Protein: SI1L1
Signal-induced proliferation-associated 1-like protein 1 (SIPA1-like protein 1) (High-risk human papilloma viruses E6 oncoproteins targeted protein 1) (E6-targeted protein 1)

Gene: SI1L1, SIPA1L1
Organism: Homo sapiens
Interactions: 163
UniProt ID: O43166

Gene Ontology (top 5):
GO:0005096 - GTPase activator activity
GO:0005737 - cytoplasm
GO:0005886 - plasma membrane
GO:0014069 - postsynaptic density
GO:0015629 - actin cytoskeleton

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

196430

DLG4
Disks large homolog 4

3

5

Small-scale

0.878

High

196421

AFAD
Afadin

2

18

High-throughput

0.754

High

196466

TRI67
Tripartite motif-containing protein 67

2

7

Small-scale

0.754

High

196383

DSCAM
Cell adhesion molecule DSCAM

1

1

High-throughput

0.698

High

196501

LZTS2
Leucine zipper putative tumor suppressor 2

4

19

High-throughput

0.694

High

196380

SI1L3
Signal-induced proliferation-associated 1-like protein 3

1

12

High-throughput

0.691

High

196519

SI1L2
Signal-induced proliferation-associated 1-like protein 2

1

9

High-throughput

0.691

High

196405

1433B
14-3-3 protein beta/alpha

4

20

High-throughput

0.691

High

196426

1433G
14-3-3 protein gamma

4

20

High-throughput

0.691

High

196386

FKBP6
Inactive peptidyl-prolyl cis-trans isomerase FKBP6

3

1

High-throughput

0.667

High

196402

1433T
14-3-3 protein theta

3

20

High-throughput

0.650

High

196429

1433Z
14-3-3 protein zeta/delta

3

20

High-throughput

0.650

High

196432

1433F
14-3-3 protein eta

3

20

High-throughput

0.650

High

196382

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

3

High-throughput

0.618

High

196392

RASK
GTPase KRas

1

19

High-throughput

0.618

High

196428

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.618

High

196434

ZO1
Tight junction protein ZO-1

1

12

High-throughput

0.618

High

196436

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

5

High-throughput

0.618

High

196437

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

2

High-throughput

0.618

High

196453

SPD2A
SH3 and PX domain-containing protein 2A

1

2

High-throughput

0.618

High

196483

PARD3
Partitioning defective 3 homolog

1

16

High-throughput

0.618

High

196496

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

13

High-throughput

0.618

High

196506

TRIM9
E3 ubiquitin-protein ligase TRIM9

1

9

Small-scale

0.618

High

196521

ZO2
Tight junction protein ZO-2

1

9

High-throughput

0.618

High

196531

AGAP1
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1

1

6

High-throughput

0.618

High

196440

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

2

11

High-throughput

0.611

High

196503

WDR83
WD repeat domain-containing protein 83

3

4

High-throughput

0.609

High

196406

1433S
14-3-3 protein sigma

2

20

High-throughput

0.601

High

196420

EPHA4
Ephrin type-A receptor 4

1

5

High-throughput

0.590

High

196516

SH3B4
SH3 domain-binding protein 4

1

0

High-throughput

0.586

High

196518

LRFN1
Leucine-rich repeat and fibronectin type III domain-containing protein 1

1

0

High-throughput

0.586

High

196389

KLHL2
Kelch-like protein 2

2

0

High-throughput

0.585

High

196409

CTNB1
Catenin beta-1

2

5

High-throughput

0.584

High

196422

HDAC4
Histone deacetylase 4

2

2

High-throughput

0.584

High

196393

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

196451

SMAG2
Protein Smaug homolog 2

1

1

High-throughput

0.553

High

196444

CEBPE
CCAAT/enhancer-binding protein epsilon

1

3

Small-scale

0.552

High

196381

LZTS3
Leucine zipper putative tumor suppressor 3

1

14

High-throughput

0.536

High

196397

MIF
Macrophage migration inhibitory factor

1

1

High-throughput

0.536

High

196413

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

6

High-throughput

0.536

High

196476

SYNPO
Synaptopodin

1

5

High-throughput

0.536

High

196492

VMP1
Vacuole membrane protein 1

1

1

High-throughput

0.536

High

196493

MYO19
Unconventional myosin-XIX

1

8

High-throughput

0.536

High

196455

CP135
Centrosomal protein of 135 kDa

2

5

High-throughput

0.533

High

196526

FBW1B
F-box/WD repeat-containing protein 11

2

6

Small-scale

0.533

High

196412

KI67
Proliferation marker protein Ki-67

1

3

High-throughput

0.489

High

196488

SPSB4
SPRY domain-containing SOCS box protein 4

1

10

High-throughput

0.489

High

196536

DYR1B
Dual specificity tyrosine-phosphorylation-regulated kinase 1B

1

11

High-throughput

0.489

High

196423

NRX1B
Neurexin-1-beta

1

1

Small-scale

0.481

High

166520

DCLK1
Serine/threonine-protein kinase DCLK1

1

2

High-throughput

0.479

High

196388

TRI37
E3 ubiquitin-protein ligase TRIM37

1

7

High-throughput

0.479

High

196394

K2C8
Keratin, type II cytoskeletal 8

1

2

High-throughput

0.479

High

196398

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.479

High

196399

BTF3
Transcription factor BTF3

1

1

High-throughput

0.479

High

196400

NF1
Neurofibromin

1

6

High-throughput

0.479

High

196401

GCSP
Glycine dehydrogenase

1

1

High-throughput

0.479

High

196403

MPIP2
M-phase inducer phosphatase 2

1

1

High-throughput

0.479

High

196404

MPIP3
M-phase inducer phosphatase 3

1

1

High-throughput

0.479

High

196408

CTNA1
Catenin alpha-1

1

2

High-throughput

0.479

High

196414

SOX2
Transcription factor SOX-2

1

6

High-throughput

0.479

High

196415

GSK3A
Glycogen synthase kinase-3 alpha

1

11

High-throughput

0.479

High

196416

GSK3B
Glycogen synthase kinase-3 beta

1

11

High-throughput

0.479

High

196417

VASP
Vasodilator-stimulated phosphoprotein

1

3

High-throughput

0.479

High

196424

ACTB
Actin, cytoplasmic 1

1

5

High-throughput

0.479

High

196425

ARP3
Actin-related protein 3

1

8

High-throughput

0.479

High

196427

1433E
14-3-3 protein epsilon

1

10

High-throughput

0.479

High

196431

CDK16
Cyclin-dependent kinase 16

1

3

High-throughput

0.479

High

196438

G3BP1
Ras GTPase-activating protein-binding protein 1

1

1

High-throughput

0.479

High

196441

MELK
Maternal embryonic leucine zipper kinase

1

2

High-throughput

0.479

High

196442

ZN638
Zinc finger protein 638

1

2

High-throughput

0.479

High

196443

PTN14
Tyrosine-protein phosphatase non-receptor type 14

1

4

High-throughput

0.479

High

196445

ZYX
Zyxin

1

4

High-throughput

0.479

High

196446

E2F4
Transcription factor E2F4

1

2

High-throughput

0.479

High

196447

OCLN
Occludin

1

5

High-throughput

0.479

High

196449

AMOT
Angiomotin

1

8

High-throughput

0.479

High

196452

M3K21
Mitogen-activated protein kinase kinase kinase 21

1

2

High-throughput

0.479

High

196454

DEN4C
DENN domain-containing protein 4C

1

3

High-throughput

0.479

High

196457

FTM
Protein fantom

1

9

High-throughput

0.479

High

196461

LARP1
La-related protein 1

1

2

High-throughput

0.479

High

196462

SAS6
Spindle assembly abnormal protein 6 homolog

1

5

High-throughput

0.479

High

196465

SYNE3
Nesprin-3

1

8

High-throughput

0.479

High

196468

SYDE1
Rho GTPase-activating protein SYDE1

1

2

High-throughput

0.479

High

196472

PHLB2
Pleckstrin homology-like domain family B member 2

1

7

High-throughput

0.479

High

196473

RGPS2
Ras-specific guanine nucleotide-releasing factor RalGPS2

1

1

High-throughput

0.479

High

196474

KSR1
Kinase suppressor of Ras 1

1

6

High-throughput

0.479

High

196475

RPTOR
Regulatory-associated protein of mTOR

1

2

High-throughput

0.479

High

196477

NIN
Ninein

1

12

High-throughput

0.479

High

196478

NAV1
Neuron navigator 1

1

3

High-throughput

0.479

High

196484

HDAC7
Histone deacetylase 7

1

2

High-throughput

0.479

High

196485

DEP1B
DEP domain-containing protein 1B

1

1

High-throughput

0.479

High

196486

SRS12
Serine/arginine-rich splicing factor 12

1

1

High-throughput

0.479

High

196498

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

1

High-throughput

0.479

High

196505

OSBL6
Oxysterol-binding protein-related protein 6

1

2

High-throughput

0.479

High

196508

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.479

High

196509

PKHA5
Pleckstrin homology domain-containing family A member 5

1

8

High-throughput

0.479

High

196510

TANC2
Protein TANC2

1

4

High-throughput

0.479

High

196511

KI13B
Kinesin-like protein KIF13B

1

5

High-throughput

0.479

High

196512

ANLN
Anillin

1

4

High-throughput

0.479

High

196520

CING
Cingulin

1

3

High-throughput

0.479

High

196522

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

196523

LIMA1
LIM domain and actin-binding protein 1

1

4

High-throughput

0.479

High

196524

NGAP
Ras GTPase-activating protein nGAP

1

6

High-throughput

0.479

High

196530

MYO6
Unconventional myosin-VI

1

4

High-throughput

0.479

High

196532

GAB2
GRB2-associated-binding protein 2

1

4

High-throughput

0.479

High

196535

STA13
StAR-related lipid transfer protein 13

1

3

High-throughput

0.479

High

196537

KCTD3
BTB/POZ domain-containing protein KCTD3

1

1

High-throughput

0.479

High

196419

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

1

High-throughput

0.470

High

117316

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

0

High-throughput

0.458

High

196384

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.458

High

196385

SRGP2
SLIT-ROBO Rho GTPase-activating protein 2

1

0

High-throughput

0.458

High

196410

BCL6
B-cell lymphoma 6 protein

1

0

High-throughput

0.458

High

196448

TBC25
TBC1 domain family member 25

1

0

High-throughput

0.458

High

196469

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.458

High

196497

TESK2
Dual specificity testis-specific protein kinase 2

1

0

High-throughput

0.458

High

196507

VP33B
Vacuolar protein sorting-associated protein 33B

1

0

High-throughput

0.458

High

196514

INP5E
Phosphatidylinositol polyphosphate 5-phosphatase type IV

1

0

High-throughput

0.458

High

196525

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

0

High-throughput

0.458

High

196529

PPM1H
Protein phosphatase 1H

1

0

High-throughput

0.458

High

196433

FMR1
Fragile X messenger ribonucleoprotein 1

1

1

High-throughput

0.457

High

196527

NRX1A
Neurexin-1

1

2

Small-scale

0.457

High

196396

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.445

High

196463

TMIG1
Transmembrane and immunoglobulin domain-containing protein 1

1

1

Small-scale

0.445

High

164328

TRI66
Tripartite motif-containing protein 66

1

2

High-throughput

0.437

High

196379

KIF1C
Kinesin-like protein KIF1C

1

5

High-throughput

0.437

High

196387

GGYF1
GRB10-interacting GYF protein 1

1

1

High-throughput

0.437

High

196391

LATS1
Serine/threonine-protein kinase LATS1

1

7

High-throughput

0.437

High

196418

CDK9
Cyclin-dependent kinase 9

1

6

High-throughput

0.437

High

196435

CAMP2
Calmodulin-regulated spectrin-associated protein 2

1

4

High-throughput

0.437

High

196450

ODFP2
Outer dense fiber protein 2

1

7

High-throughput

0.437

High

196456

A16L1
Autophagy-related protein 16-1

1

5

High-throughput

0.437

High

196458

AN34A
Ankyrin repeat domain-containing protein 34A

1

4

High-throughput

0.437

High

196460

PKHA7
Pleckstrin homology domain-containing family A member 7

1

12

High-throughput

0.437

High

196464

GGYF2
GRB10-interacting GYF protein 2

1

9

High-throughput

0.437

High

196467

CE128
Centrosomal protein of 128 kDa

1

8

High-throughput

0.437

High

196471

MYCPP
C-myc promoter-binding protein

1

2

High-throughput

0.437

High

196479

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.437

High

196480

F110B
Protein FAM110B

1

1

High-throughput

0.437

High

196481

DEN1A
DENN domain-containing protein 1A

1

4

High-throughput

0.437

High

196482

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

2

High-throughput

0.437

High

196487

ESR2
Estrogen receptor beta

1

18

High-throughput

0.437

High

196489

SPDLY
Protein Spindly

1

5

High-throughput

0.437

High

196494

CEP63
Centrosomal protein of 63 kDa

1

9

High-throughput

0.437

High

196499

F110A
Protein FAM110A

1

1

High-throughput

0.437

High

196513

LATS2
Serine/threonine-protein kinase LATS2

1

9

High-throughput

0.437

High

196517

SEP10
Septin-10

1

1

High-throughput

0.437

High

196533

NINL
Ninein-like protein

1

10

High-throughput

0.437

High

196534

CBY1
Protein chibby homolog 1

1

1

High-throughput

0.437

High

196411

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

0

High-throughput

0.426

High

89951

D6R9G5
Kelch like family member 2

1

1

High-throughput

0.407

High

196439

CTBP1
C-terminal-binding protein 1

1

1

High-throughput

0.407

High

196491

STALP
AMSH-like protease

2

0

High-throughput

0.328

High

196395

PIP
Prolactin-inducible protein

1

0

High-throughput

0.279

Low

196459

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.279

Low

196470

CENPU
Centromere protein U

1

0

High-throughput

0.279

Low

196390

NADK
NAD kinase

1

0

High-throughput

0.249

Low

196490

EDC3
Enhancer of mRNA-decapping protein 3

1

0

High-throughput

0.249

Low

196495

RAB3I
Rab-3A-interacting protein

1

0

High-throughput

0.249

Low

196500

LPIN3
Phosphatidate phosphatase LPIN3

1

0

High-throughput

0.249

Low

196502

OVOL2
Transcription factor Ovo-like 2

1

0

Small-scale

0.249

Low

196504

RTKN
Rhotekin

1

0

High-throughput

0.249

Low

196515

FA53C
Protein FAM53C

1

0

High-throughput

0.249

Low

196528

ZBT21
Zinc finger and BTB domain-containing protein 21

1

0

High-throughput

0.249

Low

196407

MCM7
DNA replication licensing factor MCM7

1

0

Small-scale

0.232

Low


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Last updated: 15 Jul 2024