Protein: F263
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (6PF-2-K/Fru-2,6-P2ase 3) (PFK/FBPase 3) (6PF-2-K/Fru-2,6-P2ase brain/placenta-type isozyme) (Renal carcinoma antigen NY-REN-56) (iPFK-2) [Includes: 6-phosphofructo-2-kinase (EC 2.7.1.105); Fructose-2,6-bisphosphatase (EC 3.1.3.46)]

Gene: F263, PFKFB3
Organism: Homo sapiens
Interactions: 62
UniProt ID: Q16875

Gene Ontology (top 5):
GO:0003873 - 6-phosphofructo-2-kinase activity
GO:0004331 - fructose-2,6-bisphosphate 2-phosphatase activity
GO:0005524 - ATP binding
GO:0005654 - nucleoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1088419

F264
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 4

3

15

Small-scale

0.861

High

241693

F262
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2

2

15

High-throughput

0.811

High

555733

F261
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1

2

15

High-throughput

0.783

High

1088418

F263
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

1

14

Small-scale

0.647

High

338494

EGFR
Epidermal growth factor receptor

3

3

High-throughput

0.633

High

132159

PESC
Pescadillo homolog

2

0

High-throughput

0.602

High

646933

1433T
14-3-3 protein theta

2

18

High-throughput

0.601

High

683382

1433B
14-3-3 protein beta/alpha

2

18

High-throughput

0.601

High

904618

1433G
14-3-3 protein gamma

2

18

High-throughput

0.601

High

927095

1433Z
14-3-3 protein zeta/delta

2

18

High-throughput

0.601

High

982053

1433F
14-3-3 protein eta

2

18

High-throughput

0.601

High

256637

CLU
Clustered mitochondria protein homolog

2

1

High-throughput

0.574

High

508028

FGFR1
Fibroblast growth factor receptor 1

2

5

High-throughput

0.571

High

671666

PEBP1
Phosphatidylethanolamine-binding protein 1

2

1

High-throughput

0.571

High

1088426

SH3K1
SH3 domain-containing kinase-binding protein 1

2

2

High-throughput

0.571

High

1069849

PTPRR
Receptor-type tyrosine-protein phosphatase R

2

0

High-throughput

0.547

High

1071093

RBP1
RalA-binding protein 1

2

0

High-throughput

0.547

High

717129

CTNB1
Catenin beta-1

1

0

Small-scale

0.537

High

497118

TAU
Microtubule-associated protein tau

1

5

High-throughput

0.536

High

685972

ARRB2
Beta-arrestin-2

1

1

High-throughput

0.536

High

827216

ARRB1
Beta-arrestin-1

1

1

High-throughput

0.536

High

851515

NEK4
Serine/threonine-protein kinase Nek4

1

11

High-throughput

0.536

High

902919

DCAF7
DDB1- and CUL4-associated factor 7

1

1

High-throughput

0.536

High

1041342

CUL2
Cullin-2

1

3

High-throughput

0.515

High

1088436

BAG5
BAG family molecular chaperone regulator 5

1

0

High-throughput

0.513

High

566406

KPCA
Protein kinase C alpha type

1

6

Small-scale

0.501

High

681879

AKT1
RAC-alpha serine/threonine-protein kinase

1

9

Small-scale

0.501

High

724405

HXK4
Hexokinase-4

1

3

Small-scale

0.481

High

227602

PRKN
E3 ubiquitin-protein ligase parkin

1

8

High-throughput

0.479

High

233480

NUPR1
Nuclear protein 1

1

1

High-throughput

0.479

High

298554

UFL1
E3 UFM1-protein ligase 1

1

3

High-throughput

0.479

High

325755

LATS1
Serine/threonine-protein kinase LATS1

1

8

High-throughput

0.479

High

369712

ESR1
Estrogen receptor

1

4

High-throughput

0.479

High

757635

IF4A3
Eukaryotic initiation factor 4A-III

1

3

High-throughput

0.479

High

867874

HIRA
Protein HIRA

1

1

Small-scale

0.479

High

896113

UBC12
NEDD8-conjugating enzyme Ubc12

1

2

High-throughput

0.479

High

899503

MGN
Protein mago nashi homolog

1

1

High-throughput

0.479

High

908630

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

934817

H31
Histone H3.1

1

1

High-throughput

0.479

High

1088421

VIR
Protein virilizer homolog

1

2

High-throughput

0.479

High

1088424

UBP33
Ubiquitin carboxyl-terminal hydrolase 33

1

5

Small-scale

0.479

High

1088425

ASB12
Ankyrin repeat and SOCS box protein 12

1

3

High-throughput

0.479

High

1088427

TRI11
E3 ubiquitin-protein ligase TRIM11

1

1

Small-scale

0.479

High

1088428

SNX27
Sorting nexin-27

1

3

High-throughput

0.479

High

1088429

CIC
Protein capicua homolog

1

9

High-throughput

0.479

High

1088430

DNJC7
DnaJ homolog subfamily C member 7

1

4

High-throughput

0.479

High

1088431

ANM1
Protein arginine N-methyltransferase 1

1

3

High-throughput

0.479

High

1088432

TXNIP
Thioredoxin-interacting protein

1

7

Small-scale

0.479

High

1088433

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

2

High-throughput

0.479

High

1088434

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

1088435

UBQL2
Ubiquilin-2

1

1

High-throughput

0.479

High

1088437

FZR1
Fizzy-related protein homolog

1

3

High-throughput

0.479

High

296920

LTN1
E3 ubiquitin-protein ligase listerin

1

0

High-throughput

0.458

High

504156

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

1088422

WAPL
Wings apart-like protein homolog

1

0

High-throughput

0.458

High

111524

K7EIH8
DnaJ heat shock protein family

1

3

High-throughput

0.445

High

609308

FGFR3
Fibroblast growth factor receptor 3

1

5

High-throughput

0.445

High

1088420

CP135
Centrosomal protein of 135 kDa

1

3

High-throughput

0.445

High

242097

PAGE4
P antigen family member 4

1

2

High-throughput

0.437

High

1032439

CTBP1
C-terminal-binding protein 1

1

0

High-throughput

0.426

High

1088423

LRRT1
Leucine-rich repeat transmembrane neuronal protein 1

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024