Protein: NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1 (NF-ATc1) (NFATc1) (NFAT transcription complex cytosolic component) (NF-ATc) (NFATc)

Gene: NFAC1, NFATC1
Organism: Homo sapiens
Interactions: 171
UniProt ID: O95644

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001223 - transcription coactivator binding
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

317888

JUN
Transcription factor Jun

3

20

High-throughput

0.861

High

317964

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

3

18

Small-scale

0.827

High

318016

FOXP3
Forkhead box protein P3

3

18

Small-scale

0.827

High

317899

CREB1
Cyclic AMP-responsive element-binding protein 1

2

3

High-throughput

0.802

High

317881

FOS
Protein c-Fos

2

20

High-throughput

0.789

High

317879

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

2

18

Small-scale

0.737

High

317898

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

20

High-throughput

0.715

High

317905

ATF1
Cyclic AMP-dependent transcription factor ATF-1

1

7

High-throughput

0.715

High

317957

PP2BA
Protein phosphatase 3 catalytic subunit alpha

4

10

Small-scale

0.708

High

317902

JUND
Transcription factor JunD

1

20

High-throughput

0.691

High

317906

ATF3
Cyclic AMP-dependent transcription factor ATF-3

1

20

High-throughput

0.691

High

317926

PP2BC
Serine/threonine-protein phosphatase 2B catalytic subunit gamma isoform

3

10

High-throughput

0.667

High

317958

EP300
Histone acetyltransferase p300

3

20

Small-scale

0.646

High

255402

OBSL1
Obscurin-like protein 1

2

1

High-throughput

0.628

High

317945

CANB1
Calcineurin subunit B type 1

2

3

High-throughput

0.628

High

317987

ARMC8
Armadillo repeat-containing protein 8

2

10

High-throughput

0.628

High

318025

KTU
Protein kintoun

2

1

High-throughput

0.628

High

318032

MKLN1
Muskelin

2

5

High-throughput

0.628

High

317981

A20A1
Ankyrin repeat domain-containing protein 20A1

1

7

High-throughput

0.618

High

317897

ETS1
Protein C-ets-1

1

14

Small-scale

0.618

High

317901

JUNB
Transcription factor JunB

1

20

High-throughput

0.618

High

317903

ATF7
Cyclic AMP-dependent transcription factor ATF-7

1

20

High-throughput

0.618

High

317916

ELF1
ETS-related transcription factor Elf-1

1

17

Small-scale

0.618

High

317948

FOXK1
Forkhead box protein K1

1

11

High-throughput

0.618

High

317949

FOXK2
Forkhead box protein K2

1

13

High-throughput

0.618

High

317954

REL
Proto-oncogene c-Rel

1

19

Small-scale

0.618

High

317886

P53
Cellular tumor antigen p53

2

10

High-throughput

0.611

High

317935

SMCA4
Transcription activator BRG1

2

10

High-throughput

0.611

High

317956

SUH
Recombining binding protein suppressor of hairless

2

2

High-throughput

0.611

High

317995

SMRC2
SWI/SNF complex subunit SMARCC2

2

16

High-throughput

0.611

High

317999

HDAC2
Histone deacetylase 2

2

20

Small-scale

0.611

High

317904

EGR1
Early growth response protein 1

2

6

Small-scale

0.608

High

318007

ZMY19
Zinc finger MYND domain-containing protein 19

2

0

High-throughput

0.602

High

317942

IL2
Interleukin-2

2

6

Small-scale

0.584

High

317890

PARP1
Poly [ADP-ribose] polymerase 1

1

8

Small-scale

0.561

High

317893

PIM1
Serine/threonine-protein kinase pim-1

1

5

Small-scale

0.561

High

318034

HDAC5
Histone deacetylase 5

1

20

Small-scale

0.561

High

317947

UBC9
SUMO-conjugating enzyme UBC9

1

8

Small-scale

0.552

High

174512

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

5

Small-scale

0.536

High

229265

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

10

High-throughput

0.536

High

309269

KIF4A
Chromosome-associated kinesin KIF4A

1

1

High-throughput

0.536

High

311449

SMC2
Structural maintenance of chromosomes protein 2

1

1

High-throughput

0.536

High

317900

HMGA1
High mobility group protein HMG-I/HMG-Y

1

2

High-throughput

0.536

High

317907

H2A1D
Histone H2A type 1-D

1

4

High-throughput

0.536

High

317914

HXA10
Homeobox protein Hox-A10

1

1

High-throughput

0.536

High

317921

CUX1
Homeobox protein cut-like 1

1

9

High-throughput

0.536

High

317925

RECQ1
ATP-dependent DNA helicase Q1

1

7

High-throughput

0.536

High

317934

BLK
Tyrosine-protein kinase Blk

1

9

High-throughput

0.536

High

317938

HMGA2
High mobility group protein HMGI-C

1

2

High-throughput

0.536

High

317941

PRD15
PR domain zinc finger protein 15

1

1

High-throughput

0.536

High

317943

ISL1
Insulin gene enhancer protein ISL-1

1

10

High-throughput

0.536

High

317944

H2B1C
Histone H2B type 1-C/E/F/G/I

1

7

High-throughput

0.536

High

317959

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

3

High-throughput

0.536

High

317967

ZMYM3
Zinc finger MYM-type protein 3

1

2

High-throughput

0.536

High

317969

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

4

High-throughput

0.536

High

317972

TEAD2
Transcriptional enhancer factor TEF-4

1

3

High-throughput

0.536

High

317974

H31T
Histone H3.1t

1

7

High-throughput

0.536

High

317980

BEND3
BEN domain-containing protein 3

1

1

High-throughput

0.536

High

317998

P66B
Transcriptional repressor p66-beta

1

3

High-throughput

0.536

High

318006

H2B1A
Histone H2B type 1-A

1

7

High-throughput

0.536

High

318010

CANB2
Calcineurin subunit B type 2

1

3

High-throughput

0.536

High

318013

NEB2
Neurabin-2

1

4

High-throughput

0.536

High

318019

ADNP
Activity-dependent neuroprotector homeobox protein

1

1

High-throughput

0.536

High

318020

EGLN3
Prolyl hydroxylase EGLN3

1

4

High-throughput

0.536

High

318028

TRPS1
Zinc finger transcription factor Trps1

1

8

High-throughput

0.536

High

318033

SMC3
Structural maintenance of chromosomes protein 3

1

1

High-throughput

0.536

High

317960

TAF10
Transcription initiation factor TFIID subunit 10

1

0

High-throughput

0.513

High

317975

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

1

0

High-throughput

0.513

High

317977

FWCH1
FLYWCH-type zinc finger-containing protein 1

1

0

High-throughput

0.513

High

317979

FRPD1
FERM and PDZ domain-containing protein 1

1

0

High-throughput

0.513

High

318029

SHPK
Sedoheptulokinase

1

0

High-throughput

0.513

High

317892

EGR2
E3 SUMO-protein ligase EGR2

1

6

Small-scale

0.501

High

317909

1433T
14-3-3 protein theta

1

20

High-throughput

0.501

High

317937

JAK3
Tyrosine-protein kinase JAK3

1

13

Small-scale

0.501

High

317970

IMB1
Importin subunit beta-1

1

5

Small-scale

0.501

High

317984

TBA1A
Tubulin alpha-1A chain

1

17

Small-scale

0.501

High

318002

KAT2B
Histone acetyltransferase KAT2B

1

8

Small-scale

0.501

High

317915

HXC13
Homeobox protein Hox-C13

1

7

High-throughput

0.500

High

277867

PIAS1
E3 SUMO-protein ligase PIAS1

1

7

Small-scale

0.481

High

146127

ARI1A
AT-rich interactive domain-containing protein 1A

1

14

High-throughput

0.479

High

154109

CHK1
Serine/threonine-protein kinase Chk1

1

3

High-throughput

0.479

High

197160

SERA
D-3-phosphoglycerate dehydrogenase

1

8

High-throughput

0.479

High

217221

ORC5
Origin recognition complex subunit 5

1

2

High-throughput

0.479

High

317880

ACL6A
Actin-like protein 6A

1

10

High-throughput

0.479

High

317882

MYC
Myc proto-oncogene protein

1

13

High-throughput

0.479

High

317883

TNFA
Tumor necrosis factor

1

16

Small-scale

0.479

High

317884

GCR
Glucocorticoid receptor

1

20

Small-scale

0.479

High

317885

MYCN
N-myc proto-oncogene protein

1

13

High-throughput

0.479

High

317887

IL4
Interleukin-4

1

2

Small-scale

0.479

High

317889

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

4

Small-scale

0.479

High

317891

BIP
Endoplasmic reticulum chaperone BiP

1

20

High-throughput

0.479

High

317894

XRCC6
X-ray repair cross-complementing protein 6

1

4

High-throughput

0.479

High

317895

XRCC5
X-ray repair cross-complementing protein 5

1

4

High-throughput

0.479

High

317908

KS6B1
Ribosomal protein S6 kinase beta-1

1

8

Small-scale

0.479

High

317910

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

317911

PYR1
Multifunctional protein CAD

1

6

High-throughput

0.479

High

317912

PML
Protein PML

1

6

Small-scale

0.479

High

317917

RFC4
Replication factor C subunit 4

1

6

High-throughput

0.479

High

317918

RFC2
Replication factor C subunit 2

1

6

High-throughput

0.479

High

317919

HXD13
Homeobox protein Hox-D13

1

3

High-throughput

0.479

High

317920

GRP75
Stress-70 protein, mitochondrial

1

20

High-throughput

0.479

High

317923

RFC5
Replication factor C subunit 5

1

6

High-throughput

0.479

High

317924

CATK
Cathepsin K

1

3

Small-scale

0.479

High

317927

KC1A
Casein kinase I isoform alpha

1

11

High-throughput

0.479

High

317928

KC1D
Casein kinase I isoform delta

1

8

High-throughput

0.479

High

317929

CX3C1
CX3C chemokine receptor 1

1

8

Small-scale

0.479

High

317930

EFTU
Elongation factor Tu, mitochondrial

1

8

High-throughput

0.479

High

317931

GSK3B
Glycogen synthase kinase-3 beta

1

9

High-throughput

0.479

High

317932

DNLI3
DNA ligase 3

1

1

High-throughput

0.479

High

317936

KS6A3
Ribosomal protein S6 kinase alpha-3

1

7

Small-scale

0.479

High

317940

HDAC4
Histone deacetylase 4

1

20

Small-scale

0.479

High

317946

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.479

High

317950

RUNX1
Runt-related transcription factor 1

1

1

High-throughput

0.479

High

317951

SATB1
DNA-binding protein SATB1

1

1

High-throughput

0.479

High

317952

IRF8
Interferon regulatory factor 8

1

20

Small-scale

0.479

High

317955

EGR4
Early growth response protein 4

1

8

Small-scale

0.479

High

317961

CTBP1
C-terminal-binding protein 1

1

8

High-throughput

0.479

High

317963

IKZF1
DNA-binding protein Ikaros

1

5

High-throughput

0.479

High

317965

HDAC1
Histone deacetylase 1

1

20

Small-scale

0.479

High

317966

PEBB
Core-binding factor subunit beta

1

1

High-throughput

0.479

High

317968

HLTF
Helicase-like transcription factor

1

13

High-throughput

0.479

High

317971

IRF4
Interferon regulatory factor 4

1

20

Small-scale

0.479

High

317973

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.479

High

317978

DCAF6
DDB1- and CUL4-associated factor 6

1

7

High-throughput

0.479

High

317982

NIPBL
Nipped-B-like protein

1

7

High-throughput

0.479

High

317983

C1TM
Monofunctional C1-tetrahydrofolate synthase, mitochondrial

1

3

High-throughput

0.479

High

317988

ABC3F
DNA dC->dU-editing enzyme APOBEC-3F

1

1

Small-scale

0.479

High

317989

RPTOR
Regulatory-associated protein of mTOR

1

9

High-throughput

0.479

High

317991

KC1AL
Casein kinase I isoform alpha-like

1

12

High-throughput

0.479

High

317992

SCAI
Protein SCAI

1

1

High-throughput

0.479

High

317994

WDR48
WD repeat-containing protein 48

1

11

High-throughput

0.479

High

317996

NEK7
Serine/threonine-protein kinase Nek7

1

8

High-throughput

0.479

High

318000

REQU
Zinc finger protein ubi-d4

1

20

High-throughput

0.479

High

318001

CBP
CREB-binding protein

1

19

High-throughput

0.479

High

318003

SMRC1
SWI/SNF complex subunit SMARCC1

1

18

High-throughput

0.479

High

318004

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

9

High-throughput

0.479

High

318005

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

10

High-throughput

0.479

High

318008

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

6

High-throughput

0.479

High

318009

CHAP1
Chromosome alignment-maintaining phosphoprotein 1

1

14

High-throughput

0.479

High

318011

CIC
Protein capicua homolog

1

16

High-throughput

0.479

High

318012

RANB9
Ran-binding protein 9

1

13

High-throughput

0.479

High

318014

DNJC7
DnaJ homolog subfamily C member 7

1

4

High-throughput

0.479

High

318017

BC11B
B-cell lymphoma/leukemia 11B

1

1

High-throughput

0.479

High

318022

NEK6
Serine/threonine-protein kinase Nek6

1

10

High-throughput

0.479

High

318023

SYSM
Serine--tRNA ligase, mitochondrial

1

4

High-throughput

0.479

High

318026

VAPA
Vesicle-associated membrane protein-associated protein A

1

6

High-throughput

0.479

High

318030

LEF1
Lymphoid enhancer-binding factor 1

1

11

High-throughput

0.479

High

318031

IKZF2
Zinc finger protein Helios

1

4

High-throughput

0.479

High

318035

TRRAP
Transformation/transcription domain-associated protein

1

7

High-throughput

0.479

High

317922

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

317933

FXR1
RNA-binding protein FXR1

1

0

High-throughput

0.458

High

317962

ORC2
Origin recognition complex subunit 2

1

0

High-throughput

0.458

High

317976

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

318018

GZF1
GDNF-inducible zinc finger protein 1

1

0

Small-scale

0.458

High

318021

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

0

High-throughput

0.458

High

318024

ZBT40
Zinc finger and BTB domain-containing protein 40

1

0

High-throughput

0.458

High

318027

LRWD1
Leucine-rich repeat and WD repeat-containing protein 1

1

0

High-throughput

0.458

High

318036

SCC4
MAU2 chromatid cohesion factor homolog

1

0

High-throughput

0.458

High

100348

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

317896

MTDC
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase

1

3

High-throughput

0.437

High

317913

CD40L
CD40 ligand

1

16

Small-scale

0.437

High

317990

LRC47
Leucine-rich repeat-containing protein 47

1

2

High-throughput

0.437

High

317993

MSPD2
Motile sperm domain-containing protein 2

1

3

High-throughput

0.437

High

259516

SEM7A
Semaphorin-7A

2

0

High-throughput

0.328

High

317939

HMCS2
Hydroxymethylglutaryl-CoA synthase, mitochondrial

2

0

High-throughput

0.328

High

317953

PLOD1
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

2

0

High-throughput

0.328

High

317985

LRC28
Leucine-rich repeat-containing protein 28

2

0

High-throughput

0.328

High

317986

LRC33
Transforming growth factor beta activator LRRC33

1

0

High-throughput

0.279

Low

317997

PO210
Nuclear pore membrane glycoprotein 210

1

0

High-throughput

0.249

Low

318015

TR61B
tRNA

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024