Protein: SCAP
Sterol regulatory element-binding protein cleavage-activating protein (SCAP) (SREBP cleavage-activating protein)

Gene: SCAP
Organism: Homo sapiens
Interactions: 114
UniProt ID: Q12770

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001666 - response to hypoxia
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005794 - Golgi apparatus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

181098

INSI1
Insulin-induced gene 1 protein

11

3

Small-scale

0.972

High

1016052

INSI2
Insulin-induced gene 2 protein

4

3

Small-scale

0.867

High

1016008

LPAR1
Lysophosphatidic acid receptor 1

3

6

High-throughput

0.770

High

1015983

CDKAL
Threonylcarbamoyladenosine tRNA methylthiotransferase

1

1

High-throughput

0.691

High

1016031

SEC12
Guanine nucleotide-exchange factor SEC12

1

18

High-throughput

0.691

High

1016033

AAAS
Aladin

1

16

High-throughput

0.691

High

1016047

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

2

High-throughput

0.691

High

1016050

TBL2
Transducin beta-like protein 2

1

18

High-throughput

0.691

High

738961

SRBP1
Sterol regulatory element-binding protein 1

4

17

Small-scale

0.686

High

1015971

SRBP2
Sterol regulatory element-binding protein 2

3

16

Small-scale

0.656

High

1016006

ZNRF4
E3 ubiquitin-protein ligase ZNRF4

2

12

High-throughput

0.628

High

1015974

MTR1L
Melatonin-related receptor

1

1

High-throughput

0.618

High

1016005

BT2A2
Butyrophilin subfamily 2 member A2

1

12

High-throughput

0.618

High

1016017

GPR21
Probable G-protein coupled receptor 21

1

4

High-throughput

0.618

High

1016030

LPAR2
Lysophosphatidic acid receptor 2

1

6

High-throughput

0.618

High

1016038

TYW1
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1

1

2

High-throughput

0.618

High

603052

OSBP1
Oxysterol-binding protein 1

1

1

Small-scale

0.618

High

1016049

TRRAP
Transformation/transcription domain-associated protein

1

7

High-throughput

0.618

High

206476

B4GA1
Beta-1,4-glucuronyltransferase 1

2

0

High-throughput

0.602

High

299884

ERLN2
Erlin-2

2

6

Small-scale

0.584

High

1016044

AT1B4
Protein ATP1B4

2

4

High-throughput

0.558

High

1015986

BTNL8
Butyrophilin-like protein 8

1

12

High-throughput

0.553

High

1015988

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.553

High

1016023

TRIM9
E3 ubiquitin-protein ligase TRIM9

1

19

Small-scale

0.553

High

1016025

PKHA4
Pleckstrin homology domain-containing family A member 4

1

14

High-throughput

0.553

High

152372

ABCD4
Lysosomal cobalamin transporter ABCD4

1

8

High-throughput

0.536

High

373114

HMDH
3-hydroxy-3-methylglutaryl-coenzyme A reductase

1

4

High-throughput

0.536

High

570835

ACHB2
Neuronal acetylcholine receptor subunit beta-2

1

3

High-throughput

0.536

High

654288

CALX
Calnexin

1

7

High-throughput

0.536

High

825400

LMAN1
Protein ERGIC-53

1

2

High-throughput

0.536

High

850313

CLCN3
H(+)/Cl(-) exchange transporter 3

1

1

High-throughput

0.536

High

854230

DGKE
Diacylglycerol kinase epsilon

1

3

High-throughput

0.536

High

871543

HSP72
Heat shock-related 70 kDa protein 2

1

10

High-throughput

0.536

High

976782

TAP2
Antigen peptide transporter 2

1

5

High-throughput

0.536

High

1015972

PDE3B
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

1

5

High-throughput

0.536

High

1015977

NOMO1
BOS complex subunit NOMO1

1

1

High-throughput

0.536

High

1015978

CP51A
Lanosterol 14-alpha demethylase

1

3

High-throughput

0.536

High

1015980

TTMP
TPA-induced transmembrane protein

1

1

High-throughput

0.536

High

1015981

S27A3
Long-chain fatty acid transport protein 3

1

5

High-throughput

0.536

High

1015984

RETST
All-trans-retinol 13,14-reductase

1

4

High-throughput

0.536

High

1015987

TMPPE
Transmembrane protein with metallophosphoesterase domain

1

1

High-throughput

0.536

High

1015989

LRP10
Low-density lipoprotein receptor-related protein 10

1

3

High-throughput

0.536

High

1015992

VRK2
Serine/threonine-protein kinase VRK2

1

16

High-throughput

0.536

High

1015993

ZDH13
Palmitoyltransferase ZDHHC13

1

5

High-throughput

0.536

High

1015994

ZDH17
Palmitoyltransferase ZDHHC17

1

15

High-throughput

0.536

High

1015995

GHDC
GH3 domain-containing protein

1

1

High-throughput

0.536

High

1016002

ST7L
Suppressor of tumorigenicity 7 protein-like

1

2

High-throughput

0.536

High

1016009

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

9

High-throughput

0.536

High

1016010

SARAF
Store-operated calcium entry-associated regulatory factor

1

1

High-throughput

0.536

High

1016012

ZDH12
Palmitoyltransferase ZDHHC12

1

4

High-throughput

0.536

High

1016013

P121A
Nuclear envelope pore membrane protein POM 121

1

13

High-throughput

0.536

High

1016015

CP2S1
Cytochrome P450 2S1

1

2

High-throughput

0.536

High

1016019

GDF15
Growth/differentiation factor 15

1

7

High-throughput

0.536

High

1016021

CA043
Protein C1orf43

1

1

High-throughput

0.536

High

1016026

PCX3
Pecanex-like protein 3

1

12

High-throughput

0.536

High

1016029

ZDH11
Palmitoyltransferase ZDHHC11

1

4

High-throughput

0.536

High

1016032

ST7
Suppressor of tumorigenicity 7 protein

1

2

High-throughput

0.536

High

1016039

ZDHC3
Palmitoyltransferase ZDHHC3

1

2

High-throughput

0.536

High

1016042

FBX2
F-box only protein 2

1

3

High-throughput

0.536

High

1016043

TSN16
Tetraspanin-16

1

3

High-throughput

0.536

High

1016048

DHRS7
Dehydrogenase/reductase SDR family member 7

1

3

High-throughput

0.536

High

1016051

PCDB3
Protocadherin beta-3

1

4

High-throughput

0.536

High

1015990

GLTL5
Inactive polypeptide N-acetylgalactosaminyltransferase-like protein 5

1

7

High-throughput

0.515

High

69475

UPK3L
Uroplakin-3b-like protein 1

1

0

High-throughput

0.513

High

146968

C2C2L
Phospholipid transfer protein C2CD2L

1

0

High-throughput

0.513

High

174204

SPTC2
Serine palmitoyltransferase 2

1

0

High-throughput

0.513

High

207199

SGCE
Epsilon-sarcoglycan

1

0

High-throughput

0.513

High

245492

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.513

High

303903

YIF1A
Protein YIF1A

1

0

High-throughput

0.513

High

741143

PIGA
Phosphatidylinositol N-acetylglucosaminyltransferase subunit A

1

0

High-throughput

0.513

High

1015997

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

0

High-throughput

0.513

High

1016000

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.513

High

1016011

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

1

0

High-throughput

0.513

High

1016016

CGRF1
Cell growth regulator with RING finger domain protein 1

1

0

High-throughput

0.513

High

1016020

NDC1
Nucleoporin NDC1

1

0

High-throughput

0.513

High

1016022

TMM59
Transmembrane protein 59

1

0

High-throughput

0.513

High

1016024

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.513

High

1016037

TM39A
Transmembrane protein 39A

1

0

High-throughput

0.513

High

315692

SC24B
Protein transport protein Sec24B

1

3

Small-scale

0.501

High

326061

TSN15
Tetraspanin-15

1

2

High-throughput

0.489

High

540288

GPIX
Platelet glycoprotein IX

1

5

High-throughput

0.489

High

802321

5HT3A
5-hydroxytryptamine receptor 3A

1

4

High-throughput

0.489

High

885340

INHBE
Inhibin beta E chain

1

4

High-throughput

0.489

High

1015976

FZD2
Frizzled-2

1

4

High-throughput

0.489

High

1016004

THEM6
Protein THEM6

1

1

High-throughput

0.489

High

1016007

BRI3B
BRI3-binding protein

1

1

High-throughput

0.489

High

1016014

DJC30
DnaJ homolog subfamily C member 30, mitochondrial

1

12

High-throughput

0.489

High

1016035

DDX28
Probable ATP-dependent RNA helicase DDX28

1

14

High-throughput

0.489

High

1016040

GPC5D
G-protein coupled receptor family C group 5 member D

1

2

High-throughput

0.489

High

205332

TGON2
Trans-Golgi network integral membrane protein 2

1

6

High-throughput

0.479

High

488201

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

7

High-throughput

0.479

High

844896

RAB7A
Ras-related protein Rab-7a

1

11

High-throughput

0.479

High

1015973

SQSTM
Sequestosome-1

1

4

Small-scale

0.479

High

1015979

NADL2
Inactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2

1

1

High-throughput

0.479

High

1015985

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

1016003

RN139
E3 ubiquitin-protein ligase RNF139

1

12

Small-scale

0.479

High

1016018

RNF5
E3 ubiquitin-protein ligase RNF5

1

6

Small-scale

0.479

High

1016027

SPRNG
SREBP regulating gene protein

1

1

Small-scale

0.479

High

1016034

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

1

Small-scale

0.479

High

1016041

VAPA
Vesicle-associated membrane protein-associated protein A

1

2

Small-scale

0.479

High

1016046

NUDC
Nuclear migration protein nudC

1

10

High-throughput

0.479

High

1015999

GOLM1
Golgi membrane protein 1

1

0

Small-scale

0.458

High

581699

VCAM1
Vascular cell adhesion protein 1

1

5

High-throughput

0.445

High

616626

GLRA2
Glycine receptor subunit alpha-2

1

1

High-throughput

0.437

High

983967

ZBT16
Zinc finger and BTB domain-containing protein 16

1

1

Small-scale

0.437

High

1015975

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

17

High-throughput

0.407

High

1015996

RYBP
RING1 and YY1-binding protein

1

2

High-throughput

0.407

High

1016001

MCLN3
Mucolipin-3

3

0

High-throughput

0.347

High

1016028

IPPK
Inositol-pentakisphosphate 2-kinase

2

0

High-throughput

0.328

High

1015982

TM201
Transmembrane protein 201

1

0

High-throughput

0.279

Low

1015991

LSR
Lipolysis-stimulated lipoprotein receptor

1

0

High-throughput

0.279

Low

1015998

MYCT1
Myc target protein 1

1

0

High-throughput

0.279

Low

1016045

TNF18
Tumor necrosis factor ligand superfamily member 18

1

0

High-throughput

0.279

Low

1016036

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024