Protein: MDM4
Protein Mdm4 (Double minute 4 protein) (Mdm2-like p53-binding protein) (Protein Mdmx) (p53-binding protein Mdm4)

Gene: MDM4
Organism: Homo sapiens
Interactions: 106
UniProt ID: O15151

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003170 - heart valve development
GO:0003181 - atrioventricular valve morphogenesis
GO:0003203 - endocardial cushion morphogenesis
GO:0003281 - ventricular septum development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

169277

MDM2
E3 ubiquitin-protein ligase Mdm2

71

5

Small-scale

0.998

High

169217

MDM4
Protein Mdm4

5

5

Small-scale

0.922

High

169270

UB2D2
Ubiquitin-conjugating enzyme E2 D2

2

14

Small-scale

0.799

High

169259

UB2D1
Ubiquitin-conjugating enzyme E2 D1

2

14

Small-scale

0.778

High

169227

P53
Cellular tumor antigen p53

67

10

Small-scale

0.773

High

169233

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

4

Small-scale

0.768

High

169256

KC1A
Casein kinase I isoform alpha

13

5

Small-scale

0.761

High

169218

P73
Tumor protein p73

6

10

Small-scale

0.732

High

169283

MKRN3
Probable E3 ubiquitin-protein ligase makorin-3

4

1

High-throughput

0.706

High

169244

1433B
14-3-3 protein beta/alpha

5

11

Small-scale

0.706

High

169299

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

4

8

Small-scale

0.700

High

169272

RL11
Large ribosomal subunit protein uL5

1

2

High-throughput

0.691

High

169269

1433E
14-3-3 protein epsilon

5

0

Small-scale

0.686

High

169241

1433T
14-3-3 protein theta

4

11

Small-scale

0.672

High

169266

1433G
14-3-3 protein gamma

6

11

Small-scale

0.670

High

169279

PPARD
Peroxisome proliferator-activated receptor delta

3

8

High-throughput

0.667

High

169292

LRSM1
E3 ubiquitin-protein ligase LRSAM1

1

0

High-throughput

0.663

High

169273

1433Z
14-3-3 protein zeta/delta

3

11

Small-scale

0.656

High

169301

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

3

0

Small-scale

0.652

High

169262

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

14

Small-scale

0.647

High

169313

CBLC
E3 ubiquitin-protein ligase CBL-C

1

1

High-throughput

0.647

High

169229

RB
Retinoblastoma-associated protein

2

1

Small-scale

0.641

High

169245

1433S
14-3-3 protein sigma

3

11

Small-scale

0.640

High

169311

E2AK4
eIF-2-alpha kinase GCN2

2

3

High-throughput

0.628

High

169220

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

2

7

Small-scale

0.624

High

169249

CDN1A
Cyclin-dependent kinase inhibitor 1

2

2

Small-scale

0.624

High

169230

CDK1
Cyclin-dependent kinase 1

2

0

Small-scale

0.619

High

169234

BCL2
Apoptosis regulator Bcl-2

2

1

Small-scale

0.611

High

169296

KC1AL
Casein kinase I isoform alpha-like

2

7

Small-scale

0.611

High

154098

CHK1
Serine/threonine-protein kinase Chk1

2

0

Small-scale

0.606

High

169265

WDR5
WD repeat-containing protein 5

2

1

High-throughput

0.606

High

169304

ZKSC3
Zinc finger protein with KRAB and SCAN domains 3

2

2

High-throughput

0.606

High

169226

S100B
Protein S100-B

2

9

Small-scale

0.602

High

169221

CCDB1
Cyclin-D1-binding protein 1

2

0

High-throughput

0.602

High

169293

ASGL1
Isoaspartyl peptidase/L-asparaginase

2

0

High-throughput

0.602

High

169280

1433F
14-3-3 protein eta

2

11

Small-scale

0.601

High

169252

CDN2A
Cyclin-dependent kinase inhibitor 2A

2

7

Small-scale

0.595

High

161181

VP26C
Vacuolar protein sorting-associated protein 26C

2

0

High-throughput

0.580

High

169250

NAA10
N-alpha-acetyltransferase 10

2

0

High-throughput

0.580

High

169310

AIRIM
AFG2-interacting ribosome maturation factor

2

0

High-throughput

0.580

High

169315

RN115
E3 ubiquitin-protein ligase RNF115

1

2

High-throughput

0.573

High

169281

UBE3A
Ubiquitin-protein ligase E3A

1

7

Small-scale

0.561

High

169286

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

1

Small-scale

0.561

High

169316

RA54B
DNA repair and recombination protein RAD54B

1

5

Small-scale

0.561

High

169290

Q3YBA8
14-3-3 tau splice variant

2

12

Small-scale

0.558

High

169295

TRI46
Tripartite motif-containing protein 46

1

6

High-throughput

0.541

High

169305

TRI55
Tripartite motif-containing protein 55

1

9

High-throughput

0.541

High

169235

TOP2A
DNA topoisomerase 2-alpha

1

0

Small-scale

0.537

High

169263

RL15
Large ribosomal subunit protein eL15

1

1

High-throughput

0.536

High

169278

E2F1
Transcription factor E2F1

1

1

Small-scale

0.527

High

169260

MAT1
CDK-activating kinase assembly factor MAT1

1

0

High-throughput

0.518

High

169223

CHK2
Serine/threonine-protein kinase Chk2

1

4

Small-scale

0.501

High

169228

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

169236

CDK4
Cyclin-dependent kinase 4

1

1

High-throughput

0.501

High

169240

S10A1
Protein S100-A1

1

9

Small-scale

0.501

High

169246

S10A5
Protein S100-A5

1

9

Small-scale

0.501

High

169247

MERL
Merlin

1

1

High-throughput

0.501

High

169253

CDN2B
Cyclin-dependent kinase 4 inhibitor B

1

6

High-throughput

0.501

High

169258

SMCA2
Probable global transcription activator SNF2L2

1

2

Small-scale

0.501

High

169276

SMAD3
Mothers against decapentaplegic homolog 3

1

1

Small-scale

0.501

High

169282

EP300
Histone acetyltransferase p300

1

4

Small-scale

0.501

High

169285

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

1

3

High-throughput

0.501

High

169287

SMAD4
Mothers against decapentaplegic homolog 4

1

1

Small-scale

0.501

High

169306

GLIS2
Zinc finger protein GLIS2

1

2

High-throughput

0.501

High

169308

P63
Tumor protein 63

1

10

Small-scale

0.501

High

169309

LATS2
Serine/threonine-protein kinase LATS2

1

6

High-throughput

0.501

High

169254

MAGA1
Melanoma-associated antigen 1

1

5

Small-scale

0.481

High

169300

ZKSC4
Zinc finger protein with KRAB and SCAN domains 4

1

3

High-throughput

0.481

High

169317

CAN7
Calpain-7

1

1

High-throughput

0.481

High

169237

HGF
Hepatocyte growth factor

1

0

High-throughput

0.480

High

169238

CD44
CD44 antigen

1

0

High-throughput

0.480

High

169284

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

0

Small-scale

0.480

High

169288

BECN1
Beclin-1

1

0

High-throughput

0.480

High

131342

IMA4
Importin subunit alpha-4

1

2

Small-scale

0.479

High

169219

NBN
Nibrin

1

2

Small-scale

0.479

High

169224

ABL1
Tyrosine-protein kinase ABL1

1

5

Small-scale

0.479

High

169225

ALBU
Albumin

1

1

Small-scale

0.479

High

169231

HS90A
Heat shock protein HSP 90-alpha

1

4

High-throughput

0.479

High

169232

HS90B
Heat shock protein HSP 90-beta

1

4

High-throughput

0.479

High

169248

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

3

Small-scale

0.479

High

169251

MTOR
Serine/threonine-protein kinase mTOR

1

1

Small-scale

0.479

High

169255

MAGB1
Melanoma-associated antigen B1

1

5

Small-scale

0.479

High

169257

MRE11
Double-strand break repair protein MRE11

1

2

Small-scale

0.479

High

169261

RS20
Small ribosomal subunit protein uS10

1

1

Small-scale

0.479

High

169267

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

3

Small-scale

0.479

High

169268

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

3

Small-scale

0.479

High

169271

RS15
Small ribosomal subunit protein uS19

1

1

Small-scale

0.479

High

169289

EZH2
Histone-lysine N-methyltransferase EZH2

1

5

Small-scale

0.479

High

169297

COP1
E3 ubiquitin-protein ligase COP1

1

3

Small-scale

0.479

High

169298

RAD50
DNA repair protein RAD50

1

2

Small-scale

0.479

High

169302

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

1

Small-scale

0.479

High

169303

RING2
E3 ubiquitin-protein ligase RING2

1

3

Small-scale

0.479

High

169307

HIPK2
Homeodomain-interacting protein kinase 2

1

8

Small-scale

0.479

High

169314

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

5

Small-scale

0.479

High

169294

Q7Z479
Calpain 7

1

1

High-throughput

0.470

High

169239

FGFR4
Fibroblast growth factor receptor 4

1

1

High-throughput

0.457

High

169242

S10A2
Protein S100-A2

1

9

Small-scale

0.457

High

169243

EPHA2
Ephrin type-A receptor 2

1

2

High-throughput

0.457

High

3497

A0A0S2Z6X0
Zinc finger with KRAB and SCAN domains 4 isoform 3

1

3

High-throughput

0.457

High

169312

DAXX
Death domain-associated protein 6

1

2

Small-scale

0.445

High

169264

RL37
Large ribosomal subunit protein eL37

1

1

Small-scale

0.437

High

169222

BY55
CD160 antigen

3

0

High-throughput

0.352

High

169291

SPT46
Spermatogenesis-associated protein 46

3

0

High-throughput

0.347

High

169274

HBB
Hemoglobin subunit beta

2

0

High-throughput

0.328

High

169275

F193A
Protein FAM193A

2

0

High-throughput

0.328

High


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024