Protein: HDGF
Hepatoma-derived growth factor (HDGF) (High mobility group protein 1-like 2) (HMG-1L2)

Gene: HDGF
Organism: Homo sapiens
Interactions: 232
UniProt ID: P51858

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000166 - nucleotide binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001222 - transcription corepressor binding
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

850895

H31
Histone H3.1

5

20

High-throughput

0.915

High

850890

H2B1C
Histone H2B type 1-C/E/F/G/I

3

20

High-throughput

0.847

High

265971

PSIP1
PC4 and SFRS1-interacting protein

2

11

High-throughput

0.789

High

850940

HDGR2
Hepatoma-derived growth factor-related protein 2

2

9

High-throughput

0.789

High

241483

H2B1K
Histone H2B type 1-K

1

20

High-throughput

0.691

High

850880

H2B1D
Histone H2B type 1-D

1

20

High-throughput

0.691

High

850943

EGFL6
Epidermal growth factor-like protein 6

2

1

High-throughput

0.628

High

850962

CPNE2
Copine-2

2

2

High-throughput

0.628

High

455242

PARP1
Poly [ADP-ribose] polymerase 1

2

20

High-throughput

0.621

High

260805

H2AY
Core histone macro-H2A.1

1

20

High-throughput

0.618

High

331751

NSD2
Histone-lysine N-methyltransferase NSD2

1

19

Small-scale

0.618

High

850901

H33
Histone H3.3

1

20

High-throughput

0.618

High

850932

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.618

High

850992

H2AW
Core histone macro-H2A.2

1

20

High-throughput

0.618

High

401674

JUN
Transcription factor Jun

2

8

Small-scale

0.614

High

650724

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

4

High-throughput

0.611

High

850926

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

2

5

High-throughput

0.611

High

838730

EMD
Emerin

2

0

Small-scale

0.585

High

226919

PRKN
E3 ubiquitin-protein ligase parkin

2

6

High-throughput

0.584

High

244144

BRD4
Bromodomain-containing protein 4

2

20

High-throughput

0.584

High

346279

MYC
Myc proto-oncogene protein

2

11

High-throughput

0.584

High

641675

U2AF2
Splicing factor U2AF 65 kDa subunit

2

4

High-throughput

0.584

High

850916

CBX3
Chromobox protein homolog 3

2

19

High-throughput

0.584

High

850972

SH3G3
Endophilin-A3

2

1

High-throughput

0.571

High

571367

DDX5
Probable ATP-dependent RNA helicase DDX5

1

2

High-throughput

0.554

High

850897

PRKDC
DNA-dependent protein kinase catalytic subunit

1

6

High-throughput

0.554

High

850910

SRSF1
Serine/arginine-rich splicing factor 1

1

17

High-throughput

0.554

High

850912

SSRP1
FACT complex subunit SSRP1

1

13

High-throughput

0.554

High

850919

HDAC1
Histone deacetylase 1

1

12

High-throughput

0.554

High

176011

GPR37
Prosaposin receptor GPR37

1

2

High-throughput

0.541

High

116803

KIF2A
Kinesin-like protein KIF2A

1

2

High-throughput

0.536

High

118854

GTPB1
GTP-binding protein 1

1

1

High-throughput

0.536

High

170305

TIF1A
Transcription intermediary factor 1-alpha

1

12

High-throughput

0.536

High

195381

DHX15
ATP-dependent RNA helicase DHX15

1

4

High-throughput

0.536

High

281192

RL1D1
Ribosomal L1 domain-containing protein 1

1

4

High-throughput

0.536

High

322360

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

15

High-throughput

0.536

High

414830

CDK1
Cyclin-dependent kinase 1

1

2

High-throughput

0.536

High

488954

H14
Histone H1.4

1

14

High-throughput

0.536

High

508405

TOP1
DNA topoisomerase 1

1

3

High-throughput

0.536

High

523614

XRCC6
X-ray repair cross-complementing protein 6

1

7

High-throughput

0.536

High

524845

XRCC5
X-ray repair cross-complementing protein 5

1

7

High-throughput

0.536

High

559355

H13
Histone H1.3

1

14

High-throughput

0.536

High

559614

H12
Histone H1.2

1

14

High-throughput

0.536

High

577852

RL17
Large ribosomal subunit protein uL22

1

2

High-throughput

0.536

High

582150

NUCL
Nucleolin

1

6

High-throughput

0.536

High

609767

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

3

High-throughput

0.536

High

721950

RFC4
Replication factor C subunit 4

1

2

High-throughput

0.536

High

722198

RFC1
Replication factor C subunit 1

1

3

High-throughput

0.536

High

722343

RL22
Large ribosomal subunit protein eL22

1

1

High-throughput

0.536

High

777829

RFC5
Replication factor C subunit 5

1

2

High-throughput

0.536

High

780634

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

1

High-throughput

0.536

High

790308

RL35
Large ribosomal subunit protein uL29

1

1

High-throughput

0.536

High

802023

NOP2
Probable 28S rRNA

1

3

High-throughput

0.536

High

850871

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

3

High-throughput

0.536

High

850872

IMA1
Importin subunit alpha-1

1

2

High-throughput

0.536

High

850875

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

2

High-throughput

0.536

High

850882

WDR5
WD repeat-containing protein 5

1

9

High-throughput

0.536

High

850889

H4
Histone H4

1

7

High-throughput

0.536

High

850892

RL32
Large ribosomal subunit protein eL32

1

1

High-throughput

0.536

High

850894

CSK21
Casein kinase II subunit alpha

1

8

High-throughput

0.536

High

850899

RL19
Large ribosomal subunit protein eL19

1

2

High-throughput

0.536

High

850900

SRSF3
Serine/arginine-rich splicing factor 3

1

20

High-throughput

0.536

High

850903

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

8

High-throughput

0.536

High

850905

SRSF2
Serine/arginine-rich splicing factor 2

1

2

High-throughput

0.536

High

850911

DHX9
ATP-dependent RNA helicase A

1

5

High-throughput

0.536

High

850913

RBBP4
Histone-binding protein RBBP4

1

15

High-throughput

0.536

High

850917

SRSF5
Serine/arginine-rich splicing factor 5

1

16

High-throughput

0.536

High

850922

RBM39
RNA-binding protein 39

1

2

High-throughput

0.536

High

850923

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

3

High-throughput

0.536

High

850924

BMS1
Ribosome biogenesis protein BMS1 homolog

1

3

High-throughput

0.536

High

850928

PWP2
Periodic tryptophan protein 2 homolog

1

4

High-throughput

0.536

High

850931

SRSF7
Serine/arginine-rich splicing factor 7

1

12

High-throughput

0.536

High

850933

TSR1
Pre-rRNA-processing protein TSR1 homolog

1

2

High-throughput

0.536

High

850938

DHX30
ATP-dependent RNA helicase DHX30

1

5

High-throughput

0.536

High

850939

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

20

High-throughput

0.536

High

850941

THOC4
THO complex subunit 4

1

4

High-throughput

0.536

High

850949

WDR36
WD repeat-containing protein 36

1

3

High-throughput

0.536

High

850950

BRX1
Ribosome biogenesis protein BRX1 homolog

1

1

High-throughput

0.536

High

850951

DDX1
ATP-dependent RNA helicase DDX1

1

2

High-throughput

0.536

High

850956

HDAC2
Histone deacetylase 2

1

12

High-throughput

0.536

High

850958

DDX17
Probable ATP-dependent RNA helicase DDX17

1

2

High-throughput

0.536

High

850960

LRC59
Leucine-rich repeat-containing protein 59

1

1

High-throughput

0.536

High

850967

SRPK1
SRSF protein kinase 1

1

6

High-throughput

0.536

High

850968

INT14
Integrator complex subunit 14

1

1

High-throughput

0.536

High

850969

CDC5L
Cell division cycle 5-like protein

1

2

High-throughput

0.536

High

850971

EBP2
Probable rRNA-processing protein EBP2

1

1

High-throughput

0.536

High

850973

DDX50
ATP-dependent RNA helicase DDX50

1

5

High-throughput

0.536

High

850974

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

15

High-throughput

0.536

High

850975

MBB1A
Myb-binding protein 1A

1

2

High-throughput

0.536

High

850978

PDIP3
Polymerase delta-interacting protein 3

1

3

High-throughput

0.536

High

850979

DDX47
Probable ATP-dependent RNA helicase DDX47

1

3

High-throughput

0.536

High

850984

DDX21
Nucleolar RNA helicase 2

1

5

High-throughput

0.536

High

850988

INT13
Integrator complex subunit 13

1

1

High-throughput

0.536

High

850989

INT10
Integrator complex subunit 10

1

1

High-throughput

0.536

High

850993

RCC2
Protein RCC2

1

2

High-throughput

0.536

High

850997

MRT4
mRNA turnover protein 4 homolog

1

2

High-throughput

0.536

High

850999

SMC3
Structural maintenance of chromosomes protein 3

1

3

High-throughput

0.536

High

851000

AKT3
RAC-gamma serine/threonine-protein kinase

1

3

High-throughput

0.536

High

850946

SH2D3
SH2 domain-containing protein 3C

2

6

High-throughput

0.521

High

571801

XBP1
X-box-binding protein 1

1

0

High-throughput

0.518

High

127475

RPOM
DNA-directed RNA polymerase, mitochondrial

1

0

High-throughput

0.513

High

242685

IF2P
Eukaryotic translation initiation factor 5B

1

0

High-throughput

0.513

High

397324

ADT2
ADP/ATP translocase 2

1

0

High-throughput

0.513

High

398671

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

0

High-throughput

0.513

High

574280

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.513

High

603405

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.513

High

813255

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

825143

RL34
Large ribosomal subunit protein eL34

1

0

High-throughput

0.513

High

850883

RS15A
Small ribosomal subunit protein uS8

1

0

High-throughput

0.513

High

850885

RS23
Small ribosomal subunit protein uS12

1

0

High-throughput

0.513

High

850886

RS11
Small ribosomal subunit protein uS17

1

0

High-throughput

0.513

High

850887

SMD1
Small nuclear ribonucleoprotein Sm D1

1

0

High-throughput

0.513

High

850904

U2AF1
Splicing factor U2AF 35 kDa subunit

1

0

High-throughput

0.513

High

850906

EXOSX
Exosome complex component 10

1

0

High-throughput

0.513

High

850920

NACA
Nascent polypeptide-associated complex subunit alpha

1

0

High-throughput

0.513

High

850921

EXOS2
Exosome complex component RRP4

1

0

High-throughput

0.513

High

850934

EXOS6
Exosome complex component MTR3

1

0

High-throughput

0.513

High

850948

ABCF1
ATP-binding cassette sub-family F member 1

1

0

High-throughput

0.513

High

850952

H1X
Histone H1.10

1

0

High-throughput

0.513

High

850976

CG050
Uncharacterized protein C7orf50

1

0

High-throughput

0.513

High

850977

GNL3
Guanine nucleotide-binding protein-like 3

1

0

High-throughput

0.513

High

850983

EXOS3
Exosome complex component RRP40

1

0

High-throughput

0.513

High

850986

SYFB
Phenylalanine--tRNA ligase beta subunit

1

0

High-throughput

0.513

High

850998

DIM1
Probable dimethyladenosine transferase

1

0

High-throughput

0.513

High

851006

SP16H
FACT complex subunit SPT16

1

0

High-throughput

0.513

High

394372

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

488626

ARAF
Serine/threonine-protein kinase A-Raf

1

2

High-throughput

0.489

High

850902

S25A3
Solute carrier family 25 member 3

1

1

High-throughput

0.489

High

850942

MYLK4
Myosin light chain kinase family member 4

1

5

High-throughput

0.489

High

850953

YLAT2
Y+L amino acid transporter 2

1

1

High-throughput

0.489

High

850987

ATD3A
ATPase family AAA domain-containing protein 3A

1

1

High-throughput

0.489

High

129719

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

1

High-throughput

0.479

High

153612

ANM5
Protein arginine N-methyltransferase 5

1

1

High-throughput

0.479

High

180251

MAGB2
Melanoma-associated antigen B2

1

4

High-throughput

0.479

High

211145

BUB3
Mitotic checkpoint protein BUB3

1

10

High-throughput

0.479

High

229343

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

20

High-throughput

0.479

High

261229

FLNB
Filamin-B

1

1

High-throughput

0.479

High

329516

AGR2
Anterior gradient protein 2 homolog

1

2

Small-scale

0.479

High

331475

ACL6A
Actin-like protein 6A

1

3

High-throughput

0.479

High

338159

EGFR
Epidermal growth factor receptor

1

4

High-throughput

0.479

High

359779

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

6

High-throughput

0.479

High

379147

MYCN
N-myc proto-oncogene protein

1

10

High-throughput

0.479

High

396904

HMGN1
Non-histone chromosomal protein HMG-14

1

1

High-throughput

0.479

High

403130

LA
Lupus La protein

1

2

High-throughput

0.479

High

503721

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

531087

EF2
Elongation factor 2

1

5

High-throughput

0.479

High

532441

TCTP
Translationally-controlled tumor protein

1

1

High-throughput

0.479

High

533280

PLST
Plastin-3

1

3

High-throughput

0.479

High

569425

CEBPB
CCAAT/enhancer-binding protein beta

1

10

High-throughput

0.479

High

578399

RCC1
Regulator of chromosome condensation

1

2

High-throughput

0.479

High

585425

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

3

High-throughput

0.479

High

649384

RL10
Large ribosomal subunit protein uL16

1

2

High-throughput

0.479

High

652788

APEX1
DNA repair nuclease/redox regulator APEX1

1

5

High-throughput

0.479

High

653938

MAP4
Microtubule-associated protein 4

1

7

High-throughput

0.479

High

727347

DEK
Protein DEK

1

2

High-throughput

0.479

High

729054

K22E
Keratin, type II cytoskeletal 2 epidermal

1

1

High-throughput

0.479

High

745099

RBMX
RNA-binding motif protein, X chromosome

1

3

High-throughput

0.479

High

751546

GRP75
Stress-70 protein, mitochondrial

1

3

High-throughput

0.479

High

777959

RFC3
Replication factor C subunit 3

1

2

High-throughput

0.479

High

779058

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

785775

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

2

High-throughput

0.479

High

826244

CDK8
Cyclin-dependent kinase 8

1

4

High-throughput

0.479

High

850873

HMGA2
High mobility group protein HMGI-C

1

2

High-throughput

0.479

High

850877

NP1L1
Nucleosome assembly protein 1-like 1

1

1

Small-scale

0.479

High

850878

FOXA1
Hepatocyte nuclear factor 3-alpha

1

5

High-throughput

0.479

High

850881

UBC12
NEDD8-conjugating enzyme Ubc12

1

1

High-throughput

0.479

High

850884

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

5

High-throughput

0.479

High

850888

RS6
Small ribosomal subunit protein eS6

1

4

High-throughput

0.479

High

850891

RAN
GTP-binding nuclear protein Ran

1

1

High-throughput

0.479

High

850893

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

1

High-throughput

0.479

High

850907

EWS
RNA-binding protein EWS

1

2

High-throughput

0.479

High

850909

CKAP4
Cytoskeleton-associated protein 4

1

6

High-throughput

0.479

High

850914

EP300
Histone acetyltransferase p300

1

20

High-throughput

0.479

High

850915

FOXC1
Forkhead box protein C1

1

7

High-throughput

0.479

High

850918

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

850925

TNIP1
TNFAIP3-interacting protein 1

1

10

High-throughput

0.479

High

850929

EZH2
Histone-lysine N-methyltransferase EZH2

1

18

High-throughput

0.479

High

850930

MK14
Mitogen-activated protein kinase 14

1

2

High-throughput

0.479

High

850935

HP1B3
Heterochromatin protein 1-binding protein 3

1

1

High-throughput

0.479

High

850936

TRI67
Tripartite motif-containing protein 67

1

10

High-throughput

0.479

High

850944

PHF6
PHD finger protein 6

1

6

High-throughput

0.479

High

850945

YAF2
YY1-associated factor 2

1

2

High-throughput

0.479

High

850955

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

850957

KAT2A
Histone acetyltransferase KAT2A

1

20

High-throughput

0.479

High

850959

KAT5
Histone acetyltransferase KAT5

1

5

High-throughput

0.479

High

850961

OPTN
Optineurin

1

9

High-throughput

0.479

High

850965

THOC3
THO complex subunit 3

1

10

High-throughput

0.479

High

850980

Q9H4D1
Protein kinase

1

1

High-throughput

0.479

High

850981

PKHA4
Pleckstrin homology domain-containing family A member 4

1

6

High-throughput

0.479

High

850990

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.479

High

850991

LYAR
Cell growth-regulating nucleolar protein

1

2

High-throughput

0.479

High

850994

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

850996

BAZ1B
Tyrosine-protein kinase BAZ1B

1

20

High-throughput

0.479

High

851002

NUDC
Nuclear migration protein nudC

1

1

High-throughput

0.479

High

851003

DRG1
Developmentally-regulated GTP-binding protein 1

1

1

High-throughput

0.479

High

850985

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

High-throughput

0.460

High

283440

SRP72
Signal recognition particle subunit SRP72

1

0

High-throughput

0.458

High

307784

ZRAB2
Zinc finger Ran-binding domain-containing protein 2

1

0

High-throughput

0.458

High

380582

K2C1
Keratin, type II cytoskeletal 1

1

0

High-throughput

0.458

High

426606

H10
Histone H1.0

1

0

High-throughput

0.458

High

531336

K1C10
Keratin, type I cytoskeletal 10

1

0

High-throughput

0.458

High

588864

IF2B
Eukaryotic translation initiation factor 2 subunit 2

1

0

High-throughput

0.458

High

666372

3MG
DNA-3-methyladenine glycosylase

1

0

High-throughput

0.458

High

681377

DNJA1
DnaJ homolog subfamily A member 1

1

0

High-throughput

0.458

High

714748

TRY3
Trypsin-3

1

0

High-throughput

0.458

High

850874

ITA8
Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain]

1

0

High-throughput

0.458

High

850876

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

850896

RPP38
Ribonuclease P protein subunit p38

1

0

High-throughput

0.458

High

850937

TM10C
tRNA methyltransferase 10 homolog C

1

0

High-throughput

0.458

High

850954

RT27
Small ribosomal subunit protein mS27

1

0

High-throughput

0.458

High

850970

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

0

High-throughput

0.458

High

850995

SRP68
Signal recognition particle subunit SRP68

1

0

High-throughput

0.458

High

851001

RUVB1
RuvB-like 1

1

0

High-throughput

0.458

High

851004

RCL1
RNA 3'-terminal phosphate cyclase-like protein

1

0

High-throughput

0.458

High

496605

TAU
Microtubule-associated protein tau

1

5

High-throughput

0.445

High

785696

LAP2A
Lamina-associated polypeptide 2, isoform alpha

1

2

High-throughput

0.445

High

850879

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

850908

TAGL
Transgelin

1

2

High-throughput

0.445

High

100614

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

384526

NTRK1
High affinity nerve growth factor receptor

1

7

High-throughput

0.437

High

377996

PRIO
Major prion protein

1

0

High-throughput

0.426

High

850963

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

831123

CEBPA
CCAAT/enhancer-binding protein alpha

1

10

High-throughput

0.408

High

795081

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.279

Low

850927

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.279

Low

850964

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

0

High-throughput

0.279

Low

850966

INT15
Integrator complex subunit 15

1

0

High-throughput

0.279

Low

850982

CH033
UPF0488 protein C8orf33

1

0

High-throughput

0.279

Low

390790

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

850898

RT22
Small ribosomal subunit protein mS22

1

0

High-throughput

0.249

Low

850947

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

851005

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024