Protein: IPYR
Inorganic pyrophosphatase (EC 3.6.1.1) (Pyrophosphate phospho-hydrolase) (PPase)

Gene: IPYR, PPA1
Organism: Homo sapiens
Interactions: 126
UniProt ID: Q15181

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004427 - inorganic diphosphate phosphatase activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006796 - phosphate-containing compound metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

346836

MYC
Myc proto-oncogene protein

3

2

High-throughput

0.640

High

779452

CCNF
Cyclin-F

2

1

High-throughput

0.584

High

383816

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

1

High-throughput

0.576

High

529146

CFTR
Cystic fibrosis transmembrane conductance regulator

2

0

High-throughput

0.576

High

1069305

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

2

High-throughput

0.571

High

1069323

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.547

High

734939

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

1

High-throughput

0.536

High

1069346

SAR1B
Small COPII coat GTPase SAR1B

1

1

High-throughput

0.536

High

1069314

LCA5
Lebercilin

2

1

High-throughput

0.521

High

386772

P53
Cellular tumor antigen p53

1

0

High-throughput

0.518

High

388460

HSPB1
Heat shock protein beta-1

1

0

High-throughput

0.518

High

1034156

U119A
Protein unc-119 homolog A

1

0

High-throughput

0.518

High

1065604

SETB1
Histone-lysine N-methyltransferase SETDB1

1

0

High-throughput

0.518

High

201338

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

High-throughput

0.513

High

336500

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.513

High

359961

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.513

High

983841

KPCZ
Protein kinase C zeta type

1

0

High-throughput

0.513

High

475791

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

4

High-throughput

0.501

High

726214

BASI
Basigin

1

0

High-throughput

0.493

High

842513

RL14
Large ribosomal subunit protein eL14

1

0

High-throughput

0.493

High

666602

LTK
Leukocyte tyrosine kinase receptor

1

2

High-throughput

0.489

High

1069325

LMTK3
Serine/threonine-protein kinase LMTK3

1

1

High-throughput

0.489

High

120449

RHOD
Rho-related GTP-binding protein RhoD

1

9

High-throughput

0.479

High

159062

UB2L6
Ubiquitin/ISG15-conjugating enzyme E2 L6

1

1

High-throughput

0.479

High

227508

PRKN
E3 ubiquitin-protein ligase parkin

1

5

High-throughput

0.479

High

436314

RHOC
Rho-related GTP-binding protein RhoC

1

7

High-throughput

0.479

High

518668

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

2

High-throughput

0.479

High

533304

PLST
Plastin-3

1

1

High-throughput

0.479

High

545391

RAC2
Ras-related C3 botulinum toxin substrate 2

1

7

High-throughput

0.479

High

564538

RHOQ
Rho-related GTP-binding protein RhoQ

1

8

High-throughput

0.479

High

569755

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

749517

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.479

High

773378

RL13A
Large ribosomal subunit protein uL13

1

2

High-throughput

0.479

High

835771

GSK3B
Glycogen synthase kinase-3 beta

1

1

Small-scale

0.479

High

852486

RND2
Rho-related GTP-binding protein RhoN

1

8

High-throughput

0.479

High

892384

RAC3
Ras-related C3 botulinum toxin substrate 3

1

7

High-throughput

0.479

High

894030

CDC42
Cell division control protein 42 homolog

1

8

High-throughput

0.479

High

900492

RHOA
Transforming protein RhoA

1

8

High-throughput

0.479

High

908575

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

915689

RHOB
Rho-related GTP-binding protein RhoB

1

9

High-throughput

0.479

High

925293

RAC1
Ras-related C3 botulinum toxin substrate 1

1

7

High-throughput

0.479

High

1035763

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

1064316

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

1069302

RHOH
Rho-related GTP-binding protein RhoH

1

9

High-throughput

0.479

High

1069310

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

1

High-throughput

0.479

High

1069311

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

1069312

RHOU
Rho-related GTP-binding protein RhoU

1

9

High-throughput

0.479

High

1069321

CSN5
COP9 signalosome complex subunit 5

1

1

High-throughput

0.479

High

1069332

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

1069341

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1069342

DS13B
Dual specificity protein phosphatase 13B

1

1

High-throughput

0.479

High

329733

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.470

High

1069343

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.470

High

477742

HMN1
Humanin-like 1

1

0

Small-scale

0.460

High

1069316

MCPH1
Microcephalin

1

0

Small-scale

0.460

High

117409

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

0

High-throughput

0.458

High

148842

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

155361

NRP1
Neuropilin-1

1

0

High-throughput

0.458

High

177896

TMPS2
Transmembrane protease serine 2

1

0

High-throughput

0.458

High

303253

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

322662

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

337096

HPRT
Hypoxanthine-guanine phosphoribosyltransferase

1

0

High-throughput

0.458

High

363161

FINC
Fibronectin

1

0

High-throughput

0.458

High

374263

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

417728

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.458

High

418299

NPM
Nucleophosmin

1

0

High-throughput

0.458

High

444895

ANXA5
Annexin A5

1

0

High-throughput

0.458

High

456872

FURIN
Furin

1

0

High-throughput

0.458

High

504112

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

649111

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

0

High-throughput

0.458

High

714846

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

0

High-throughput

0.458

High

796749

RANG
Ran-specific GTPase-activating protein

1

0

High-throughput

0.458

High

896096

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

896447

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

0

High-throughput

0.458

High

932172

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.458

High

1041618

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1045326

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

0

High-throughput

0.458

High

1069303

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

1069306

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

1069309

CDC73
Parafibromin

1

0

High-throughput

0.458

High

1069313

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1069315

RPTOR
Regulatory-associated protein of mTOR

1

0

High-throughput

0.458

High

1069317

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

1069320

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

1069322

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.458

High

1069326

NECD
Necdin

1

0

High-throughput

0.458

High

1069327

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

1069328

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

1069334

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.458

High

1069335

MYO10
Unconventional myosin-X

1

0

Small-scale

0.458

High

1069336

SIAS
Sialic acid synthase

1

0

High-throughput

0.458

High

1069337

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

1069338

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

1069339

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.458

High

1069344

PA2G4
Proliferation-associated protein 2G4

1

0

High-throughput

0.458

High

1069304

WIPI1
WD repeat domain phosphoinositide-interacting protein 1

1

1

High-throughput

0.457

High

306183

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

1

High-throughput

0.445

High

378056

PRIO
Major prion protein

1

1

High-throughput

0.445

High

1069308

PKHA7
Pleckstrin homology domain-containing family A member 7

1

2

High-throughput

0.445

High

1069331

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

1

High-throughput

0.445

High

100781

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

244467

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.437

High

297625

RHBT1
Rho-related BTB domain-containing protein 1

1

8

High-throughput

0.437

High

379425

MYCN
N-myc proto-oncogene protein

1

2

High-throughput

0.437

High

384879

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.437

High

525938

IFM1
Interferon-induced transmembrane protein 1

1

1

High-throughput

0.437

High

720521

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

824029

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

1

High-throughput

0.437

High

965676

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.437

High

1069319

CLC4D
C-type lectin domain family 4 member D

1

1

High-throughput

0.437

High

1069324

RHOV
Rho-related GTP-binding protein RhoV

1

8

High-throughput

0.437

High

1069329

RHBT2
Rho-related BTB domain-containing protein 2

1

8

High-throughput

0.437

High

173892

MK13
Mitogen-activated protein kinase 13

1

0

Small-scale

0.426

High

497052

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

581742

VCAM1
Vascular cell adhesion protein 1

1

0

High-throughput

0.426

High

402039

JUN
Transcription factor Jun

1

1

High-throughput

0.407

High

831343

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.373

High

452785

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

651263

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

781370

BCL6
B-cell lymphoma 6 protein

1

0

High-throughput

0.249

Low

1069307

IQEC1
IQ motif and SEC7 domain-containing protein 1

1

0

High-throughput

0.249

Low

1069318

ENOX1
Ecto-NOX disulfide-thiol exchanger 1

1

0

High-throughput

0.249

Low

1069330

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

1069333

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.249

Low

1069340

EPHA6
Ephrin type-A receptor 6

1

0

High-throughput

0.249

Low

1069345

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024