Protein: RUNX2
Runt-related transcription factor 2 (Acute myeloid leukemia 3 protein) (Core-binding factor subunit alpha-1) (CBF-alpha-1) (Oncogene AML-3) (Osteoblast-specific transcription factor 2) (OSF-2) (Polyomavirus enhancer-binding protein 2 alpha A subunit) (PEA2-alpha A) (PEBP2-alpha A) (SL3-3 enhancer factor 1 alpha A subunit) (SL3/AKV core-binding factor alpha A subunit)

Gene: RUNX2
Organism: Homo sapiens
Interactions: 76
UniProt ID: Q13950

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001503 - ossification

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1047408

PEBB
Core-binding factor subunit beta

5

8

Small-scale

0.922

High

808593

YAP1
Transcriptional coactivator YAP1

5

19

Small-scale

0.704

High

964324

RUNX1
Runt-related transcription factor 1

1

2

High-throughput

0.691

High

1045121

RUNX3
Runt-related transcription factor 3

1

2

High-throughput

0.691

High

950176

SMAD3
Mothers against decapentaplegic homolog 3

3

16

Small-scale

0.664

High

345430

FOS
Protein c-Fos

2

3

Small-scale

0.651

High

401979

JUN
Transcription factor Jun

2

3

Small-scale

0.651

High

567692

UBF1
Nucleolar transcription factor 1

3

8

Small-scale

0.646

High

880723

HDAC4
Histone deacetylase 4

3

16

Small-scale

0.640

High

998689

EP300
Histone acetyltransferase p300

3

8

Small-scale

0.640

High

1038362

HDAC1
Histone deacetylase 1

3

10

Small-scale

0.640

High

1047413

SMAD1
Mothers against decapentaplegic homolog 1

3

16

Small-scale

0.640

High

177291

HDAC3
Histone deacetylase 3

2

9

Small-scale

0.624

High

818802

SOX9
Transcription factor SOX-9

2

8

Small-scale

0.602

High

414278

RB
Retinoblastoma-associated protein

2

2

Small-scale

0.595

High

1037930

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

1

Small-scale

0.589

High

572357

LEG3
Galectin-3

2

1

Small-scale

0.584

High

1047428

SMAD5
Mothers against decapentaplegic homolog 5

2

16

Small-scale

0.584

High

1047432

HDAC6
Histone deacetylase 6

2

16

Small-scale

0.584

High

1047435

HDAC5
Histone deacetylase 5

2

16

Small-scale

0.584

High

1047423

KAT6B
Histone acetyltransferase KAT6B

1

4

Small-scale

0.578

High

1047410

HES1
Transcription factor HES-1

2

0

Small-scale

0.569

High

1047409

FHL2
Four and a half LIM domains protein 2

1

1

Small-scale

0.561

High

1047414

HIF1A
Hypoxia-inducible factor 1-alpha

1

2

Small-scale

0.561

High

1047422

HDAC7
Histone deacetylase 7

1

16

Small-scale

0.561

High

1047426

RBM14
RNA-binding protein 14

1

3

Small-scale

0.561

High

175385

PPM1D
Protein phosphatase 1D

1

0

Small-scale

0.554

High

1047434

CHIP
E3 ubiquitin-protein ligase CHIP

1

1

Small-scale

0.552

High

1047415

ZEP3
Transcription factor HIVEP3

1

0

Small-scale

0.537

High

324391

BAG3
BAG family molecular chaperone regulator 3

1

2

High-throughput

0.536

High

980602

TLE1
Transducin-like enhancer protein 1

1

9

Small-scale

0.536

High

1018383

TCF15
Transcription factor 15

1

6

High-throughput

0.536

High

1047417

FBW12
F-box/WD repeat-containing protein 12

1

2

High-throughput

0.536

High

499744

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.513

High

596049

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

1

0

High-throughput

0.513

High

1047433

FEM1B
Protein fem-1 homolog B

1

0

High-throughput

0.513

High

542011

ETS1
Protein C-ets-1

1

4

Small-scale

0.501

High

1047419

THOC4
THO complex subunit 4

1

2

Small-scale

0.501

High

1047430

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

11

Small-scale

0.501

High

82410

IGLL5
Immunoglobulin lambda-like polypeptide 5

1

2

High-throughput

0.489

High

513861

DMD
Dystrophin

1

0

High-throughput

0.480

High

125446

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

11

Small-scale

0.479

High

175875

P73
Tumor protein p73

1

2

Small-scale

0.479

High

203683

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

2

Small-scale

0.479

High

206960

SMAD6
Mothers against decapentaplegic homolog 6

1

16

Small-scale

0.479

High

386707

P53
Cellular tumor antigen p53

1

2

Small-scale

0.479

High

523742

XRCC6
X-ray repair cross-complementing protein 6

1

2

Small-scale

0.479

High

524920

XRCC5
X-ray repair cross-complementing protein 5

1

2

Small-scale

0.479

High

668671

PML
Protein PML

1

6

Small-scale

0.479

High

717071

CTNB1
Catenin beta-1

1

2

High-throughput

0.479

High

724233

MSX2
Homeobox protein MSX-2

1

1

Small-scale

0.479

High

776678

STAT3
Signal transducer and activator of transcription 3

1

1

Small-scale

0.479

High

786608

STA5A
Signal transducer and activator of transcription 5A

1

1

Small-scale

0.479

High

818032

SOX2
Transcription factor SOX-2

1

6

High-throughput

0.479

High

831307

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.479

High

881172

CTBP2
C-terminal-binding protein 2

1

2

High-throughput

0.479

High

921560

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

1

High-throughput

0.479

High

1031193

SKP2
S-phase kinase-associated protein 2

1

1

Small-scale

0.479

High

1042968

CUL4A
Cullin-4A

1

1

High-throughput

0.479

High

1043345

CUL4B
Cullin-4B

1

1

High-throughput

0.479

High

1047411

NR0B2
Nuclear receptor subfamily 0 group B member 2

1

2

Small-scale

0.479

High

1047412

SMAD2
Mothers against decapentaplegic homolog 2

1

16

Small-scale

0.479

High

1047424

CBP
CREB-binding protein

1

8

Small-scale

0.479

High

1047425

KAT2B
Histone acetyltransferase KAT2B

1

5

Small-scale

0.479

High

1047427

CIC
Protein capicua homolog

1

7

High-throughput

0.479

High

1047429

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

11

Small-scale

0.479

High

1047431

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

11

Small-scale

0.479

High

738343

BMR1A
Bone morphogenetic protein receptor type-1A

1

0

Small-scale

0.458

High

1047416

PMF1
Polyamine-modulated factor 1

1

0

Small-scale

0.458

High

1047418

DET1
DET1 homolog

1

0

High-throughput

0.458

High

346744

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.445

High

1047420

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.445

High

1047421

POC5
Centrosomal protein POC5

1

0

Small-scale

0.426

High

354061

IGHA1
Immunoglobulin heavy constant alpha 1

1

2

High-throughput

0.407

High

354156

IGHA2
Immunoglobulin heavy constant alpha 2

1

3

High-throughput

0.407

High

353119

IGJ
Immunoglobulin J chain

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024