Protein: MADD
MAP kinase-activating death domain protein (Differentially expressed in normal and neoplastic cells) (Insulinoma glucagonoma clone 20) (Rab3 GDP/GTP exchange factor) (RabGEF) (Rab3 GDP/GTP exchange protein) (Rab3GEP)

Gene: MADD
Organism: Homo sapiens
Interactions: 78
UniProt ID: Q8WXG6

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005123 - death receptor binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1134920

SYT6
Synaptotagmin-6

3

4

High-throughput

0.667

High

1217015

SYT12
Synaptotagmin-12

2

4

High-throughput

0.628

High

1263668

SYT3
Synaptotagmin-3

2

4

High-throughput

0.628

High

297653

RHBT1
Rho-related BTB domain-containing protein 1

1

11

High-throughput

0.618

High

591645

RAB3B
Ras-related protein Rab-3B

1

4

High-throughput

0.618

High

845114

RAB7A
Ras-related protein Rab-7a

1

9

High-throughput

0.618

High

1263663

MTMR8
Myotubularin-related protein 8

2

9

High-throughput

0.611

High

456355

LOX5
Polyunsaturated fatty acid 5-lipoxygenase

2

0

High-throughput

0.602

High

1219948

BBS7
Bardet-Biedl syndrome 7 protein

2

0

High-throughput

0.602

High

1263672

DOCK5
Dedicator of cytokinesis protein 5

2

0

High-throughput

0.602

High

927349

1433Z
14-3-3 protein zeta/delta

2

20

High-throughput

0.586

High

1263671

Q9H4D1
Protein kinase

2

3

High-throughput

0.584

High

1263662

SNX21
Sorting nexin-21

2

1

High-throughput

0.574

High

1088217

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

1

6

Small-scale

0.573

High

317312

PCNT
Pericentrin

1

1

High-throughput

0.541

High

1255630

RBCC1
RB1-inducible coiled-coil protein 1

1

2

High-throughput

0.541

High

181881

SOCS1
Suppressor of cytokine signaling 1

1

5

High-throughput

0.536

High

622816

COT2
COUP transcription factor 2

1

3

High-throughput

0.536

High

669190

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

14

High-throughput

0.536

High

734984

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

1

High-throughput

0.536

High

795555

AL3B1
Aldehyde dehydrogenase family 3 member B1

1

1

High-throughput

0.536

High

817716

PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

1

5

High-throughput

0.536

High

933546

TBA4A
Tubulin alpha-4A chain

1

1

High-throughput

0.536

High

933913

TBB4B
Tubulin beta-4B chain

1

3

High-throughput

0.536

High

942428

PI42B
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

1

5

High-throughput

0.536

High

1037325

TBB3
Tubulin beta-3 chain

1

3

High-throughput

0.536

High

1046526

TBB2A
Tubulin beta-2A chain

1

3

High-throughput

0.536

High

1114173

TBB8
Tubulin beta-8 chain

1

3

High-throughput

0.536

High

1197916

SYT9
Synaptotagmin-9

1

4

High-throughput

0.536

High

1238327

SYT2
Synaptotagmin-2

1

4

High-throughput

0.536

High

1253103

PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

1

5

High-throughput

0.536

High

1263666

MTMR9
Myotubularin-related protein 9

1

9

High-throughput

0.536

High

1263673

ECT2
Protein ECT2

1

1

High-throughput

0.536

High

1263676

MTMR4
Myotubularin-related protein 4

1

9

High-throughput

0.536

High

616926

PTPRB
Receptor-type tyrosine-protein phosphatase beta

1

1

High-throughput

0.515

High

1244613

NUP37
Nucleoporin Nup37

1

2

High-throughput

0.515

High

441628

TRFM
Melanotransferrin

1

0

High-throughput

0.513

High

1218610

FXRD2
FAD-dependent oxidoreductase domain-containing protein 2

1

0

High-throughput

0.513

High

1224560

CDK20
Cyclin-dependent kinase 20

1

0

High-throughput

0.513

High

1252987

F174A
Membrane protein FAM174A

1

0

High-throughput

0.513

High

1263680

NUBP2
Cytosolic Fe-S cluster assembly factor NUBP2

1

0

High-throughput

0.513

High

476117

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

High-throughput

0.501

High

1232939

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

2

High-throughput

0.489

High

1238741

TAC2N
Tandem C2 domains nuclear protein

1

5

High-throughput

0.489

High

1263677

DHDH
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

1

2

High-throughput

0.489

High

584440

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

0

Small-scale

0.480

High

147539

SOCS6
Suppressor of cytokine signaling 6

1

8

High-throughput

0.479

High

163063

XPO1
Exportin-1

1

4

High-throughput

0.479

High

205757

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.479

High

228198

PRKN
E3 ubiquitin-protein ligase parkin

1

3

High-throughput

0.479

High

385246

NTRK1
High affinity nerve growth factor receptor

1

7

High-throughput

0.479

High

714561

GRK5
G protein-coupled receptor kinase 5

1

2

High-throughput

0.479

High

931764

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.479

High

982335

1433F
14-3-3 protein eta

1

20

High-throughput

0.479

High

1171012

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

1263669

CAB45
45 kDa calcium-binding protein

1

7

High-throughput

0.479

High

1263674

PIDD1
p53-induced death domain-containing protein 1

1

2

Small-scale

0.479

High

1263679

TR150
Thyroid hormone receptor-associated protein 3

1

1

High-throughput

0.470

High

533154

HLAE
HLA class I histocompatibility antigen, alpha chain E

1

0

High-throughput

0.458

High

1042159

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1263670

WNK1
Serine/threonine-protein kinase WNK1

1

2

High-throughput

0.457

High

883584

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

3

High-throughput

0.445

High

1263667

Q96T11
cDNA FLJ14518 fis, clone NT2RM1000850, weakly similar to ANKYRIN R

1

3

High-throughput

0.445

High

1263678

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.445

High

101009

APRIO
Alternative prion protein

1

3

High-throughput

0.437

High

1263661

ESR2
Estrogen receptor beta

1

6

High-throughput

0.437

High

305226

NXPH2
Neurexophilin-2

3

0

High-throughput

0.347

High

1263665

ANM6
Protein arginine N-methyltransferase 6

2

0

High-throughput

0.318

High

1263675

POTE1
Protection of telomeres protein 1

1

0

High-throughput

0.296

High

882954

RBM11
Splicing regulator RBM11

1

0

High-throughput

0.282

High

319610

LY86
Lymphocyte antigen 86

1

0

High-throughput

0.279

Low

894883

SPCS3
Signal peptidase complex subunit 3

1

0

High-throughput

0.279

Low

1237370

TSYL6
Testis-specific Y-encoded-like protein 6

1

0

High-throughput

0.279

Low

1254617

HUMMR
Protein MGARP

1

0

High-throughput

0.279

Low

1261281

RN138
E3 ubiquitin-protein ligase RNF138

1

0

High-throughput

0.279

Low

1263664

ZN625
Zinc finger protein 625

1

0

High-throughput

0.269

Low

1136976

VP13D
Intermembrane lipid transfer protein VPS13D

1

0

Small-scale

0.265

Low

1054467

RBM39
RNA-binding protein 39

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024