Protein: FLCN
Folliculin (BHD skin lesion fibrofolliculoma protein) (Birt-Hogg-Dube syndrome protein)

Gene: FLCN
Organism: Homo sapiens
Interactions: 100
UniProt ID: Q8NFG4

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001701 - in utero embryonic development
GO:0004857 - enzyme inhibitor activity
GO:0005096 - GTPase activator activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1244353

FNIP1
Folliculin-interacting protein 1

5

2

Small-scale

0.935

High

1244375

FNIP2
Folliculin-interacting protein 2

5

2

Small-scale

0.919

High

1184608

RRAGA
Ras-related GTP-binding protein A

1

3

Small-scale

0.724

High

1244358

AGAP3
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3

2

3

High-throughput

0.628

High

306238

GBRAP
Gamma-aminobutyric acid receptor-associated protein

2

2

Small-scale

0.619

High

1139772

RRAGB
Ras-related GTP-binding protein B

1

3

Small-scale

0.618

High

1244369

RRAGC
Ras-related GTP-binding protein C

1

3

Small-scale

0.618

High

1244372

RRAGD
Ras-related GTP-binding protein D

1

3

Small-scale

0.618

High

1244380

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

2

3

High-throughput

0.611

High

164242

ZN609
Zinc finger protein 609

2

0

High-throughput

0.602

High

422695

PGK2
Phosphoglycerate kinase 2

2

0

High-throughput

0.602

High

560286

DPEP1
Dipeptidase 1

2

0

High-throughput

0.602

High

1224680

WDFY3
WD repeat and FYVE domain-containing protein 3

2

0

High-throughput

0.602

High

1244356

F120B
Constitutive coactivator of peroxisome proliferator-activated receptor gamma

2

0

High-throughput

0.602

High

982298

1433F
14-3-3 protein eta

2

1

High-throughput

0.601

High

262290

ULK1
Serine/threonine-protein kinase ULK1

2

0

Small-scale

0.598

High

845087

RAB7A
Ras-related protein Rab-7a

2

6

Small-scale

0.584

High

1244378

FBW1B
F-box/WD repeat-containing protein 11

2

1

High-throughput

0.584

High

393821

ALDOB
Fructose-bisphosphate aldolase B

1

1

High-throughput

0.541

High

432074

HS90A
Heat shock protein HSP 90-alpha

1

0

Small-scale

0.537

High

271970

CTAG2
Cancer/testis antigen 2

1

1

High-throughput

0.536

High

871442

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

1

High-throughput

0.536

High

942534

CTG1B
Cancer/testis antigen 1

1

1

High-throughput

0.536

High

1087058

H2A2C
Histone H2A type 2-C

1

1

High-throughput

0.536

High

1216231

H2A2B
Histone H2A type 2-B

1

1

High-throughput

0.536

High

450916

F16P1
Fructose-1,6-bisphosphatase 1

1

0

High-throughput

0.518

High

1223495

TEFF1
Tomoregulin-1

1

0

High-throughput

0.518

High

1244373

SIAS
Sialic acid synthase

1

0

High-throughput

0.518

High

499943

CH60
60 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.515

High

1012671

LTOR4
Ragulator complex protein LAMTOR4

1

0

High-throughput

0.513

High

1151987

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.513

High

1232041

LRC25
Leucine-rich repeat-containing protein 25

1

0

High-throughput

0.513

High

1244363

SEM4C
Semaphorin-4C

1

0

High-throughput

0.513

High

1244366

BTBD1
BTB/POZ domain-containing protein 1

1

0

High-throughput

0.513

High

1244371

VTA1
Vacuolar protein sorting-associated protein VTA1 homolog

1

0

High-throughput

0.513

High

1244382

RPC10
DNA-directed RNA polymerase III subunit RPC10

1

0

High-throughput

0.513

High

1244364

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

2

Small-scale

0.501

High

395253

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

871039

AAKG1
5'-AMP-activated protein kinase subunit gamma-1

1

0

Small-scale

0.479

High

160939

RAB7L
Ras-related protein Rab-7L1

1

8

Small-scale

0.479

High

375979

ALDOA
Fructose-bisphosphate aldolase A

1

1

Small-scale

0.479

High

591632

RAB3B
Ras-related protein Rab-3B

1

3

Small-scale

0.479

High

842961

TCPQ
T-complex protein 1 subunit theta

1

2

Small-scale

0.479

High

843293

TCPD
T-complex protein 1 subunit delta

1

1

Small-scale

0.479

High

844631

RAB5C
Ras-related protein Rab-5C

1

1

Small-scale

0.479

High

845619

RAB9A
Ras-related protein Rab-9A

1

5

Small-scale

0.479

High

845870

RAB13
Ras-related protein Rab-13

1

3

Small-scale

0.479

High

894774

RAB8A
Ras-related protein Rab-8A

1

3

Small-scale

0.479

High

895189

RAB2A
Ras-related protein Rab-2A

1

2

Small-scale

0.479

High

895521

RAB10
Ras-related protein Rab-10

1

3

Small-scale

0.479

High

896657

RAB14
Ras-related protein Rab-14

1

2

Small-scale

0.479

High

918910

RAB1A
Ras-related protein Rab-1A

1

2

Small-scale

0.479

High

943361

TCPB
T-complex protein 1 subunit beta

1

1

Small-scale

0.479

High

1044501

RAB32
Ras-related protein Rab-32

1

8

Small-scale

0.479

High

1070310

RAB35
Ras-related protein Rab-35

1

4

Small-scale

0.479

High

1126223

RABL3
Rab-like protein 3

1

8

Small-scale

0.479

High

1153242

RAB12
Ras-related protein Rab-12

1

4

Small-scale

0.479

High

1244355

RAB7B
Ras-related protein Rab-7b

1

7

Small-scale

0.479

High

1244359

TCPH
T-complex protein 1 subunit eta

1

1

Small-scale

0.479

High

1244362

RAB34
Ras-related protein Rab-34

1

4

Small-scale

0.479

High

1244370

RAB18
Ras-related protein Rab-18

1

5

Small-scale

0.479

High

1244379

CHIP
E3 ubiquitin-protein ligase CHIP

1

1

Small-scale

0.479

High

1244381

FBW1A
F-box/WD repeat-containing protein 1A

1

1

High-throughput

0.479

High

205708

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

268794

SF3B1
Splicing factor 3B subunit 1

1

0

Small-scale

0.458

High

314359

AHSA1
Activator of 90 kDa heat shock protein ATPase homolog 1

1

0

Small-scale

0.458

High

324510

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

377506

GCR
Glucocorticoid receptor

1

0

High-throughput

0.458

High

649616

RL10
Large ribosomal subunit protein uL16

1

0

Small-scale

0.458

High

684894

STIP1
Stress-induced-phosphoprotein 1

1

0

Small-scale

0.458

High

858654

PPP5
Serine/threonine-protein phosphatase 5

1

0

Small-scale

0.458

High

933284

TBA1B
Tubulin alpha-1B chain

1

0

Small-scale

0.458

High

999628

AHNK
Neuroblast differentiation-associated protein AHNAK

1

0

Small-scale

0.458

High

1019031

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

1042082

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1044792

RIN1
Ras and Rab interactor 1

1

0

Small-scale

0.458

High

1065390

RB3GP
Rab3 GTPase-activating protein catalytic subunit

1

0

Small-scale

0.458

High

1069432

TEBP
Prostaglandin E synthase 3

1

0

Small-scale

0.458

High

1073073

SF3B3
Splicing factor 3B subunit 3

1

0

Small-scale

0.458

High

1082885

CDC37
Hsp90 co-chaperone Cdc37

1

0

Small-scale

0.458

High

1167457

RFIP1
Rab11 family-interacting protein 1

1

0

Small-scale

0.458

High

1216126

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

0

Small-scale

0.458

High

1244352

PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

1

0

Small-scale

0.458

High

1244354

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

0

Small-scale

0.458

High

1244357

TSN17
Tetraspanin-17

1

0

Small-scale

0.458

High

1244360

MEP50
Methylosome protein WDR77

1

0

Small-scale

0.458

High

1244368

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1244377

FEM1B
Protein fem-1 homolog B

1

0

Small-scale

0.458

High

91539

E7EUN2
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1

1

3

High-throughput

0.445

High

904886

1433G
14-3-3 protein gamma

1

1

High-throughput

0.445

High

1244367

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

2

High-throughput

0.445

High

73232

B4DZK1
cDNA FLJ50036, weakly similar to Myosin-11

1

1

High-throughput

0.439

High

1244365

RB33B
Ras-related protein Rab-33B

1

4

Small-scale

0.437

High

1244376

LTOR3
Ragulator complex protein LAMTOR3

1

0

High-throughput

0.426

High

1244374

CC180
Coiled-coil domain-containing protein 180

1

1

High-throughput

0.417

High

170555

LRAD4
Low-density lipoprotein receptor class A domain-containing protein 4

3

0

High-throughput

0.347

High

1238460

BANP
Protein BANP

2

0

High-throughput

0.328

High

1135026

TSTD2
Thiosulfate sulfurtransferase/rhodanese-like domain-containing protein 2

1

0

High-throughput

0.282

High

1244361

HEMGN
Hemogen

1

0

High-throughput

0.282

High

1156936

HIBCH
3-hydroxyisobutyryl-CoA hydrolase, mitochondrial

1

0

High-throughput

0.269

Low


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Last updated: 15 Jul 2024