Protein: PFKAL
ATP-dependent 6-phosphofructokinase, liver type (ATP-PFK) (PFK-L) (EC 2.7.1.11) (6-phosphofructokinase type B) (Phosphofructo-1-kinase isozyme B) (PFK-B) (Phosphohexokinase)

Gene: PFKAL, PFKL
Organism: Homo sapiens
Interactions: 168
UniProt ID: P17858

Gene Ontology (top 5):
GO:0003872 - 6-phosphofructokinase activity
GO:0005524 - ATP binding
GO:0005576 - extracellular region
GO:0005829 - cytosol
GO:0005945 - 6-phosphofructokinase complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

571705

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

3

13

High-throughput

0.861

High

571662

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

2

13

Small-scale

0.793

High

437712

PFKAM
ATP-dependent 6-phosphofructokinase, muscle type

2

13

Small-scale

0.757

High

322158

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

3

0

High-throughput

0.613

High

528499

CFTR
Cystic fibrosis transmembrane conductance regulator

2

2

High-throughput

0.601

High

226463

PRKN
E3 ubiquitin-protein ligase parkin

2

9

High-throughput

0.584

High

337899

EGFR
Epidermal growth factor receptor

2

7

High-throughput

0.584

High

571667

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

2

Small-scale

0.573

High

571670

KRA59
Keratin-associated protein 5-9

1

2

High-throughput

0.573

High

571696

KR107
Keratin-associated protein 10-7

1

1

High-throughput

0.573

High

368945

ESR1
Estrogen receptor

2

3

High-throughput

0.571

High

571729

CE162
Centrosomal protein of 162 kDa

2

3

High-throughput

0.571

High

571735

TBA1A
Tubulin alpha-1A chain

2

2

High-throughput

0.571

High

571754

GTPB3
tRNA modification GTPase GTPBP3, mitochondrial

1

0

High-throughput

0.549

High

571766

KR412
Keratin-associated protein 4-12

1

1

High-throughput

0.541

High

571770

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

3

High-throughput

0.541

High

153078

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

5

High-throughput

0.536

High

362789

FINC
Fibronectin

1

1

High-throughput

0.536

High

571688

GRK6
G protein-coupled receptor kinase 6

1

5

High-throughput

0.536

High

571694

NEK4
Serine/threonine-protein kinase Nek4

1

7

High-throughput

0.536

High

571707

TIE2
Angiopoietin-1 receptor

1

10

High-throughput

0.536

High

571741

FOXP4
Forkhead box protein P4

1

2

High-throughput

0.536

High

571757

FAF2
FAS-associated factor 2

1

1

High-throughput

0.536

High

571769

DUS16
Dual specificity protein phosphatase 16

1

2

High-throughput

0.536

High

571772

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

2

High-throughput

0.536

High

571722

TESK1
Dual specificity testis-specific protein kinase 1

1

0

High-throughput

0.518

High

571736

CSN6
COP9 signalosome complex subunit 6

1

0

High-throughput

0.518

High

571765

MYD88
Myeloid differentiation primary response protein MyD88

1

0

High-throughput

0.518

High

177816

TMPS2
Transmembrane protease serine 2

1

6

High-throughput

0.515

High

429821

CATL1
Procathepsin L

1

3

High-throughput

0.515

High

431173

CATB
Cathepsin B

1

5

High-throughput

0.515

High

456799

FURIN
Furin

1

1

High-throughput

0.515

High

571669

CATS
Cathepsin S

1

3

High-throughput

0.515

High

571673

DPP4
Dipeptidyl peptidase 4

1

1

High-throughput

0.515

High

571738

TM11B
Transmembrane protease serine 11B

1

6

High-throughput

0.515

High

571748

CLC4D
C-type lectin domain family 4 member D

1

3

High-throughput

0.515

High

571782

TMPS4
Transmembrane protease serine 4

1

6

High-throughput

0.515

High

571787

CLC4E
C-type lectin domain family 4 member E

1

3

High-throughput

0.515

High

571726

LRRF1
Leucine-rich repeat flightless-interacting protein 1

1

0

High-throughput

0.513

High

571742

DDX60
Probable ATP-dependent RNA helicase DDX60

1

0

High-throughput

0.513

High

571747

COQ8A
Atypical kinase COQ8A, mitochondrial

1

0

High-throughput

0.513

High

571763

TSNAX
Translin-associated protein X

1

0

High-throughput

0.513

High

571768

TX101
Testis-expressed protein 101

1

0

High-throughput

0.513

High

571781

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.513

High

571727

UBP39
Ubiquitin carboxyl-terminal hydrolase 39

1

4

Small-scale

0.512

High

263509

PR40A
Pre-mRNA-processing factor 40 homolog A

1

4

High-throughput

0.508

High

571672

1433T
14-3-3 protein theta

1

6

High-throughput

0.501

High

383594

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

7

High-throughput

0.500

High

571675

EPHA8
Ephrin type-A receptor 8

1

7

High-throughput

0.500

High

571714

SNW1
SNW domain-containing protein 1

1

2

Small-scale

0.489

High

394079

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

123490

PGRC1
Membrane-associated progesterone receptor component 1

1

2

Small-scale

0.479

High

148374

CTRO
Citron Rho-interacting kinase

1

5

High-throughput

0.479

High

155264

NRP1
Neuropilin-1

1

2

High-throughput

0.479

High

209653

PRC1
Protein regulator of cytokinesis 1

1

1

High-throughput

0.479

High

224297

RAD21
Double-strand-break repair protein rad21 homolog

1

1

High-throughput

0.479

High

304023

UBR5
E3 ubiquitin-protein ligase UBR5

1

2

Small-scale

0.479

High

354283

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.479

High

384225

NTRK1
High affinity nerve growth factor receptor

1

14

High-throughput

0.479

High

411587

LCK
Tyrosine-protein kinase Lck

1

3

High-throughput

0.479

High

445819

ROS1
Proto-oncogene tyrosine-protein kinase ROS

1

13

High-throughput

0.479

High

503398

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

525840

IFM1
Interferon-induced transmembrane protein 1

1

3

High-throughput

0.479

High

530410

ITA4
Integrin alpha-4

1

2

High-throughput

0.479

High

571663

VGFR1
Vascular endothelial growth factor receptor 1

1

11

High-throughput

0.479

High

571665

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

3

High-throughput

0.479

High

571666

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

1

High-throughput

0.479

High

571668

FGFR3
Fibroblast growth factor receptor 3

1

18

High-throughput

0.479

High

571671

EF1G
Elongation factor 1-gamma

1

1

High-throughput

0.479

High

571674

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

571676

PML
Protein PML

1

2

High-throughput

0.479

High

571677

UFO
Tyrosine-protein kinase receptor UFO

1

13

High-throughput

0.479

High

571679

BASI
Basigin

1

1

High-throughput

0.479

High

571681

VGFR3
Vascular endothelial growth factor receptor 3

1

11

High-throughput

0.479

High

571682

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

10

High-throughput

0.479

High

571685

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

571686

M3K8
Mitogen-activated protein kinase kinase kinase 8

1

3

High-throughput

0.479

High

571689

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.479

High

571690

KC1A
Casein kinase I isoform alpha

1

2

High-throughput

0.479

High

571693

CDK9
Cyclin-dependent kinase 9

1

10

High-throughput

0.479

High

571700

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

571701

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

3

High-throughput

0.479

High

571702

NFKB2
Nuclear factor NF-kappa-B p100 subunit

1

2

High-throughput

0.479

High

571703

RELB
Transcription factor RelB

1

2

High-throughput

0.479

High

571706

KIF23
Kinesin-like protein KIF23

1

2

High-throughput

0.479

High

571708

MECOM
Histone-lysine N-methyltransferase MECOM

1

3

High-throughput

0.479

High

571711

TRAF2
TNF receptor-associated factor 2

1

2

High-throughput

0.479

High

571713

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

571715

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

3

High-throughput

0.479

High

571716

CUL7
Cullin-7

1

1

High-throughput

0.479

High

571718

TNIP1
TNFAIP3-interacting protein 1

1

5

High-throughput

0.479

High

571719

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

571725

DDR2
Discoidin domain-containing receptor 2

1

12

High-throughput

0.479

High

571731

RN123
E3 ubiquitin-protein ligase RNF123

1

1

High-throughput

0.479

High

571732

VIR
Protein virilizer homolog

1

2

High-throughput

0.479

High

571733

ZN746
Zinc finger protein 746

1

1

High-throughput

0.479

High

571737

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

571739

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

571745

NHLC2
NHL repeat-containing protein 2

1

1

High-throughput

0.479

High

571746

RN149
E3 ubiquitin-protein ligase RNF149

1

2

High-throughput

0.479

High

571749

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

571753

FBXW7
F-box/WD repeat-containing protein 7

1

2

High-throughput

0.479

High

571758

RNF31
E3 ubiquitin-protein ligase RNF31

1

2

High-throughput

0.479

High

571759

AURKB
Aurora kinase B

1

7

High-throughput

0.479

High

571761

RUFY1
RUN and FYVE domain-containing protein 1

1

1

High-throughput

0.479

High

571764

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

3

High-throughput

0.479

High

571767

ATGA1
Autophagy-related protein 101

1

1

High-throughput

0.479

High

571771

ACE2
Angiotensin-converting enzyme 2

1

2

High-throughput

0.479

High

571774

SPRTN
DNA-dependent metalloprotease SPRTN

1

2

High-throughput

0.479

High

571775

CCDC8
Coiled-coil domain-containing protein 8

1

1

High-throughput

0.479

High

571777

PRD16
Histone-lysine N-methyltransferase PRDM16

1

3

High-throughput

0.479

High

571779

ANLN
Anillin

1

1

High-throughput

0.479

High

571780

FBX6
F-box only protein 6

1

2

High-throughput

0.479

High

571784

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.479

High

571785

HDAC6
Histone deacetylase 6

1

5

Small-scale

0.479

High

571786

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

571790

LOXL2
Lysyl oxidase homolog 2

1

1

High-throughput

0.479

High

182543

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

519119

KCRB
Creatine kinase B-type

1

0

High-throughput

0.458

High

571680

FUS
RNA-binding protein FUS

1

0

High-throughput

0.458

High

571684

COIL
Coilin

1

0

High-throughput

0.458

High

571697

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.458

High

571724

HIF1A
Hypoxia-inducible factor 1-alpha

1

0

High-throughput

0.458

High

571756

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

571783

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

0

High-throughput

0.458

High

571698

SUMO2
Small ubiquitin-related modifier 2

1

4

High-throughput

0.457

High

371354

ANGI
Angiogenin

1

1

High-throughput

0.445

High

496252

TAU
Microtubule-associated protein tau

1

9

High-throughput

0.445

High

571664

VCAM1
Vascular cell adhesion protein 1

1

2

High-throughput

0.445

High

571728

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

571743

RYBP
RING1 and YY1-binding protein

1

2

High-throughput

0.445

High

571773

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.445

High

571789

ITM2B
Integral membrane protein 2B

1

3

High-throughput

0.445

High

328729

TOP3B
DNA topoisomerase 3-beta-1

1

1

High-throughput

0.437

High

345868

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.437

High

551900

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

571678

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

571683

BRCA1
Breast cancer type 1 susceptibility protein

1

3

High-throughput

0.437

High

571699

WDR5
WD repeat-containing protein 5

1

2

High-throughput

0.437

High

571704

IFM3
Interferon-induced transmembrane protein 3

1

3

High-throughput

0.437

High

571709

DMWD
Dystrophia myotonica WD repeat-containing protein

1

5

High-throughput

0.437

High

571717

HAPR1
HUWE1-associated protein modifying stress responses 1

1

1

Small-scale

0.437

High

571721

TERF2
Telomeric repeat-binding factor 2

1

1

High-throughput

0.437

High

571723

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.437

High

571734

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

571744

KDF1
Keratinocyte differentiation factor 1

1

2

High-throughput

0.437

High

571750

ESR2
Estrogen receptor beta

1

3

High-throughput

0.437

High

571751

HDAC2
Histone deacetylase 2

1

6

High-throughput

0.437

High

571755

VP33A
Vacuolar protein sorting-associated protein 33A

1

1

High-throughput

0.437

High

571762

RING2
E3 ubiquitin-protein ligase RING2

1

5

High-throughput

0.437

High

571776

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.437

High

571778

SHCAF
SIN3-HDAC complex-associated factor

1

1

Small-scale

0.437

High

571788

TFR2
Transferrin receptor protein 2

1

1

High-throughput

0.437

High

571687

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

0

Small-scale

0.426

High

571692

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

91496

E7ET36
Transferrin receptor 2

1

1

High-throughput

0.407

High

571710

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

1

High-throughput

0.407

High

571740

DAAF5
Dynein axonemal assembly factor 5

1

0

Small-scale

0.292

High

571695

ATN1
Atrophin-1

1

0

High-throughput

0.265

Low

214078

SPOP
Speckle-type POZ protein

1

0

High-throughput

0.249

Low

233203

NUPR1
Nuclear protein 1

1

0

High-throughput

0.249

Low

571691

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

571712

TAF10
Transcription initiation factor TFIID subunit 10

1

0

High-throughput

0.249

Low

571720

TAF13
Transcription initiation factor TFIID subunit 13

1

0

High-throughput

0.249

Low

571730

TET5C
Terminal nucleotidyltransferase 5C

1

0

High-throughput

0.249

Low

571752

DPF3
Zinc finger protein DPF3

1

0

Small-scale

0.249

Low

571760

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024