Protein: NEDD4
E3 ubiquitin-protein ligase NEDD4 (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase NEDD4)

Gene: NEDD4
Organism: Rattus norvegicus
Interactions: 20
UniProt ID: Q62940

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000151 - ubiquitin ligase complex
GO:0000785 - chromatin
GO:0002250 - adaptive immune response
GO:0003151 - outflow tract morphogenesis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

465235

CXA1
Gap junction alpha-1 protein

5

2

Small-scale

0.719

High

788565

SCNNB
Epithelial sodium channel subunit beta

3

20

Small-scale

0.653

High

1224332

GRB7
Growth factor receptor-bound protein 7

1

20

Small-scale

0.618

High

788568

SCNNG
Epithelial sodium channel subunit gamma

2

20

Small-scale

0.614

High

236501

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

2

12

Small-scale

0.584

High

1216890

NFIP1
NEDD4 family-interacting protein 1

2

17

Small-scale

0.584

High

788562

SCNNA
Epithelial sodium channel subunit alpha

1

20

Small-scale

0.552

High

93275

D4A7Q7
non-specific serine/threonine protein kinase

1

9

Small-scale

0.479

High

98920

F1MAL5
Insulin receptor substrate 2

1

8

Small-scale

0.479

High

205704

S22A6
Solute carrier family 22 member 6

1

8

Small-scale

0.479

High

313191

KCNQ2
Potassium voltage-gated channel subfamily KQT member 2

1

20

Small-scale

0.479

High

663646

SC6A3
Sodium-dependent dopamine transporter

1

2

Small-scale

0.479

High

764213

1433B
14-3-3 protein beta/alpha

1

20

Small-scale

0.479

High

967132

1433G
14-3-3 protein gamma [Cleaved into: 14-3-3 protein gamma, N-terminally processed]

1

20

Small-scale

0.479

High

972334

1433E
14-3-3 protein epsilon

1

12

Small-scale

0.479

High

996640

1433T
14-3-3 protein theta

1

20

Small-scale

0.479

High

999300

1433F
14-3-3 protein eta

1

20

Small-scale

0.479

High

1224245

NMDE4
Glutamate receptor ionotropic, NMDA 2D

1

4

Small-scale

0.479

High

1224331

Q8VBU7
Beta-2 adrenergic receptor

1

4

Small-scale

0.479

High

1224333

AAGAB
Alpha- and gamma-adaptin-binding protein p34

1

0

Small-scale

0.458

High


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Last updated: 11Aug2025