Protein: KS6A2
Ribosomal protein S6 kinase alpha-2 (S6K-alpha-2) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 2) (p90-RSK 2) (p90RSK2) (MAP kinase-activated protein kinase 1c) (MAPK-activated protein kinase 1c) (MAPKAP kinase 1c) (MAPKAPK-1c) (Ribosomal S6 kinase 3) (RSK-3) (pp90RSK3)

Gene: KS6A2, RPS6KA2
Organism: Homo sapiens
Interactions: 182
UniProt ID: Q15349

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004674 - protein serine/threonine kinase activity
GO:0004711 - ribosomal protein S6 kinase activity
GO:0004712 - protein serine/threonine/tyrosine kinase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

658953

MK01
Mitogen-activated protein kinase 1

11

20

Small-scale

0.979

High

647585

MK03
Mitogen-activated protein kinase 3

6

20

Small-scale

0.949

High

1071640

KS6A1
Ribosomal protein S6 kinase alpha-1

5

16

High-throughput

0.925

High

931649

CSK2B
Casein kinase II subunit beta

4

7

High-throughput

0.897

High

850654

KS6A3
Ribosomal protein S6 kinase alpha-3

4

15

High-throughput

0.892

High

1017902

GRSF1
G-rich sequence factor 1

3

12

High-throughput

0.861

High

412203

FYN
Tyrosine-protein kinase Fyn

2

20

High-throughput

0.811

High

601516

FGFR2
Fibroblast growth factor receptor 2

2

20

High-throughput

0.811

High

1015753

KIF1A
Kinesin-like protein KIF1A

2

1

High-throughput

0.789

High

1071639

KS6A2
Ribosomal protein S6 kinase alpha-2

2

15

Small-scale

0.768

High

1071722

SHAN1
SH3 and multiple ankyrin repeat domains protein 1

1

3

High-throughput

0.692

High

173894

MK13
Mitogen-activated protein kinase 13

1

20

High-throughput

0.691

High

508015

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.691

High

785541

ACTY
Beta-centractin

1

10

High-throughput

0.691

High

1071643

CDC37
Hsp90 co-chaperone Cdc37

1

15

High-throughput

0.691

High

1071645

AMHR2
Anti-Muellerian hormone type-2 receptor

1

3

High-throughput

0.691

High

1071696

STRAB
STE20-related kinase adapter protein beta

1

15

High-throughput

0.691

High

1071709

ARP10
Actin-related protein 10

1

10

High-throughput

0.691

High

1049957

SCRIB
Protein scribble homolog

3

6

Small-scale

0.684

High

157912

KLF11
Krueppel-like factor 11

1

6

High-throughput

0.665

High

456327

LOX5
Polyunsaturated fatty acid 5-lipoxygenase

2

2

High-throughput

0.628

High

1071675

TRI11
E3 ubiquitin-protein ligase TRIM11

2

2

High-throughput

0.628

High

153130

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

17

High-throughput

0.618

High

227519

PRKN
E3 ubiquitin-protein ligase parkin

1

17

High-throughput

0.618

High

236420

RNBP6
Ran-binding protein 6

1

5

High-throughput

0.618

High

309484

MTMR5
Myotubularin-related protein 5

1

2

High-throughput

0.618

High

331014

PAK4
Serine/threonine-protein kinase PAK 4

1

19

High-throughput

0.618

High

431873

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

433360

YES
Tyrosine-protein kinase Yes

1

20

High-throughput

0.618

High

438190

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

542883

BRAF
Serine/threonine-protein kinase B-raf

1

15

Small-scale

0.618

High

566395

KPCA
Protein kinase C alpha type

1

17

Small-scale

0.618

High

586765

CSK22
Casein kinase II subunit alpha'

1

13

High-throughput

0.618

High

665243

EPHA2
Ephrin type-A receptor 2

1

9

High-throughput

0.618

High

796581

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.618

High

940428

CXAR
Coxsackievirus and adenovirus receptor

1

1

High-throughput

0.618

High

968381

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.618

High

969084

KPCE
Protein kinase C epsilon type

1

17

Small-scale

0.618

High

980378

NOTC2
Neurogenic locus notch homolog protein 2

1

2

High-throughput

0.618

High

1071652

BCOR
BCL-6 corepressor

1

1

High-throughput

0.618

High

1071653

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.618

High

1071655

LIPB1
Liprin-beta-1

1

10

High-throughput

0.618

High

1071670

FERM2
Fermitin family homolog 2

1

1

High-throughput

0.618

High

1071703

PKHA5
Pleckstrin homology domain-containing family A member 5

1

16

High-throughput

0.618

High

1071710

IBTK
Inhibitor of Bruton tyrosine kinase

1

2

High-throughput

0.618

High

1071711

STK39
STE20/SPS1-related proline-alanine-rich protein kinase

1

13

High-throughput

0.618

High

1071717

MACF1
Microtubule-actin cross-linking factor 1, isoforms 1/2/3/4/5

1

3

High-throughput

0.618

High

1071723

MRCKB
Serine/threonine-protein kinase MRCK beta

1

19

High-throughput

0.618

High

312276

IPO7
Importin-7

2

11

High-throughput

0.611

High

1071713

ZMYM5
Zinc finger MYM-type protein 5

2

1

High-throughput

0.611

High

1071650

IIGP5
Interferon-inducible GTPase 5

2

2

High-throughput

0.574

High

1071657

MISP
Mitotic interactor and substrate of PLK1

2

2

High-throughput

0.574

High

919986

RS15
Small ribosomal subunit protein uS19

2

1

High-throughput

0.571

High

793320

MUC18
Cell surface glycoprotein MUC18

1

4

High-throughput

0.553

High

1071666

NECT2
Nectin-2

1

3

High-throughput

0.553

High

1071679

KIRR1
Kin of IRRE-like protein 1

1

2

High-throughput

0.553

High

1071692

EFHD1
EF-hand domain-containing protein D1

1

1

High-throughput

0.553

High

825191

RL34
Large ribosomal subunit protein eL34

2

0

High-throughput

0.547

High

278613

DCTN3
Dynactin subunit 3

1

1

High-throughput

0.536

High

858261

TXTP
Tricarboxylate transport protein, mitochondrial

1

3

High-throughput

0.536

High

1054983

FAT1
Protocadherin Fat 1

1

1

High-throughput

0.536

High

1069349

TEBP
Prostaglandin E synthase 3

1

3

High-throughput

0.536

High

1071654

SPRE2
Sprouty-related, EVH1 domain-containing protein 2

1

7

High-throughput

0.536

High

1071665

PDC6I
Programmed cell death 6-interacting protein

1

12

High-throughput

0.536

High

1071669

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

7

High-throughput

0.536

High

1071671

EFMT3
EEF1A lysine methyltransferase 3

1

6

High-throughput

0.536

High

1071685

NEB2
Neurabin-2

1

16

High-throughput

0.536

High

1071691

DCTN5
Dynactin subunit 5

1

1

High-throughput

0.536

High

1071698

KLH25
Kelch-like protein 25

1

3

High-throughput

0.536

High

394747

A4
Amyloid-beta precursor protein

1

9

High-throughput

0.515

High

126691

DCTN6
Dynactin subunit 6

1

0

High-throughput

0.513

High

557384

BGAL
Beta-galactosidase

1

0

High-throughput

0.513

High

345441

FOS
Protein c-Fos

1

6

Small-scale

0.501

High

402044

JUN
Transcription factor Jun

1

12

Small-scale

0.501

High

916599

RS6
Small ribosomal subunit protein eS6

1

10

Small-scale

0.501

High

1021498

DLG1
Disks large homolog 1

1

9

High-throughput

0.501

High

957401

IDD
Integral membrane protein DGCR2/IDD

1

3

High-throughput

0.489

High

1071649

RL7L
Ribosomal protein uL30-like

1

2

High-throughput

0.489

High

1071663

SHRM3
Protein Shroom3

1

2

High-throughput

0.489

High

1071676

I17RA
Interleukin-17 receptor A

1

3

High-throughput

0.489

High

1071694

CDHR2
Cadherin-related family member 2

1

3

High-throughput

0.489

High

1071719

ADA18
Disintegrin and metalloproteinase domain-containing protein 18

1

1

High-throughput

0.489

High

386780

P53
Cellular tumor antigen p53

1

5

Small-scale

0.481

High

1052880

FLNC
Filamin-C

1

3

High-throughput

0.481

High

118033

SNP23
Synaptosomal-associated protein 23

1

1

High-throughput

0.479

High

119637

STXB3
Syntaxin-binding protein 3

1

1

High-throughput

0.479

High

129296

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

1

20

High-throughput

0.479

High

131440

IMA4
Importin subunit alpha-4

1

5

High-throughput

0.479

High

150707

DVL1
Segment polarity protein dishevelled homolog DVL-1

1

8

High-throughput

0.479

High

151801

IRS4
Insulin receptor substrate 4

1

4

High-throughput

0.479

High

176788

EIF3D
Eukaryotic translation initiation factor 3 subunit D

1

1

High-throughput

0.479

High

178169

IPO8
Importin-8

1

8

High-throughput

0.479

High

216511

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

2

High-throughput

0.479

High

239137

CTND1
Catenin delta-1

1

7

High-throughput

0.479

High

257178

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

1

3

High-throughput

0.479

High

296914

LTN1
E3 ubiquitin-protein ligase listerin

1

4

High-throughput

0.479

High

403889

ITB1
Integrin beta-1

1

5

High-throughput

0.479

High

437364

4F2
Amino acid transporter heavy chain SLC3A2

1

1

High-throughput

0.479

High

607660

NDKB
Nucleoside diphosphate kinase B

1

2

High-throughput

0.479

High

655378

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

10

High-throughput

0.479

High

670037

MARCS
Myristoylated alanine-rich C-kinase substrate

1

3

High-throughput

0.479

High

684052

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

823258

MRP
MARCKS-related protein

1

1

High-throughput

0.479

High

840256

PEX5
Peroxisomal targeting signal 1 receptor

1

3

High-throughput

0.479

High

876798

NP1L1
Nucleosome assembly protein 1-like 1

1

3

High-throughput

0.479

High

908583

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

4

High-throughput

0.479

High

909590

1433E
14-3-3 protein epsilon

1

4

High-throughput

0.479

High

958810

EM55
55 kDa erythrocyte membrane protein

1

6

High-throughput

0.479

High

966067

LAT1
Large neutral amino acids transporter small subunit 1

1

2

High-throughput

0.479

High

1037238

TBB3
Tubulin beta-3 chain

1

17

High-throughput

0.479

High

1040861

MTMR1
Myotubularin-related protein 1

1

3

High-throughput

0.479

High

1058668

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

2

High-throughput

0.479

High

1071647

MPP7
MAGUK p55 subfamily member 7

1

6

High-throughput

0.479

High

1071648

STEA3
Metalloreductase STEAP3

1

2

High-throughput

0.479

High

1071651

RICTR
Rapamycin-insensitive companion of mTOR

1

3

High-throughput

0.479

High

1071656

CNDG2
Condensin-2 complex subunit G2

1

1

High-throughput

0.479

High

1071658

ABI1
Abl interactor 1

1

14

High-throughput

0.479

High

1071659

VPS52
Vacuolar protein sorting-associated protein 52 homolog

1

1

High-throughput

0.479

High

1071660

DOCK4
Dedicator of cytokinesis protein 4

1

6

High-throughput

0.479

High

1071664

FRS2
Fibroblast growth factor receptor substrate 2

1

2

High-throughput

0.479

High

1071667

CBP
CREB-binding protein

1

13

Small-scale

0.479

High

1071668

RENT1
Regulator of nonsense transcripts 1

1

2

High-throughput

0.479

High

1071674

AP2M1
AP-2 complex subunit mu

1

6

High-throughput

0.479

High

1071677

LTV1
Protein LTV1 homolog

1

1

High-throughput

0.479

High

1071678

SAHH3
Adenosylhomocysteinase 3

1

2

High-throughput

0.479

High

1071682

IPO9
Importin-9

1

11

High-throughput

0.479

High

1071683

S38A2
Sodium-coupled neutral amino acid symporter 2

1

1

High-throughput

0.479

High

1071686

PKP4
Plakophilin-4

1

8

High-throughput

0.479

High

1071687

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

7

High-throughput

0.479

High

1071688

CDCA3
Cell division cycle-associated protein 3

1

1

High-throughput

0.479

High

1071689

NP1L4
Nucleosome assembly protein 1-like 4

1

3

High-throughput

0.479

High

1071695

YTHD1
YTH domain-containing family protein 1

1

2

High-throughput

0.479

High

1071701

E41LB
Band 4.1-like protein 4B

1

6

High-throughput

0.479

High

1071704

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

20

High-throughput

0.479

High

1071705

WDR6
tRNA

1

11

High-throughput

0.479

High

1071707

PAPD1
Poly(A) RNA polymerase, mitochondrial

1

2

High-throughput

0.479

High

1071708

GTSE1
G2 and S phase-expressed protein 1

1

2

High-throughput

0.479

High

1071712

ADDG
Gamma-adducin

1

2

High-throughput

0.479

High

1071714

DDX41
Probable ATP-dependent RNA helicase DDX41

1

8

High-throughput

0.479

High

1071718

NISCH
Nischarin

1

5

High-throughput

0.479

High

1071721

TELO2
Telomere length regulation protein TEL2 homolog

1

1

High-throughput

0.479

High

180871

YKT6
Synaptobrevin homolog YKT6

1

0

High-throughput

0.458

High

327666

ECD
Protein ecdysoneless homolog

1

0

High-throughput

0.458

High

536090

CD99
CD99 antigen

1

0

High-throughput

0.458

High

1046837

BYST
Bystin

1

0

High-throughput

0.458

High

1049753

EFR3A
Protein EFR3 homolog A

1

0

High-throughput

0.458

High

1071642

VAMP3
Vesicle-associated membrane protein 3

1

0

High-throughput

0.458

High

1071646

TSR1
Pre-rRNA-processing protein TSR1 homolog

1

0

High-throughput

0.458

High

1071661

BBS1
Bardet-Biedl syndrome 1 protein

1

0

High-throughput

0.458

High

1071673

HAUS1
HAUS augmin-like complex subunit 1

1

0

High-throughput

0.458

High

1071680

ELMO2
Engulfment and cell motility protein 2

1

0

High-throughput

0.458

High

1071693

THUM3
tRNA

1

0

High-throughput

0.458

High

1071697

NAT10
RNA cytidine acetyltransferase

1

0

High-throughput

0.458

High

1071702

SDS3
Sin3 histone deacetylase corepressor complex component SDS3

1

0

High-throughput

0.458

High

1071706

ZCHC3
Zinc finger CCHC domain-containing protein 3

1

0

High-throughput

0.458

High

1071720

WAC2C
WASH complex subunit 2C

1

0

High-throughput

0.458

High

1057468

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

3

High-throughput

0.445

High

78307

EIFCL
Eukaryotic translation initiation factor 3 subunit C-like protein

1

7

High-throughput

0.437

High

438766

SRPRA
Signal recognition particle receptor subunit alpha

1

1

High-throughput

0.437

High

815777

SC6A8
Sodium- and chloride-dependent creatine transporter 1

1

2

High-throughput

0.437

High

873921

S12A2
Solute carrier family 12 member 2

1

1

High-throughput

0.437

High

974832

CAV1
Caveolin-1

1

1

High-throughput

0.437

High

1048588

DSG2
Desmoglein-2

1

4

High-throughput

0.437

High

1052400

FLOT2
Flotillin-2

1

5

High-throughput

0.437

High

1071644

OCLN
Occludin

1

1

High-throughput

0.437

High

1071662

VANG1
Vang-like protein 1

1

3

High-throughput

0.437

High

1071690

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

2

High-throughput

0.437

High

1071699

S38A1
Sodium-coupled neutral amino acid symporter 1

1

1

High-throughput

0.437

High

1071700

S6A15
Sodium-dependent neutral amino acid transporter B(0)AT2

1

2

High-throughput

0.437

High

1071716

VANG2
Vang-like protein 2

1

3

High-throughput

0.437

High

1071724

ALG5
Dolichyl-phosphate beta-glucosyltransferase

1

2

High-throughput

0.437

High

1071725

S4A7
Sodium bicarbonate cotransporter 3

1

1

High-throughput

0.437

High

484509

ECE2
Endothelin-converting enzyme 2

1

2

High-throughput

0.407

High

280250

CBPD
Carboxypeptidase D

1

0

High-throughput

0.249

Low

315831

AGRL2
Adhesion G protein-coupled receptor L2

1

0

High-throughput

0.249

Low

872028

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

1

0

High-throughput

0.249

Low

1071641

AAAT
Neutral amino acid transporter B(0)

1

0

High-throughput

0.249

Low

1071672

ENTR1
Endosome-associated-trafficking regulator 1

1

0

High-throughput

0.249

Low

1071681

CLP1L
Lipid scramblase CLPTM1L

1

0

High-throughput

0.249

Low

1071684

PANX1
Pannexin-1

1

0

High-throughput

0.249

Low

1071715

S39AA
Zinc transporter ZIP10

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024