Protein: M3K2
Mitogen-activated protein kinase kinase kinase 2 (EC 2.7.11.25) (MAPK/ERK kinase kinase 2) (MEK kinase 2) (MEKK 2)

Gene: M3K2, MAP3K2
Organism: Homo sapiens
Interactions: 72
UniProt ID: Q9Y2U5

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004709 - MAP kinase kinase kinase activity
GO:0005524 - ATP binding
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1026841

MP2K5
Dual specificity mitogen-activated protein kinase kinase 5

9

16

Small-scale

0.978

High

1377411

M3K2
Mitogen-activated protein kinase kinase kinase 2

5

15

Small-scale

0.927

High

801007

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

3

18

Small-scale

0.840

High

1306407

M3K3
Mitogen-activated protein kinase kinase kinase 3

3

16

Small-scale

0.834

High

1026893

MK07
Mitogen-activated protein kinase 7

2

18

Small-scale

0.789

High

153192

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

2

16

Small-scale

0.768

High

683841

1433B
14-3-3 protein beta/alpha

10

20

High-throughput

0.756

High

476603

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

2

13

Small-scale

0.754

High

1069672

STK38
Serine/threonine-protein kinase 38

2

14

Small-scale

0.754

High

905286

1433G
14-3-3 protein gamma

8

20

High-throughput

0.753

High

910191

1433E
14-3-3 protein epsilon

7

14

Small-scale

0.750

High

647404

1433T
14-3-3 protein theta

6

20

High-throughput

0.735

High

927688

1433Z
14-3-3 protein zeta/delta

6

20

High-throughput

0.735

High

982646

1433F
14-3-3 protein eta

6

20

High-throughput

0.732

High

325947

LATS1
Serine/threonine-protein kinase LATS1

1

16

Small-scale

0.724

High

436763

GLI1
Zinc finger protein GLI1

1

1

Small-scale

0.724

High

647990

MARK3
MAP/microtubule affinity-regulating kinase 3

1

11

High-throughput

0.691

High

861996

PLK1
Serine/threonine-protein kinase PLK1

1

15

High-throughput

0.691

High

1037017

SQSTM
Sequestosome-1

1

4

High-throughput

0.691

High

1038949

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

4

High-throughput

0.691

High

684413

1433S
14-3-3 protein sigma

3

20

High-throughput

0.662

High

957801

XIAP
E3 ubiquitin-protein ligase XIAP

2

10

Small-scale

0.657

High

805494

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

1

16

Small-scale

0.647

High

808330

NEDD4
E3 ubiquitin-protein ligase NEDD4

2

10

High-throughput

0.619

High

170740

AXIN1
Axin-1

1

6

Small-scale

0.618

High

201478

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

7

Small-scale

0.618

High

229115

PRKN
E3 ubiquitin-protein ligase parkin

1

15

High-throughput

0.618

High

432386

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

438643

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

475248

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

13

High-throughput

0.618

High

800853

MK08
Mitogen-activated protein kinase 8

1

19

Small-scale

0.618

High

836106

GSK3B
Glycogen synthase kinase-3 beta

1

17

Small-scale

0.618

High

924221

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

12

High-throughput

0.618

High

924440

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

11

High-throughput

0.618

High

1344981

LATS2
Serine/threonine-protein kinase LATS2

1

14

Small-scale

0.618

High

1377226

ST38L
Serine/threonine-protein kinase 38-like

1

14

Small-scale

0.618

High

1377394

AXIN2
Axin-2

1

6

Small-scale

0.618

High

1163055

TRAF7
E3 ubiquitin-protein ligase TRAF7

3

6

High-throughput

0.609

High

1332945

SMYD3
Histone-lysine N-methyltransferase SMYD3

2

0

Small-scale

0.606

High

1357483

CHIP
E3 ubiquitin-protein ligase CHIP

1

8

Small-scale

0.596

High

1299665

NED4L
E3 ubiquitin-protein ligase NEDD4-like

2

11

Small-scale

0.595

High

1336125

SMUF1
E3 ubiquitin-protein ligase SMURF1

2

10

Small-scale

0.595

High

717455

CTNB1
Catenin beta-1

1

2

Small-scale

0.578

High

111436

J3QRB6
Mitogen-activated protein kinase kinase kinase 3

1

16

High-throughput

0.575

High

809043

YAP1
Transcriptional coactivator YAP1

1

16

Small-scale

0.561

High

1377415

NEMO
NF-kappa-B essential modulator

1

8

High-throughput

0.561

High

1342254

SH22A
SH2 domain-containing protein 2A

1

14

Small-scale

0.552

High

204761

E41L2
Band 4.1-like protein 2

1

2

High-throughput

0.536

High

211696

ACTN4
Alpha-actinin-4

1

3

High-throughput

0.536

High

304405

UBR5
E3 ubiquitin-protein ligase UBR5

1

14

High-throughput

0.536

High

627395

MCM3
DNA replication licensing factor MCM3

1

4

High-throughput

0.536

High

1242167

LS14A
Protein LSM14 homolog A

1

1

High-throughput

0.536

High

1377412

SGT1
Protein SGT1 homolog

1

5

High-throughput

0.536

High

598387

FLNA
Filamin-A

1

10

High-throughput

0.515

High

278570

SPF27
Pre-mRNA-splicing factor SPF27

1

0

High-throughput

0.513

High

679647

RIR2
Ribonucleoside-diphosphate reductase subunit M2

1

0

High-throughput

0.513

High

1377174

NCKP1
Nck-associated protein 1

1

0

High-throughput

0.513

High

271223

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

2

Small-scale

0.501

High

1036372

BIRC2
Baculoviral IAP repeat-containing protein 2

1

10

Small-scale

0.501

High

1294887

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

11

High-throughput

0.501

High

1030207

STX3
Syntaxin-3

1

1

High-throughput

0.489

High

1357068

COR1C
Coronin-1C

1

5

High-throughput

0.489

High

317778

STABP
STAM-binding protein

1

0

Small-scale

0.480

High

1080501

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.479

High

1300454

RAB3I
Rab-3A-interacting protein

1

2

High-throughput

0.479

High

1308737

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

1

Small-scale

0.479

High

1326796

WWTR1
WW domain-containing transcription regulator protein 1

1

16

Small-scale

0.479

High

1377156

FBW1A
F-box/WD repeat-containing protein 1A

1

8

Small-scale

0.479

High

1377413

CBY1
Protein chibby homolog 1

1

2

High-throughput

0.479

High

1264143

PIBF1
Progesterone-induced-blocking factor 1

1

0

High-throughput

0.460

High

1377414

TCAF1
TRPM8 channel-associated factor 1

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024