Protein: SYAC
Alanine--tRNA ligase, cytoplasmic (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) (Renal carcinoma antigen NY-REN-42)

Gene: SYAC, AARS1
Organism: Homo sapiens
Interactions: 104
UniProt ID: P49588

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0002161 - aminoacyl-tRNA editing activity
GO:0002196 - Ser-tRNA(Ala) hydrolase activity
GO:0004813 - alanine-tRNA ligase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

496561

TAU
Microtubule-associated protein tau

2

2

High-throughput

0.601

High

581545

VCAM1
Vascular cell adhesion protein 1

2

3

High-throughput

0.601

High

226846

PRKN
E3 ubiquitin-protein ligase parkin

2

5

High-throughput

0.584

High

829164

RAC1
Ras-related C3 botulinum toxin substrate 1

2

3

High-throughput

0.571

High

829180

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

5

High-throughput

0.571

High

362941

FINC
Fibronectin

1

3

High-throughput

0.536

High

437990

HS90B
Heat shock protein HSP 90-beta

1

4

Small-scale

0.536

High

528770

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.536

High

829154

NEK4
Serine/threonine-protein kinase Nek4

1

1

High-throughput

0.536

High

829192

NEK7
Serine/threonine-protein kinase Nek7

1

1

High-throughput

0.536

High

829204

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

1

High-throughput

0.536

High

829155

HUNK
Hormonally up-regulated neu tumor-associated kinase

1

0

High-throughput

0.518

High

208544

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

1

High-throughput

0.515

High

336414

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.513

High

829189

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.513

High

829156

CDC42
Cell division control protein 42 homolog

1

3

High-throughput

0.501

High

127742

SAP18
Histone deacetylase complex subunit SAP18

1

0

High-throughput

0.493

High

829201

RMC1
Regulator of MON1-CCZ1 complex

1

1

High-throughput

0.489

High

214143

SPOP
Speckle-type POZ protein

1

1

High-throughput

0.479

High

346227

MYC
Myc proto-oncogene protein

1

3

High-throughput

0.479

High

384482

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

386310

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

431651

HS90A
Heat shock protein HSP 90-alpha

1

4

Small-scale

0.479

High

527965

RINI
Ribonuclease inhibitor

1

1

High-throughput

0.479

High

530508

ITA4
Integrin alpha-4

1

1

High-throughput

0.479

High

541989

ETS1
Protein C-ets-1

1

1

High-throughput

0.479

High

569383

CEBPB
CCAAT/enhancer-binding protein beta

1

4

High-throughput

0.479

High

580463

GNAT2
Guanine nucleotide-binding protein G(t) subunit alpha-2

1

5

High-throughput

0.479

High

625231

CDK2
Cyclin-dependent kinase 2

1

1

High-throughput

0.479

High

683902

1433S
14-3-3 protein sigma

1

4

High-throughput

0.479

High

749228

BRCA1
Breast cancer type 1 susceptibility protein

1

4

High-throughput

0.479

High

777428

MDHC
Malate dehydrogenase, cytoplasmic

1

1

High-throughput

0.479

High

779015

CCNF
Cyclin-F

1

3

High-throughput

0.479

High

827865

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

2

High-throughput

0.479

High

829153

GSK3B
Glycogen synthase kinase-3 beta

1

3

High-throughput

0.479

High

829158

ABCE1
ATP-binding cassette sub-family E member 1

1

1

High-throughput

0.479

High

829161

1433G
14-3-3 protein gamma

1

4

High-throughput

0.479

High

829162

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

3

High-throughput

0.479

High

829163

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

2

High-throughput

0.479

High

829165

1433Z
14-3-3 protein zeta/delta

1

4

High-throughput

0.479

High

829168

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

829169

SQSTM
Sequestosome-1

1

2

High-throughput

0.479

High

829170

CUL3
Cullin-3

1

3

High-throughput

0.479

High

829172

NBR1
Next to BRCA1 gene 1 protein

1

1

High-throughput

0.479

High

829173

EMC2
ER membrane protein complex subunit 2

1

2

High-throughput

0.479

High

829175

TNIP1
TNFAIP3-interacting protein 1

1

2

High-throughput

0.479

High

829176

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

829179

ANR55
Ankyrin repeat domain-containing protein 55

1

3

High-throughput

0.479

High

829182

RICTR
Rapamycin-insensitive companion of mTOR

1

2

High-throughput

0.479

High

829184

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.479

High

829188

RHG24
Rho GTPase-activating protein 24

1

2

High-throughput

0.479

High

829194

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

829195

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

829196

HDAC2
Histone deacetylase 2

1

2

High-throughput

0.479

High

829197

FBXW7
F-box/WD repeat-containing protein 7

1

4

High-throughput

0.479

High

829199

CHM4C
Charged multivesicular body protein 4c

1

2

High-throughput

0.479

High

829200

OPTN
Optineurin

1

3

High-throughput

0.479

High

829203

AURKB
Aurora kinase B

1

2

High-throughput

0.479

High

829205

ANM1
Protein arginine N-methyltransferase 1

1

2

High-throughput

0.479

High

829211

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.479

High

829212

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

2

High-throughput

0.479

High

829216

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

829217

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.479

High

148536

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

209775

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

273400

PPM1B
Protein phosphatase 1B

1

0

High-throughput

0.458

High

525866

IFM1
Interferon-induced transmembrane protein 1

1

0

High-throughput

0.458

High

566973

CXA1
Gap junction alpha-1 protein

1

0

Small-scale

0.458

High

829157

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

829178

CDKN3
Cyclin-dependent kinase inhibitor 3

1

0

High-throughput

0.458

High

829186

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

829187

GOLI
E3 ubiquitin-protein ligase RNF130

1

0

High-throughput

0.458

High

829190

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.458

High

829191

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

829198

ARMC5
Armadillo repeat-containing protein 5

1

0

High-throughput

0.458

High

829206

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

829207

MICU1
Calcium uptake protein 1, mitochondrial

1

0

High-throughput

0.458

High

829209

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

0

High-throughput

0.458

High

829210

PININ
Pinin

1

0

High-throughput

0.458

High

829214

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

829159

SUMO2
Small ubiquitin-related modifier 2

1

1

High-throughput

0.457

High

829213

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.457

High

829166

TAGL
Transgelin

1

1

High-throughput

0.445

High

829202

OTUB1
Ubiquitin thioesterase OTUB1

1

1

High-throughput

0.445

High

829167

MEF2C
Myocyte-specific enhancer factor 2C

1

0

High-throughput

0.438

High

829181

Q6NSK7
RIN3 protein

1

0

High-throughput

0.438

High

100591

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

225567

PCDH7
Protocadherin-7

1

1

High-throughput

0.437

High

244109

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.437

High

329497

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

552216

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.437

High

650655

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.437

High

719956

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

829160

WDR5
WD repeat-containing protein 5

1

3

High-throughput

0.437

High

829171

RBM39
RNA-binding protein 39

1

1

High-throughput

0.437

High

829183

LMBRL
Protein LMBR1L

1

2

High-throughput

0.437

High

829193

CLC4D
C-type lectin domain family 4 member D

1

1

High-throughput

0.437

High

829218

AAR2
Protein AAR2 homolog

1

1

High-throughput

0.437

High

829208

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

829152

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.373

High

829174

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.279

Low

829177

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.249

Low

829185

KCTD9
BTB/POZ domain-containing protein KCTD9

1

0

High-throughput

0.249

Low

829215

HACD3
Very-long-chain

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024