Protein: SMG1
Serine/threonine-protein kinase SMG1 (SMG-1) (hSMG-1) (EC 2.7.11.1) (Lambda/iota protein kinase C-interacting protein) (Lambda-interacting protein) (Nonsense mediated mRNA decay-associated PI3K-related kinase SMG1)

Gene: SMG1
Organism: Homo sapiens
Interactions: 94
UniProt ID: Q96Q15

Gene Ontology (top 5):
GO:0000184 - nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0003723 - RNA binding
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004697 - diacylglycerol-dependent serine/threonine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1241995

SMG8
Nonsense-mediated mRNA decay factor SMG8

2

0

Small-scale

0.801

High

1272308

RENT1
Regulator of nonsense transcripts 1

6

8

Small-scale

0.747

High

1300097

RBM8A
RNA-binding protein 8A

4

4

Small-scale

0.697

High

1300081

RENT2
Regulator of nonsense transcripts 2

5

0

Small-scale

0.694

High

1300078

SMG9
Nonsense-mediated mRNA decay factor SMG9

4

0

Small-scale

0.678

High

195935

TTI1
TELO2-interacting protein 1 homolog

3

16

Small-scale

0.671

High

757724

IF4A3
Eukaryotic initiation factor 4A-III

3

5

Small-scale

0.671

High

1266655

SMG7
Nonsense-mediated mRNA decay factor SMG7

3

1

Small-scale

0.662

High

1300079

REN3A
Regulator of nonsense transcripts 3A

3

1

Small-scale

0.650

High

1300070

SMG1
Serine/threonine-protein kinase SMG1

1

17

Small-scale

0.647

High

899545

MGN
Protein mago nashi homolog

3

0

Small-scale

0.638

High

600653

EPHA1
Ephrin type-A receptor 1

2

7

High-throughput

0.628

High

1300092

FZR1
Fizzy-related protein homolog

1

10

High-throughput

0.618

High

1300071

REN3B
Regulator of nonsense transcripts 3B

2

1

Small-scale

0.611

High

1300095

TELO2
Telomere length regulation protein TEL2 homolog

2

16

Small-scale

0.611

High

1051903

IF4A2
Eukaryotic initiation factor 4A-II

2

4

High-throughput

0.584

High

1219223

Z3H7A
Zinc finger CCCH domain-containing protein 7A

2

13

High-throughput

0.584

High

784071

KPCI
Protein kinase C iota type

1

13

Small-scale

0.573

High

914563

ERF1
Eukaryotic peptide chain release factor subunit 1

2

1

Small-scale

0.571

High

362272

GLPA
Glycophorin-A

1

3

High-throughput

0.536

High

516650

PABP1
Polyadenylate-binding protein 1

1

1

Small-scale

0.536

High

538362

ENPL
Endoplasmin

1

12

High-throughput

0.536

High

583772

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

1

Small-scale

0.536

High

801319

KI67
Proliferation marker protein Ki-67

1

7

High-throughput

0.536

High

853963

NCBP2
Nuclear cap-binding protein subunit 2

1

5

Small-scale

0.536

High

914797

CNBP
CCHC-type zinc finger nucleic acid binding protein

1

3

High-throughput

0.536

High

1222970

ERF3B
Eukaryotic peptide chain release factor GTP-binding subunit ERF3B

1

1

Small-scale

0.536

High

1300072

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

1

High-throughput

0.536

High

1300093

RUVB2
RuvB-like 2

1

19

Small-scale

0.536

High

1300094

RUVB1
RuvB-like 1

1

19

Small-scale

0.536

High

310997

SNAPN
SNARE-associated protein Snapin

1

0

High-throughput

0.518

High

858118

NKX25
Homeobox protein Nkx-2.5

1

6

High-throughput

0.500

High

1300091

CC018
Uncharacterized protein C3orf18

1

3

High-throughput

0.489

High

1300099

NPTN
Neuroplastin

1

8

High-throughput

0.489

High

134174

DDX3X
ATP-dependent RNA helicase DDX3X

1

1

High-throughput

0.479

High

200898

CTIF
CBP80/20-dependent translation initiation factor

1

1

High-throughput

0.479

High

228416

PRKN
E3 ubiquitin-protein ligase parkin

1

6

High-throughput

0.479

High

338863

EGFR
Epidermal growth factor receptor

1

6

High-throughput

0.479

High

377609

GCR
Glucocorticoid receptor

1

16

High-throughput

0.479

High

409201

K2C8
Keratin, type II cytoskeletal 8

1

1

High-throughput

0.479

High

432171

HS90A
Heat shock protein HSP 90-alpha

1

12

Small-scale

0.479

High

531245

EF2
Elongation factor 2

1

1

Small-scale

0.479

High

545894

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

1

1

Small-scale

0.479

High

553480

RFA2
Replication protein A 32 kDa subunit

1

9

High-throughput

0.479

High

591059

BTF3
Transcription factor BTF3

1

1

High-throughput

0.479

High

614104

TBG1
Tubulin gamma-1 chain

1

6

Small-scale

0.479

High

640595

DDX6
Probable ATP-dependent RNA helicase DDX6

1

4

High-throughput

0.479

High

714367

HSP74
Heat shock 70 kDa protein 4

1

10

Small-scale

0.479

High

721203

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.479

High

821013

PRC2A
Protein PRRC2A

1

7

High-throughput

0.479

High

843858

FXR1
RNA-binding protein FXR1

1

3

High-throughput

0.479

High

844202

FXR2
RNA-binding protein FXR2

1

3

High-throughput

0.479

High

989068

FMR1
Fragile X messenger ribonucleoprotein 1

1

3

High-throughput

0.479

High

1036825

SQSTM
Sequestosome-1

1

2

High-throughput

0.479

High

1168819

MEX3B
RNA-binding protein MEX3B

1

1

High-throughput

0.479

High

1171310

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.479

High

1175116

TBA1A
Tubulin alpha-1A chain

1

3

Small-scale

0.479

High

1187724

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

9

High-throughput

0.479

High

1192359

YTHD3
YTH domain-containing family protein 3

1

1

High-throughput

0.479

High

1200052

EST1A
Telomerase-binding protein EST1A

1

1

High-throughput

0.479

High

1236449

SIR6
NAD-dependent protein deacylase sirtuin-6

1

9

High-throughput

0.479

High

1242041

RN214
RING finger protein 214

1

2

High-throughput

0.479

High

1242109

LS14A
Protein LSM14 homolog A

1

4

High-throughput

0.479

High

1272465

DAZL
Deleted in azoospermia-like

1

2

High-throughput

0.479

High

1300073

UNK
RING finger protein unkempt homolog

1

1

High-throughput

0.479

High

1300075

DDX24
ATP-dependent RNA helicase DDX24

1

5

High-throughput

0.479

High

1300076

MKRN2
E3 ubiquitin-protein ligase makorin-2

1

1

High-throughput

0.479

High

1300077

SIK2
Serine/threonine-protein kinase SIK2

1

4

Small-scale

0.479

High

1300082

MOV10
Helicase MOV-10

1

8

High-throughput

0.479

High

1300088

IF2B1
Insulin-like growth factor 2 mRNA-binding protein 1

1

5

High-throughput

0.479

High

1300089

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

1300096

YTHD2
YTH domain-containing family protein 2

1

1

High-throughput

0.479

High

1300100

IF2B2
Insulin-like growth factor 2 mRNA-binding protein 2

1

5

High-throughput

0.479

High

742480

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

908095

RS16
Small ribosomal subunit protein uS9

1

0

Small-scale

0.458

High

923165

RL11
Large ribosomal subunit protein uL5

1

0

Small-scale

0.458

High

1300080

TDRD3
Tudor domain-containing protein 3

1

0

High-throughput

0.458

High

1300084

HAUS2
HAUS augmin-like complex subunit 2

1

0

High-throughput

0.458

High

1300087

F120C
Constitutive coactivator of PPAR-gamma-like protein 2

1

0

High-throughput

0.458

High

1300074

NDEL1
Nuclear distribution protein nudE-like 1

1

4

High-throughput

0.457

High

123306

CBX4
E3 SUMO-protein ligase CBX4

1

3

High-throughput

0.445

High

236024

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

3

Small-scale

0.445

High

360310

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

2

Small-scale

0.445

High

382112

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

1

Small-scale

0.445

High

1300083

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

839285

5HT6R
5-hydroxytryptamine receptor 6

1

6

Small-scale

0.437

High

1102500

LIN41
E3 ubiquitin-protein ligase TRIM71

1

13

Small-scale

0.437

High

1222077

S15A3
Solute carrier family 15 member 3

1

4

High-throughput

0.437

High

1300085

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

2

High-throughput

0.437

High

99662

F5H1C8
Solute carrier family 15 member 3

1

4

High-throughput

0.407

High

1300086

NECP2
Adaptin ear-binding coat-associated protein 2

1

0

High-throughput

0.279

Low

1300090

SUN2
SUN domain-containing protein 2

1

0

High-throughput

0.279

Low

1300098

IR3IP
Immediate early response 3-interacting protein 1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024