Protein: NFL
Neurofilament light polypeptide (NF-L) (68 kDa neurofilament protein) (Neurofilament triplet L protein)

Gene: NFL, NEFL
Organism: Homo sapiens
Interactions: 228
UniProt ID: P07196

Gene Ontology (top 5):
GO:0000226 - microtubule cytoskeleton organization
GO:0005200 - structural constituent of cytoskeleton
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005882 - intermediate filament

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

422126

VIME
Vimentin

8

20

High-throughput

0.971

High

422125

NFM
Neurofilament medium polypeptide

7

20

High-throughput

0.962

High

422142

DESM
Desmin

6

20

High-throughput

0.946

High

422140

GFAP
Glial fibrillary acidic protein

5

20

High-throughput

0.931

High

422292

SYNCI
Syncoilin

3

20

High-throughput

0.866

High

422136

NFH
Neurofilament heavy polypeptide

3

20

Small-scale

0.855

High

422144

K1C15
Keratin, type I cytoskeletal 15

2

20

High-throughput

0.791

High

408709

K1C18
Keratin, type I cytoskeletal 18

1

20

High-throughput

0.698

High

422138

K1C13
Keratin, type I cytoskeletal 13

1

20

High-throughput

0.698

High

359291

K1C14
Keratin, type I cytoskeletal 14

1

20

High-throughput

0.691

High

422128

K2C7
Keratin, type II cytoskeletal 7

1

20

High-throughput

0.691

High

422152

NEST
Nestin

1

20

High-throughput

0.691

High

422184

K1H1
Keratin, type I cuticular Ha1

1

20

High-throughput

0.691

High

422215

K1C27
Keratin, type I cytoskeletal 27

1

20

High-throughput

0.691

High

422284

K1C23
Keratin, type I cytoskeletal 23

1

20

High-throughput

0.691

High

422272

NECD
Necdin

3

7

High-throughput

0.667

High

422127

K1C19
Keratin, type I cytoskeletal 19

1

20

High-throughput

0.665

High

422178

KT33B
Keratin, type I cuticular Ha3-II

1

20

High-throughput

0.665

High

271020

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

3

15

High-throughput

0.654

High

422320

NDK7
Nucleoside diphosphate kinase homolog 7

3

3

High-throughput

0.654

High

422183

RABE1
Rab GTPase-binding effector protein 1

2

11

High-throughput

0.628

High

422209

FA83H
Protein FAM83H

2

12

High-throughput

0.628

High

422217

DPP9
Dipeptidyl peptidase 9

2

1

High-throughput

0.628

High

422245

BICD2
Protein bicaudal D homolog 2

2

20

High-throughput

0.628

High

422256

RSPRY
RING finger and SPRY domain-containing protein 1

2

5

High-throughput

0.628

High

422257

BICD1
Protein bicaudal D homolog 1

2

20

High-throughput

0.628

High

422137

SKIL
Ski-like protein

2

2

High-throughput

0.628

High

422148

S100P
Protein S100-P

2

3

High-throughput

0.621

High

422189

PKN1
Serine/threonine-protein kinase N1

2

12

Small-scale

0.618

High

422227

CCD13
Coiled-coil domain-containing protein 13

2

11

High-throughput

0.606

High

422241

SMYD1
Histone-lysine N-methyltransferase SMYD1

2

1

High-throughput

0.606

High

422294

NEK6
Serine/threonine-protein kinase Nek6

2

16

High-throughput

0.606

High

148291

CTRO
Citron Rho-interacting kinase

2

15

High-throughput

0.584

High

422250

TSC1
Hamartin

1

20

Small-scale

0.573

High

422203

PPR18
Phostensin

1

16

High-throughput

0.573

High

422308

RHG23
Rho GTPase-activating protein 23

2

11

High-throughput

0.571

High

422279

KIFC3
Kinesin-like protein KIFC3

2

16

High-throughput

0.559

High

393930

A4
Amyloid-beta precursor protein

1

7

Small-scale

0.554

High

422156

TERF1
Telomeric repeat-binding factor 1

1

0

High-throughput

0.543

High

234463

DSCAM
Cell adhesion molecule DSCAM

1

6

High-throughput

0.541

High

422154

FXR1
RNA-binding protein FXR1

1

13

High-throughput

0.541

High

422187

ITSN1
Intersectin-1

1

20

High-throughput

0.541

High

422206

KLC3
Kinesin light chain 3

1

8

High-throughput

0.541

High

422280

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

14

High-throughput

0.541

High

164753

SC16A
Protein transport protein Sec16A

1

5

High-throughput

0.536

High

422141

IDE
Insulin-degrading enzyme

1

11

High-throughput

0.536

High

422150

HD
Huntingtin

1

9

High-throughput

0.536

High

422177

MAP7
Ensconsin

1

20

High-throughput

0.536

High

422247

TBCK
TBC domain-containing protein kinase-like protein

1

10

High-throughput

0.536

High

422251

CDKL2
Cyclin-dependent kinase-like 2

1

5

High-throughput

0.536

High

422228

TEX11
Testis-expressed protein 11

2

2

High-throughput

0.533

High

422165

ECT2L
Epithelial cell-transforming sequence 2 oncogene-like

2

16

High-throughput

0.521

High

422248

DEP1B
DEP domain-containing protein 1B

2

7

High-throughput

0.521

High

422130

CC172
Coiled-coil domain-containing protein 172

1

0

High-throughput

0.518

High

422160

1433G
14-3-3 protein gamma

1

20

High-throughput

0.515

High

324170

BAG3
BAG family molecular chaperone regulator 3

1

6

High-throughput

0.515

High

422139

ANXA8
Annexin A8

1

3

High-throughput

0.515

High

422146

VATB2
V-type proton ATPase subunit B, brain isoform

1

2

High-throughput

0.515

High

422155

MECP2
Methyl-CpG-binding protein 2

1

3

High-throughput

0.515

High

422162

DYLT1
Dynein light chain Tctex-type 1

1

2

High-throughput

0.515

High

422176

IL16
Pro-interleukin-16 [Cleaved into: Interleukin-16

1

17

High-throughput

0.515

High

422179

LASP1
LIM and SH3 domain protein 1

1

17

High-throughput

0.515

High

422181

MLC1
Membrane protein MLC1

1

1

High-throughput

0.515

High

422197

DCAF8
DDB1- and CUL4-associated factor 8

1

8

High-throughput

0.515

High

422199

TASO2
Protein TASOR 2

1

13

High-throughput

0.515

High

422200

TUT7
Terminal uridylyltransferase 7

1

6

High-throughput

0.515

High

422208

NSMF
NMDA receptor synaptonuclear signaling and neuronal migration factor

1

2

High-throughput

0.515

High

422212

CYFP1
Cytoplasmic FMR1-interacting protein 1

1

3

High-throughput

0.515

High

422213

G2E3
G2/M phase-specific E3 ubiquitin-protein ligase

1

3

High-throughput

0.515

High

422223

CRLF3
Cytokine receptor-like factor 3

1

1

High-throughput

0.515

High

422225

MSRB3
Methionine-R-sulfoxide reductase B3

1

1

High-throughput

0.515

High

422234

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.515

High

422236

KKCC1
Calcium/calmodulin-dependent protein kinase kinase 1

1

6

High-throughput

0.515

High

422243

FANK1
Fibronectin type 3 and ankyrin repeat domains protein 1

1

9

High-throughput

0.515

High

422244

RHPN1
Rhophilin-1

1

11

High-throughput

0.515

High

422259

MY15B
Unconventional myosin-XVB

1

11

High-throughput

0.515

High

422266

ZN641
Zinc finger protein 641

1

8

High-throughput

0.515

High

422270

EYA3
Eyes absent homolog 3

1

1

High-throughput

0.515

High

422285

ZN436
Zinc finger protein 436

1

5

High-throughput

0.515

High

422291

ES8L2
Epidermal growth factor receptor kinase substrate 8-like protein 2

1

7

High-throughput

0.515

High

422295

ARFG3
ADP-ribosylation factor GTPase-activating protein 3

1

5

High-throughput

0.515

High

422302

MBIP1
MAP3K12-binding inhibitory protein 1

1

1

High-throughput

0.515

High

422309

PAK5
Serine/threonine-protein kinase PAK 5

1

12

High-throughput

0.515

High

422310

RCOR3
REST corepressor 3

1

5

High-throughput

0.515

High

422311

GCP4
Gamma-tubulin complex component 4

1

7

High-throughput

0.515

High

422315

CLC11
C-type lectin domain family 11 member A

1

1

High-throughput

0.515

High

422319

ASB3
Ankyrin repeat and SOCS box protein 3

1

19

High-throughput

0.515

High

422170

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

17

High-throughput

0.508

High

422232

PIAS4
E3 SUMO-protein ligase PIAS4

1

8

High-throughput

0.508

High

422296

BRD7
Bromodomain-containing protein 7

1

4

High-throughput

0.508

High

422174

MTMR2
Myotubularin-related protein 2

1

3

Small-scale

0.506

High

422135

MTAP2
Microtubule-associated protein 2

1

20

Small-scale

0.501

High

422175

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

10

Small-scale

0.501

High

422158

RBM11
Splicing regulator RBM11

1

2

High-throughput

0.494

High

422168

GOGA2
Golgin subfamily A member 2

1

14

High-throughput

0.494

High

422145

ASPG
N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase

1

0

High-throughput

0.493

High

422172

TDG
G/T mismatch-specific thymine DNA glycosylase

1

0

High-throughput

0.493

High

422205

FAHD1
Oxaloacetate decarboxylase, mitochondrial

1

0

High-throughput

0.493

High

422216

NUFP2
FMR1-interacting protein NUFIP2

1

0

High-throughput

0.493

High

422222

KRA81
Keratin-associated protein 8-1

1

0

High-throughput

0.493

High

422226

BAP18
Chromatin complexes subunit BAP18

1

0

High-throughput

0.493

High

422239

SMIP4
Sperm-associated microtubule inner protein 4

1

0

High-throughput

0.493

High

422267

RBM14
RNA-binding protein 14

1

0

High-throughput

0.493

High

422274

SPAG8
Sperm-associated antigen 8

1

0

High-throughput

0.493

High

422277

PELO
Protein pelota homolog

1

0

High-throughput

0.493

High

422190

CF184
Cilia- and flagella-associated protein 184

1

3

High-throughput

0.489

High

422317

CRBG1
Beta/gamma crystallin domain-containing protein 1

1

16

High-throughput

0.489

High

159844

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

16

High-throughput

0.481

High

231969

KDM1A
Lysine-specific histone demethylase 1A

1

6

High-throughput

0.481

High

422195

MTUS2
Microtubule-associated tumor suppressor candidate 2

1

20

High-throughput

0.481

High

422198

MYOME
Myomegalin

1

17

High-throughput

0.481

High

422229

CE57L
Centrosomal protein CEP57L1

1

7

High-throughput

0.481

High

422233

TXLNB
Beta-taxilin

1

20

High-throughput

0.481

High

422238

USBP1
Harmonin-binding protein USHBP1

1

14

High-throughput

0.481

High

422252

TRI63
E3 ubiquitin-protein ligase TRIM63

1

20

High-throughput

0.481

High

422269

PP16B
Protein phosphatase 1 regulatory inhibitor subunit 16B

1

13

High-throughput

0.481

High

422282

TRI55
Tripartite motif-containing protein 55

1

20

High-throughput

0.481

High

63064

RHG42
Rho GTPase-activating protein 42

1

10

High-throughput

0.479

High

127990

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

3

High-throughput

0.479

High

130697

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

12

High-throughput

0.479

High

209592

PRC1
Protein regulator of cytokinesis 1

1

11

High-throughput

0.479

High

226276

PRKN
E3 ubiquitin-protein ligase parkin

1

16

High-throughput

0.479

High

255437

OBSL1
Obscurin-like protein 1

1

14

High-throughput

0.479

High

358954

CRYAB
Alpha-crystallin B chain

1

9

High-throughput

0.479

High

422129

HXB5
Homeobox protein Hox-B5

1

11

High-throughput

0.479

High

422131

SCHI1
Schwannomin-interacting protein 1

1

1

High-throughput

0.479

High

422132

ANDR
Androgen receptor

1

19

Small-scale

0.479

High

422134

MCF2
Proto-oncogene DBL

1

10

High-throughput

0.479

High

422143

RL7
Large ribosomal subunit protein uL30

1

1

High-throughput

0.479

High

422149

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

3

Small-scale

0.479

High

422153

TSC2
Tuberin

1

8

Small-scale

0.479

High

422157

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

11

High-throughput

0.479

High

422163

BASP1
Brain acid soluble protein 1

1

10

High-throughput

0.479

High

422164

PSG9
Pregnancy-specific beta-1-glycoprotein 9

1

3

High-throughput

0.479

High

422169

FOXO1
Forkhead box protein O1

1

2

High-throughput

0.479

High

422182

KIF14
Kinesin-like protein KIF14

1

20

High-throughput

0.479

High

422188

EZH2
Histone-lysine N-methyltransferase EZH2

1

11

High-throughput

0.479

High

422220

ARHGP
Rho guanine nucleotide exchange factor 25

1

9

High-throughput

0.479

High

422221

SKAP1
Src kinase-associated phosphoprotein 1

1

18

High-throughput

0.479

High

422224

ARHGJ
Rho guanine nucleotide exchange factor 19

1

19

High-throughput

0.479

High

422231

RHG24
Rho GTPase-activating protein 24

1

11

High-throughput

0.479

High

422237

NGEF
Ephexin-1

1

19

High-throughput

0.479

High

422249

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

11

High-throughput

0.479

High

422263

FGD4
FYVE, RhoGEF and PH domain-containing protein 4

1

20

High-throughput

0.479

High

422273

ANM1
Protein arginine N-methyltransferase 1

1

9

High-throughput

0.479

High

422287

CCDC8
Coiled-coil domain-containing protein 8

1

5

High-throughput

0.479

High

422289

GAN
Gigaxonin

1

15

High-throughput

0.479

High

422290

CHM4B
Charged multivesicular body protein 4b

1

5

High-throughput

0.479

High

422293

ECT2
Protein ECT2

1

20

High-throughput

0.479

High

422297

ANLN
Anillin

1

12

High-throughput

0.479

High

422299

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

7

High-throughput

0.479

High

422307

GMIP
GEM-interacting protein

1

10

High-throughput

0.479

High

422314

CC14A
Dual specificity protein phosphatase CDC14A

1

1

High-throughput

0.479

High

422323

SETBP
SET-binding protein

1

1

High-throughput

0.479

High

4639

A0A1B0GWI1
Coiled-coil domain containing 196

1

3

High-throughput

0.470

High

182404

ZSC9
Zinc finger and SCAN domain-containing protein 9

1

12

High-throughput

0.470

High

204274

MS18B
Protein Mis18-beta

1

6

High-throughput

0.470

High

282299

NEBL
Nebulette

1

20

High-throughput

0.470

High

422151

VDAC2
Voltage-dependent anion-selective channel protein 2

1

2

High-throughput

0.470

High

422159

VSX2
Visual system homeobox 2

1

3

High-throughput

0.470

High

422173

SNW1
SNW domain-containing protein 1

1

3

High-throughput

0.470

High

422186

ZKSC8
Zinc finger protein with KRAB and SCAN domains 8

1

10

High-throughput

0.470

High

422191

ZN829
Zinc finger protein 829

1

7

High-throughput

0.470

High

422193

ZC21C
Zinc finger C2HC domain-containing protein 1C

1

3

High-throughput

0.470

High

422194

FAKD1
FAST kinase domain-containing protein 1, mitochondrial

1

4

High-throughput

0.470

High

422201

TTC23
Tetratricopeptide repeat protein 23

1

7

High-throughput

0.470

High

422202

ZNF57
Zinc finger protein 57

1

4

High-throughput

0.470

High

422207

ELAP1
Endosome/lysosome-associated apoptosis and autophagy regulator 1

1

1

High-throughput

0.470

High

422210

K0408
Uncharacterized protein KIAA0408

1

3

High-throughput

0.470

High

422214

ZN572
Zinc finger protein 572

1

9

High-throughput

0.470

High

422218

TAD2B
Transcriptional adapter 2-beta

1

1

High-throughput

0.470

High

422219

Q86V28
AP-1 complex subunit gamma

1

2

High-throughput

0.470

High

422246

TCP1L
T-complex protein 10A homolog 1

1

3

High-throughput

0.470

High

422264

ZN488
Zinc finger protein 488

1

1

High-throughput

0.470

High

422298

ZN302
Zinc finger protein 302

1

4

High-throughput

0.470

High

422312

ZN180
Zinc finger protein 180

1

3

High-throughput

0.470

High

422260

ANM6
Protein arginine N-methyltransferase 6

1

9

High-throughput

0.464

High

422167

QOR
Quinone oxidoreductase

1

0

High-throughput

0.458

High

422253

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

High-throughput

0.458

High

422254

CHCH1
Small ribosomal subunit protein mS37

1

0

High-throughput

0.458

High

232766

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

11

High-throughput

0.457

High

422161

RAN
GTP-binding nuclear protein Ran

1

3

High-throughput

0.457

High

422171

HSPB3
Heat shock protein beta-3

1

9

High-throughput

0.457

High

422268

CK5P2
CDK5 regulatory subunit-associated protein 2

1

20

High-throughput

0.457

High

422300

PICK1
PRKCA-binding protein

1

1

High-throughput

0.457

High

422301

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.457

High

422313

TNIK
TRAF2 and NCK-interacting protein kinase

1

9

High-throughput

0.457

High

239713

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

3

High-throughput

0.445

High

377883

PRIO
Major prion protein

1

1

High-throughput

0.445

High

422133

TAU
Microtubule-associated protein tau

1

20

High-throughput

0.445

High

422166

ANK2
Ankyrin-2

1

15

High-throughput

0.445

High

422196

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

9

High-throughput

0.445

High

422240

POC5
Centrosomal protein POC5

1

2

High-throughput

0.445

High

422265

CEP63
Centrosomal protein of 63 kDa

1

13

High-throughput

0.445

High

422147

CCNC
Cyclin-C

1

4

High-throughput

0.439

High

422286

ENKD1
Enkurin domain-containing protein 1

1

3

High-throughput

0.439

High

422258

SPTCS
Spatacsin

1

0

Small-scale

0.438

High

100390

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

308322

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.437

High

352445

TNFA
Tumor necrosis factor

1

4

High-throughput

0.437

High

422211

COX15
Heme A synthase COX15

1

2

High-throughput

0.437

High

422283

RHBT2
Rho-related BTB domain-containing protein 2

1

8

High-throughput

0.437

High

422288

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

3

High-throughput

0.437

High

422304

OCAD1
OCIA domain-containing protein 1

1

2

High-throughput

0.437

High

422305

MARH5
E3 ubiquitin-protein ligase MARCHF5

1

1

High-throughput

0.437

High

422322

MTCH2
Mitochondrial carrier homolog 2

1

3

High-throughput

0.437

High

422204

Q6P2R3
C6orf182 protein

1

7

High-throughput

0.417

High

422271

ZBT18
Zinc finger and BTB domain-containing protein 18

1

8

High-throughput

0.407

High

422316

ITM2B
Integral membrane protein 2B

1

9

High-throughput

0.407

High

422255

RMC1
Regulator of MON1-CCZ1 complex

2

0

High-throughput

0.328

High

422276

GORS1
Golgi reassembly-stacking protein 1

1

0

High-throughput

0.282

High

58395

A2RU56
LOC401296 protein

1

0

High-throughput

0.268

Low

422192

CP100
Cilia- and flagella-associated protein 100

1

0

High-throughput

0.268

Low

422230

FAM9A
Protein FAM9A

1

0

High-throughput

0.268

Low

422242

PPTC7
Protein phosphatase PTC7 homolog

1

0

High-throughput

0.268

Low

422261

PGRP3
Peptidoglycan recognition protein 3

1

0

High-throughput

0.268

Low

422262

CH048
Uncharacterized protein C8orf48

1

0

High-throughput

0.268

Low

422275

SYT3
Synaptotagmin-3

1

0

High-throughput

0.268

Low

422306

GFOD1
Glucose-fructose oxidoreductase domain-containing protein 1

1

0

High-throughput

0.268

Low

422321

RAI2
Retinoic acid-induced protein 2

1

0

High-throughput

0.268

Low

422235

CCD33
Coiled-coil domain-containing protein 33

1

0

High-throughput

0.251

Low

118166

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.249

Low

422180

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.249

Low

422185

SURF1
Surfeit locus protein 1

1

0

High-throughput

0.249

Low

422278

PHAF1
Phagosome assembly factor 1

1

0

High-throughput

0.249

Low

422281

RM04
Large ribosomal subunit protein uL4m

1

0

High-throughput

0.249

Low

422303

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

0

High-throughput

0.249

Low

422318

SAM50
Sorting and assembly machinery component 50 homolog

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024