Protein: PLD3
5'-3' exonuclease PLD3 (EC 3.1.16.1) (Choline phosphatase 3) (HindIII K4L homolog) (Hu-K4) (Phosphatidylcholine-hydrolyzing phospholipase D3) (Phospholipase D3) (PLD 3)

Gene: PLD3
Organism: Homo sapiens
Interactions: 234
UniProt ID: Q8IV08

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0002376 - immune system process
GO:0004630 - phospholipase D activity
GO:0005765 - lysosomal membrane
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

529379

CFTR
Cystic fibrosis transmembrane conductance regulator

2

0

High-throughput

0.585

High

567153

CXA1
Gap junction alpha-1 protein

2

2

High-throughput

0.584

High

1217056

CNIH3
Protein cornichon homolog 3

2

0

High-throughput

0.580

High

654511

CALX
Calnexin

2

1

High-throughput

0.571

High

847543

BAP31
B-cell receptor-associated protein 31

2

0

High-throughput

0.559

High

587625

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

0

High-throughput

0.554

High

531894

PDIA4
Protein disulfide-isomerase A4

2

8

High-throughput

0.533

High

1079099

STK11
Serine/threonine-protein kinase STK11

1

0

High-throughput

0.518

High

177935

TMPS2
Transmembrane protease serine 2

1

2

High-throughput

0.515

High

637270

CATS
Cathepsin S

1

1

High-throughput

0.515

High

1198086

TM11B
Transmembrane protease serine 11B

1

2

High-throughput

0.515

High

1217089

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.513

High

1217095

SG196
Protein O-mannose kinase

1

0

High-throughput

0.513

High

160084

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

1

Small-scale

0.501

High

987265

TYRO3
Tyrosine-protein kinase receptor TYRO3

1

1

High-throughput

0.500

High

1217097

GPR35
G-protein coupled receptor 35

1

3

High-throughput

0.494

High

648817

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.493

High

729308

VGFR3
Vascular endothelial growth factor receptor 3

1

2

High-throughput

0.489

High

834077

CLK3
Dual specificity protein kinase CLK3

1

2

High-throughput

0.489

High

1067532

P2RY6
P2Y purinoceptor 6

1

2

High-throughput

0.489

High

589213

ANXA7
Annexin A7

1

0

High-throughput

0.486

High

116691

UBXN8
UBX domain-containing protein 8

1

1

High-throughput

0.479

High

156528

SCAM3
Secretory carrier-associated membrane protein 3

1

1

High-throughput

0.479

High

159376

PLD2
Phospholipase D2

1

1

High-throughput

0.479

High

161104

CLGN
Calmegin

1

1

High-throughput

0.479

High

163871

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

1

High-throughput

0.479

High

168558

SCAM2
Secretory carrier-associated membrane protein 2

1

1

High-throughput

0.479

High

175572

TM9S1
Transmembrane 9 superfamily member 1

1

5

High-throughput

0.479

High

217183

EXTL3
Exostosin-like 3

1

1

High-throughput

0.479

High

282438

ERG24
Delta(14)-sterol reductase TM7SF2

1

1

High-throughput

0.479

High

295743

B3GA3
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 3

1

2

High-throughput

0.479

High

338663

EGFR
Epidermal growth factor receptor

1

1

High-throughput

0.479

High

348764

RASN
GTPase NRas

1

3

High-throughput

0.479

High

349453

RASH
GTPase HRas

1

2

High-throughput

0.479

High

350319

RASK
GTPase KRas

1

3

High-throughput

0.479

High

385123

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

391002

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.479

High

403917

ITB1
Integrin beta-1

1

1

High-throughput

0.479

High

419220

ITAV
Integrin alpha-V

1

3

High-throughput

0.479

High

423285

PDIA1
Protein disulfide-isomerase

1

8

High-throughput

0.479

High

429912

CATL1
Procathepsin L

1

1

High-throughput

0.479

High

437408

4F2
Amino acid transporter heavy chain SLC3A2

1

1

High-throughput

0.479

High

525981

IFM1
Interferon-induced transmembrane protein 1

1

1

High-throughput

0.479

High

538306

ENPL
Endoplasmin

1

1

High-throughput

0.479

High

671860

PDIA3
Protein disulfide-isomerase A3

1

9

High-throughput

0.479

High

674475

UFO
Tyrosine-protein kinase receptor UFO

1

1

High-throughput

0.479

High

933878

TBB4B
Tubulin beta-4B chain

1

2

High-throughput

0.479

High

935949

NOMO3
BOS complex subunit NOMO3

1

1

High-throughput

0.479

High

965742

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.479

High

966088

LAT1
Large neutral amino acids transporter small subunit 1

1

1

High-throughput

0.479

High

1028074

DNJC3
DnaJ homolog subfamily C member 3

1

8

High-throughput

0.479

High

1032986

PLD1
Phospholipase D1

1

1

High-throughput

0.479

High

1034481

OS9
Protein OS-9

1

3

High-throughput

0.479

High

1058468

GANAB
Neutral alpha-glucosidase AB

1

1

High-throughput

0.479

High

1058760

LBR
Delta(14)-sterol reductase LBR

1

1

High-throughput

0.479

High

1067758

PDIA6
Protein disulfide-isomerase A6

1

9

High-throughput

0.479

High

1172934

PLPL7
Patatin-like phospholipase domain-containing protein 7

1

1

High-throughput

0.479

High

1183453

RHOU
Rho-related GTP-binding protein RhoU

1

1

High-throughput

0.479

High

1217037

PLD3
5'-3' exonuclease PLD3

1

2

High-throughput

0.479

High

1217041

PLPL6
Patatin-like phospholipase domain-containing protein 6

1

1

High-throughput

0.479

High

1217042

S15A3
Solute carrier family 15 member 3

1

1

High-throughput

0.479

High

1217047

ABD12
Lysophosphatidylserine lipase ABHD12

1

1

High-throughput

0.479

High

1217048

EMC1
ER membrane protein complex subunit 1

1

1

High-throughput

0.479

High

1217059

NICA
Nicastrin

1

1

High-throughput

0.479

High

1217060

LGAT1
Acyl-CoA:lysophosphatidylglycerol acyltransferase 1

1

1

High-throughput

0.479

High

1217062

GPI8
GPI-anchor transamidase

1

1

High-throughput

0.479

High

1217066

EXT2
Exostosin-2

1

1

High-throughput

0.479

High

1217068

PLD4
5'-3' exonuclease PLD4

1

2

High-throughput

0.479

High

1217073

DNJC1
DnaJ homolog subfamily C member 1

1

7

High-throughput

0.479

High

1217079

TM9S2
Transmembrane 9 superfamily member 2

1

5

High-throughput

0.479

High

1217084

RAB34
Ras-related protein Rab-34

1

1

High-throughput

0.479

High

1217088

MAGT1
Magnesium transporter protein 1

1

1

High-throughput

0.479

High

1217090

DJC25
DnaJ homolog subfamily C member 25

1

4

High-throughput

0.479

High

1217093

DNJC5
DnaJ homolog subfamily C member 5

1

4

High-throughput

0.479

High

1217100

ITM2C
Integral membrane protein 2C

1

1

High-throughput

0.479

High

1217109

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

1

1

High-throughput

0.479

High

1217110

SELN
Selenoprotein N

1

1

High-throughput

0.479

High

1217111

HACD3
Very-long-chain

1

1

High-throughput

0.479

High

1217113

CHPF2
Chondroitin sulfate glucuronyltransferase

1

2

High-throughput

0.479

High

1217114

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

2

High-throughput

0.479

High

1217120

MA1B1
Endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase

1

1

High-throughput

0.479

High

1217058

CLC4D
C-type lectin domain family 4 member D

1

1

High-throughput

0.470

High

1217103

TMPS4
Transmembrane protease serine 4

1

2

High-throughput

0.470

High

1217122

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.470

High

489601

OSTP
Osteopontin

1

0

Small-scale

0.460

High

126826

ACATN
Acetyl-coenzyme A transporter 1

1

0

High-throughput

0.458

High

132525

RCAS1
Receptor-binding cancer antigen expressed on SiSo cells

1

0

High-throughput

0.458

High

173734

SURF4
Surfeit locus protein 4

1

0

High-throughput

0.458

High

234126

FADS1
Acyl-CoA

1

0

High-throughput

0.458

High

260197

MPU1
Mannose-P-dolichol utilization defect 1 protein

1

0

High-throughput

0.458

High

390344

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.458

High

438803

SRPRA
Signal recognition particle receptor subunit alpha

1

0

High-throughput

0.458

High

474501

GPHRB
Golgi pH regulator B

1

0

High-throughput

0.458

High

507109

LAMP1
Lysosome-associated membrane glycoprotein 1

1

0

High-throughput

0.458

High

564601

RHOQ
Rho-related GTP-binding protein RhoQ

1

0

High-throughput

0.458

High

592358

RAB5A
Ras-related protein Rab-5A

1

0

High-throughput

0.458

High

649194

CERS1
Ceramide synthase 1

1

0

High-throughput

0.458

High

702622

ACSL1
Long-chain-fatty-acid--CoA ligase 1

1

0

High-throughput

0.458

High

718973

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

740933

FDFT
Squalene synthase

1

0

High-throughput

0.458

High

825464

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.458

High

842367

PPT1
Palmitoyl-protein thioesterase 1

1

0

High-throughput

0.458

High

875093

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

890246

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

974906

CAV1
Caveolin-1

1

0

High-throughput

0.458

High

1017695

STX4
Syntaxin-4

1

0

High-throughput

0.458

High

1034761

ADA15
Disintegrin and metalloproteinase domain-containing protein 15

1

0

High-throughput

0.458

High

1040157

STIM1
Stromal interaction molecule 1

1

0

High-throughput

0.458

High

1041976

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1131282

MANEA
Glycoprotein endo-alpha-1,2-mannosidase

1

0

High-throughput

0.458

High

1165734

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1189534

MON2
Protein MON2 homolog

1

0

High-throughput

0.458

High

1193119

SLN11
Schlafen family member 11

1

0

High-throughput

0.458

High

1205745

DOPP1
Dolichyldiphosphatase 1

1

0

High-throughput

0.458

High

1216470

ZDH13
Palmitoyltransferase ZDHHC13

1

0

High-throughput

0.458

High

1217040

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.458

High

1217043

TM192
Transmembrane protein 192

1

0

High-throughput

0.458

High

1217053

B3GL2
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2

1

0

High-throughput

0.458

High

1217054

NNRE
NAD(P)H-hydrate epimerase

1

0

High-throughput

0.458

High

1217055

DIK2A
Divergent protein kinase domain 2A

1

0

High-throughput

0.458

High

1217074

CLCC1
Chloride channel CLIC-like protein 1

1

0

High-throughput

0.458

High

1217075

RUFY1
RUN and FYVE domain-containing protein 1

1

0

High-throughput

0.458

High

1217077

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

1217080

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

0

High-throughput

0.458

High

1217081

ESYT1
Extended synaptotagmin-1

1

0

High-throughput

0.458

High

1217086

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

1217087

WWP1
NEDD4-like E3 ubiquitin-protein ligase WWP1

1

0

Small-scale

0.458

High

1217091

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

0

High-throughput

0.458

High

1217092

SPNS1
Protein spinster homolog 1

1

0

High-throughput

0.458

High

1217099

RTN4
Reticulon-4

1

0

High-throughput

0.458

High

1217105

T106B
Transmembrane protein 106B

1

0

High-throughput

0.458

High

1217107

CC50A
Cell cycle control protein 50A

1

0

High-throughput

0.458

High

1217108

S38A7
Sodium-coupled neutral amino acid transporter 7

1

0

High-throughput

0.458

High

1217121

PSME2
Proteasome activator complex subunit 2

1

0

High-throughput

0.458

High

1217125

ALG5
Dolichyl-phosphate beta-glucosyltransferase

1

0

High-throughput

0.458

High

175022

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

4

High-throughput

0.457

High

383872

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

1

High-throughput

0.457

High

99634

F5H1C8
Solute carrier family 15 member 3

1

1

High-throughput

0.445

High

279320

DNJB5
DnaJ homolog subfamily B member 5

1

2

High-throughput

0.437

High

299411

UBXN7
UBX domain-containing protein 7

1

1

High-throughput

0.437

High

302731

SLIK5
SLIT and NTRK-like protein 5

1

1

High-throughput

0.437

High

347246

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.437

High

379581

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.437

High

489138

H14
Histone H1.4

1

1

High-throughput

0.437

High

526518

GP1BB
Platelet glycoprotein Ib beta chain

1

1

High-throughput

0.437

High

795030

GPDM
Glycerol-3-phosphate dehydrogenase, mitochondrial

1

1

High-throughput

0.437

High

839328

CPT1A
Carnitine O-palmitoyltransferase 1, liver isoform

1

1

High-throughput

0.437

High

871929

AT12A
Potassium-transporting ATPase alpha chain 2

1

1

High-throughput

0.437

High

878687

HNRH2
Heterogeneous nuclear ribonucleoprotein H2

1

1

High-throughput

0.437

High

1031150

PTK7
Inactive tyrosine-protein kinase 7

1

4

High-throughput

0.437

High

1051883

IF4A2
Eukaryotic initiation factor 4A-II

1

2

High-throughput

0.437

High

1139395

ECM29
Proteasome adapter and scaffold protein ECM29

1

1

High-throughput

0.437

High

1170007

QSOX2
Sulfhydryl oxidase 2

1

10

High-throughput

0.437

High

1173489

TMTC3
Protein O-mannosyl-transferase TMTC3

1

5

High-throughput

0.437

High

1204781

GOLI
E3 ubiquitin-protein ligase RNF130

1

1

High-throughput

0.437

High

1217039

DJC10
DnaJ homolog subfamily C member 10

1

9

High-throughput

0.437

High

1217045

CXD3
Gap junction delta-3 protein

1

2

High-throughput

0.437

High

1217049

TTC13
Tetratricopeptide repeat protein 13

1

6

High-throughput

0.437

High

1217051

RN149
E3 ubiquitin-protein ligase RNF149

1

1

High-throughput

0.437

High

1217052

LEMD2
LEM domain-containing protein 2

1

1

High-throughput

0.437

High

1217061

GCN1
Stalled ribosome sensor GCN1

1

1

High-throughput

0.437

High

1217070

ERLEC
Endoplasmic reticulum lectin 1

1

3

High-throughput

0.437

High

1217078

ROAA
Heterogeneous nuclear ribonucleoprotein A/B

1

1

High-throughput

0.437

High

1217083

TBB2B
Tubulin beta-2B chain

1

2

High-throughput

0.437

High

1217085

EDEM3
ER degradation-enhancing alpha-mannosidase-like protein 3

1

1

High-throughput

0.437

High

1217098

TM9S3
Transmembrane 9 superfamily member 3

1

5

High-throughput

0.437

High

1217115

DJB11
DnaJ homolog subfamily B member 11

1

2

High-throughput

0.437

High

1217117

SEC63
Translocation protein SEC63 homolog

1

2

High-throughput

0.437

High

1217123

MAN1
Inner nuclear membrane protein Man1

1

1

High-throughput

0.437

High

1043930

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

1

High-throughput

0.407

High

1217104

CLTR2
Cysteinyl leukotriene receptor 2

1

2

Small-scale

0.407

High

1217101

FBX6
F-box only protein 6

3

0

High-throughput

0.334

High

723067

OPRM
Mu-type opioid receptor

2

0

High-throughput

0.316

High

1217102

SMCO4
Single-pass membrane and coiled-coil domain-containing protein 4

2

0

High-throughput

0.316

High

296940

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.279

Low

1217044

LSME2
Leucine-rich single-pass membrane protein 2

1

0

High-throughput

0.279

Low

378731

KITH
Thymidine kinase, cytosolic

1

0

High-throughput

0.265

Low

992098

B2CL1
Bcl-2-like protein 1

1

0

High-throughput

0.265

Low

989540

SOX4
Transcription factor SOX-4

1

0

Small-scale

0.251

Low

100924

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

147101

NEMP1
Nuclear envelope integral membrane protein 1

1

0

High-throughput

0.249

Low

205628

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

360120

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.249

Low

374495

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.249

Low

418436

NPM
Nucleophosmin

1

0

High-throughput

0.249

Low

536395

GLU2B
Glucosidase 2 subunit beta

1

0

High-throughput

0.249

Low

553119

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

619257

AT2B4
Plasma membrane calcium-transporting ATPase 4

1

0

High-throughput

0.249

Low

651619

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

720858

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

738559

TGFR1
TGF-beta receptor type-1

1

0

High-throughput

0.249

Low

779701

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

792724

EAA1
Excitatory amino acid transporter 1

1

0

High-throughput

0.249

Low

908778

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

1025448

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

0

High-throughput

0.249

Low

1028322

NDK3
Nucleoside diphosphate kinase 3

1

0

High-throughput

0.249

Low

1056073

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.249

Low

1058659

MFS10
Major facilitator superfamily domain-containing protein 10

1

0

High-throughput

0.249

Low

1061488

CUL7
Cullin-7

1

0

High-throughput

0.249

Low

1078976

NPTX1
Neuronal pentraxin-1

1

0

High-throughput

0.249

Low

1100526

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

1

0

High-throughput

0.249

Low

1103980

PGPS1
CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase, mitochondrial

1

0

High-throughput

0.249

Low

1147985

LMBD2
G-protein coupled receptor-associated protein LMBRD2

1

0

High-throughput

0.249

Low

1157062

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.249

Low

1170685

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1183168

COX15
Heme A synthase COX15

1

0

High-throughput

0.249

Low

1199589

LBN
Limbin

1

0

High-throughput

0.249

Low

1203757

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

1205257

DAAF5
Dynein axonemal assembly factor 5

1

0

High-throughput

0.249

Low

1217038

GLBL2
Beta-galactosidase-1-like protein 2

1

0

High-throughput

0.249

Low

1217046

PLD6
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.249

Low

1217050

DHB11
Estradiol 17-beta-dehydrogenase 11

1

0

High-throughput

0.249

Low

1217057

NEUFC
Neuferricin

1

0

High-throughput

0.249

Low

1217063

RND1
Rho-related GTP-binding protein Rho6

1

0

High-throughput

0.249

Low

1217064

ESR2
Estrogen receptor beta

1

0

High-throughput

0.249

Low

1217065

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.249

Low

1217067

ARRD3
Arrestin domain-containing protein 3

1

0

Small-scale

0.249

Low

1217069

RSPRY
RING finger and SPRY domain-containing protein 1

1

0

High-throughput

0.249

Low

1217071

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

0

High-throughput

0.249

Low

1217072

TECT2
Tectonic-2

1

0

High-throughput

0.249

Low

1217076

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

0

High-throughput

0.249

Low

1217082

CNPY3
Protein canopy homolog 3

1

0

High-throughput

0.249

Low

1217094

FZD8
Frizzled-8

1

0

High-throughput

0.249

Low

1217096

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.249

Low

1217106

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

1217112

TM216
Transmembrane protein 216

1

0

High-throughput

0.249

Low

1217116

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

1217118

SUN2
SUN domain-containing protein 2

1

0

High-throughput

0.249

Low

1217119

EGFL7
Epidermal growth factor-like protein 7

1

0

High-throughput

0.249

Low

1217124

TELO2
Telomere length regulation protein TEL2 homolog

1

0

High-throughput

0.249

Low

240082

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.232

Low

497268

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.232

Low

1047149

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024