Protein: MSX2
Homeobox protein MSX-2 (Homeobox protein Hox-8)

Gene: MSX2
Organism: Homo sapiens
Interactions: 186
UniProt ID: P35548

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

211800

TLX3
T-cell leukemia homeobox protein 3

2

19

High-throughput

0.783

High

447471

PO2F2
POU domain, class 2, transcription factor 2

2

20

High-throughput

0.783

High

656395

PIT1
Pituitary-specific positive transcription factor 1

2

20

High-throughput

0.783

High

678990

HXC9
Homeobox protein Hox-C9

2

20

High-throughput

0.783

High

724215

PITX1
Pituitary homeobox 1

2

18

High-throughput

0.783

High

724216

PO6F2
POU domain, class 6, transcription factor 2

2

20

High-throughput

0.783

High

724241

ZFHX3
Zinc finger homeobox protein 3

2

12

High-throughput

0.783

High

724273

RHXF2
Rhox homeobox family member 2

2

20

High-throughput

0.783

High

658622

MSX1
Homeobox protein MSX-1

1

20

Small-scale

0.680

High

724279

ZN703
Zinc finger protein 703

3

19

High-throughput

0.667

High

724291

HBS1L
HBS1-like protein

3

2

High-throughput

0.667

High

724174

MSX2
Homeobox protein MSX-2

1

17

Small-scale

0.647

High

724194

DLX5
Homeobox protein DLX-5

1

18

Small-scale

0.647

High

724227

DLX2
Homeobox protein DLX-2

1

17

Small-scale

0.647

High

171291

EPHB6
Ephrin type-B receptor 6

2

3

High-throughput

0.606

High

270768

FOXH1
Forkhead box protein H1

2

20

High-throughput

0.606

High

325511

CLIC3
Chloride intracellular channel protein 3

2

1

High-throughput

0.606

High

620305

GATA2
Endothelial transcription factor GATA-2

2

13

High-throughput

0.606

High

658815

MK01
Mitogen-activated protein kinase 1

2

2

High-throughput

0.606

High

724175

SOX5
Transcription factor SOX-5

2

20

High-throughput

0.606

High

724228

TLE5
TLE family member 5

2

20

High-throughput

0.606

High

724234

VEZF1
Vascular endothelial zinc finger 1

2

3

High-throughput

0.606

High

724247

RBPS2
RNA-binding protein with multiple splicing 2

2

2

High-throughput

0.606

High

724255

SMAP2
Stromal membrane-associated protein 2

2

1

High-throughput

0.606

High

724268

LENG8
Leukocyte receptor cluster member 8

2

7

High-throughput

0.606

High

724280

PATZ1
POZ-, AT hook-, and zinc finger-containing protein 1

2

2

High-throughput

0.606

High

724282

TF7L2
Transcription factor 7-like 2

2

20

High-throughput

0.606

High

724221

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

3

8

High-throughput

0.596

High

724262

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

2

0

High-throughput

0.580

High

724263

ZC3HA
Zinc finger CCCH domain-containing protein 10

2

0

High-throughput

0.580

High

724277

TOLIP
Toll-interacting protein

2

0

High-throughput

0.580

High

724284

PRR13
Proline-rich protein 13

2

0

High-throughput

0.580

High

724288

FBXW2
F-box/WD repeat-containing protein 2

1

7

Small-scale

0.561

High

724245

C102B
Coiled-coil domain-containing protein 102B

2

2

High-throughput

0.553

High

724252

MISSL
MAPK-interacting and spindle-stabilizing protein-like

2

3

High-throughput

0.553

High

724276

YTHD1
YTH domain-containing family protein 1

2

4

High-throughput

0.553

High

377142

GCR
Glucocorticoid receptor

1

14

High-throughput

0.541

High

724176

PPARG
Peroxisome proliferator-activated receptor gamma

1

16

High-throughput

0.541

High

724191

ATX1
Ataxin-1

1

7

High-throughput

0.541

High

724224

TLE1
Transducin-like enhancer protein 1

1

20

High-throughput

0.541

High

724225

TLE2
Transducin-like enhancer protein 2

1

20

High-throughput

0.541

High

278236

PIAS2
E3 SUMO-protein ligase PIAS2

1

4

Small-scale

0.527

High

402718

RPC4
DNA-directed RNA polymerase III subunit RPC4

1

0

High-throughput

0.518

High

724181

HD
Huntingtin

1

3

High-throughput

0.515

High

724248

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

10

High-throughput

0.515

High

724185

CEBPA
CCAAT/enhancer-binding protein alpha

1

8

Small-scale

0.501

High

724287

ZDHC2
Palmitoyltransferase ZDHHC2

1

2

High-throughput

0.494

High

724249

Q86WV8
TSC complex subunit 1

1

0

High-throughput

0.493

High

534073

T2FB
General transcription factor IIF subunit 2

1

0

Small-scale

0.480

High

722564

T2FA
General transcription factor IIF subunit 1

1

0

Small-scale

0.480

High

156239

PSA7
Proteasome subunit alpha type-7

1

2

High-throughput

0.479

High

334147

LDHA
L-lactate dehydrogenase A chain

1

2

High-throughput

0.479

High

369094

ESR1
Estrogen receptor

1

17

High-throughput

0.479

High

375892

ALDOA
Fructose-bisphosphate aldolase A

1

1

High-throughput

0.479

High

421977

LDHB
L-lactate dehydrogenase B chain

1

2

High-throughput

0.479

High

427469

ANXA2
Annexin A2

1

1

High-throughput

0.479

High

432574

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

3

High-throughput

0.479

High

437944

HS90B
Heat shock protein HSP 90-beta

1

4

High-throughput

0.479

High

443368

VIME
Vimentin

1

6

High-throughput

0.479

High

449571

HMGB1
High mobility group protein B1

1

20

High-throughput

0.479

High

453186

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

1

High-throughput

0.479

High

455153

PARP1
Poly [ADP-ribose] polymerase 1

1

5

High-throughput

0.479

High

488925

H14
Histone H1.4

1

6

High-throughput

0.479

High

503270

MTAP2
Microtubule-associated protein 2

1

8

High-throughput

0.479

High

516381

PABP1
Polyadenylate-binding protein 1

1

1

High-throughput

0.479

High

519136

KCRB
Creatine kinase B-type

1

1

High-throughput

0.479

High

523553

XRCC6
X-ray repair cross-complementing protein 6

1

7

Small-scale

0.479

High

524816

XRCC5
X-ray repair cross-complementing protein 5

1

7

Small-scale

0.479

High

528361

MYH6
Myosin-6

1

1

High-throughput

0.479

High

533270

PLST
Plastin-3

1

1

High-throughput

0.479

High

537825

KPYM
Pyruvate kinase PKM

1

2

High-throughput

0.479

High

538128

ENPL
Endoplasmin

1

4

High-throughput

0.479

High

551622

DESP
Desmoplakin

1

4

High-throughput

0.479

High

558999

H15
Histone H1.5

1

6

High-throughput

0.479

High

597479

GSTM3
Glutathione S-transferase Mu 3

1

1

High-throughput

0.479

High

597753

CSRP1
Cysteine and glycine-rich protein 1

1

4

High-throughput

0.479

High

643436

PTBP1
Polypyrimidine tract-binding protein 1

1

2

High-throughput

0.479

High

643948

EF1G
Elongation factor 1-gamma

1

1

High-throughput

0.479

High

723953

CBS
Cystathionine beta-synthase

1

1

High-throughput

0.479

High

724177

SYUA
Alpha-synuclein

1

1

High-throughput

0.479

High

724178

MDHC
Malate dehydrogenase, cytoplasmic

1

2

High-throughput

0.479

High

724180

RL35
Large ribosomal subunit protein uL29

1

1

High-throughput

0.479

High

724182

RS5
Small ribosomal subunit protein uS7

1

2

High-throughput

0.479

High

724183

NASP
Nuclear autoantigenic sperm protein

1

3

High-throughput

0.479

High

724184

SYSC
Serine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.479

High

724186

RBM25
RNA-binding protein 25

1

5

High-throughput

0.479

High

724187

DHB4
Peroxisomal multifunctional enzyme type 2

1

2

High-throughput

0.479

High

724195

MTPN
Myotrophin

1

14

High-throughput

0.479

High

724196

H2B1D
Histone H2B type 1-D

1

1

High-throughput

0.479

High

724200

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

4

High-throughput

0.479

High

724202

1433E
14-3-3 protein epsilon

1

1

High-throughput

0.479

High

724206

RS24
Small ribosomal subunit protein eS24

1

1

High-throughput

0.479

High

724211

FKB1A
Peptidyl-prolyl cis-trans isomerase FKBP1A

1

2

High-throughput

0.479

High

724212

1433Z
14-3-3 protein zeta/delta

1

3

High-throughput

0.479

High

724214

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

4

High-throughput

0.479

High

724218

BASP1
Brain acid soluble protein 1

1

2

High-throughput

0.479

High

724219

FKBP3
Peptidyl-prolyl cis-trans isomerase FKBP3

1

2

High-throughput

0.479

High

724229

DHX9
ATP-dependent RNA helicase A

1

2

High-throughput

0.479

High

724230

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

1

7

High-throughput

0.479

High

724231

GOGA4
Golgin subfamily A member 4

1

2

High-throughput

0.479

High

724233

RUNX2
Runt-related transcription factor 2

1

1

Small-scale

0.479

High

724235

GOGB1
Golgin subfamily B member 1

1

3

High-throughput

0.479

High

724236

SF3A1
Splicing factor 3A subunit 1

1

11

High-throughput

0.479

High

724238

PCH2
Pachytene checkpoint protein 2 homolog

1

1

High-throughput

0.479

High

724240

NEDD8
NEDD8

1

1

High-throughput

0.479

High

724251

FA98A
Protein FAM98A

1

1

High-throughput

0.479

High

724258

SMRC1
SWI/SNF complex subunit SMARCC1

1

20

High-throughput

0.479

High

724266

TIGD1
Tigger transposable element-derived protein 1

1

3

High-throughput

0.479

High

724270

RSF1
Remodeling and spacing factor 1

1

20

High-throughput

0.479

High

724272

TBA1C
Tubulin alpha-1C chain

1

1

High-throughput

0.479

High

724275

SRBS1
Sorbin and SH3 domain-containing protein 1

1

5

High-throughput

0.479

High

724281

SEC12
Guanine nucleotide-exchange factor SEC12

1

1

High-throughput

0.479

High

724283

DDX21
Nucleolar RNA helicase 2

1

2

High-throughput

0.479

High

724285

CLIP2
CAP-Gly domain-containing linker protein 2

1

4

High-throughput

0.479

High

724292

SERC
Phosphoserine aminotransferase

1

1

High-throughput

0.479

High

103707

G5E9A7
DM1 locus, WD repeat containing

1

9

High-throughput

0.470

High

275991

EIF3J
Eukaryotic translation initiation factor 3 subunit J

1

0

High-throughput

0.458

High

340397

PGK1
Phosphoglycerate kinase 1

1

0

High-throughput

0.458

High

396895

HMGN1
Non-histone chromosomal protein HMG-14

1

0

High-throughput

0.458

High

415231

ATPB
ATP synthase subunit beta, mitochondrial

1

0

High-throughput

0.458

High

428050

TBB5
Tubulin beta chain

1

0

High-throughput

0.458

High

438921

ASNS
Asparagine synthetase [glutamine-hydrolyzing]

1

0

High-throughput

0.458

High

517875

HARS1
Histidine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

555089

CD44
CD44 antigen

1

0

High-throughput

0.458

High

564818

HMGA1
High mobility group protein HMG-I/HMG-Y

1

0

High-throughput

0.458

High

574937

RL7
Large ribosomal subunit protein uL30

1

0

High-throughput

0.458

High

606372

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.458

High

616147

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

671150

RL12
Large ribosomal subunit protein uL11

1

0

High-throughput

0.458

High

675299

SORCN
Sorcin

1

0

High-throughput

0.458

High

724179

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

724188

GDIR1
Rho GDP-dissociation inhibitor 1

1

0

High-throughput

0.458

High

724189

RIDA
2-iminobutanoate/2-iminopropanoate deaminase

1

0

High-throughput

0.458

High

724190

ACLY
ATP-citrate synthase

1

0

High-throughput

0.458

High

724192

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

724193

MANF
Mesencephalic astrocyte-derived neurotrophic factor

1

0

High-throughput

0.458

High

724197

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

0

High-throughput

0.458

High

724198

RL27
Large ribosomal subunit protein eL27

1

0

High-throughput

0.458

High

724199

CH10
10 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

724201

RS8
Small ribosomal subunit protein eS8

1

0

High-throughput

0.458

High

724203

RS18
Small ribosomal subunit protein uS13

1

0

High-throughput

0.458

High

724204

RL7A
Large ribosomal subunit protein eL8

1

0

High-throughput

0.458

High

724205

CNBP
CCHC-type zinc finger nucleic acid binding protein

1

0

High-throughput

0.458

High

724207

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.458

High

724208

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.458

High

724209

RL10A
Large ribosomal subunit protein uL1

1

0

High-throughput

0.458

High

724210

RL11
Large ribosomal subunit protein uL5

1

0

High-throughput

0.458

High

724213

IF5A1
Eukaryotic translation initiation factor 5A-1

1

0

High-throughput

0.458

High

724217

MT1X
Metallothionein-1X

1

0

High-throughput

0.458

High

724220

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

0

High-throughput

0.458

High

724223

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

1

0

High-throughput

0.458

High

724226

PRDX1
Peroxiredoxin-1

1

0

High-throughput

0.458

High

724232

NACA
Nascent polypeptide-associated complex subunit alpha

1

0

High-throughput

0.458

High

724237

TSN
Translin

1

0

High-throughput

0.458

High

724239

HMGN3
High mobility group nucleosome-binding domain-containing protein 3

1

0

High-throughput

0.458

High

724250

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

724254

DTD1
D-aminoacyl-tRNA deacylase 1

1

0

High-throughput

0.458

High

724257

H1X
Histone H1.10

1

0

High-throughput

0.458

High

724259

RNF34
E3 ubiquitin-protein ligase RNF34

1

0

High-throughput

0.458

High

724260

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.458

High

724269

VPS35
Vacuolar protein sorting-associated protein 35

1

0

High-throughput

0.458

High

724271

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

0

High-throughput

0.458

High

724274

PYM1
Partner of Y14 and mago

1

0

High-throughput

0.458

High

724278

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

0

High-throughput

0.458

High

724290

RL36
Large ribosomal subunit protein eL36

1

0

High-throughput

0.458

High

724243

MGT5B
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

1

1

High-throughput

0.439

High

429269

PGS2
Decorin

1

2

High-throughput

0.437

High

660413

GRN
Progranulin

1

4

High-throughput

0.437

High

669902

MARCS
Myristoylated alanine-rich C-kinase substrate

1

4

High-throughput

0.437

High

724222

TAGL
Transgelin

1

2

High-throughput

0.437

High

724244

STYL2
Serine/threonine/tyrosine-interacting-like protein 2

1

4

High-throughput

0.437

High

724261

LRC59
Leucine-rich repeat-containing protein 59

1

3

High-throughput

0.437

High

724264

DNJC1
DnaJ homolog subfamily C member 1

1

4

High-throughput

0.437

High

724265

CFA44
Cilia- and flagella-associated protein 44

1

2

High-throughput

0.437

High

724246

ANR40
Ankyrin repeat domain-containing protein 40

2

0

High-throughput

0.328

High

724253

TET5D
Terminal nucleotidyltransferase 5D

2

0

High-throughput

0.316

High

724267

TSSK3
Testis-specific serine/threonine-protein kinase 3

2

0

High-throughput

0.316

High

724242

OBF1
POU domain class 2-associating factor 1

1

0

High-throughput

0.282

High

207711

DENR
Density-regulated protein

1

0

High-throughput

0.249

Low

393074

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

0

High-throughput

0.249

Low

474686

TB15B
Thymosin beta-15B

1

0

High-throughput

0.249

Low

597366

PTN
Pleiotrophin

1

0

High-throughput

0.249

Low

724256

TM263
Transmembrane protein 263

1

0

High-throughput

0.249

Low

724286

CHRD1
Cysteine and histidine-rich domain-containing protein 1

1

0

High-throughput

0.249

Low

724289

TMA7
Translation machinery-associated protein 7

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024