Protein: PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit (PP6C) (EC 3.1.3.16) [Cleaved into: Serine/threonine-protein phosphatase 6 catalytic subunit, N-terminally processed]

Gene: PPP6, PPP6C
Organism: Homo sapiens
Interactions: 209
UniProt ID: O00743

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0004722 - protein serine/threonine phosphatase activity
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

135430

IGBP1
Immunoglobulin-binding protein 1

11

20

Small-scale

0.982

High

135322

TIPRL
TIP41-like protein

5

7

Small-scale

0.927

High

135515

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

10

8

Small-scale

0.758

High

135321

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

10

9

Small-scale

0.758

High

135451

PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

9

8

Small-scale

0.755

High

135315

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

8

3

Small-scale

0.754

High

135468

ANR52
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C

6

3

Small-scale

0.741

High

135432

PRKDC
DNA-dependent protein kinase catalytic subunit

4

10

Small-scale

0.703

High

135431

TCPB
T-complex protein 1 subunit beta

4

20

High-throughput

0.699

High

135479

ARHG2
Rho guanine nucleotide exchange factor 2

4

6

Small-scale

0.697

High

135312

ML12B
Myosin regulatory light chain 12B

1

3

High-throughput

0.691

High

135313

AURKA
Aurora kinase A

4

18

High-throughput

0.686

High

135317

M3K7
Mitogen-activated protein kinase kinase kinase 7

3

7

Small-scale

0.675

High

135467

ANR44
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B

6

3

Small-scale

0.674

High

135409

PLK1
Serine/threonine-protein kinase PLK1

3

11

High-throughput

0.667

High

135481

AURKB
Aurora kinase B

3

19

High-throughput

0.640

High

135348

HSP7C
Heat shock cognate 71 kDa protein

3

10

High-throughput

0.633

High

135501

MOB1A
MOB kinase activator 1A

2

6

High-throughput

0.621

High

135412

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

1

High-throughput

0.618

High

135416

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

12

High-throughput

0.618

High

135421

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

13

High-throughput

0.618

High

135329

MYC
Myc proto-oncogene protein

2

11

High-throughput

0.611

High

135436

VAC14
Protein VAC14 homolog

2

6

High-throughput

0.606

High

135387

BRCA1
Breast cancer type 1 susceptibility protein

2

7

High-throughput

0.584

High

135441

TRI14
Tripartite motif-containing protein 14

1

6

High-throughput

0.573

High

135365

RASA1
Ras GTPase-activating protein 1

2

6

High-throughput

0.571

High

135408

BMX
Cytoplasmic tyrosine-protein kinase BMX

2

1

High-throughput

0.571

High

135420

RHOA
Transforming protein RhoA

2

6

High-throughput

0.571

High

135459

RHG22
Rho GTPase-activating protein 22

2

5

High-throughput

0.571

High

135477

ESR2
Estrogen receptor beta

2

14

High-throughput

0.571

High

135478

BAD
Bcl2-associated agonist of cell death

2

2

High-throughput

0.571

High

135456

MOB1B
MOB kinase activator 1B

1

6

High-throughput

0.554

High

135364

ELK1
ETS domain-containing protein Elk-1

2

0

High-throughput

0.547

High

135470

ZNRF2
E3 ubiquitin-protein ligase ZNRF2

1

0

Small-scale

0.537

High

135320

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

15

High-throughput

0.536

High

135345

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

2

High-throughput

0.536

High

135346

ARAF
Serine/threonine-protein kinase A-Raf

1

16

High-throughput

0.536

High

135349

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

1

3

High-throughput

0.536

High

135350

ODBA
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

1

2

High-throughput

0.536

High

135360

TCPA
T-complex protein 1 subunit alpha

1

20

High-throughput

0.536

High

135366

ODBB
2-oxoisovalerate dehydrogenase subunit beta, mitochondrial

1

2

High-throughput

0.536

High

135382

CLIP1
CAP-Gly domain-containing linker protein 1

1

10

High-throughput

0.536

High

135389

TCPZ
T-complex protein 1 subunit zeta

1

20

High-throughput

0.536

High

135392

HD
Huntingtin

1

3

High-throughput

0.536

High

135396

UTRN
Utrophin

1

3

High-throughput

0.536

High

135397

TCPE
T-complex protein 1 subunit epsilon

1

20

High-throughput

0.536

High

135401

TCPG
T-complex protein 1 subunit gamma

1

20

High-throughput

0.536

High

135405

TCPD
T-complex protein 1 subunit delta

1

20

High-throughput

0.536

High

135407

IRAK1
Interleukin-1 receptor-associated kinase 1

1

2

High-throughput

0.536

High

135411

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

1

9

High-throughput

0.536

High

135428

TPM4
Tropomyosin alpha-4 chain

1

2

High-throughput

0.536

High

135439

ILK
Integrin-linked protein kinase

1

3

High-throughput

0.536

High

135462

DDX60
Probable ATP-dependent RNA helicase DDX60

1

6

High-throughput

0.536

High

135491

TCPH
T-complex protein 1 subunit eta

1

20

High-throughput

0.536

High

135493

TBB6
Tubulin beta-6 chain

1

5

High-throughput

0.536

High

135506

BIRC6
Baculoviral IAP repeat-containing protein 6

1

9

High-throughput

0.536

High

135448

RCN1
Reticulocalbin-1

1

0

High-throughput

0.517

High

127412

RPOM
DNA-directed RNA polymerase, mitochondrial

1

0

High-throughput

0.513

High

135338

K2C8
Keratin, type II cytoskeletal 8

1

0

High-throughput

0.513

High

135464

TRM2A
tRNA

1

0

High-throughput

0.513

High

135497

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.513

High

135341

SP1
Transcription factor Sp1

1

9

High-throughput

0.500

High

135472

SP7
Transcription factor Sp7

1

8

High-throughput

0.500

High

135447

P2RY6
P2Y purinoceptor 6

1

2

High-throughput

0.489

High

121545

IKBE
NF-kappa-B inhibitor epsilon

1

11

High-throughput

0.479

High

123414

PGRC1
Membrane-associated progesterone receptor component 1

1

1

Small-scale

0.479

High

135314

XPO1
Exportin-1

1

8

High-throughput

0.479

High

135319

PRKN
E3 ubiquitin-protein ligase parkin

1

18

High-throughput

0.479

High

135324

RECQ4
ATP-dependent DNA helicase Q4

1

9

High-throughput

0.479

High

135325

UFL1
E3 UFM1-protein ligase 1

1

1

High-throughput

0.479

High

135326

IPO7
Importin-7

1

4

High-throughput

0.479

High

135327

RIGI
Antiviral innate immune response receptor RIG-I

1

10

High-throughput

0.479

High

135328

EGFR
Epidermal growth factor receptor

1

10

High-throughput

0.479

High

135330

RASK
GTPase KRas

1

3

High-throughput

0.479

High

135332

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

16

High-throughput

0.479

High

135334

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

3

High-throughput

0.479

High

135337

LA
Lupus La protein

1

10

High-throughput

0.479

High

135340

HS90A
Heat shock protein HSP 90-alpha

1

2

High-throughput

0.479

High

135343

HS90B
Heat shock protein HSP 90-beta

1

2

High-throughput

0.479

High

135347

BIP
Endoplasmic reticulum chaperone BiP

1

16

High-throughput

0.479

High

135351

XRCC6
X-ray repair cross-complementing protein 6

1

2

High-throughput

0.479

High

135352

XRCC5
X-ray repair cross-complementing protein 5

1

2

High-throughput

0.479

High

135354

EF2
Elongation factor 2

1

3

High-throughput

0.479

High

135356

BRAF
Serine/threonine-protein kinase B-raf

1

16

High-throughput

0.479

High

135357

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

135359

CEBPB
CCAAT/enhancer-binding protein beta

1

5

High-throughput

0.479

High

135362

RL7
Large ribosomal subunit protein uL30

1

2

High-throughput

0.479

High

135363

NUCL
Nucleolin

1

7

High-throughput

0.479

High

135367

NDKB
Nucleoside diphosphate kinase B

1

1

High-throughput

0.479

High

135368

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.479

High

135369

PSA1
Proteasome subunit alpha type-1

1

3

High-throughput

0.479

High

135370

PSA2
Proteasome subunit alpha type-2

1

6

High-throughput

0.479

High

135371

PSA4
Proteasome subunit alpha type-4

1

5

High-throughput

0.479

High

135372

SYVC
Valine--tRNA ligase

1

3

High-throughput

0.479

High

135373

EF1G
Elongation factor 1-gamma

1

3

High-throughput

0.479

High

135374

1433T
14-3-3 protein theta

1

14

High-throughput

0.479

High

135375

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.479

High

135376

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

135377

PYR1
Multifunctional protein CAD

1

6

High-throughput

0.479

High

135379

PSA5
Proteasome subunit alpha type-5

1

4

High-throughput

0.479

High

135380

PSB5
Proteasome subunit beta type-5

1

6

High-throughput

0.479

High

135381

UFO
Tyrosine-protein kinase receptor UFO

1

7

High-throughput

0.479

High

135384

NOS2
Nitric oxide synthase, inducible

1

3

High-throughput

0.479

High

135385

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

135386

PRS7
26S proteasome regulatory subunit 7

1

4

High-throughput

0.479

High

135388

RL3
Large ribosomal subunit protein uL3

1

1

High-throughput

0.479

High

135390

CCNF
Cyclin-F

1

10

High-throughput

0.479

High

135391

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.479

High

135393

PRS6B
26S proteasome regulatory subunit 6B

1

5

High-throughput

0.479

High

135394

RL27A
Large ribosomal subunit protein uL15

1

1

High-throughput

0.479

High

135395

RL5
Large ribosomal subunit protein uL18

1

1

High-throughput

0.479

High

135398

KC1D
Casein kinase I isoform delta

1

6

Small-scale

0.479

High

135399

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

6

High-throughput

0.479

High

135400

FAS
Fatty acid synthase

1

2

High-throughput

0.479

High

135402

EFTU
Elongation factor Tu, mitochondrial

1

4

High-throughput

0.479

High

135403

GUAA
GMP synthase [glutamine-hydrolyzing]

1

3

High-throughput

0.479

High

135404

TCPQ
T-complex protein 1 subunit theta

1

20

High-throughput

0.479

High

135410

COPA
Coatomer subunit alpha

1

2

High-throughput

0.479

High

135413

XPO2
Exportin-2

1

3

High-throughput

0.479

High

135414

TERA
Transitional endoplasmic reticulum ATPase

1

8

High-throughput

0.479

High

135418

ABCE1
ATP-binding cassette sub-family E member 1

1

1

High-throughput

0.479

High

135419

RL27
Large ribosomal subunit protein eL27

1

1

High-throughput

0.479

High

135422

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

5

High-throughput

0.479

High

135423

1433E
14-3-3 protein epsilon

1

4

High-throughput

0.479

High

135424

PRS10
26S proteasome regulatory subunit 10B

1

4

High-throughput

0.479

High

135425

RL7A
Large ribosomal subunit protein eL8

1

2

High-throughput

0.479

High

135426

RL8
Large ribosomal subunit protein uL2

1

1

High-throughput

0.479

High

135427

AP2B1
AP-2 complex subunit beta

1

1

High-throughput

0.479

High

135429

TBA4A
Tubulin alpha-4A chain

1

7

High-throughput

0.479

High

135433

ZXDA
Zinc finger X-linked protein ZXDA

1

5

Small-scale

0.479

High

135434

PO5F1
POU domain, class 5, transcription factor 1

1

2

High-throughput

0.479

High

135435

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

20

High-throughput

0.479

High

135437

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

1

High-throughput

0.479

High

135438

TIF1B
Transcription intermediary factor 1-beta

1

9

High-throughput

0.479

High

135440

CUL3
Cullin-3

1

11

High-throughput

0.479

High

135442

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

1

High-throughput

0.479

High

135443

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

2

High-throughput

0.479

High

135445

LASP1
LIM and SH3 domain protein 1

1

1

High-throughput

0.479

High

135446

SUZ12
Polycomb protein SUZ12

1

1

High-throughput

0.479

High

135449

PCBP1
Poly(rC)-binding protein 1

1

6

High-throughput

0.479

High

135455

TRI67
Tripartite motif-containing protein 67

1

13

High-throughput

0.479

High

135457

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

135458

MAVS
Mitochondrial antiviral-signaling protein

1

9

High-throughput

0.479

High

135460

HOOK3
Protein Hook homolog 3

1

8

High-throughput

0.479

High

135463

S15A3
Solute carrier family 15 member 3

1

1

High-throughput

0.479

High

135465

STK40
Serine/threonine-protein kinase 40

1

15

Small-scale

0.479

High

135471

RIN3
Ras and Rab interactor 3

1

3

High-throughput

0.479

High

135473

DDX1
ATP-dependent RNA helicase DDX1

1

5

High-throughput

0.479

High

135474

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

3

High-throughput

0.479

High

135475

HS105
Heat shock protein 105 kDa

1

16

High-throughput

0.479

High

135476

GCN1
Stalled ribosome sensor GCN1

1

18

High-throughput

0.479

High

135480

EFMT3
EEF1A lysine methyltransferase 3

1

4

High-throughput

0.479

High

135482

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.479

High

135484

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

1

High-throughput

0.479

High

135485

FMNL2
Formin-like protein 2

1

3

High-throughput

0.479

High

135486

CIC
Protein capicua homolog

1

12

High-throughput

0.479

High

135489

RING2
E3 ubiquitin-protein ligase RING2

1

9

High-throughput

0.479

High

135490

DNJC2
DnaJ homolog subfamily C member 2

1

1

High-throughput

0.479

High

135492

PCGF1
Polycomb group RING finger protein 1

1

5

High-throughput

0.479

High

135495

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

7

High-throughput

0.479

High

135498

Q9H4D1
Protein kinase

1

7

High-throughput

0.479

High

135499

PKHA4
Pleckstrin homology domain-containing family A member 4

1

19

High-throughput

0.479

High

135500

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.479

High

135502

PIDD1
p53-induced death domain-containing protein 1

1

13

Small-scale

0.479

High

135503

NMRL1
NmrA-like family domain-containing protein 1

1

4

High-throughput

0.479

High

135504

MYO10
Unconventional myosin-X

1

9

Small-scale

0.479

High

135507

FBX6
F-box only protein 6

1

3

High-throughput

0.479

High

135509

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

1

High-throughput

0.479

High

135510

TAB2
TGF-beta-activated kinase 1 and MAP3K7-binding protein 2

1

4

Small-scale

0.479

High

135512

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

135513

TBK1
Serine/threonine-protein kinase TBK1

1

20

High-throughput

0.479

High

135514

FZR1
Fizzy-related protein homolog

1

6

High-throughput

0.479

High

135516

NUDC
Nuclear migration protein nudC

1

2

High-throughput

0.479

High

135316

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

0

High-throughput

0.458

High

135323

IDHC
Isocitrate dehydrogenase [NADP] cytoplasmic

1

0

High-throughput

0.458

High

135339

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

0

High-throughput

0.458

High

135344

ANXA5
Annexin A5

1

0

High-throughput

0.458

High

135355

ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial

1

0

High-throughput

0.458

High

135361

ARF4
ADP-ribosylation factor 4

1

0

High-throughput

0.458

High

135383

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

0

High-throughput

0.458

High

135406

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.458

High

135417

RAB10
Ras-related protein Rab-10

1

0

High-throughput

0.458

High

135453

RNF43
E3 ubiquitin-protein ligase RNF43

1

0

High-throughput

0.458

High

135466

CGAS
Cyclic GMP-AMP synthase

1

0

High-throughput

0.458

High

135483

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.458

High

135488

WRIP1
ATPase WRNIP1

1

0

High-throughput

0.458

High

135494

API5
Apoptosis inhibitor 5

1

0

High-throughput

0.458

High

135496

CEP44
Centrosomal protein of 44 kDa

1

0

High-throughput

0.458

High

135505

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

135508

OLA1
Obg-like ATPase 1

1

0

High-throughput

0.458

High

135511

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

135333

HG2A
HLA class II histocompatibility antigen gamma chain

1

2

High-throughput

0.445

High

135353

CFTR
Cystic fibrosis transmembrane conductance regulator

1

3

High-throughput

0.445

High

135415

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

7

High-throughput

0.445

High

135452

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

10

High-throughput

0.445

High

135331

TNFA
Tumor necrosis factor

1

2

Small-scale

0.437

High

135335

NTRK1
High affinity nerve growth factor receptor

1

4

High-throughput

0.437

High

135336

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

3

High-throughput

0.437

High

135342

IGF1R
Insulin-like growth factor 1 receptor

1

5

High-throughput

0.437

High

135358

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

3

High-throughput

0.437

High

135487

RB40C
Ras-related protein Rab-40C

1

1

Small-scale

0.437

High

135318

AKA10
A-kinase anchor protein 10, mitochondrial

1

0

High-throughput

0.426

High

99507

F5H1C8
Solute carrier family 15 member 3

1

1

High-throughput

0.407

High

135469

MOT11
Monocarboxylate transporter 11

1

3

High-throughput

0.407

High

135461

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

0

High-throughput

0.279

Low

135378

CALX
Calnexin

1

0

High-throughput

0.249

Low

135444

GANAB
Neutral alpha-glucosidase AB

1

0

High-throughput

0.249

Low

135450

MINY4
Probable ubiquitin carboxyl-terminal hydrolase MINDY-4

1

0

Small-scale

0.249

Low

135454

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024