Protein: IMDH1
Inosine-5'-monophosphate dehydrogenase 1 (IMP dehydrogenase 1) (IMPD 1) (IMPDH 1) (EC 1.1.1.205) (IMPDH-I)

Gene: IMDH1, IMPDH1
Organism: Homo sapiens
Interactions: 124
UniProt ID: P20839

Gene Ontology (top 5):
GO:0000166 - nucleotide binding
GO:0003676 - nucleic acid binding
GO:0003677 - DNA binding
GO:0003723 - RNA binding
GO:0003938 - IMP dehydrogenase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

518580

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

6

16

High-throughput

0.946

High

596028

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

3

16

Small-scale

0.840

High

596081

ANKR9
Ankyrin repeat domain-containing protein 9

3

1

Small-scale

0.667

High

134446

PODXL
Podocalyxin

2

2

High-throughput

0.628

High

596029

GATA2
Endothelial transcription factor GATA-2

2

2

High-throughput

0.628

High

596047

SKP2
S-phase kinase-associated protein 2

2

1

High-throughput

0.628

High

596068

KLD8B
Kelch domain-containing protein 8B

2

1

High-throughput

0.628

High

596069

PUSL1
tRNA pseudouridine synthase-like 1

2

2

High-throughput

0.628

High

596077

SMCR8
Guanine nucleotide exchange protein SMCR8

2

1

High-throughput

0.628

High

596091

PI51A
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

2

1

High-throughput

0.628

High

596095

MET22
Methyltransferase-like protein 22

2

1

High-throughput

0.628

High

596098

DPH1
2-(3-amino-3-carboxypropyl)histidine synthase subunit 1

2

1

High-throughput

0.628

High

596104

WDR76
WD repeat-containing protein 76

2

4

High-throughput

0.628

High

596114

MOK
MAPK/MAK/MRK overlapping kinase

2

3

High-throughput

0.628

High

596120

MTCH2
Mitochondrial carrier homolog 2

2

4

High-throughput

0.628

High

596103

DUS21
Dual specificity protein phosphatase 21

1

1

High-throughput

0.618

High

278226

PIAS2
E3 SUMO-protein ligase PIAS2

2

1

High-throughput

0.606

High

596042

RNF4
E3 ubiquitin-protein ligase RNF4

2

1

High-throughput

0.606

High

230465

TYW4
tRNA wybutosine-synthesizing protein 4

2

0

High-throughput

0.602

High

596036

STK19
Inactive serine/threonine-protein kinase 19

2

0

High-throughput

0.602

High

596045

ABD18
Protein ABHD18

2

0

High-throughput

0.602

High

596048

PEX6
Peroxisomal ATPase PEX6

2

0

High-throughput

0.602

High

596059

CAF17
Putative transferase CAF17, mitochondrial

2

0

High-throughput

0.602

High

596061

QTGAL
Queuosine-tRNA galactosyltransferase

2

0

High-throughput

0.602

High

596062

LRC8E
Volume-regulated anion channel subunit LRRC8E

2

0

High-throughput

0.602

High

596066

ATG4D
Cysteine protease ATG4D

2

0

High-throughput

0.602

High

596083

MTMR8
Myotubularin-related protein 8

2

0

High-throughput

0.602

High

596084

F120B
Constitutive coactivator of peroxisome proliferator-activated receptor gamma

2

0

High-throughput

0.602

High

596090

C560
Succinate dehydrogenase cytochrome b560 subunit, mitochondrial

2

0

High-throughput

0.602

High

596093

SOST
Sclerostin

2

0

High-throughput

0.602

High

596100

TRIM6
Tripartite motif-containing protein 6

2

0

High-throughput

0.602

High

307156

KLHL2
Kelch-like protein 2

2

0

High-throughput

0.585

High

596082

DDT4L
DNA damage-inducible transcript 4-like protein

2

0

High-throughput

0.580

High

596118

ARIP4
Helicase ARIP4

2

0

High-throughput

0.580

High

596055

ACSF3
Malonate--CoA ligase ACSF3, mitochondrial

2

3

High-throughput

0.574

High

596060

WDR25
WD repeat-containing protein 25

2

1

High-throughput

0.574

High

596071

ARG39
Rho guanine nucleotide exchange factor 39

2

2

High-throughput

0.574

High

596079

DCAKD
Dephospho-CoA kinase domain-containing protein

2

2

High-throughput

0.574

High

596086

S2544
Solute carrier family 25 member 44

2

3

High-throughput

0.574

High

596109

MTCH1
Mitochondrial carrier homolog 1

2

2

High-throughput

0.574

High

596112

MRM2
rRNA methyltransferase 2, mitochondrial

2

1

High-throughput

0.574

High

596115

BCS1
Mitochondrial chaperone BCS1

2

1

High-throughput

0.574

High

368978

ESR1
Estrogen receptor

2

3

High-throughput

0.571

High

117584

MYO1C
Unconventional myosin-Ic

1

2

High-throughput

0.536

High

164780

SC16A
Protein transport protein Sec16A

1

3

High-throughput

0.536

High

207013

XRCC3
DNA repair protein XRCC3

1

1

High-throughput

0.536

High

455085

PARP1
Poly [ADP-ribose] polymerase 1

1

2

High-throughput

0.536

High

567795

HXB8
Homeobox protein Hox-B8

1

1

High-throughput

0.536

High

596038

LIMK1
LIM domain kinase 1

1

3

High-throughput

0.536

High

596039

DLX1
Homeobox protein DLX-1

1

3

High-throughput

0.536

High

596050

BOP1
Ribosome biogenesis protein BOP1

1

1

High-throughput

0.536

High

596051

HLTF
Helicase-like transcription factor

1

5

High-throughput

0.536

High

596052

EMC2
ER membrane protein complex subunit 2

1

4

High-throughput

0.536

High

596058

NOL9
Polynucleotide 5'-hydroxyl-kinase NOL9

1

1

High-throughput

0.536

High

596075

ARRD2
Arrestin domain-containing protein 2

1

2

High-throughput

0.536

High

596096

SCRT1
Transcriptional repressor scratch 1

1

1

High-throughput

0.536

High

596107

SETD4
SET domain-containing protein 4

1

1

High-throughput

0.536

High

267120

GEMI
Geminin

1

0

High-throughput

0.518

High

596065

Q7KZS0
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.515

High

258660

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

1

0

High-throughput

0.513

High

270180

RPC9
DNA-directed RNA polymerase III subunit RPC9

1

0

High-throughput

0.513

High

311148

NDUC2
NADH dehydrogenase [ubiquinone] 1 subunit C2

1

0

High-throughput

0.513

High

596030

KAP1
cAMP-dependent protein kinase type I-beta regulatory subunit

1

0

High-throughput

0.513

High

596034

KC1D
Casein kinase I isoform delta

1

0

High-throughput

0.513

High

596043

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.513

High

596046

DYH14
Dynein axonemal heavy chain 14

1

0

High-throughput

0.513

High

596049

RUNX2
Runt-related transcription factor 2

1

0

High-throughput

0.513

High

596063

ZN704
Zinc finger protein 704

1

0

High-throughput

0.513

High

596070

GTPB8
GTP-binding protein 8

1

0

High-throughput

0.513

High

596073

ENDOV
Endonuclease V

1

0

High-throughput

0.513

High

596085

HBAP1
HSPB1-associated protein 1

1

0

High-throughput

0.513

High

596092

KLDC3
Kelch domain-containing protein 3

1

0

High-throughput

0.513

High

174618

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

3

High-throughput

0.501

High

596033

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

0

High-throughput

0.493

High

596054

HSDL1
Inactive hydroxysteroid dehydrogenase-like protein 1

1

1

High-throughput

0.489

High

596072

EMC5
ER membrane protein complex subunit 5

1

1

High-throughput

0.489

High

596076

S2540
Mitochondrial glutathione transporter SLC25A40

1

2

High-throughput

0.489

High

596099

S2539
Mitochondrial glutathione transporter SLC25A39

1

5

High-throughput

0.489

High

596101

S2532
Solute carrier family 25 member 32

1

1

High-throughput

0.489

High

596108

DJC11
DnaJ homolog subfamily C member 11

1

2

High-throughput

0.489

High

596041

UBC9
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.481

High

165811

KDM6B
Lysine-specific demethylase 6B

1

2

Small-scale

0.479

High

226508

PRKN
E3 ubiquitin-protein ligase parkin

1

5

High-throughput

0.479

High

351252

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

1

High-throughput

0.479

High

373673

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

453049

HXB7
Homeobox protein Hox-B7

1

2

High-throughput

0.479

High

569176

CEBPB
CCAAT/enhancer-binding protein beta

1

2

High-throughput

0.479

High

596032

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

596064

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

596097

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

2

Small-scale

0.479

High

596102

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.479

High

596110

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

596113

VAX2
Ventral anterior homeobox 2

1

1

High-throughput

0.479

High

596119

MAFB
Transcription factor MafB

1

1

High-throughput

0.479

High

596080

HTRA1
Serine protease HTRA1

1

0

High-throughput

0.460

High

596035

FAS
Fatty acid synthase

1

0

High-throughput

0.458

High

596044

SUH
Recombining binding protein suppressor of hairless

1

0

High-throughput

0.458

High

596074

TXND5
Thioredoxin domain-containing protein 5

1

0

High-throughput

0.458

High

596111

DPOLL
DNA polymerase lambda

1

0

High-throughput

0.458

High

596031

BMI1
Polycomb complex protein BMI-1

1

2

High-throughput

0.445

High

384250

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.437

High

596117

NR2E1
Nuclear receptor subfamily 2 group E member 1

1

3

High-throughput

0.437

High

596089

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

596116

ITM2B
Integral membrane protein 2B

1

0

High-throughput

0.426

High

89955

D6R9G5
Kelch like family member 2

1

1

High-throughput

0.407

High

309894

UCP5
Brain mitochondrial carrier protein 1

2

0

High-throughput

0.328

High

596056

ZRAB3
DNA annealing helicase and endonuclease ZRANB3

2

0

High-throughput

0.328

High

596078

DCAF4
DDB1- and CUL4-associated factor 4

2

0

High-throughput

0.328

High

596088

GUCD1
Protein GUCD1

2

0

High-throughput

0.328

High

596105

ABCBA
ATP-binding cassette sub-family B member 10, mitochondrial

2

0

High-throughput

0.328

High

157524

MGST3
Glutathione S-transferase 3, mitochondrial

1

0

High-throughput

0.279

Low

177578

BCAT2
Branched-chain-amino-acid aminotransferase, mitochondrial

1

0

High-throughput

0.279

Low

565337

TMM11
Transmembrane protein 11, mitochondrial

1

0

High-throughput

0.279

Low

596037

NAR1
GPI-linked NAD(P)(+)--arginine ADP-ribosyltransferase 1

1

0

High-throughput

0.279

Low

596040

C1QT8
Complement C1q tumor necrosis factor-related protein 8

1

0

High-throughput

0.279

Low

596053

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.279

Low

596087

SFXN2
Sideroflexin-2

1

0

High-throughput

0.279

Low

596094

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.279

Low

596106

PLCE
1-acyl-sn-glycerol-3-phosphate acyltransferase epsilon

1

0

High-throughput

0.279

Low

100471

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

329025

TCL1B
T-cell leukemia/lymphoma protein 1B

1

0

High-throughput

0.249

Low

596057

SPXN3
Sperm protein associated with the nucleus on the X chromosome N3

1

0

High-throughput

0.249

Low

596067

CQ082
Putative uncharacterized protein LINC02875

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024