HitPredict

Interactor 1: B7Z207 (B7Z207)
Protein-serine/threonine kinase (EC 2.7.11.-)
Gene: B7Z207

Interactor 2: PDK4 (Q16654)
[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial (EC 2.7.11.2) (Pyruvate dehydrogenase kinase isoform 4)
Gene: PDK4

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	28514442
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	BCDHK_Adom3~HATPase_c, HATPase_c~HATPase_c
Common GO terms	GO:0004740 - pyruvate dehydrogenase (acetyl-transferring) kinase activity GO:0005524 - ATP binding GO:0005759 - mitochondrial matrix GO:0010906 - regulation of glucose metabolic process GO:0016310 - phosphorylation
Homologous interactions	11

Homologous interactions

Color coding for hit scores

	1 281 Hs			1 411
+	Hs
		1067967 PDK1_HUMAN (1-281): 1.15e-168: 475: 100.00		PDK4_HUMAN (1-411): 0: 644: 100.00
+	Hs
		1067961 PDK1_HUMAN (1-281): 1.15e-168: 475: 100.00		PDK1_HUMAN (17-406): 0: 632: 66.67
+	Hs
		1067963 PDK1_HUMAN (1-281): 1.15e-168: 475: 100.00		PDK3_HUMAN (1-407): 0: 602: 61.37
+	Hs
		1067962 PDK1_HUMAN (1-281): 1.15e-168: 475: 100.00		PDK2_HUMAN (1-406): 0: 600: 63.88
+	Hs
		81553 B7Z207_HUMAN (1-281): 3.3e-169: 471: 100.00		PDK3_HUMAN (1-407): 0: 602: 61.37
+	Hs
		81552 B7Z207_HUMAN (1-281): 3.3e-169: 471: 100.00		PDK2_HUMAN (1-406): 0: 600: 63.88
+	Hs
		1068153 PDK4_HUMAN (1-278): 3.62e-157: 445: 67.27		PDK3_HUMAN (1-407): 0: 602: 61.37
+	Hs
		1068140 PDK4_HUMAN (1-278): 3.62e-157: 445: 67.27		PDK2_HUMAN (1-406): 0: 600: 63.88
+	Hs
		1068139 PDK2_HUMAN (1-281): 6.13e-155: 439: 69.40		PDK3_HUMAN (1-407): 0: 602: 61.37
+	Mm
		222968 BCKD_MOUSE (1-243): 8.92e-87: 266: 32.43		BCKD_MOUSE (52-369): 7.11e-125: 369: 29.43
+	Sc
		775145 PDK1_YEAST (1-242): 1.45e-82: 255: 24.80		PDK2_YEAST (24-305): 1.58e-80: 257: 25.42