Protein: SPEE
Spermidine synthase (SPDSY) (EC 2.5.1.16) (Putrescine aminopropyltransferase)

Gene: SPEE, SRM
Organism: Homo sapiens
Interactions: 51
UniProt ID: P19623

Gene Ontology (top 5):
GO:0004766 - spermidine synthase activity
GO:0005829 - cytosol
GO:0006595 - polyamine metabolic process
GO:0008295 - spermidine biosynthetic process
GO:0042802 - identical protein binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

585949

SPEE
Spermidine synthase

5

9

Small-scale

0.912

High

585954

CCNF
Cyclin-F

2

2

High-throughput

0.601

High

585956

TERF1
Telomeric repeat-binding factor 1

1

0

High-throughput

0.543

High

585957

CDC42
Cell division control protein 42 homolog

1

0

High-throughput

0.480

High

226491

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.479

High

384243

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

585963

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

1

High-throughput

0.479

High

585964

DUS6
Dual specificity protein phosphatase 6

1

6

High-throughput

0.479

High

585975

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.479

High

585978

DUS9
Dual specificity protein phosphatase 9

1

5

High-throughput

0.479

High

585982

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

1

High-throughput

0.479

High

585985

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

585958

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

585959

ABCE1
ATP-binding cassette sub-family E member 1

1

0

High-throughput

0.458

High

585960

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

585965

CRY2
Cryptochrome-2

1

0

High-throughput

0.458

High

585973

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

585976

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

585984

HDAC6
Histone deacetylase 6

1

0

High-throughput

0.458

High

585987

FBX7
F-box only protein 7

1

0

High-throughput

0.458

High

585969

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

585967

MTUS2
Microtubule-associated tumor suppressor candidate 2

1

0

High-throughput

0.438

High

100462

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

243916

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.437

High

329342

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

345900

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.437

High

551919

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

585950

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.437

High

585951

DUS1
Dual specificity protein phosphatase 1

1

5

High-throughput

0.437

High

585952

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

585962

DUS4
Dual specificity protein phosphatase 4

1

5

High-throughput

0.437

High

585966

DUS28
Dual specificity phosphatase 28

1

6

High-throughput

0.437

High

585971

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

585974

DUS19
Dual specificity protein phosphatase 19

1

6

High-throughput

0.437

High

585983

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

585977

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

585955

CEBPA
CCAAT/enhancer-binding protein alpha

1

2

High-throughput

0.408

High

581415

VCAM1
Vascular cell adhesion protein 1

2

0

High-throughput

0.313

High

176664

SOX12
Transcription factor SOX-12

1

0

High-throughput

0.282

High

585968

EFHC1
EF-hand domain-containing protein 1

1

0

High-throughput

0.279

Low

585979

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.279

Low

585961

DMWD
Dystrophia myotonica WD repeat-containing protein

1

0

High-throughput

0.269

Low

362802

FINC
Fibronectin

1

0

High-throughput

0.249

Low

530418

ITA4
Integrin alpha-4

1

0

High-throughput

0.249

Low

585953

BASI
Basigin

1

0

High-throughput

0.249

Low

585970

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

585972

F184A
Protein FAM184A

1

0

High-throughput

0.249

Low

585980

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.249

Low

585981

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.232

Low

585986

ITM2B
Integral membrane protein 2B

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024