Protein: KPCE
Protein kinase C epsilon type (EC 2.7.11.13) (nPKC-epsilon)

Gene: KPCE, PRKCE
Organism: Homo sapiens
Interactions: 134
UniProt ID: Q02156

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0002281 - macrophage activation involved in immune response
GO:0003785 - actin monomer binding
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

926942

1433Z
14-3-3 protein zeta/delta

5

20

Small-scale

0.919

High

438085

HS90B
Heat shock protein HSP 90-beta

4

20

Small-scale

0.875

High

431752

HS90A
Heat shock protein HSP 90-alpha

4

20

Small-scale

0.867

High

338299

EGFR
Epidermal growth factor receptor

3

20

High-throughput

0.843

High

969068

KPCE
Protein kinase C epsilon type

3

16

Small-scale

0.840

High

969088

CDC37
Hsp90 co-chaperone Cdc37

3

8

High-throughput

0.839

High

566359

KPCA
Protein kinase C alpha type

3

17

Small-scale

0.817

High

683974

1433S
14-3-3 protein sigma

3

20

High-throughput

0.817

High

909458

1433E
14-3-3 protein epsilon

3

3

High-throughput

0.817

High

542864

BRAF
Serine/threonine-protein kinase B-raf

2

12

Small-scale

0.776

High

273517

ADAP1
Arf-GAP with dual PH domain-containing protein 1

1

13

Small-scale

0.771

High

646812

1433T
14-3-3 protein theta

2

20

High-throughput

0.737

High

681410

DNJA1
DnaJ homolog subfamily A member 1

2

7

High-throughput

0.737

High

683276

1433B
14-3-3 protein beta/alpha

2

20

High-throughput

0.737

High

904456

1433G
14-3-3 protein gamma

2

20

High-throughput

0.737

High

923962

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

2

11

High-throughput

0.737

High

969070

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

2

7

High-throughput

0.737

High

969080

RCN2
Reticulocalbin-2

2

5

High-throughput

0.737

High

969087

NEDD8
NEDD8

2

8

High-throughput

0.737

High

969118

KS6B2
Ribosomal protein S6 kinase beta-2

2

17

Small-scale

0.737

High

158448

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

20

Small-scale

0.724

High

324791

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

20

High-throughput

0.698

High

969083

KPCD1
Serine/threonine-protein kinase D1

1

17

Small-scale

0.692

High

167524

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

20

High-throughput

0.691

High

623873

KPCL
Protein kinase C eta type

1

18

High-throughput

0.691

High

969081

FAK2
Protein-tyrosine kinase 2-beta

1

20

High-throughput

0.691

High

969096

VRK3
Serine/threonine-protein kinase VRK3

1

15

High-throughput

0.691

High

969098

ST32A
Serine/threonine-protein kinase 32A

1

18

High-throughput

0.691

High

969111

TSSK1
Testis-specific serine/threonine-protein kinase 1

1

18

High-throughput

0.691

High

374078

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

17

Small-scale

0.665

High

658893

MK01
Mitogen-activated protein kinase 1

1

9

Small-scale

0.665

High

969077

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

19

Small-scale

0.647

High

969086

ELAV1
ELAV-like protein 1

1

4

Small-scale

0.647

High

969093

MARK2
Serine/threonine-protein kinase MARK2

1

10

Small-scale

0.647

High

969095

GRP3
Ras guanyl-releasing protein 3

1

8

Small-scale

0.647

High

969097

AFAP1
Actin filament-associated protein 1

1

5

Small-scale

0.647

High

969116

OGFR
Opioid growth factor receptor

2

5

High-throughput

0.628

High

182135

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

19

Small-scale

0.618

High

227208

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.618

High

580979

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

2

Small-scale

0.618

High

786316

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

7

Small-scale

0.618

High

932958

ACTS
Actin, alpha skeletal muscle

1

8

Small-scale

0.618

High

969075

ZBT16
Zinc finger and BTB domain-containing protein 16

1

1

Small-scale

0.618

High

969084

KS6A2
Ribosomal protein S6 kinase alpha-2

1

17

Small-scale

0.618

High

969117

IBTK
Inhibitor of Bruton tyrosine kinase

1

7

Small-scale

0.618

High

969101

PP14A
Protein phosphatase 1 regulatory subunit 14A

1

3

Small-scale

0.598

High

781342

BCL6
B-cell lymphoma 6 protein

1

0

Small-scale

0.586

High

621547

IL32
Interleukin-32

2

3

Small-scale

0.584

High

601219

VDAC1
Voltage-dependent anion-selective channel protein 1

1

3

Small-scale

0.578

High

929405

RACK1
Small ribosomal subunit protein RACK1

1

12

Small-scale

0.578

High

669161

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

20

Small-scale

0.575

High

969092

H90B2
Putative heat shock protein HSP 90-beta 2

1

20

High-throughput

0.575

High

225866

KPRB
Phosphoribosyl pyrophosphate synthase-associated protein 2

2

10

High-throughput

0.571

High

388384

HSPB1
Heat shock protein beta-1

2

13

High-throughput

0.571

High

397347

ADT2
ADP/ATP translocase 2

2

11

High-throughput

0.571

High

428148

TBB5
Tubulin beta chain

2

14

High-throughput

0.571

High

503922

HSP7C
Heat shock cognate 71 kDa protein

2

10

High-throughput

0.571

High

509226

G6PD
Glucose-6-phosphate 1-dehydrogenase

2

1

High-throughput

0.571

High

515835

PRPS2
Ribose-phosphate pyrophosphokinase 2

2

10

High-throughput

0.571

High

518320

ADT3
ADP/ATP translocase 3

2

11

High-throughput

0.571

High

653231

PYR1
Multifunctional protein CAD

2

2

High-throughput

0.571

High

713493

GLYM
Serine hydroxymethyltransferase, mitochondrial

2

2

High-throughput

0.571

High

838627

GDIB
Rab GDP dissociation inhibitor beta

2

1

High-throughput

0.571

High

839476

SPB8
Serpin B8

2

5

High-throughput

0.571

High

839518

SPB9
Serpin B9

2

4

High-throughput

0.571

High

933175

TBA1B
Tubulin alpha-1B chain

2

12

High-throughput

0.571

High

933762

TBB4B
Tubulin beta-4B chain

2

14

High-throughput

0.571

High

959188

S25A3
Solute carrier family 25 member 3

2

16

High-throughput

0.571

High

961971

DHSO
Sorbitol dehydrogenase

2

1

High-throughput

0.571

High

969071

AKA12
A-kinase anchor protein 12

2

4

High-throughput

0.571

High

969078

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

2

4

High-throughput

0.571

High

969079

KEAP1
Kelch-like ECH-associated protein 1

2

3

High-throughput

0.571

High

969089

FSCN1
Fascin

2

3

High-throughput

0.571

High

969090

PCKGM
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial

2

2

High-throughput

0.571

High

969091

TBB8
Tubulin beta-8 chain

2

14

High-throughput

0.571

High

969108

TBA1C
Tubulin alpha-1C chain

2

13

High-throughput

0.571

High

969115

BCLF1
Bcl-2-associated transcription factor 1

2

2

High-throughput

0.571

High

969120

TR150
Thyroid hormone receptor-associated protein 3

2

3

High-throughput

0.571

High

969100

KAT5
Histone acetyltransferase KAT5

1

1

Small-scale

0.561

High

199042

PAPS1
Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1

2

0

High-throughput

0.547

High

660956

AMPL
Cytosol aminopeptidase

2

0

High-throughput

0.547

High

682497

PUR9
Bifunctional purine biosynthesis protein ATIC

2

0

High-throughput

0.547

High

969109

NTM1A
N-terminal Xaa-Pro-Lys N-methyltransferase 1

2

0

High-throughput

0.547

High

969119

DPP2
Dipeptidyl peptidase 2

2

0

High-throughput

0.547

High

969122

SERC
Phosphoserine aminotransferase

2

0

High-throughput

0.547

High

551672

DESP
Desmoplakin

1

9

High-throughput

0.541

High

969106

RAD9A
Cell cycle checkpoint control protein RAD9A

1

0

Small-scale

0.537

High

969094

TCAM2
TIR domain-containing adapter molecule 2

1

1

Small-scale

0.536

High

344853

CYTS
Cystatin-S

1

1

High-throughput

0.536

High

448441

CYTT
Cystatin-SA

1

1

High-throughput

0.536

High

884296

PCBP3
Poly(rC)-binding protein 3

1

4

High-throughput

0.536

High

276116

SPI2
Serpin I2

2

4

High-throughput

0.521

High

675638

ILEU
Leukocyte elastase inhibitor

2

5

High-throughput

0.521

High

969107

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

3

Small-scale

0.515

High

394562

A4
Amyloid-beta precursor protein

1

6

High-throughput

0.515

High

742230

SYUA
Alpha-synuclein

1

6

High-throughput

0.515

High

894929

SRP54
Signal recognition particle subunit SRP54

1

0

High-throughput

0.513

High

969102

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

0

High-throughput

0.513

High

969110

PAPOG
Poly(A) polymerase gamma

1

0

High-throughput

0.513

High

969121

T10B
Mitochondrial import inner membrane translocase subunit Tim10 B

1

0

High-throughput

0.513

High

396624

ITB2
Integrin beta-2

1

13

Small-scale

0.501

High

496879

TAU
Microtubule-associated protein tau

1

12

Small-scale

0.501

High

547787

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

3

High-throughput

0.501

High

557449

PECA1
Platelet endothelial cell adhesion molecule

1

1

Small-scale

0.501

High

833582

NUMB
Protein numb homolog

1

11

Small-scale

0.501

High

969069

H11
Histone H1.1

1

18

Small-scale

0.501

High

969072

GNA12
Guanine nucleotide-binding protein subunit alpha-12

1

6

Small-scale

0.501

High

969074

DCE2
Glutamate decarboxylase 2

1

3

Small-scale

0.501

High

969082

GNA13
Guanine nucleotide-binding protein subunit alpha-13

1

6

Small-scale

0.501

High

969105

DCE1
Glutamate decarboxylase 1

1

3

Small-scale

0.501

High

969113

NANOG
Homeobox protein NANOG

1

5

Small-scale

0.501

High

969104

PDLI5
PDZ and LIM domain protein 5

1

16

Small-scale

0.481

High

969114

UD17
UDP-glucuronosyltransferase 1A7

1

0

Small-scale

0.480

High

380596

K2C1
Keratin, type II cytoskeletal 1

1

1

Small-scale

0.479

High

408781

K1C18
Keratin, type I cytoskeletal 18

1

3

Small-scale

0.479

High

409052

K2C8
Keratin, type II cytoskeletal 8

1

2

Small-scale

0.479

High

518124

ADT1
ADP/ATP translocase 1

1

11

Small-scale

0.479

High

567017

CXA1
Gap junction alpha-1 protein

1

9

Small-scale

0.479

High

724784

MYH9
Myosin-9

1

4

Small-scale

0.479

High

725421

COPB2
Coatomer subunit beta'

1

4

Small-scale

0.479

High

787366

PK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

1

7

Small-scale

0.479

High

856202

HXK2
Hexokinase-2

1

1

Small-scale

0.479

High

969073

KCNC4
Potassium voltage-gated channel subfamily C member 4

1

5

Small-scale

0.479

High

969076

BAX
Apoptosis regulator BAX

1

3

Small-scale

0.479

High

969099

BAD
Bcl2-associated agonist of cell death

1

4

Small-scale

0.479

High

969123

NEMO
NF-kappa-B essential modulator

1

16

Small-scale

0.479

High

275406

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

0

High-throughput

0.458

High

528993

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

Small-scale

0.458

High

969085

TOM20
Mitochondrial import receptor subunit TOM20 homolog

1

0

Small-scale

0.458

High

86686

C6GKH1
Interleukin 32

1

3

Small-scale

0.437

High

969103

BPIA2
BPI fold-containing family A member 2

1

0

High-throughput

0.279

Low

969112

CPVL
Probable serine carboxypeptidase CPVL

1

0

High-throughput

0.279

Low

484815

AMY1B
Alpha-amylase 1B

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024