Protein: RNF12
E3 ubiquitin-protein ligase RLIM (EC 2.3.2.27) (LIM domain-interacting RING finger protein) (RING finger LIM domain-binding protein) (R-LIM) (RING finger protein 12) (RING-type E3 ubiquitin transferase RLIM) (Renal carcinoma antigen NY-REN-43)

Gene: RNF12, RLIM
Organism: Homo sapiens
Interactions: 95
UniProt ID: Q9NVW2

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003714 - transcription corepressor activity
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

849459

UB2D1
Ubiquitin-conjugating enzyme E2 D1

5

20

Small-scale

0.924

High

919877

UB2D2
Ubiquitin-conjugating enzyme E2 D2

3

20

Small-scale

0.871

High

1297371

UB2E2
Ubiquitin-conjugating enzyme E2 E2

3

20

Small-scale

0.868

High

1346935

RNF12
E3 ubiquitin-protein ligase RLIM

3

17

Small-scale

0.840

High

851893

UB2E1
Ubiquitin-conjugating enzyme E2 E1

2

20

Small-scale

0.800

High

896385

UBE2K
Ubiquitin-conjugating enzyme E2 K

2

20

Small-scale

0.778

High

476458

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

19

Small-scale

0.768

High

895927

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

20

High-throughput

0.698

High

1346940

UB2D4
Ubiquitin-conjugating enzyme E2 D4

1

20

High-throughput

0.698

High

1199145

LDB1
LIM domain-binding protein 1

3

4

Small-scale

0.631

High

636524

DNJB2
DnaJ homolog subfamily B member 2

2

7

High-throughput

0.628

High

803773

BAG6
Large proline-rich protein BAG6

1

14

Small-scale

0.618

High

1319081

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

20

Small-scale

0.618

High

979364

UBXN1
UBX domain-containing protein 1

2

8

High-throughput

0.611

High

562961

STMN1
Stathmin

2

0

Small-scale

0.607

High

167401

SMAD7
Mothers against decapentaplegic homolog 7

2

8

Small-scale

0.595

High

962993

MDM2
E3 ubiquitin-protein ligase Mdm2

1

4

Small-scale

0.578

High

181647

CFLAR
CASP8 and FADD-like apoptosis regulator

1

3

Small-scale

0.561

High

370550

ESR1
Estrogen receptor

1

13

Small-scale

0.561

High

1334874

SMUF2
E3 ubiquitin-protein ligase SMURF2

1

6

Small-scale

0.561

High

1273561

TF3B
Transcription factor IIIB 90 kDa subunit

1

0

Small-scale

0.554

High

869760

TERF1
Telomeric repeat-binding factor 1

1

0

Small-scale

0.549

High

257526

CREST
Calcium-responsive transactivator

1

2

High-throughput

0.541

High

786502

STAT6
Signal transducer and activator of transcription 6

1

2

High-throughput

0.541

High

910591

RS14
Small ribosomal subunit protein uS11

1

1

High-throughput

0.541

High

1232915

LNX2
Ligand of Numb protein X 2

1

1

High-throughput

0.541

High

210852

LDB2
LIM domain-binding protein 2

1

4

Small-scale

0.536

High

149927

RFXK
DNA-binding protein RFXANK

1

3

High-throughput

0.536

High

277364

ST1C4
Sulfotransferase 1C4

1

1

High-throughput

0.536

High

428467

TBB5
Tubulin beta chain

1

2

High-throughput

0.536

High

609702

KAPCG
cAMP-dependent protein kinase catalytic subunit gamma

1

7

High-throughput

0.536

High

884402

PCBP4
Poly(rC)-binding protein 4

1

4

High-throughput

0.536

High

1224582

CDK20
Cyclin-dependent kinase 20

1

3

High-throughput

0.536

High

1306163

NPAS1
Neuronal PAS domain-containing protein 1

1

2

High-throughput

0.536

High

1327590

TOLIP
Toll-interacting protein

1

1

High-throughput

0.536

High

1328410

CST11
Cystatin-11

1

1

High-throughput

0.536

High

1330184

TXNIP
Thioredoxin-interacting protein

1

6

High-throughput

0.536

High

1332564

ANTR1
Anthrax toxin receptor 1

1

1

High-throughput

0.536

High

1346942

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

1

5

High-throughput

0.536

High

1220824

ASXL1
Polycomb group protein ASXL1

1

0

High-throughput

0.529

High

1065089

SNX17
Sorting nexin-17

1

0

High-throughput

0.518

High

311769

ATG7
Ubiquitin-like modifier-activating enzyme ATG7

1

0

High-throughput

0.513

High

1059461

NAA30
N-alpha-acetyltransferase 30

1

0

High-throughput

0.513

High

1291638

TRM61
tRNA

1

0

High-throughput

0.513

High

1294218

HES6
Transcription cofactor HES-6

1

0

High-throughput

0.513

High

1307476

CITE1
Cbp/p300-interacting transactivator 1

1

0

High-throughput

0.513

High

1318297

NMNA2
Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2

1

0

High-throughput

0.513

High

1318399

UBXN6
UBX domain-containing protein 6

1

0

High-throughput

0.513

High

1326119

COMD5
COMM domain-containing protein 5

1

0

High-throughput

0.513

High

1331190

SENP3
Sentrin-specific protease 3

1

0

High-throughput

0.513

High

1346941

SALL2
Sal-like protein 2

1

0

High-throughput

0.513

High

1346936

LHX3
LIM/homeobox protein Lhx3

1

4

Small-scale

0.501

High

135166

NFIB
Nuclear factor 1 B-type

1

2

High-throughput

0.500

High

443259

NFIC
Nuclear factor 1 C-type

1

2

High-throughput

0.500

High

1018273

NFIA
Nuclear factor 1 A-type

1

2

High-throughput

0.500

High

854142

GDS1
Rap1 GTPase-GDP dissociation stimulator 1

1

0

High-throughput

0.493

High

1318134

REN3B
Regulator of nonsense transcripts 3B

1

0

High-throughput

0.493

High

276278

CIB2
Calcium and integrin-binding family member 2

1

4

High-throughput

0.489

High

341469

FA12
Coagulation factor XII

1

3

High-throughput

0.489

High

968933

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

2

High-throughput

0.489

High

1100159

INF2
Inverted formin-2

1

2

High-throughput

0.489

High

1190158

PK1L2
Polycystin-1-like protein 2

1

2

High-throughput

0.489

High

1300183

CIB3
Calcium and integrin-binding family member 3

1

4

High-throughput

0.489

High

1306419

APBA2
Amyloid-beta A4 precursor protein-binding family A member 2

1

5

High-throughput

0.489

High

1346938

VSIG4
V-set and immunoglobulin domain-containing protein 4

1

2

High-throughput

0.489

High

599738

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

2

High-throughput

0.481

High

1230908

REXO1
RNA exonuclease 1 homolog

1

0

Small-scale

0.480

High

117310

PDLI1
PDZ and LIM domain protein 1

1

3

Small-scale

0.479

High

339043

EGFR
Epidermal growth factor receptor

1

6

High-throughput

0.479

High

348034

MYC
Myc proto-oncogene protein

1

7

Small-scale

0.479

High

611516

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

11

Small-scale

0.479

High

682040

AKT1
RAC-alpha serine/threonine-protein kinase

1

7

Small-scale

0.479

High

1021574

DLG1
Disks large homolog 1

1

1

Small-scale

0.479

High

1042654

CUL3
Cullin-3

1

4

High-throughput

0.479

High

1085698

HIF1A
Hypoxia-inducible factor 1-alpha

1

2

Small-scale

0.479

High

1101334

CL16A
Protein CLEC16A

1

2

High-throughput

0.479

High

1201348

SERC5
Serine incorporator 5

1

1

Small-scale

0.479

High

1216723

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

4

Small-scale

0.479

High

1346937

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1346939

AXIN2
Axin-2

1

4

Small-scale

0.479

High

271798

PRDM1
PR domain zinc finger protein 1

1

0

Small-scale

0.458

High

414382

RB
Retinoblastoma-associated protein

1

0

Small-scale

0.458

High

1024302

ZBT17
Zinc finger and BTB domain-containing protein 17

1

0

Small-scale

0.458

High

1270471

HDAC2
Histone deacetylase 2

1

0

Small-scale

0.458

High

1302456

SIN3A
Paired amphipathic helix protein Sin3a

1

0

Small-scale

0.458

High

1343976

ZC4H2
Zinc finger C4H2 domain-containing protein

1

0

Small-scale

0.458

High

600686

EPHA1
Ephrin type-A receptor 1

1

2

High-throughput

0.437

High

638413

RBTN2
Rhombotin-2

1

3

Small-scale

0.408

High

1169910

PKHG7
Pleckstrin homology domain-containing family G member 7

1

1

High-throughput

0.407

High

272396

MTU1
Mitochondrial tRNA-specific 2-thiouridylase 1

1

0

High-throughput

0.279

Low

1253045

F174A
Membrane protein FAM174A

1

0

High-throughput

0.279

Low

1291445

ASIC4
Acid-sensing ion channel 4

1

0

High-throughput

0.279

Low

101224

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

1001536

ZNFS1
Putative uncharacterized protein ZNF252P-AS1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024