Protein: DHE3
Glutamate dehydrogenase 1, mitochondrial (GDH 1) (EC 1.4.1.3)

Gene: DHE3, GLUD1
Organism: Homo sapiens
Interactions: 233
UniProt ID: P00367

Gene Ontology (top 5):
GO:0004352 - glutamate dehydrogenase (NAD+) activity
GO:0004353 - glutamate dehydrogenase [NAD(P)+] activity
GO:0004354 - glutamate dehydrogenase (NADP+) activity
GO:0005524 - ATP binding
GO:0005525 - GTP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

335073

DHE4
Glutamate dehydrogenase 2, mitochondrial

3

5

High-throughput

0.848

High

335165

BIRC8
Baculoviral IAP repeat-containing protein 8

3

1

High-throughput

0.667

High

335123

KLH22
Kelch-like protein 22

2

1

High-throughput

0.628

High

335021

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

1

High-throughput

0.611

High

335101

ILK
Integrin-linked protein kinase

2

0

High-throughput

0.602

High

335023

NTRK1
High affinity nerve growth factor receptor

2

6

High-throughput

0.594

High

335103

CUL3
Cullin-3

2

0

High-throughput

0.585

High

226189

PRKN
E3 ubiquitin-protein ligase parkin

2

2

High-throughput

0.584

High

262665

CISY
Citrate synthase, mitochondrial

2

1

High-throughput

0.584

High

335120

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

1

High-throughput

0.584

High

335175

SH3G3
Endophilin-A3

2

2

High-throughput

0.571

High

335170

SEC62
Translocation protein SEC62

2

0

High-throughput

0.561

High

324971

AIFM1
Apoptosis-inducing factor 1, mitochondrial

2

0

High-throughput

0.559

High

335125

RN213
E3 ubiquitin-protein ligase RNF213

1

0

Small-scale

0.537

High

153062

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

1

High-throughput

0.536

High

335022

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

3

High-throughput

0.536

High

335029

IGF1R
Insulin-like growth factor 1 receptor

1

4

High-throughput

0.536

High

335031

MET
Hepatocyte growth factor receptor

1

3

High-throughput

0.536

High

335042

ERF3A
Eukaryotic peptide chain release factor GTP-binding subunit ERF3A

1

2

High-throughput

0.536

High

335055

VGFR3
Vascular endothelial growth factor receptor 3

1

1

High-throughput

0.536

High

335060

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

4

High-throughput

0.536

High

335064

GRK6
G protein-coupled receptor kinase 6

1

1

High-throughput

0.536

High

335100

G3BP1
Ras GTPase-activating protein-binding protein 1

1

1

High-throughput

0.536

High

335108

CAPR1
Caprin-1

1

1

High-throughput

0.536

High

335129

PKN3
Serine/threonine-protein kinase N3

1

1

High-throughput

0.536

High

335135

ST32C
Serine/threonine-protein kinase 32C

1

2

High-throughput

0.536

High

335182

STK33
Serine/threonine-protein kinase 33

1

1

High-throughput

0.536

High

335189

PTN23
Tyrosine-protein phosphatase non-receptor type 23

1

1

High-throughput

0.536

High

335215

G3BP2
Ras GTPase-activating protein-binding protein 2

1

1

High-throughput

0.536

High

335217

DRG1
Developmentally-regulated GTP-binding protein 1

1

1

High-throughput

0.536

High

255017

ATG13
Autophagy-related protein 13

1

0

High-throughput

0.513

High

270357

KS6A5
Ribosomal protein S6 kinase alpha-5

1

0

High-throughput

0.513

High

335033

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.513

High

335039

TOP2A
DNA topoisomerase 2-alpha

1

0

High-throughput

0.513

High

335056

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.513

High

335076

MAP2
Methionine aminopeptidase 2

1

0

High-throughput

0.513

High

335077

IRAK1
Interleukin-1 receptor-associated kinase 1

1

0

High-throughput

0.513

High

335087

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

0

High-throughput

0.513

High

335089

RL19
Large ribosomal subunit protein eL19

1

0

High-throughput

0.513

High

335091

CDK5
Cyclin-dependent kinase 5

1

0

High-throughput

0.513

High

335105

TFDP1
Transcription factor Dp-1

1

0

High-throughput

0.513

High

335106

ICT1
Large ribosomal subunit protein mL62

1

0

High-throughput

0.513

High

335116

TESK1
Dual specificity testis-specific protein kinase 1

1

0

High-throughput

0.513

High

335167

PSKH2
Serine/threonine-protein kinase H2

1

0

High-throughput

0.513

High

335171

DNJC2
DnaJ homolog subfamily C member 2

1

0

High-throughput

0.513

High

335181

DUS16
Dual specificity protein phosphatase 16

1

0

High-throughput

0.513

High

335192

SG196
Protein O-mannose kinase

1

0

High-throughput

0.513

High

335198

ENY2
Transcription and mRNA export factor ENY2

1

0

High-throughput

0.513

High

335201

NRBP2
Nuclear receptor-binding protein 2

1

0

High-throughput

0.513

High

335214

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.513

High

335219

EMC9
ER membrane protein complex subunit 9

1

0

High-throughput

0.513

High

335223

ATG4B
Cysteine protease ATG4B

1

0

High-throughput

0.513

High

171276

EPHB6
Ephrin type-B receptor 6

1

3

High-throughput

0.500

High

335026

INSR
Insulin receptor

1

5

High-throughput

0.500

High

335028

SP1
Transcription factor Sp1

1

1

High-throughput

0.500

High

335047

FGFR4
Fibroblast growth factor receptor 4

1

3

High-throughput

0.500

High

335058

STAT3
Signal transducer and activator of transcription 3

1

1

High-throughput

0.500

High

335117

NTRK3
NT-3 growth factor receptor

1

6

High-throughput

0.500

High

335151

SP7
Transcription factor Sp7

1

1

High-throughput

0.500

High

335062

STA5A
Signal transducer and activator of transcription 5A

1

1

High-throughput

0.494

High

265574

E2F6
Transcription factor E2F6

1

1

High-throughput

0.489

High

335199

PAR6A
Partitioning defective 6 homolog alpha

1

1

High-throughput

0.489

High

167655

LSM1
U6 snRNA-associated Sm-like protein LSm1

1

1

High-throughput

0.481

High

335020

VTNC
Vitronectin

1

1

High-throughput

0.481

High

207531

RNF13
E3 ubiquitin-protein ligase RNF13

1

1

Small-scale

0.479

High

264807

MPPB
Mitochondrial-processing peptidase subunit beta

1

2

High-throughput

0.479

High

269962

RF1M
Peptide chain release factor 1, mitochondrial

1

1

High-throughput

0.479

High

335015

OTC
Ornithine transcarbamylase, mitochondrial

1

2

High-throughput

0.479

High

335030

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.479

High

335035

ARAF
Serine/threonine-protein kinase A-Raf

1

1

High-throughput

0.479

High

335044

RHOQ
Rho-related GTP-binding protein RhoQ

1

5

High-throughput

0.479

High

335045

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

335054

FUS
RNA-binding protein FUS

1

1

High-throughput

0.479

High

335067

IF2M
Translation initiation factor IF-2, mitochondrial

1

1

High-throughput

0.479

High

335072

EFTU
Elongation factor Tu, mitochondrial

1

3

High-throughput

0.479

High

335074

MCM2
DNA replication licensing factor MCM2

1

1

High-throughput

0.479

High

335078

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.479

High

335082

RHOA
Transforming protein RhoA

1

4

High-throughput

0.479

High

335083

RND3
Rho-related GTP-binding protein RhoE

1

6

High-throughput

0.479

High

335088

RHOG
Rho-related GTP-binding protein RhoG

1

5

High-throughput

0.479

High

335095

MPPA
Mitochondrial-processing peptidase subunit alpha

1

2

High-throughput

0.479

High

335097

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

4

High-throughput

0.479

High

335102

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

335107

SRC8
Src substrate cortactin

1

2

High-throughput

0.479

High

335113

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

335118

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

1

High-throughput

0.479

High

335121

DDR2
Discoidin domain-containing receptor 2

1

6

High-throughput

0.479

High

335130

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

335134

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

2

High-throughput

0.479

High

335143

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

1

High-throughput

0.479

High

335146

MCU
Calcium uniporter protein, mitochondrial

1

1

High-throughput

0.479

High

335149

RIN3
Ras and Rab interactor 3

1

1

High-throughput

0.479

High

335153

PSPC1
Paraspeckle component 1

1

1

High-throughput

0.479

High

335155

AKAP1
A-kinase anchor protein 1, mitochondrial

1

1

High-throughput

0.479

High

335158

RRF2M
Ribosome-releasing factor 2, mitochondrial

1

3

High-throughput

0.479

High

335159

FAKD4
FAST kinase domain-containing protein 4

1

2

High-throughput

0.479

High

335160

MCUR1
Mitochondrial calcium uniporter regulator 1

1

1

High-throughput

0.479

High

335168

EFGM
Elongation factor G, mitochondrial

1

3

High-throughput

0.479

High

335169

CRBN
Protein cereblon

1

1

Small-scale

0.479

High

335172

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

1

High-throughput

0.479

High

335183

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

2

High-throughput

0.479

High

335185

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

1

High-throughput

0.479

High

335190

MTG2
Mitochondrial ribosome-associated GTPase 2

1

1

High-throughput

0.479

High

335191

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

335202

SIR3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

1

3

Small-scale

0.479

High

335203

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

2

High-throughput

0.479

High

335206

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

1

High-throughput

0.479

High

335209

HYPK
Huntingtin-interacting protein K

1

1

Small-scale

0.479

High

335212

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

1

High-throughput

0.479

High

335224

RBM8A
RNA-binding protein 8A

1

2

High-throughput

0.479

High

335048

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

0

High-throughput

0.460

High

335174

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

0

Small-scale

0.460

High

148258

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

199637

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

1

0

High-throughput

0.458

High

214816

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.458

High

327328

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

1

0

High-throughput

0.458

High

335024

HSPB1
Heat shock protein beta-1

1

0

Small-scale

0.458

High

335032

RSSA
Small ribosomal subunit protein uS2

1

0

High-throughput

0.458

High

335034

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

335037

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

335038

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

335040

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.458

High

335046

RAB4A
Ras-related protein Rab-4A

1

0

High-throughput

0.458

High

335051

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

0

High-throughput

0.458

High

335052

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

335059

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

335061

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

335063

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

335066

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

335070

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

0

High-throughput

0.458

High

335075

GSK3A
Glycogen synthase kinase-3 alpha

1

0

High-throughput

0.458

High

335079

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.458

High

335084

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

335085

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

335086

IF5A1
Eukaryotic translation initiation factor 5A-1

1

0

High-throughput

0.458

High

335090

TFAM
Transcription factor A, mitochondrial

1

0

High-throughput

0.458

High

335092

PO5F1
POU domain, class 5, transcription factor 1

1

0

High-throughput

0.458

High

335093

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

335094

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

335096

GRSF1
G-rich sequence factor 1

1

0

High-throughput

0.458

High

335099

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

0

High-throughput

0.458

High

335104

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.458

High

335110

CUL7
Cullin-7

1

0

High-throughput

0.458

High

335114

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

335115

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

335119

HIF1A
Hypoxia-inducible factor 1-alpha

1

0

High-throughput

0.458

High

335124

SYAM
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

335126

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

335127

ZN746
Zinc finger protein 746

1

0

High-throughput

0.458

High

335133

MOB2
MOB kinase activator 2

1

0

High-throughput

0.458

High

335137

DDX42
ATP-dependent RNA helicase DDX42

1

0

High-throughput

0.458

High

335138

DCP2
m7GpppN-mRNA hydrolase

1

0

High-throughput

0.458

High

335139

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.458

High

335154

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

335161

ARMC5
Armadillo repeat-containing protein 5

1

0

High-throughput

0.458

High

335163

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

335176

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

335178

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.458

High

335179

TR61B
tRNA

1

0

High-throughput

0.458

High

335180

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.458

High

335184

RHG39
Rho GTPase-activating protein 39

1

0

High-throughput

0.458

High

335187

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

335193

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

335194

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

0

High-throughput

0.458

High

335195

SFXN1
Sideroflexin-1

1

0

High-throughput

0.458

High

335207

RMND1
Required for meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.458

High

335208

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

335211

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

335213

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

335216

HDAC5
Histone deacetylase 5

1

0

High-throughput

0.458

High

335218

PTN22
Tyrosine-protein phosphatase non-receptor type 22

1

0

High-throughput

0.458

High

335220

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

335222

TRAF6
TNF receptor-associated factor 6

1

0

High-throughput

0.458

High

335036

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.445

High

335080

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.445

High

335111

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

2

Small-scale

0.445

High

335132

NEK10
Serine/threonine-protein kinase Nek10

1

1

High-throughput

0.445

High

335204

ATD3A
ATPase family AAA domain-containing protein 3A

1

2

High-throughput

0.445

High

335225

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

3

High-throughput

0.445

High

335019

HEMO
Hemopexin

1

1

High-throughput

0.439

High

335049

U2AF2
Splicing factor U2AF 65 kDa subunit

1

2

High-throughput

0.437

High

335068

MAP1B
Microtubule-associated protein 1B

1

1

High-throughput

0.437

High

335081

KLF3
Krueppel-like factor 3

1

1

High-throughput

0.437

High

335122

CL16A
Protein CLEC16A

1

1

High-throughput

0.437

High

335131

CE128
Centrosomal protein of 128 kDa

1

1

High-throughput

0.437

High

335157

PTPR2
Receptor-type tyrosine-protein phosphatase N2

1

1

High-throughput

0.437

High

335166

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

1

1

High-throughput

0.437

High

335197

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

1

High-throughput

0.437

High

330799

PAK4
Serine/threonine-protein kinase PAK 4

1

0

High-throughput

0.426

High

335041

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

335141

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.426

High

335164

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.426

High

335025

JUN
Transcription factor Jun

1

2

High-throughput

0.407

High

335098

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

0

High-throughput

0.282

High

156589

PPE1
Serine/threonine-protein phosphatase with EF-hands 1

1

0

High-throughput

0.279

Low

335017

FINC
Fibronectin

1

0

High-throughput

0.279

Low

335057

PSB10
Proteasome subunit beta type-10

1

0

High-throughput

0.279

Low

335069

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.279

Low

335112

CND2
Condensin complex subunit 2

1

0

High-throughput

0.279

Low

335188

KDM4C
Lysine-specific demethylase 4C

1

0

High-throughput

0.279

Low

335221

LMBL1
Lethal(3)malignant brain tumor-like protein 1

1

0

High-throughput

0.279

Low

174524

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.261

Low

335016

CRP

1

0

High-throughput

0.251

Low

335018

A1AG1
Alpha-1-acid glycoprotein 1

1

0

High-throughput

0.251

Low

335027

ASGR2
Asialoglycoprotein receptor 2

1

0

High-throughput

0.251

Low

100357

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

169354

BET1
BET1 homolog

1

0

High-throughput

0.249

Low

279388

FLOT1
Flotillin-1

1

0

High-throughput

0.249

Low

335043

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

335050

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

335053

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

335065

NKX21
Homeobox protein Nkx-2.1

1

0

High-throughput

0.249

Low

335071

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

335109

RBM39
RNA-binding protein 39

1

0

High-throughput

0.249

Low

335128

CH082
UPF0598 protein C8orf82

1

0

High-throughput

0.249

Low

335136

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.249

Low

335140

NUP93
Nuclear pore complex protein Nup93

1

0

High-throughput

0.249

Low

335142

NGEF
Ephexin-1

1

0

High-throughput

0.249

Low

335144

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.249

Low

335147

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.249

Low

335148

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.249

Low

335150

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.249

Low

335152

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

1

0

High-throughput

0.249

Low

335156

KAT6A
Histone acetyltransferase KAT6A

1

0

High-throughput

0.249

Low

335162

KLH29
Kelch-like protein 29

1

0

High-throughput

0.249

Low

335173

NECD
Necdin

1

0

High-throughput

0.249

Low

335177

CQ080
Mitochondrial nucleoid-associated protein 1

1

0

High-throughput

0.249

Low

335186

NSRP1
Nuclear speckle splicing regulatory protein 1

1

0

High-throughput

0.249

Low

335196

RC3H2
Roquin-2

1

0

High-throughput

0.249

Low

335200

ANLN
Anillin

1

0

High-throughput

0.249

Low

335205

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

0

Small-scale

0.249

Low

335210

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.249

Low

335145

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024