Protein: DLG4
Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)

Gene: DLG4
Organism: Homo sapiens
Interactions: 143
UniProt ID: P78352

Gene Ontology (top 5):
GO:0002091 - negative regulation of receptor internalization
GO:0005737 - cytoplasm
GO:0005783 - endoplasmic reticulum
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

942346

ERBB4
Receptor tyrosine-protein kinase erbB-4

4

17

Small-scale

0.903

High

196430

SI1L1
Signal-induced proliferation-associated 1-like protein 1

3

5

Small-scale

0.878

High

667750

NOS1
Nitric oxide synthase 1

3

4

Small-scale

0.877

High

942321

DLG4
Disks large homolog 4

2

17

Small-scale

0.793

High

942349

DLG2
Disks large homolog 2

2

17

Small-scale

0.793

High

942364

DLG3
Disks large homolog 3

2

17

Small-scale

0.783

High

227141

PRKN
E3 ubiquitin-protein ligase parkin

2

12

Small-scale

0.776

High

942337

NMDE2
Glutamate receptor ionotropic, NMDA 2B

18

20

Small-scale

0.765

High

942334

NMDE1
Glutamate receptor ionotropic, NMDA 2A

17

20

Small-scale

0.764

High

608221

KCNA4
Potassium voltage-gated channel subfamily A member 4

9

20

Small-scale

0.757

High

412128

FYN
Tyrosine-protein kinase Fyn

2

16

Small-scale

0.754

High

942399

SHAN2
SH3 and multiple ankyrin repeat domains protein 2

2

17

Small-scale

0.754

High

145945

DLGP1
Disks large-associated protein 1

9

20

Small-scale

0.754

High

942340

FAK2
Protein-tyrosine kinase 2-beta

1

20

Small-scale

0.724

High

159190

CSKP
Peripheral plasma membrane protein CASK

1

15

Small-scale

0.713

High

383736

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

Small-scale

0.713

High

942335

GRIK2
Glutamate receptor ionotropic, kainate 2

4

20

Small-scale

0.703

High

234499

DSCAM
Cell adhesion molecule DSCAM

1

11

High-throughput

0.698

High

942325

EM55
55 kDa erythrocyte membrane protein

1

18

High-throughput

0.698

High

942336

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

10

High-throughput

0.698

High

942390

CRIPT
Cysteine-rich PDZ-binding protein

4

3

Small-scale

0.694

High

942327

APBA1
Amyloid-beta A4 precursor protein-binding family A member 1

1

19

High-throughput

0.691

High

942387

LIN7C
Protein lin-7 homolog C

1

19

High-throughput

0.691

High

942384

KI13B
Kinesin-like protein KIF13B

1

18

Small-scale

0.681

High

942329

NMDZ1
Glutamate receptor ionotropic, NMDA 1

4

20

Small-scale

0.680

High

608268

KCNA5
Potassium voltage-gated channel subfamily A member 5

3

20

Small-scale

0.669

High

942385

PICK1
PRKCA-binding protein

1

0

High-throughput

0.663

High

816146

KCNJ4
Inward rectifier potassium channel 4

3

20

Small-scale

0.661

High

942361

NLGN1
Neuroligin-1

3

19

Small-scale

0.658

High

942370

SYGP1
Ras/Rap GTPase-activating protein SynGAP

3

11

Small-scale

0.654

High

231496

KIF1B
Kinesin-like protein KIF1B

1

18

Small-scale

0.653

High

158271

LIN7A
Protein lin-7 homolog A

1

20

Small-scale

0.647

High

942344

FRPD4
FERM and PDZ domain-containing protein 4

1

12

High-throughput

0.647

High

942359

ARHG8
Neuroepithelial cell-transforming gene 1 protein

1

14

High-throughput

0.647

High

942379

TANC1
Protein TANC1

1

13

High-throughput

0.647

High

942324

LRP2
Low-density lipoprotein receptor-related protein 2

2

8

Small-scale

0.633

High

441650

ADRB1
Beta-1 adrenergic receptor

2

15

Small-scale

0.631

High

942333

KCNA1
Potassium voltage-gated channel subfamily A member 1

2

20

Small-scale

0.626

High

942350

GRIK5
Glutamate receptor ionotropic, kainate 5

2

20

Small-scale

0.624

High

942365

EXOC4
Exocyst complex component 4

2

3

Small-scale

0.624

High

617101

PTPRG
Receptor-type tyrosine-protein phosphatase gamma

1

7

Small-scale

0.621

High

725643

ACTN2
Alpha-actinin-2

2

13

Small-scale

0.619

High

942347

RBP1
RalA-binding protein 1

2

9

High-throughput

0.619

High

872140

RD23A
UV excision repair protein RAD23 homolog A

1

3

Small-scale

0.618

High

924466

GRB2
Growth factor receptor-bound protein 2

1

19

High-throughput

0.618

High

942328

M3K10
Mitogen-activated protein kinase kinase kinase 10

1

11

Small-scale

0.618

High

942351

M3K11
Mitogen-activated protein kinase kinase kinase 11

1

3

Small-scale

0.618

High

942352

NTRK2
BDNF/NT-3 growth factors receptor

1

20

Small-scale

0.618

High

942369

LRRC7
Leucine-rich repeat-containing protein 7

1

12

Small-scale

0.618

High

942382

LIN7B
Protein lin-7 homolog B

1

19

Small-scale

0.618

High

942395

DP13A
DCC-interacting protein 13-alpha

1

7

Small-scale

0.618

High

942401

BAIP2
BAR/IMD domain-containing adapter protein 2

1

6

Small-scale

0.618

High

942404

SHAN1
SH3 and multiple ankyrin repeat domains protein 1

1

14

Small-scale

0.618

High

327234

DLGP3
Disks large-associated protein 3

2

20

Small-scale

0.613

High

942402

DLGP4
Disks large-associated protein 4

2

20

Small-scale

0.613

High

558713

KCNA2
Potassium voltage-gated channel subfamily A member 2

2

20

Small-scale

0.606

High

942331

LRP1
Prolow-density lipoprotein receptor-related protein 1

2

9

Small-scale

0.606

High

704958

GCYA2
Guanylate cyclase soluble subunit alpha-2

2

9

Small-scale

0.595

High

714731

CRFR1
Corticotropin-releasing factor receptor 1

2

10

Small-scale

0.595

High

942343

NMDE3
Glutamate receptor ionotropic, NMDA 2C

1

20

Small-scale

0.589

High

942339

LRP8
Low-density lipoprotein receptor-related protein 8

2

8

Small-scale

0.586

High

602901

KCNA3
Potassium voltage-gated channel subfamily A member 3

2

20

Small-scale

0.584

High

942342

KCJ12
ATP-sensitive inward rectifier potassium channel 12

2

20

Small-scale

0.584

High

942405

CCG2
Voltage-dependent calcium channel gamma-2 subunit

2

8

Small-scale

0.584

High

942378

SEM4C
Semaphorin-4C

1

7

Small-scale

0.573

High

942326

MDM2
E3 ubiquitin-protein ligase Mdm2

1

3

Small-scale

0.569

High

146752

AGRB1
Adhesion G protein-coupled receptor B1

2

10

Small-scale

0.563

High

600726

DRD1
D(1A) dopamine receptor

1

18

Small-scale

0.561

High

761199

GRIK1
Glutamate receptor ionotropic, kainate 1

1

20

Small-scale

0.561

High

928259

DYL1
Dynein light chain 1, cytoplasmic

1

7

Small-scale

0.561

High

942366

DYL2
Dynein light chain 2, cytoplasmic

1

7

Small-scale

0.561

High

942393

PCD10
Protocadherin-10

1

3

Small-scale

0.561

High

942406

S4A7
Sodium bicarbonate cotransporter 3

1

3

Small-scale

0.561

High

159954

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

5

Small-scale

0.552

High

254162

FZD7
Frizzled-7

1

13

Small-scale

0.552

High

929762

KCNJ2
Inward rectifier potassium channel 2

1

20

Small-scale

0.552

High

942322

MAP1A
Microtubule-associated protein 1A

1

9

Small-scale

0.552

High

225263

AGRB2
Adhesion G protein-coupled receptor B2

1

10

High-throughput

0.541

High

365185

FRIH
Ferritin heavy chain

1

1

High-throughput

0.541

High

432648

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

1

High-throughput

0.541

High

500766

CLUS
Clusterin

1

1

High-throughput

0.541

High

644005

EF1G
Elongation factor 1-gamma

1

1

High-throughput

0.541

High

942323

GPSM2
G-protein-signaling modulator 2

1

8

High-throughput

0.541

High

942353

VMAC
Vimentin-type intermediate filament-associated coiled-coil protein

1

1

High-throughput

0.541

High

942356

TJAP1
Tight junction-associated protein 1

1

5

High-throughput

0.541

High

942374

LZTS2
Leucine zipper putative tumor suppressor 2

1

9

High-throughput

0.541

High

942376

BEGIN
Brain-enriched guanylate kinase-associated protein

1

5

High-throughput

0.541

High

942377

TBB2B
Tubulin beta-2B chain

1

9

High-throughput

0.541

High

942381

RASF4
Ras association domain-containing protein 4

1

1

High-throughput

0.541

High

942392

DLGP2
Disks large-associated protein 2

1

20

Small-scale

0.527

High

603143

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

0

High-throughput

0.518

High

777174

PEX19
Peroxisomal biogenesis factor 19

1

0

High-throughput

0.518

High

942367

AB17A
Alpha/beta hydrolase domain-containing protein 17A

1

0

High-throughput

0.518

High

499679

CH60
60 kDa heat shock protein, mitochondrial

1

3

High-throughput

0.515

High

722887

SPR2A
Small proline-rich protein 2A

1

0

Small-scale

0.513

High

942375

LRRC1
Leucine-rich repeat-containing protein 1

1

16

Small-scale

0.508

High

178305

NMDE4
Glutamate receptor ionotropic, NMDA 2D

1

20

Small-scale

0.501

High

658221

5HT2C
5-hydroxytryptamine receptor 2C

1

18

Small-scale

0.501

High

942371

CDC5L
Cell division cycle 5-like protein

1

2

High-throughput

0.501

High

942372

PKP4
Plakophilin-4

1

12

High-throughput

0.501

High

942383

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

Small-scale

0.501

High

942386

CLTR2
Cysteinyl leukotriene receptor 2

1

20

High-throughput

0.501

High

942400

CTND2
Catenin delta-2

1

10

High-throughput

0.501

High

942403

TRAF6
TNF receptor-associated factor 6

1

10

Small-scale

0.501

High

942332

GOGA2
Golgin subfamily A member 2

1

3

High-throughput

0.494

High

942357

WDR74
WD repeat-containing protein 74

1

3

High-throughput

0.494

High

942362

MPND
MPN domain-containing protein

1

1

High-throughput

0.494

High

942368

THOC3
THO complex subunit 3

1

1

High-throughput

0.494

High

942341

FZD2
Frizzled-2

1

13

Small-scale

0.481

High

942363

NLGN2
Neuroligin-2

1

19

Small-scale

0.481

High

942388

NLGN3
Neuroligin-3

1

19

Small-scale

0.481

High

942389

KCND2
Potassium voltage-gated channel subfamily D member 2

1

20

Small-scale

0.481

High

942397

FZD4
Frizzled-4

1

13

Small-scale

0.481

High

942398

FZD1
Frizzled-1

1

13

Small-scale

0.481

High

685901

ARRB2
Beta-arrestin-2

1

0

Small-scale

0.480

High

328209

LGI1
Leucine-rich glioma-inactivated protein 1

1

9

Small-scale

0.479

High

394515

A4
Amyloid-beta precursor protein

1

3

Small-scale

0.479

High

566353

KPCA
Protein kinase C alpha type

1

9

Small-scale

0.479

High

656994

5HT2A
5-hydroxytryptamine receptor 2A

1

15

Small-scale

0.479

High

786726

GRIA2
Glutamate receptor 2

1

20

Small-scale

0.479

High

786757

GRIA3
Glutamate receptor 3

1

20

Small-scale

0.479

High

792762

EAA3
Excitatory amino acid transporter 3

1

4

Small-scale

0.479

High

873123

PTN5
Tyrosine-protein phosphatase non-receptor type 5

1

9

Small-scale

0.479

High

942338

CUL3
Cullin-3

1

5

High-throughput

0.479

High

942355

DCAF6
DDB1- and CUL4-associated factor 6

1

1

High-throughput

0.479

High

942358

ARC
Activity-regulated cytoskeleton-associated protein

1

2

Small-scale

0.479

High

942360

NLGNX
Neuroligin-4, X-linked

1

19

Small-scale

0.479

High

942391

ADA22
Disintegrin and metalloproteinase domain-containing protein 22

1

12

Small-scale

0.479

High

942394

ASIC3
Acid-sensing ion channel 3

1

1

Small-scale

0.479

High

942396

BRPF3
Bromodomain and PHD finger-containing protein 3

1

2

High-throughput

0.479

High

942407

DUS10
Dual specificity protein phosphatase 10

1

5

High-throughput

0.479

High

548835

MCP
Membrane cofactor protein

1

0

Small-scale

0.460

High

942373

SGMR1
Sigma non-opioid intracellular receptor 1

1

0

Small-scale

0.458

High

239931

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

4

High-throughput

0.445

High

378026

PRIO
Major prion protein

1

3

High-throughput

0.445

High

100672

APRIO
Alternative prion protein

1

5

High-throughput

0.437

High

942330

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

4

Small-scale

0.408

High

942348

KS6A1
Ribosomal protein S6 kinase alpha-1

1

11

Small-scale

0.408

High

335670

COX1
Cytochrome c oxidase subunit 1

1

0

High-throughput

0.282

High

942345

NOMO1
BOS complex subunit NOMO1

1

0

High-throughput

0.282

High

942354

LARGN
Protein Largen

1

0

High-throughput

0.282

High

942380

MED28
Mediator of RNA polymerase II transcription subunit 28

1

0

Small-scale

0.269

Low


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Last updated: 15 Jul 2024