Protein: TXND5
Thioredoxin domain-containing protein 5 (EC 1.8.4.-) (EC 5.3.4.1) (Endoplasmic reticulum resident protein 46) (ER protein 46) (ERp46) (Thioredoxin-like protein p46)

Gene: TXND5, TXNDC5
Organism: Homo sapiens
Interactions: 161
UniProt ID: Q8NBS9

Gene Ontology (top 5):
GO:0003756 - protein disulfide isomerase activity
GO:0005576 - extracellular region
GO:0005783 - endoplasmic reticulum
GO:0005788 - endoplasmic reticulum lumen
GO:0006457 - protein folding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

685729

PRDX2
Peroxiredoxin-2

1

9

Small-scale

0.724

High

1026726

PRDX4
Peroxiredoxin-4

1

9

Small-scale

0.647

High

531910

PDIA4
Protein disulfide-isomerase A4

1

16

High-throughput

0.618

High

623754

PPAC
Low molecular weight phosphotyrosine protein phosphatase

1

1

High-throughput

0.618

High

1028081

DNJC3
DnaJ homolog subfamily C member 3

1

20

High-throughput

0.618

High

1220434

DJC10
DnaJ homolog subfamily C member 10

1

17

High-throughput

0.618

High

1240429

PD1L1
Programmed cell death 1 ligand 1

1

3

High-throughput

0.618

High

1240431

DNJB9
DnaJ homolog subfamily B member 9

1

20

High-throughput

0.618

High

1240432

DJB11
DnaJ homolog subfamily B member 11

1

8

High-throughput

0.618

High

281023

KRT38
Keratin, type I cuticular Ha8

2

4

High-throughput

0.613

High

1240412

JMJD8
JmjC domain-containing protein 8

2

3

High-throughput

0.611

High

1016975

FBLN3
EGF-containing fibulin-like extracellular matrix protein 1

2

13

Small-scale

0.586

High

502329

BIP
Endoplasmic reticulum chaperone BiP

2

17

High-throughput

0.584

High

1240407

CALR3
Calreticulin-3

2

20

High-throughput

0.584

High

1189359

NT2NA
Notch homolog 2 N-terminal-like protein A

2

4

High-throughput

0.576

High

1240419

EDEM3
ER degradation-enhancing alpha-mannosidase-like protein 3

1

9

Small-scale

0.561

High

506829

SPTB1
Spectrin beta chain, erythrocytic

2

1

High-throughput

0.558

High

1121480

KLH26
Kelch-like protein 26

2

2

High-throughput

0.558

High

1162285

WDR59
GATOR2 complex protein WDR59

2

14

High-throughput

0.558

High

1217325

VRK3
Serine/threonine-protein kinase VRK3

2

3

High-throughput

0.558

High

1240434

UBQL2
Ubiquilin-2

2

3

High-throughput

0.553

High

1240408

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

20

High-throughput

0.553

High

734977

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

7

High-throughput

0.536

High

983875

KPCZ
Protein kinase C zeta type

1

5

High-throughput

0.536

High

1240400

HDAC2
Histone deacetylase 2

1

6

High-throughput

0.536

High

1240435

DS13B
Dual specificity protein phosphatase 13B

2

8

High-throughput

0.533

High

1240439

GMPPB
Mannose-1-phosphate guanyltransferase beta

2

1

High-throughput

0.526

High

992484

SOS1
Son of sevenless homolog 1

2

4

High-throughput

0.521

High

648829

DPP4
Dipeptidyl peptidase 4

1

6

High-throughput

0.515

High

487594

ANDR
Androgen receptor

1

10

Small-scale

0.512

High

395223

A4
Amyloid-beta precursor protein

1

5

High-throughput

0.501

High

175974

FOXN1
Forkhead box protein N1

1

1

High-throughput

0.489

High

902965

DCAF7
DDB1- and CUL4-associated factor 7

1

14

High-throughput

0.489

High

986946

SUH
Recombining binding protein suppressor of hairless

1

1

High-throughput

0.489

High

1077850

MYLK
Myosin light chain kinase, smooth muscle

1

7

High-throughput

0.489

High

1176129

MTSS2
Protein MTSS 2

1

3

High-throughput

0.489

High

1206119

MYLK4
Myosin light chain kinase family member 4

1

9

High-throughput

0.489

High

1240403

HDA10
Polyamine deacetylase HDAC10

1

10

High-throughput

0.489

High

1240418

KPCD2
Serine/threonine-protein kinase D2

1

2

High-throughput

0.489

High

1240425

MKNK2
MAP kinase-interacting serine/threonine-protein kinase 2

1

2

High-throughput

0.489

High

1240426

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

3

High-throughput

0.489

High

208167

SPY2
Protein sprouty homolog 2

1

1

High-throughput

0.481

High

1240402

LHX4
LIM/homeobox protein Lhx4

1

1

High-throughput

0.481

High

160663

AURKA
Aurora kinase A

1

3

High-throughput

0.479

High

205688

TGON2
Trans-Golgi network integral membrane protein 2

1

10

High-throughput

0.479

High

216275

CALU
Calumenin

1

12

High-throughput

0.479

High

228073

PRKN
E3 ubiquitin-protein ligase parkin

1

8

High-throughput

0.479

High

329840

AGR2
Anterior gradient protein 2 homolog

1

4

High-throughput

0.479

High

338707

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.479

High

344212

A1AT
Alpha-1-antitrypsin

1

3

Small-scale

0.479

High

347350

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.479

High

352187

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

2

High-throughput

0.479

High

374547

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

11

High-throughput

0.479

High

385177

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.479

High

411442

INSR
Insulin receptor

1

20

High-throughput

0.479

High

504411

HSP7C
Heat shock cognate 71 kDa protein

1

3

High-throughput

0.479

High

570556

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

16

High-throughput

0.479

High

577042

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

1

13

High-throughput

0.479

High

578339

PGAM1
Phosphoglycerate mutase 1

1

5

High-throughput

0.479

High

674480

UFO
Tyrosine-protein kinase receptor UFO

1

20

High-throughput

0.479

High

714312

HSP74
Heat shock 70 kDa protein 4

1

6

Small-scale

0.479

High

813613

CAPZB
F-actin-capping protein subunit beta

1

2

High-throughput

0.479

High

821875

HSP13
Heat shock 70 kDa protein 13

1

10

High-throughput

0.479

High

875118

TERA
Transitional endoplasmic reticulum ATPase

1

5

High-throughput

0.479

High

890268

SC61B
Protein transport protein Sec61 subunit beta

1

8

High-throughput

0.479

High

1035895

BIRC3
Baculoviral IAP repeat-containing protein 3

1

6

High-throughput

0.479

High

1042060

CUL3
Cullin-3

1

14

High-throughput

0.479

High

1128917

EPHAA
Ephrin type-A receptor 10

1

20

High-throughput

0.479

High

1220944

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

5

High-throughput

0.479

High

1240401

TP4A1
Protein tyrosine phosphatase type IVA 1

1

9

High-throughput

0.479

High

1240404

LRC59
Leucine-rich repeat-containing protein 59

1

8

High-throughput

0.479

High

1240414

SEC62
Translocation protein SEC62

1

4

High-throughput

0.479

High

1240430

VAPA
Vesicle-associated membrane protein-associated protein A

1

7

High-throughput

0.479

High

258856

Z780A
Zinc finger protein 780A

1

8

High-throughput

0.470

High

1138193

BRE1A
E3 ubiquitin-protein ligase BRE1A

1

5

High-throughput

0.470

High

1240413

NODAL
Nodal homolog

1

2

High-throughput

0.470

High

233546

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

262512

TULP3
Tubby-related protein 3

1

0

High-throughput

0.458

High

596074

IMDH1
Inosine-5'-monophosphate dehydrogenase 1

1

0

High-throughput

0.458

High

714867

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

0

High-throughput

0.458

High

916270

RL23A
Large ribosomal subunit protein uL23

1

0

High-throughput

0.458

High

1240409

RN157
E3 ubiquitin ligase RNF157

1

0

Small-scale

0.458

High

175045

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

14

High-throughput

0.457

High

1240397

PJA1
E3 ubiquitin-protein ligase Praja-1

1

1

Small-scale

0.457

High

358537

CO1A1
Collagen alpha-1(I) chain

1

8

Small-scale

0.445

High

497310

TAU
Microtubule-associated protein tau

1

5

High-throughput

0.445

High

555549

H2AX
Histone H2AX

1

3

High-throughput

0.445

High

1130334

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

11

High-throughput

0.445

High

734695

TRI23
E3 ubiquitin-protein ligase TRIM23

1

2

High-throughput

0.439

High

888933

KR103
Keratin-associated protein 10-3

1

20

High-throughput

0.439

High

889335

KR107
Keratin-associated protein 10-7

1

20

High-throughput

0.439

High

889583

KR108
Keratin-associated protein 10-8

1

20

High-throughput

0.439

High

889836

KR109
Keratin-associated protein 10-9

1

20

High-throughput

0.439

High

1076470

TRIP6
Thyroid receptor-interacting protein 6

1

2

High-throughput

0.439

High

1149233

K1C40
Keratin, type I cytoskeletal 40

1

4

High-throughput

0.439

High

1219883

TRI42
Tripartite motif-containing protein 42

1

20

High-throughput

0.439

High

1240410

FACC1
Flagellum-associated coiled-coil domain-containing protein 1

1

1

High-throughput

0.439

High

1240416

KR412
Keratin-associated protein 4-12

1

20

High-throughput

0.439

High

1240417

KRA42
Keratin-associated protein 4-2

1

20

High-throughput

0.439

High

1240422

GO45
Golgin-45

1

1

High-throughput

0.439

High

100963

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

214321

SPOP
Speckle-type POZ protein

1

2

High-throughput

0.437

High

225653

PCDH7
Protocadherin-7

1

3

High-throughput

0.437

High

255928

OBSL1
Obscurin-like protein 1

1

7

High-throughput

0.437

High

268179

EED
Polycomb protein EED

1

12

High-throughput

0.437

High

274584

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

1

High-throughput

0.437

High

295025

RECQ4
ATP-dependent DNA helicase Q4

1

5

High-throughput

0.437

High

303361

HEXI1
Protein HEXIM1

1

4

High-throughput

0.437

High

377498

GCR
Glucocorticoid receptor

1

10

High-throughput

0.437

High

525994

IFM1
Interferon-induced transmembrane protein 1

1

2

High-throughput

0.437

High

529425

CFTR
Cystic fibrosis transmembrane conductance regulator

1

5

High-throughput

0.437

High

537760

INSRR
Insulin receptor-related protein

1

20

High-throughput

0.437

High

569878

CEBPB
CCAAT/enhancer-binding protein beta

1

11

High-throughput

0.437

High

684887

STIP1
Stress-induced-phosphoprotein 1

1

12

High-throughput

0.437

High

713843

RYK
Tyrosine-protein kinase RYK

1

20

High-throughput

0.437

High

873142

PTN5
Tyrosine-protein phosphatase non-receptor type 5

1

15

High-throughput

0.437

High

896147

UBC12
NEDD8-conjugating enzyme Ubc12

1

4

High-throughput

0.437

High

903370

WDR5
WD repeat-containing protein 5

1

10

High-throughput

0.437

High

908833

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

5

High-throughput

0.437

High

941174

RNF4
E3 ubiquitin-protein ligase RNF4

1

10

High-throughput

0.437

High

969860

KIF23
Kinesin-like protein KIF23

1

8

High-throughput

0.437

High

981894

RON
Macrophage-stimulating protein receptor

1

20

High-throughput

0.437

High

1045339

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

2

High-throughput

0.437

High

1061503

CUL7
Cullin-7

1

4

High-throughput

0.437

High

1064496

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

4

High-throughput

0.437

High

1080123

EZH2
Histone-lysine N-methyltransferase EZH2

1

6

High-throughput

0.437

High

1088210

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

1

18

High-throughput

0.437

High

1101937

TECT1
Tectonic-1

1

15

High-throughput

0.437

High

1103001

SMU1
WD40 repeat-containing protein SMU1

1

11

High-throughput

0.437

High

1156637

TECT3
Tectonic-3

1

15

High-throughput

0.437

High

1159195

PRP8
Pre-mRNA-processing-splicing factor 8

1

2

High-throughput

0.437

High

1168587

SYNE3
Nesprin-3

1

8

High-throughput

0.437

High

1170850

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.437

High

1229925

TAGAP
T-cell activation Rho GTPase-activating protein

1

4

High-throughput

0.437

High

1240396

NUP35
Nucleoporin NUP35

1

1

High-throughput

0.437

High

1240398

COP1
E3 ubiquitin-protein ligase COP1

1

16

High-throughput

0.437

High

1240399

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

6

High-throughput

0.437

High

1240405

MTMR8
Myotubularin-related protein 8

1

3

High-throughput

0.437

High

1240406

DCNL1
DCN1-like protein 1

1

1

High-throughput

0.437

High

1240415

ANM1
Protein arginine N-methyltransferase 1

1

3

High-throughput

0.437

High

1240421

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

3

High-throughput

0.437

High

1240423

Q9H4D1
Protein kinase

1

5

High-throughput

0.437

High

1240424

PKHA4
Pleckstrin homology domain-containing family A member 4

1

9

High-throughput

0.437

High

1240427

T106B
Transmembrane protein 106B

1

7

High-throughput

0.437

High

1240428

PIHD1
PIH1 domain-containing protein 1

1

3

High-throughput

0.437

High

1240433

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.437

High

1240436

CLC4E
C-type lectin domain family 4 member E

1

3

High-throughput

0.437

High

1240437

FBW1A
F-box/WD repeat-containing protein 1A

1

11

High-throughput

0.437

High

1240438

AAR2
Protein AAR2 homolog

1

4

High-throughput

0.437

High

1022550

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

0

High-throughput

0.426

High

402253

JUN
Transcription factor Jun

1

13

High-throughput

0.407

High

547829

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

8

High-throughput

0.407

High

882436

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

7

High-throughput

0.407

High

883565

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

6

High-throughput

0.407

High

831497

CEBPA
CCAAT/enhancer-binding protein alpha

1

11

High-throughput

0.373

High

1113750

MGT5B
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

1

0

High-throughput

0.251

Low

1240411

RAB3I
Rab-3A-interacting protein

1

0

High-throughput

0.251

Low

182829

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.249

Low

1076262

TRIP4
Activating signal cointegrator 1

1

0

High-throughput

0.249

Low

1138840

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.249

Low

1240420

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024