Protein: MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCase subunit beta) (EC 6.4.1.4) (3-methylcrotonyl-CoA carboxylase 2) (3-methylcrotonyl-CoA carboxylase non-biotin-containing subunit) (3-methylcrotonyl-CoA:carbon dioxide ligase subunit beta)

Gene: MCCB, MCCC2
Organism: Homo sapiens
Interactions: 132
UniProt ID: Q9HCC0

Gene Ontology (top 5):
GO:0002169 - 3-methylcrotonyl-CoA carboxylase complex, mitochondrial
GO:0004485 - methylcrotonoyl-CoA carboxylase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1301283

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

3

18

High-throughput

0.847

High

1022605

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

4

1

High-throughput

0.694

High

228760

PRKN
E3 ubiquitin-protein ligase parkin

3

8

High-throughput

0.640

High

398298

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

18

High-throughput

0.618

High

398405

PCCB
Propionyl-CoA carboxylase beta chain, mitochondrial

1

16

High-throughput

0.618

High

513632

PYC
Pyruvate carboxylase, mitochondrial

1

18

High-throughput

0.618

High

1024098

ACACA
Acetyl-CoA carboxylase 1

1

18

High-throughput

0.618

High

1335922

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

15

High-throughput

0.618

High

529745

CFTR
Cystic fibrosis transmembrane conductance regulator

2

2

High-throughput

0.614

High

1042583

CUL3
Cullin-3

2

1

High-throughput

0.611

High

387551

P53
Cellular tumor antigen p53

2

2

Small-scale

0.584

High

1291586

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.547

High

176500

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

1

2

High-throughput

0.536

High

258802

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

1

1

High-throughput

0.536

High

270946

KBL
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial

1

1

High-throughput

0.536

High

456296

IFIT1
Interferon-induced protein with tetratricopeptide repeats 1

1

4

High-throughput

0.536

High

787975

EPS15
Epidermal growth factor receptor substrate 15

1

1

High-throughput

0.536

High

1051100

ICT1
Large ribosomal subunit protein mL62

1

1

High-throughput

0.536

High

1160896

FXL19
F-box/LRR-repeat protein 19

1

1

High-throughput

0.536

High

1335931

NPS3A
Protein NipSnap homolog 3A

1

1

High-throughput

0.536

High

347944

MYC
Myc proto-oncogene protein

2

3

High-throughput

0.533

High

780136

CCNF
Cyclin-F

1

3

High-throughput

0.515

High

1309235

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

0

High-throughput

0.513

High

1080903

HSPB2
Heat shock protein beta-2

1

2

High-throughput

0.508

High

175221

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

2

High-throughput

0.501

High

1237158

PAF1
RNA polymerase II-associated factor 1 homolog

1

2

High-throughput

0.489

High

1257135

UBS3B
Ubiquitin-associated and SH3 domain-containing protein B

1

1

High-throughput

0.489

High

1285074

ARRD3
Arrestin domain-containing protein 3

1

5

High-throughput

0.489

High

1288033

HDA11
Histone deacetylase 11

1

7

High-throughput

0.489

High

1289893

RT24
Small ribosomal subunit protein uS3m

1

1

High-throughput

0.489

High

958773

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

3

High-throughput

0.484

High

125723

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

5

Small-scale

0.479

High

151205

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

1

High-throughput

0.479

High

166012

PER2
Period circadian protein homolog 2

1

3

Small-scale

0.479

High

265045

MPPB
Mitochondrial-processing peptidase subunit beta

1

2

High-throughput

0.479

High

268292

EED
Polycomb protein EED

1

18

High-throughput

0.479

High

295275

RECQ4
ATP-dependent DNA helicase Q4

1

2

High-throughput

0.479

High

385550

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.479

High

388741

HSPB1
Heat shock protein beta-1

1

2

Small-scale

0.479

High

504790

HSP7C
Heat shock cognate 71 kDa protein

1

1

High-throughput

0.479

High

549925

PHKG2
Phosphorylase b kinase gamma catalytic chain, liver/testis isoform

1

2

High-throughput

0.479

High

572456

LEG3
Galectin-3

1

2

Small-scale

0.479

High

611507

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

4

Small-scale

0.479

High

793033

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

16

High-throughput

0.479

High

808946

YAP1
Transcriptional coactivator YAP1

1

6

High-throughput

0.479

High

890849

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

4

Small-scale

0.479

High

909148

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

921436

RBX1
E3 ubiquitin-protein ligase RBX1

1

3

High-throughput

0.479

High

967978

PO5F1
POU domain, class 5, transcription factor 1

1

1

High-throughput

0.479

High

999108

EP300
Histone acetyltransferase p300

1

3

High-throughput

0.479

High

1014511

MPPA
Mitochondrial-processing peptidase subunit alpha

1

2

High-throughput

0.479

High

1038728

HDAC1
Histone deacetylase 1

1

5

High-throughput

0.479

High

1101304

CL16A
Protein CLEC16A

1

2

High-throughput

0.479

High

1116557

LARP7
La-related protein 7

1

1

High-throughput

0.479

High

1192223

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

5

High-throughput

0.479

High

1234384

WDTC1
WD and tetratricopeptide repeats protein 1

1

20

High-throughput

0.479

High

1244507

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.479

High

1263218

NALP7
NACHT, LRR and PYD domains-containing protein 7

1

1

High-throughput

0.479

High

1269668

ESR2
Estrogen receptor beta

1

4

High-throughput

0.479

High

1282431

FBXW5
F-box/WD repeat-containing protein 5

1

2

High-throughput

0.479

High

1291705

BICD1
Protein bicaudal D homolog 1

1

2

High-throughput

0.479

High

1302764

RUFY1
RUN and FYVE domain-containing protein 1

1

2

High-throughput

0.479

High

1313651

KTNB1
Katanin p80 WD40 repeat-containing subunit B1

1

15

High-throughput

0.479

High

1326746

WWTR1
WW domain-containing transcription regulator protein 1

1

5

High-throughput

0.479

High

1332634

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.479

High

1335927

WSB2
WD repeat and SOCS box-containing protein 2

1

18

High-throughput

0.479

High

1335929

WWOX
WW domain-containing oxidoreductase

1

1

High-throughput

0.479

High

1335932

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

1335935

FBW1A
F-box/WD repeat-containing protein 1A

1

17

High-throughput

0.479

High

329953

AGR2
Anterior gradient protein 2 homolog

1

2

High-throughput

0.470

High

374910

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

440745

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.458

High

719161

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

736063

ATPG
ATP synthase subunit gamma, mitochondrial

1

0

High-throughput

0.458

High

880472

ATP5E
ATP synthase subunit epsilon, mitochondrial

1

0

High-throughput

0.458

High

990323

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1036101

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1193184

SLN11
Schlafen family member 11

1

0

Small-scale

0.458

High

1327576

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

1335928

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

497617

TAU
Microtubule-associated protein tau

1

2

High-throughput

0.445

High

587713

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

3

High-throughput

0.445

High

891328

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

3

High-throughput

0.445

High

1023120

STK4
Serine/threonine-protein kinase 4

1

6

High-throughput

0.445

High

1130614

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

1145939

CP135
Centrosomal protein of 135 kDa

1

1

High-throughput

0.445

High

1199532

TLK2
Serine/threonine-protein kinase tousled-like 2

1

2

High-throughput

0.445

High

1330631

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

3

High-throughput

0.445

High

1335937

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

5

High-throughput

0.445

High

232522

KDM1A
Lysine-specific histone demethylase 1A

1

3

High-throughput

0.437

High

553769

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

652305

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

721498

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

734781

TRI23
E3 ubiquitin-protein ligase TRIM23

1

7

High-throughput

0.437

High

824404

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

3

High-throughput

0.437

High

869748

TERF1
Telomeric repeat-binding factor 1

1

1

High-throughput

0.437

High

903534

WDR5
WD repeat-containing protein 5

1

16

High-throughput

0.437

High

917961

H4
Histone H4

1

2

High-throughput

0.437

High

946665

SSBP2
Single-stranded DNA-binding protein 2

1

1

Small-scale

0.437

High

1062674

EMC2
ER membrane protein complex subunit 2

1

1

High-throughput

0.437

High

1075001

TERF2
Telomeric repeat-binding factor 2

1

1

High-throughput

0.437

High

1103024

SMU1
WD40 repeat-containing protein SMU1

1

20

High-throughput

0.437

High

1129910

DCA10
DDB1- and CUL4-associated factor 10

1

20

High-throughput

0.437

High

1146186

DCA15
DDB1- and CUL4-associated factor 15

1

2

High-throughput

0.437

High

1171795

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.437

High

1185095

DET1
DET1 homolog

1

3

High-throughput

0.437

High

1260916

DCAF4
DDB1- and CUL4-associated factor 4

1

3

High-throughput

0.437

High

1285358

PF21A
PHD finger protein 21A

1

3

High-throughput

0.437

High

1327108

SPRTN
DNA-dependent metalloprotease SPRTN

1

2

High-throughput

0.437

High

1331339

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.437

High

1334022

WDR76
WD repeat-containing protein 76

1

20

High-throughput

0.437

High

1334419

NANOG
Homeobox protein NANOG

1

1

High-throughput

0.437

High

1335923

DNJC4
DnaJ homolog subfamily C member 4

1

3

High-throughput

0.437

High

1335924

NLE1
Notchless protein homolog 1

1

11

High-throughput

0.437

High

1335925

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

2

High-throughput

0.437

High

1335926

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.437

High

1335930

VSX1
Visual system homeobox 1

1

2

High-throughput

0.437

High

1335933

HOOK1
Protein Hook homolog 1

1

5

High-throughput

0.437

High

1335934

RCOR1
REST corepressor 1

1

3

High-throughput

0.437

High

1335936

ARL5A
ADP-ribosylation factor-like protein 5A

1

8

High-throughput

0.437

High

1062276

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

0

Small-scale

0.426

High

1288192

CMBL
Carboxymethylenebutenolidase homolog

1

0

High-throughput

0.426

High

328463

RECK
Reversion-inducing cysteine-rich protein with Kazal motifs

2

0

High-throughput

0.328

High

101193

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

196869

CYB5B
Cytochrome b5 type B

1

0

High-throughput

0.249

Low

429131

ADRB2
Beta-2 adrenergic receptor

1

0

High-throughput

0.249

Low

1298858

NP1L5
Nucleosome assembly protein 1-like 5

1

0

High-throughput

0.249

Low

230659

KATIP
Katanin-interacting protein

1

0

High-throughput

0.232

Low

240189

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.232

Low

402495

JUN
Transcription factor Jun

1

0

High-throughput

0.232

Low

1134773

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024