Protein: IF5
Eukaryotic translation initiation factor 5 (eIF-5)

Gene: IF5, EIF5
Organism: Homo sapiens
Interactions: 164
UniProt ID: P55010

Gene Ontology (top 5):
GO:0001731 - formation of translation preinitiation complex
GO:0001732 - formation of cytoplasmic translation initiation complex
GO:0003723 - RNA binding
GO:0003743 - translation initiation factor activity
GO:0005092 - GDP-dissociation inhibitor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

780637

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

6

High-throughput

0.691

High

783574

EIF1
Eukaryotic translation initiation factor 1

1

2

High-throughput

0.691

High

873818

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.691

High

873832

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

5

High-throughput

0.691

High

873886

DUS12
Dual specificity protein phosphatase 12

3

0

High-throughput

0.646

High

157122

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

3

0

High-throughput

0.638

High

873873

CLPB
Mitochondrial disaggregase

2

4

High-throughput

0.628

High

588867

IF2B
Eukaryotic translation initiation factor 2 subunit 2

2

3

Small-scale

0.619

High

275827

EIF3G
Eukaryotic translation initiation factor 3 subunit G

2

4

Small-scale

0.611

High

873809

1433E
14-3-3 protein epsilon

2

1

Small-scale

0.611

High

322377

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

1

High-throughput

0.584

High

369251

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

873846

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

1

High-throughput

0.571

High

412107

FYN
Tyrosine-protein kinase Fyn

2

0

High-throughput

0.547

High

78285

EIFCL
Eukaryotic translation initiation factor 3 subunit C-like protein

1

3

High-throughput

0.536

High

176977

EIF3H
Eukaryotic translation initiation factor 3 subunit H

1

5

High-throughput

0.536

High

275313

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.536

High

283442

SRP72
Signal recognition particle subunit SRP72

1

1

High-throughput

0.536

High

398673

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

6

High-throughput

0.536

High

445332

RSSA
Small ribosomal subunit protein uS2

1

2

High-throughput

0.536

High

516428

PABP1
Polyadenylate-binding protein 1

1

1

High-throughput

0.536

High

550680

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.536

High

586638

CSK22
Casein kinase II subunit alpha'

1

4

High-throughput

0.536

High

616198

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.536

High

736329

RL4
Large ribosomal subunit protein uL4

1

2

High-throughput

0.536

High

759572

RS19
Small ribosomal subunit protein eS19

1

2

High-throughput

0.536

High

773283

RL13A
Large ribosomal subunit protein uL13

1

3

High-throughput

0.536

High

788789

RS27
Small ribosomal subunit protein eS27

1

2

High-throughput

0.536

High

805604

RL27A
Large ribosomal subunit protein uL15

1

1

High-throughput

0.536

High

813271

CAPZB
F-actin-capping protein subunit beta

1

1

High-throughput

0.536

High

820858

PRC2A
Protein PRRC2A

1

1

High-throughput

0.536

High

834401

EI2BB
Translation initiation factor eIF2B subunit beta

1

7

High-throughput

0.536

High

873793

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

5

High-throughput

0.536

High

873796

IF4A1
Eukaryotic initiation factor 4A-I

1

2

High-throughput

0.536

High

873797

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.536

High

873800

ABCE1
ATP-binding cassette sub-family E member 1

1

1

High-throughput

0.536

High

873803

1433G
14-3-3 protein gamma

1

2

High-throughput

0.536

High

873804

RS7
Small ribosomal subunit protein eS7

1

3

High-throughput

0.536

High

873805

RS8
Small ribosomal subunit protein eS8

1

1

High-throughput

0.536

High

873806

RS15A
Small ribosomal subunit protein uS8

1

2

High-throughput

0.536

High

873807

RS16
Small ribosomal subunit protein uS9

1

1

High-throughput

0.536

High

873810

RS14
Small ribosomal subunit protein uS11

1

3

High-throughput

0.536

High

873812

RS18
Small ribosomal subunit protein uS13

1

1

High-throughput

0.536

High

873813

RS11
Small ribosomal subunit protein uS17

1

2

High-throughput

0.536

High

873814

RS4X
Small ribosomal subunit protein eS4, X isoform

1

1

High-throughput

0.536

High

873815

RL23A
Large ribosomal subunit protein uL23

1

2

High-throughput

0.536

High

873816

RS6
Small ribosomal subunit protein eS6

1

2

High-throughput

0.536

High

873819

RS24
Small ribosomal subunit protein eS24

1

1

High-throughput

0.536

High

873824

RL31
Large ribosomal subunit protein eL31

1

2

High-throughput

0.536

High

873830

RACK1
Small ribosomal subunit protein RACK1

1

5

High-throughput

0.536

High

873835

PABP4
Polyadenylate-binding protein 4

1

1

High-throughput

0.536

High

873836

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

4

High-throughput

0.536

High

873838

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

2

High-throughput

0.536

High

873840

EI2BA
Translation initiation factor eIF2B subunit alpha

1

7

High-throughput

0.536

High

873845

PRC2B
Protein PRRC2B

1

2

High-throughput

0.536

High

873852

RS27L
Ribosomal protein eS27-like

1

2

High-throughput

0.536

High

873853

EIF3M
Eukaryotic translation initiation factor 3 subunit M

1

1

High-throughput

0.536

High

873860

PSPC1
Paraspeckle component 1

1

3

High-throughput

0.536

High

873870

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

3

High-throughput

0.536

High

873877

EI2BG
Translation initiation factor eIF2B subunit gamma

1

4

High-throughput

0.536

High

873880

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

High-throughput

0.536

High

873885

EI2BD
Translation initiation factor eIF2B subunit delta

1

5

High-throughput

0.536

High

873889

CD2AP
CD2-associated protein

1

1

High-throughput

0.536

High

388336

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.518

High

873843

PUM1
Pumilio homolog 1

1

0

High-throughput

0.518

High

873863

NEUG
Neurogranin

1

0

High-throughput

0.518

High

791416

HD
Huntingtin

1

2

High-throughput

0.515

High

176745

EIF3D
Eukaryotic translation initiation factor 3 subunit D

1

0

High-throughput

0.513

High

275999

EIF3J
Eukaryotic translation initiation factor 3 subunit J

1

0

High-throughput

0.513

High

362972

FINC
Fibronectin

1

0

High-throughput

0.513

High

400265

RLA1
Large ribosomal subunit protein P1

1

0

High-throughput

0.513

High

400493

RLA2
Large ribosomal subunit protein P2

1

0

High-throughput

0.513

High

416954

IF4E
Eukaryotic translation initiation factor 4E

1

0

High-throughput

0.513

High

649388

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.513

High

722348

RL22
Large ribosomal subunit protein eL22

1

0

High-throughput

0.513

High

790312

RL35
Large ribosomal subunit protein uL29

1

0

High-throughput

0.513

High

806258

RL21
Large ribosomal subunit protein eL21

1

0

High-throughput

0.513

High

873795

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

0

High-throughput

0.513

High

873811

RS23
Small ribosomal subunit protein uS12

1

0

High-throughput

0.513

High

873820

RS25
Small ribosomal subunit protein eS25

1

0

High-throughput

0.513

High

873821

RS26
Small ribosomal subunit protein eS26

1

0

High-throughput

0.513

High

873822

RS28
Small ribosomal subunit protein eS28

1

0

High-throughput

0.513

High

873825

RL10A
Large ribosomal subunit protein uL1

1

0

High-throughput

0.513

High

873826

RL32
Large ribosomal subunit protein eL32

1

0

High-throughput

0.513

High

873827

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.513

High

873828

RL38
Large ribosomal subunit protein eL38

1

0

High-throughput

0.513

High

873829

RS21
Small ribosomal subunit protein eS21

1

0

High-throughput

0.513

High

873841

FA50A
Protein FAM50A

1

0

High-throughput

0.513

High

873855

NUFP2
FMR1-interacting protein NUFIP2

1

0

High-throughput

0.513

High

873881

SAE1
SUMO-activating enzyme subunit 1

1

0

High-throughput

0.513

High

873883

EIF3K
Eukaryotic translation initiation factor 3 subunit K

1

0

High-throughput

0.513

High

873887

EIF3L
Eukaryotic translation initiation factor 3 subunit L

1

0

High-throughput

0.513

High

873888

RL36
Large ribosomal subunit protein eL36

1

0

High-throughput

0.513

High

814064

IF1AX
Eukaryotic translation initiation factor 1A, X-chromosomal

1

1

Small-scale

0.506

High

174753

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

1

High-throughput

0.501

High

394405

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

873867

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.489

High

873868

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.489

High

873798

CDC42
Cell division control protein 42 homolog

1

0

High-throughput

0.480

High

162545

XPO1
Exportin-1

1

5

High-throughput

0.479

High

226974

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

232826

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

2

High-throughput

0.479

High

241486

H2B1K
Histone H2B type 1-K

1

2

High-throughput

0.479

High

384561

NTRK1
High affinity nerve growth factor receptor

1

6

High-throughput

0.479

High

568599

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

5

Small-scale

0.479

High

569461

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.479

High

642244

RL13
Large ribosomal subunit protein eL13

1

2

High-throughput

0.479

High

668544

PML
Protein PML

1

3

High-throughput

0.479

High

779093

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

873794

H2B1D
Histone H2B type 1-D

1

2

High-throughput

0.479

High

873801

RS3A
Small ribosomal subunit protein eS1

1

3

High-throughput

0.479

High

873808

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

873817

H2B1C
Histone H2B type 1-C/E/F/G/I

1

2

High-throughput

0.479

High

873823

RL39
Large ribosomal subunit protein eL39

1

1

High-throughput

0.479

High

873831

RL6
Large ribosomal subunit protein eL6

1

1

High-throughput

0.479

High

873834

TIF1B
Transcription intermediary factor 1-beta

1

2

High-throughput

0.479

High

873837

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

873848

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.479

High

873849

RHDF2
Inactive rhomboid protein 2

1

1

High-throughput

0.479

High

873850

RICTR
Rapamycin-insensitive companion of mTOR

1

1

High-throughput

0.479

High

873851

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

873856

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

1

High-throughput

0.479

High

873858

SMC5
Structural maintenance of chromosomes protein 5

1

1

High-throughput

0.479

High

873862

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

873864

CSN5
COP9 signalosome complex subunit 5

1

5

High-throughput

0.479

High

873875

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

873876

ANLN
Anillin

1

1

High-throughput

0.479

High

873878

BRWD1
Bromodomain and WD repeat-containing protein 1

1

3

High-throughput

0.479

High

873882

HDAC6
Histone deacetylase 6

1

2

High-throughput

0.479

High

873884

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

129726

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

0

High-throughput

0.458

High

344957

CYTN
Cystatin-SN

1

0

Small-scale

0.458

High

359798

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

503759

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

521827

CADH1
Cadherin-1

1

0

High-throughput

0.458

High

873799

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

873833

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

0

High-throughput

0.458

High

873839

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

0

High-throughput

0.458

High

873842

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

873857

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

873861

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

0

High-throughput

0.458

High

873865

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

873866

SNX27
Sorting nexin-27

1

0

High-throughput

0.458

High

873869

NECD
Necdin

1

0

High-throughput

0.458

High

873874

TXNIP
Thioredoxin-interacting protein

1

0

Small-scale

0.458

High

90070

D6RAT0
Small ribosomal subunit protein eS1

1

3

High-throughput

0.445

High

110719

H3BUK8
Large ribosomal subunit protein eL13

1

1

High-throughput

0.445

High

401701

JUN
Transcription factor Jun

1

3

High-throughput

0.445

High

496644

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

528831

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.445

High

873872

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.445

High

100626

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

352002

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

1

High-throughput

0.437

High

552336

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

650781

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

720069

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

873802

WDR5
WD repeat-containing protein 5

1

2

High-throughput

0.437

High

873854

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

873859

RHBL4
Rhomboid-related protein 4

1

1

High-throughput

0.437

High

873844

R39L5
Putative ribosomal protein eL39-like 5

1

1

High-throughput

0.407

High

831144

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.373

High

873879

POTE1
Protection of telomeres protein 1

1

0

High-throughput

0.279

Low

873847

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low

873871

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024