Protein: EP300
Histone acetyltransferase p300 (p300 HAT) (EC 2.3.1.48) (E1A-associated protein p300) (Histone butyryltransferase p300) (EC 2.3.1.-) (Histone crotonyltransferase p300) (EC 2.3.1.-) (Protein 2-hydroxyisobutyryltransferase p300) (EC 2.3.1.-) (Protein lactyltransferas p300) (EC 2.3.1.-) (Protein propionyltransferase p300) (EC 2.3.1.-)

Gene: EP300
Organism: Mus musculus
Interactions: 72
UniProt ID: B2RWS6

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000123 - histone acetyltransferase complex
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000987 - cis-regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

70883

P53
Cellular tumor antigen p53

6

18

Small-scale

0.937

High

70940

KAT2B
Histone acetyltransferase KAT2B

3

20

Small-scale

0.835

High

70907

NCOA1
Nuclear receptor coactivator 1

2

20

Small-scale

0.806

High

70914

TF65
Transcription factor p65

4

15

Small-scale

0.677

High

70912

CREB1
Cyclic AMP-responsive element-binding protein 1

1

7

Small-scale

0.647

High

70932

H2A3
Histone H2A type 3

1

20

Small-scale

0.647

High

70941

KAT2A
Histone acetyltransferase KAT2A

1

20

Small-scale

0.647

High

70879

F8VPR5
histone acetyltransferase

1

17

Small-scale

0.618

High

70908

IRF3
Interferon regulatory factor 3

1

17

Small-scale

0.618

High

70923

HIF1A
Hypoxia-inducible factor 1-alpha

1

20

Small-scale

0.618

High

70929

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

20

Small-scale

0.618

High

70946

FOXO3
Forkhead box protein O3

1

20

Small-scale

0.618

High

70888

MYOD1
Myoblast determination protein 1

2

7

Small-scale

0.584

High

70891

SPI1
Transcription factor PU.1

2

20

Small-scale

0.584

High

70916

GATA4
Transcription factor GATA-4

1

20

Small-scale

0.561

High

70945

TLE6
Transducin-like enhancer protein 6

1

13

High-throughput

0.541

High

70943

NUPR1
Nuclear protein 1

1

3

Small-scale

0.527

High

70897

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

7

Small-scale

0.515

High

57642

A2AWT7
Upstream binding transcription factor, RNA polymerase I

1

20

Small-scale

0.501

High

70918

BMAL2
Basic helix-loop-helix ARNT-like protein 2

1

20

Small-scale

0.501

High

70944

BMAL1
Basic helix-loop-helix ARNT-like protein 1

1

20

Small-scale

0.501

High

70948

MECP2
Methyl-CpG-binding protein 2

1

13

Small-scale

0.501

High

377

AUTS2
Autism susceptibility gene 2 protein homolog

1

20

Small-scale

0.500

High

70881

INAR2
Interferon alpha/beta receptor 2

1

3

Small-scale

0.479

High

70882

IFNB
Interferon beta

1

10

Small-scale

0.479

High

70885

GRAB
Granzyme B(G,H)

1

1

Small-scale

0.479

High

70886

SRC
Proto-oncogene tyrosine-protein kinase Src

1

15

Small-scale

0.479

High

70887

JUN
Transcription factor Jun

1

20

High-throughput

0.479

High

70889

RARA
Retinoic acid receptor alpha

1

20

Small-scale

0.479

High

70892

RARG
Retinoic acid receptor gamma

1

20

Small-scale

0.479

High

70893

ESR1
Estrogen receptor

1

20

Small-scale

0.479

High

70894

RARB
Retinoic acid receptor beta

1

20

Small-scale

0.479

High

70895

PPARA
Peroxisome proliferator-activated receptor alpha

1

20

Small-scale

0.479

High

70896

MDM2
E3 ubiquitin-protein ligase Mdm2

1

3

Small-scale

0.479

High

70898

CEBPB
CCAAT/enhancer-binding protein beta

1

20

Small-scale

0.479

High

70899

ETV4
ETS translocation variant 4

1

20

Small-scale

0.479

High

70901

INAR1
Interferon alpha/beta receptor 1

1

2

Small-scale

0.479

High

70903

THB
Thyroid hormone receptor beta

1

20

High-throughput

0.479

High

70904

HSF2
Heat shock factor protein 2

1

6

Small-scale

0.479

High

70905

STAT6
Signal transducer and transcription activator 6

1

15

Small-scale

0.479

High

70906

CEBPA
CCAAT/enhancer-binding protein alpha

1

20

Small-scale

0.479

High

70909

C2TA
MHC class II transactivator

1

6

Small-scale

0.479

High

70910

PITX2
Pituitary homeobox 2

1

19

Small-scale

0.479

High

70911

TYY1
Transcriptional repressor protein YY1

1

14

Small-scale

0.479

High

70913

CTNB1
Catenin beta-1

1

20

Small-scale

0.479

High

70915

BAX
Apoptosis regulator BAX

1

5

Small-scale

0.479

High

70917

RUNX2
Runt-related transcription factor 2

1

8

Small-scale

0.479

High

70919

DDB1
DNA damage-binding protein 1

1

9

Small-scale

0.479

High

70920

Q3UM65
Runt-related transcription factor

1

8

Small-scale

0.479

High

70921

NR1H4
Bile acid receptor

1

20

Small-scale

0.479

High

70922

USF1
Upstream stimulatory factor 1

1

20

Small-scale

0.479

High

70924

HTF4
Transcription factor 12

1

9

Small-scale

0.479

High

70925

CNTN2
Contactin-2

1

1

Small-scale

0.479

High

70926

IL17
Interleukin-17A

1

1

Small-scale

0.479

High

70927

ZBT7B
Zinc finger and BTB domain-containing protein 7B

1

14

Small-scale

0.479

High

70928

Q6P7T9
Nuclear factor of activated T-cells c1 isoform IA-IXS

1

19

Small-scale

0.479

High

70931

IL17F
Interleukin-17F

1

1

Small-scale

0.479

High

70933

SNIP1
Smad nuclear-interacting protein 1

1

5

Small-scale

0.479

High

70934

EPC1
Enhancer of polycomb homolog 1

1

2

Small-scale

0.479

High

70936

MYCD
Myocardin

1

14

Small-scale

0.479

High

70937

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

11

Small-scale

0.479

High

70938

FOXP3
Forkhead box protein P3

1

19

Small-scale

0.479

High

70939

BC11B
B-cell lymphoma/leukemia 11B

1

6

Small-scale

0.479

High

70880

XBP1
X-box-binding protein 1

1

0

Small-scale

0.458

High

70900

NOS2
Nitric oxide synthase, inducible

1

0

Small-scale

0.458

High

70902

TAP2
Antigen peptide transporter 2

1

0

Small-scale

0.458

High

70890

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

14

Small-scale

0.445

High

70947

NR1H3
Oxysterols receptor LXR-alpha

1

20

Small-scale

0.445

High

70884

CFAD
Complement factor D

1

1

High-throughput

0.437

High

70930

Q6PED7
Auts2 protein

1

4

Small-scale

0.437

High

70935

FNDC5
Fibronectin type III domain-containing protein 5

1

0

High-throughput

0.249

Low

70942

TPSN
Tapasin

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024