

High

1317207

FEZ1
Fasciculation and elongation protein zeta-1

1

1

High-throughput

0.481

High

1317401

SPG16
Sperm-associated antigen 16 protein

1

7

Small-scale

0.481

High

1341716

CADM1
Cell adhesion molecule 1

1

1

High-throughput

0.481

High

1353929

TTC8
Tetratricopeptide repeat protein 8

1

7

High-throughput

0.481

High

1354002

GPSM2
G-protein-signaling modulator 2

1

7

High-throughput

0.481

High

1354035

VPS4A
Vacuolar protein sorting-associated protein 4A

1

6

High-throughput

0.481

High

1362418

PRP6
Pre-mRNA-processing factor 6

1

7

High-throughput

0.481

High

1408764

PLST
Plastin-3

1

2

High-throughput

0.481

High

1424156

SNX5
Sorting nexin-5

1

1

High-throughput

0.481

High

1440848

COPB
Coatomer subunit beta

1

2

High-throughput

0.481

High

1440910

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

5

High-throughput

0.481

High

1440911

CDC7
Cell division cycle 7-related protein kinase

1

7

High-throughput

0.481

High

59299

MEIOC
Meiosis-specific coiled-coil domain-containing protein MEIOC

1

0

High-throughput

0.460

High

92752

RBM24
RNA-binding protein 24

1

0

High-throughput

0.460

High

467771

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.460

High

585191

GSTM2
Glutathione S-transferase Mu 2

1

0

High-throughput

0.460

High

625755

MGP
Matrix Gla protein

1

0

High-throughput

0.460

High

627912

TYB4
Thymosin beta-4

1

0

High-throughput

0.460

High

835041

TKN1
Protachykinin-1

1

0

High-throughput

0.460

High

841637

LIFR
Leukemia inhibitory factor receptor

1

0

High-throughput

0.460

High

989522

IF4E
Eukaryotic translation initiation factor 4E

1

0

High-throughput

0.460

High

1010842

DEFB2
Beta-defensin 2

1

0

High-throughput

0.460

High

1190301

NEPR1
Nuclear envelope phosphatase-regulatory subunit 1

1

0

High-throughput

0.460

High

1210579

PSME4
Proteasome activator complex subunit 4

1

0

High-throughput

0.460

High

1210670

MYBPP
MYCBP-associated protein

1

0

High-throughput

0.460

High

1221283

AKAP4
A-kinase anchor protein 4

1

0

High-throughput

0.460

High

1222754

HCDH
Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial

1

0

High-throughput

0.460

High

1225707

DAZL
Deleted in azoospermia-like

1

0

High-throughput

0.460

High

1240288

SORCN
Sorcin

1

0

High-throughput

0.460

High

1282923

ARM12
Armadillo repeat-containing protein 12

1

0

High-throughput

0.460

High

1296543

CFA69
Cilia- and flagella-associated protein 69

1

0

High-throughput

0.460

High

1296641

CGBP1
CGG triplet repeat-binding protein 1

1

0

High-throughput

0.460

High

1297322

PHF23
PHD finger protein 23

1

0

High-throughput

0.460

High

1297378

KAT1
Kynurenine--oxoglutarate transaminase 1

1

0

High-throughput

0.460

High

1298189

SPEF2
Sperm flagellar protein 2

1

0

High-throughput

0.460

High

1298200

PGM2L
Glucose 1,6-bisphosphate synthase

1

0

High-throughput

0.460

High

1317364

DP13B
DCC-interacting protein 13-beta

1

0

High-throughput

0.460

High

1317378

BABA2
BRISC and BRCA1-A complex member 2

1

0

High-throughput

0.460

High

1354001

CE57L
Centrosomal protein CEP57L1

1

0

High-throughput

0.460

High

1362487

FPPS
Farnesyl pyrophosphate synthase

1

0

High-throughput

0.460

High

1423791

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

0

High-throughput

0.460

High

1424084

VATE2
V-type proton ATPase subunit E 2

1

0

High-throughput

0.460

High

1424177

Q9DAA5
Sperm acrosome associated 7B

1

0

High-throughput

0.460

High

1424268

RMD1
Regulator of microtubule dynamics protein 1

1

0

High-throughput

0.460

High

1440908

GUAD
Guanine deaminase

1

0

High-throughput

0.460

High

98266

E9QAE3
B-TFIID TATA-box binding protein associated factor 1

1

20

High-throughput

0.439

High

107941

G3UVU7
WD repeat domain 17

1

8

High-throughput

0.439

High

109246

ZBT11
Zinc finger and BTB domain-containing protein 11

1

5

High-throughput

0.439

High

312538

ZFR
Zinc finger RNA-binding protein

1

6

High-throughput

0.439

High

517847

ZFP28
Zinc finger protein 28

1

5

High-throughput

0.439

High

938877

STMN2
Stathmin-2

1

1

High-throughput

0.439

High

1081345

TIGD2
Tigger transposable element-derived protein 2

1

4

High-throughput

0.439

High

1081797

PP4R2
Serine/threonine-protein phosphatase 4 regulatory subunit 2

1

3

High-throughput

0.439

High

1190275

NOL8
Nucleolar protein 8

1

1

High-throughput

0.439

High

1190927

Q3UV11
Keratin 6B

1

1

High-throughput

0.439

High

1192183

SNX25
Sorting nexin-25

1

1

High-throughput

0.439

High

1204105

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

4

High-throughput

0.439

High

1205404

CAGE1
Cancer-associated gene 1 protein homolog

1

3

High-throughput

0.439

High

1210650

LC7L3
Luc7-like protein 3

1

3

High-throughput

0.439

High

1221944

SLAP1
Src-like-adapter

1

2

High-throughput

0.439

High

1222725

TCPW
T-complex protein 1 subunit zeta-2

1

3

High-throughput

0.439

High

1222785

DAF1
Complement decay-accelerating factor, GPI-anchored

1

1

High-throughput

0.439

High

1224617

TP4A1
Protein tyrosine phosphatase type IVA 1

1

5

High-throughput

0.439

High

1225694

IFIT3
Interferon-induced protein with tetratricopeptide repeats 3

1

8

High-throughput

0.439

High

1282857

HOMEZ
Homeobox and leucine zipper protein Homez

1

2

High-throughput

0.439

High

1282973

DDHD1
Phospholipase DDHD1

1

1

High-throughput

0.439

High

1296814

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

10

High-throughput

0.439

High

1296915

SMG1
Serine/threonine-protein kinase SMG1

1

7

High-throughput

0.439

High

1296929

CDKL3
Cyclin-dependent kinase-like 3

1

4

High-throughput

0.439

High

1297138

Q8BPC3
Uncharacterized protein

1

8

High-throughput

0.439

High

1297371

NUP54
Nuclear pore complex protein Nup54

1

8

High-throughput

0.439

High

1298094

BHE22
Class E basic helix-loop-helix protein 22

1

1

High-throughput

0.439

High

1298108

BTBD9
BTB/POZ domain-containing protein 9

1

10

High-throughput

0.439

High

1298217

MIC60
MICOS complex subunit Mic60

1

2

High-throughput

0.439

High

1298568

TCRG1
Transcription elongation regulator 1

1

11

High-throughput

0.439

High

1317278

INT10
Integrator complex subunit 10

1

1

High-throughput

0.439

High

1341543

PSPC1
Paraspeckle component 1

1

2

High-throughput

0.439

High

1362952

TRI59
Tripartite motif-containing protein 59

1

8

High-throughput

0.439

High

1423684

PCYOX
Prenylcysteine oxidase 1

1

1

High-throughput

0.439

High

1423850

NOPC1
NOP protein chaperone 1

1

3

High-throughput

0.439

High

1423974

PEX13
Peroxisomal membrane protein PEX13

1

1

High-throughput

0.439

High

1424072

Q9D496
Coiled-coil domain containing 121

1

2

High-throughput

0.439

High

1440833

NGLY1
Peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase

1

1

High-throughput

0.439

High

1440907

ZRAB2
Zinc finger Ran-binding domain-containing protein 2

1

1

High-throughput

0.439

High

1440909

CUL1
Cullin-1

1

16

High-throughput

0.439

High

1440915

AEBP2
Zinc finger protein AEBP2

1

7

High-throughput

0.439

High

1440917

BAZ1B
Tyrosine-protein kinase BAZ1B

1

19

High-throughput

0.439

High

1440918

SUCB1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

1

4

High-throughput

0.439

High

59416

D19L4
Probable C-mannosyltransferase DPY19L4

1

0

High-throughput

0.251

Low

59705

FA209
Protein FAM209

1

0

High-throughput

0.251

Low

62786

GBP4
Guanylate-binding protein 4

1

0

High-throughput

0.251

Low

73890

B2RQ99
6820408C15Rik protein

1

0

High-throughput

0.251

Low

74313

HSBPL
Heat shock factor-binding protein 1-like protein 1

1

0

High-throughput

0.251

Low

92604

RFX8
DNA-binding protein RFX8

1

0

High-throughput

0.251

Low

92739

CIP1
E3 ubiquitin-protein ligase CCNB1IP1

1

0

High-throughput

0.251

Low

97759

E9PXD1
Serine protease 51

1

0

High-throughput

0.251

Low

116827

I6L970
Lipid droplet-regulating VLDL assembly factor AUP1

1

0

High-throughput

0.251

Low

204882

C1D
Nuclear nucleic acid-binding protein C1D

1

0

High-throughput

0.251

Low

236989

FKBP7
Peptidyl-prolyl cis-trans isomerase FKBP7

1

0

High-throughput

0.251

Low

237335

LDB2
LIM domain-binding protein 2

1

0

High-throughput

0.251

Low

726637

DPEP1
Dipeptidase 1

1

0

High-throughput

0.251

Low

753982

PRI2
DNA primase large subunit

1

0

High-throughput

0.251

Low

849283

SDC2
Syndecan-2

1

0

High-throughput

0.251

Low

897446

BTG3
Protein BTG3

1

0

High-throughput

0.251

Low

906381

GPC4
Glypican-4

1

0

High-throughput

0.251

Low

937616

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

0

High-throughput

0.251

Low

945759

RT06
Small ribosomal subunit protein bS6m

1

0

High-throughput

0.251

Low

947398

CSRN3
Cysteine/serine-rich nuclear protein 3

1

0

High-throughput

0.251

Low

964562

UFM1
Ubiquitin-fold modifier 1

1

0

High-throughput

0.251

Low

1021879

GFRA1
GDNF family receptor alpha-1

1

0

High-throughput

0.251

Low

1180890

MSTO1
Protein misato homolog 1

1

0

High-throughput

0.251

Low

1189607

CH048
Uncharacterized protein C8orf48 homolog

1

0

High-throughput

0.251

Low

1190028

RSH3A
Radial spoke head protein 3 homolog A

1

0

High-throughput

0.251

Low

1190321

CE034
Uncharacterized protein C5orf34 homolog

1

0

High-throughput

0.251

Low

1190952

ERMP1
Endoplasmic reticulum metallopeptidase 1

1

0

High-throughput

0.251

Low

1223116

GPAT1
Glycerol-3-phosphate acyltransferase 1, mitochondrial

1

0

High-throughput

0.251

Low

1223288

RT31
Small ribosomal subunit protein mS31

1

0

High-throughput

0.251

Low

1225338

ASPG
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase

1

0

High-throughput

0.251

Low

1231040

SIDT1
SID1 transmembrane family member 1

1

0

High-throughput

0.251

Low

1240004

K1328
Protein hinderin

1

0

High-throughput

0.251

Low

1282044

INT2
Integrator complex subunit 2

1

0

High-throughput

0.251

Low

1282873

LYRIC
Protein LYRIC

1

0

High-throughput

0.251

Low

1283509

CCD50
Coiled-coil domain-containing protein 50

1

0

High-throughput

0.251

Low

1296508

MID51
Mitochondrial dynamics protein MID51

1

0

High-throughput

0.251

Low

1296514

IF5A2
Eukaryotic translation initiation factor 5A-2

1

0

High-throughput

0.251

Low

1297365

Q8BTS0
Probable ATP-dependent RNA helicase DDX5

1

0

High-throughput

0.251

Low

1297607

NMUR2
Neuromedin-U receptor 2

1

0

High-throughput

0.251

Low

1298065

U119B
Protein unc-119 homolog B

1

0

High-throughput

0.251

Low

1298246

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.251

Low

1298247

DCNL4
DCN1-like protein 4

1

0

High-throughput

0.251

Low

1298397

NUP88
Nuclear pore complex protein Nup88

1

0

High-throughput

0.251

Low

1298599

CS2IP
Casein kinase II subunit alpha'-interacting protein

1

0

High-throughput

0.251

Low

1317219

T11L2
T-complex protein 11-like protein 2

1

0

High-throughput

0.251

Low

1317266

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.251

Low

1317311

BROX
BRO1 domain-containing protein BROX

1

0

High-throughput

0.251

Low

1317382

I2BPL
Probable E3 ubiquitin-protein ligase IRF2BPL

1

0

High-throughput

0.251

Low

1341553

CLMP
CXADR-like membrane protein

1

0

High-throughput

0.251

Low

1354069

DRC2
Dynein regulatory complex subunit 2

1

0

High-throughput

0.251

Low

1362501

REV1
DNA repair protein REV1

1

0

High-throughput

0.251

Low

1362910

TFIP8
Tumor necrosis factor alpha-induced protein 8

1

0

High-throughput

0.251

Low

1365319

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

0

High-throughput

0.251

Low

1408742

EIF3M
Eukaryotic translation initiation factor 3 subunit M

1

0

High-throughput

0.251

Low

1408865

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.251

Low

1423849

PSMD8
26S proteasome non-ATPase regulatory subunit 8

1

0

High-throughput

0.251

Low

1423853

ROA0
Heterogeneous nuclear ribonucleoprotein A0

1

0

High-throughput

0.251

Low

1423900

PSF1
DNA replication complex GINS protein PSF1

1

0

High-throughput

0.251

Low

1423940

Q9D031
Ras suppressor protein 1

1

0

High-throughput

0.251

Low

1423968

RT30
Large ribosomal subunit protein mL65

1

0

High-throughput

0.251

Low

1423990

MESH1
Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase MESH1

1

0

High-throughput

0.251

Low

1424033

COA3
Cytochrome c oxidase assembly factor 3 homolog, mitochondrial

1

0

High-throughput

0.251

Low

1424135

DIESL
DGAT1/2-independent enzyme synthesizing storage lipids

1

0

High-throughput

0.251

Low

1424158

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

0

High-throughput

0.251

Low

1424173

F217A
Protein FAM217A

1

0

High-throughput

0.251

Low

1440867

SPP2A
Signal peptide peptidase-like 2A

1

0

High-throughput

0.251

Low

1440905

ARPC3
Actin-related protein 2/3 complex subunit 3

1

0

High-throughput

0.251

Low

1440906

NUFP1
FMR1-interacting protein NUFIP1

1

0

High-throughput

0.251

Low

1440912

CPXM1
Probable carboxypeptidase X1

1

0

High-throughput

0.251

Low

1440914

RED
Protein Red

1

0

High-throughput

0.251

Low

1440919

UBL3
Ubiquitin-like protein 3

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025