Protein: PESC
Pescadillo homolog

Gene: PESC, PES1
Organism: Homo sapiens
Interactions: 207
UniProt ID: O00541

Gene Ontology (top 5):
GO:0000463 - maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000466 - maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003723 - RNA binding
GO:0005654 - nucleoplasm
GO:0005694 - chromosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

132144

BOP1
Ribosome biogenesis protein BOP1

9

3

Small-scale

0.972

High

132046

PESC
Pescadillo homolog

2

1

Small-scale

0.754

High

132213

WDR12
Ribosome biogenesis protein WDR12

9

4

Small-scale

0.754

High

132166

RL7L
Ribosomal protein uL30-like

5

2

Small-scale

0.718

High

132129

CSK21
Casein kinase II subunit alpha

4

4

High-throughput

0.704

High

132192

DDX27
Probable ATP-dependent RNA helicase DDX27

4

5

Small-scale

0.694

High

132074

MYC
Myc proto-oncogene protein

4

1

High-throughput

0.676

High

132183

NOC3L
Nucleolar complex protein 3 homolog

3

3

Small-scale

0.667

High

132158

IF16
Gamma-interferon-inducible protein 16

3

3

High-throughput

0.656

High

132066

BRD4
Bromodomain-containing protein 4

3

2

High-throughput

0.640

High

132112

MAGAA
Melanoma-associated antigen 10

3

0

High-throughput

0.638

High

132052

SET1A
Histone-lysine N-methyltransferase SETD1A

2

1

High-throughput

0.628

High

132054

NVL
Nuclear valosin-containing protein-like

2

2

High-throughput

0.628

High

132090

UBF1
Nucleolar transcription factor 1

2

1

High-throughput

0.628

High

132094

CSK22
Casein kinase II subunit alpha'

2

4

High-throughput

0.628

High

132098

BRD2
Bromodomain-containing protein 2

2

4

High-throughput

0.628

High

132185

KBTB7
Kelch repeat and BTB domain-containing protein 7

2

1

High-throughput

0.628

High

132194

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

2

1

High-throughput

0.628

High

132218

WDR55
WD repeat-containing protein 55

2

2

High-throughput

0.628

High

132087

PARP1
Poly [ADP-ribose] polymerase 1

1

2

High-throughput

0.618

High

132051

CASQ2
Calsequestrin-2

3

1

High-throughput

0.609

High

119885

AP3B1
AP-3 complex subunit beta-1

2

0

High-throughput

0.602

High

132055

TNC18
Trinucleotide repeat-containing gene 18 protein

2

0

High-throughput

0.602

High

132084

CENPB
Major centromere autoantigen B

2

0

High-throughput

0.602

High

132110

AF9
Protein AF-9

2

0

High-throughput

0.602

High

132136

TRI26
Tripartite motif-containing protein 26

2

0

High-throughput

0.602

High

132155

RNPS1
RNA-binding protein with serine-rich domain 1

2

0

High-throughput

0.602

High

132159

F263
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3

2

0

High-throughput

0.602

High

132172

CCD91
Coiled-coil domain-containing protein 91

2

0

High-throughput

0.602

High

132204

INP5K
Inositol polyphosphate 5-phosphatase K

2

0

High-throughput

0.602

High

132216

PININ
Pinin

2

0

High-throughput

0.602

High

132220

CWC22
Pre-mRNA-splicing factor CWC22 homolog

2

0

High-throughput

0.602

High

132231

CXXC1
CXXC-type zinc finger protein 1

2

0

High-throughput

0.602

High

132236

AFF4
AF4/FMR2 family member 4

2

0

High-throughput

0.602

High

132140

G3BP1
Ras GTPase-activating protein-binding protein 1

2

0

Small-scale

0.585

High

132125

RS6
Small ribosomal subunit protein eS6

2

1

High-throughput

0.584

High

132130

H31
Histone H3.1

2

2

High-throughput

0.584

High

132156

EZH2
Histone-lysine N-methyltransferase EZH2

2

1

High-throughput

0.584

High

132211

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

2

1

High-throughput

0.584

High

132075

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

132148

RRP1B
Ribosomal RNA processing protein 1 homolog B

2

1

Small-scale

0.571

High

132187

ESR2
Estrogen receptor beta

2

1

High-throughput

0.571

High

132062

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

132067

OBSL1
Obscurin-like protein 1

2

0

High-throughput

0.559

High

132108

CCNF
Cyclin-F

2

0

High-throughput

0.559

High

132223

ANLN
Anillin

2

0

High-throughput

0.559

High

132135

FOXM1
Forkhead box protein M1

1

1

High-throughput

0.554

High

132050

AIM2
Interferon-inducible protein AIM2

1

3

High-throughput

0.536

High

132070

NPM3
Nucleoplasmin-3

1

1

High-throughput

0.536

High

132083

NPM
Nucleophosmin

1

1

High-throughput

0.536

High

132109

MNDA
Myeloid cell nuclear differentiation antigen

1

3

High-throughput

0.536

High

132113

KI67
Proliferation marker protein Ki-67

1

2

High-throughput

0.536

High

132123

FOXL2
Forkhead box protein L2

1

1

High-throughput

0.536

High

132142

KRR1
KRR1 small subunit processome component homolog

1

1

High-throughput

0.536

High

132207

UT14A
U3 small nucleolar RNA-associated protein 14 homolog A

1

1

High-throughput

0.536

High

132222

TF7L2
Transcription factor 7-like 2

1

1

High-throughput

0.536

High

132234

NXF1
Nuclear RNA export factor 1

1

1

High-throughput

0.536

High

132242

DRG1
Developmentally-regulated GTP-binding protein 1

1

2

High-throughput

0.536

High

132103

ARRB2
Beta-arrestin-2

1

1

High-throughput

0.515

High

132118

ARRB1
Beta-arrestin-1

1

1

High-throughput

0.515

High

132240

BRPF3
Bromodomain and PHD finger-containing protein 3

1

2

High-throughput

0.515

High

132122

ATX1
Ataxin-1

1

1

High-throughput

0.515

High

132079

P53
Cellular tumor antigen p53

1

0

High-throughput

0.513

High

132095

LMNB1
Lamin-B1

1

0

High-throughput

0.513

High

132132

SRPK2
SRSF protein kinase 2

1

0

High-throughput

0.513

High

132143

CUL3
Cullin-3

1

0

High-throughput

0.513

High

132175

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.513

High

132177

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.513

High

132184

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

1

0

High-throughput

0.513

High

132197

XPO6
Exportin-6

1

0

High-throughput

0.513

High

132241

SRRM2
Serine/arginine repetitive matrix protein 2

1

0

High-throughput

0.513

High

132246

RL36
Large ribosomal subunit protein eL36

1

0

High-throughput

0.513

High

132188

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

1

High-throughput

0.501

High

132146

CAPR1
Caprin-1

1

0

High-throughput

0.493

High

132196

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.493

High

132238

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

High-throughput

0.493

High

132111

HD
Huntingtin

1

0

High-throughput

0.493

High

132081

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

124991

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

1

High-throughput

0.479

High

132047

NOP56
Nucleolar protein 56

1

1

High-throughput

0.479

High

132048

DDX3X
ATP-dependent RNA helicase DDX3X

1

1

Small-scale

0.479

High

132058

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

1

1

Small-scale

0.479

High

132061

BUB3
Mitotic checkpoint protein BUB3

1

1

Small-scale

0.479

High

132064

CC14B
Dual specificity protein phosphatase CDC14B

1

1

High-throughput

0.479

High

132065

DKC1
H/ACA ribonucleoprotein complex subunit DKC1

1

1

Small-scale

0.479

High

132069

PR40A
Pre-mRNA-processing factor 40 homolog A

1

2

Small-scale

0.479

High

132071

DNJC8
DnaJ homolog subfamily C member 8

1

2

High-throughput

0.479

High

132073

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

132077

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

132086

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

2

High-throughput

0.479

High

132091

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

132093

NUCL
Nucleolin

1

1

High-throughput

0.479

High

132097

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

1

High-throughput

0.479

High

132114

NOP2
Probable 28S rRNA

1

2

Small-scale

0.479

High

132115

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.479

High

132117

CDK8
Cyclin-dependent kinase 8

1

1

High-throughput

0.479

High

132119

CENPA
Histone H3-like centromeric protein A

1

2

High-throughput

0.479

High

132127

RS24
Small ribosomal subunit protein eS24

1

1

High-throughput

0.479

High

132128

RL31
Large ribosomal subunit protein eL31

1

1

High-throughput

0.479

High

132133

RED1
Double-stranded RNA-specific editase 1

1

2

High-throughput

0.479

High

132137

ILF3
Interleukin enhancer-binding factor 3

1

2

High-throughput

0.479

High

132139

TIF1B
Transcription intermediary factor 1-beta

1

1

High-throughput

0.479

High

132152

TNIP1
TNFAIP3-interacting protein 1

1

2

High-throughput

0.479

High

132153

RRS1
Ribosome biogenesis regulatory protein homolog

1

1

Small-scale

0.479

High

132154

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

132160

LARP7
La-related protein 7

1

2

High-throughput

0.479

High

132162

RRP12
RRP12-like protein

1

1

Small-scale

0.479

High

132163

HABP4
Intracellular hyaluronan-binding protein 4

1

1

High-throughput

0.479

High

132165

RC3H1
Roquin-1

1

1

High-throughput

0.479

High

132167

IFIX
Pyrin and HIN domain-containing protein 1

1

3

High-throughput

0.479

High

132170

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

2

Small-scale

0.479

High

132174

ZCH18
Zinc finger CCCH domain-containing protein 18

1

1

High-throughput

0.479

High

132176

SLX4
Structure-specific endonuclease subunit SLX4

1

1

High-throughput

0.479

High

132180

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

132181

BRX1
Ribosome biogenesis protein BRX1 homolog

1

5

Small-scale

0.479

High

132186

DNJC9
DnaJ homolog subfamily C member 9

1

2

High-throughput

0.479

High

132189

FBXW7
F-box/WD repeat-containing protein 7

1

1

High-throughput

0.479

High

132199

RING2
E3 ubiquitin-protein ligase RING2

1

1

High-throughput

0.479

High

132201

EBP2
Probable rRNA-processing protein EBP2

1

1

Small-scale

0.479

High

132203

RIOK1
Serine/threonine-protein kinase RIO1

1

1

High-throughput

0.479

High

132206

DDX23
Probable ATP-dependent RNA helicase DDX23

1

2

High-throughput

0.479

High

132209

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.479

High

132212

GTPB4
GTP-binding protein 4

1

4

Small-scale

0.479

High

132219

RC3H2
Roquin-2

1

1

High-throughput

0.479

High

132221

BRD7
Bromodomain-containing protein 7

1

3

High-throughput

0.479

High

132226

DCA13
DDB1- and CUL4-associated factor 13

1

1

Small-scale

0.479

High

132227

DDX18
ATP-dependent RNA helicase DDX18

1

6

Small-scale

0.479

High

132229

AATF
Protein AATF

1

1

High-throughput

0.479

High

132230

NOP53
Ribosome biogenesis protein NOP53

1

1

High-throughput

0.479

High

132233

RRBP1
Ribosome-binding protein 1

1

3

Small-scale

0.479

High

132239

MRT4
mRNA turnover protein 4 homolog

1

2

Small-scale

0.479

High

132245

NOC2L
Nucleolar complex protein 2 homolog

1

1

Small-scale

0.479

High

116731

KIF2A
Kinesin-like protein KIF2A

1

0

Small-scale

0.458

High

122356

MEN1
Menin

1

0

High-throughput

0.458

High

132049

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

132053

BET1
BET1 homolog

1

0

High-throughput

0.458

High

132056

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.458

High

132057

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.458

High

132059

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

132060

PRC1
Protein regulator of cytokinesis 1

1

0

High-throughput

0.458

High

132063

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

132068

DNJB6
DnaJ homolog subfamily B member 6

1

0

High-throughput

0.458

High

132072

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

132076

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

132085

LYN
Tyrosine-protein kinase Lyn

1

0

High-throughput

0.458

High

132088

TOP1
DNA topoisomerase 1

1

0

Small-scale

0.458

High

132089

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

132099

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

132100

APEX1
DNA repair nuclease/redox regulator APEX1

1

0

High-throughput

0.458

High

132101

PDIA3
Protein disulfide-isomerase A3

1

0

Small-scale

0.458

High

132102

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

132104

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

132105

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

132106

MYH9
Myosin-9

1

0

Small-scale

0.458

High

132116

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

132121

CDK7
Cyclin-dependent kinase 7

1

0

High-throughput

0.458

High

132124

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

132126

H4
Histone H4

1

0

High-throughput

0.458

High

132131

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

132134

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

132138

NFX1
Transcriptional repressor NF-X1

1

0

High-throughput

0.458

High

132141

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

132145

ELOA1
Elongin-A

1

0

Small-scale

0.458

High

132147

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

132149

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

0

High-throughput

0.458

High

132150

CUL7
Cullin-7

1

0

High-throughput

0.458

High

132151

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.458

High

132157

FSCN1
Fascin

1

0

High-throughput

0.458

High

132161

MIDN
Midnolin

1

0

High-throughput

0.458

High

132173

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

132178

CGAS
Cyclic GMP-AMP synthase

1

0

High-throughput

0.458

High

132182

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

132193

PRR11
Proline-rich protein 11

1

0

High-throughput

0.458

High

132195

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

132198

RANB9
Ran-binding protein 9

1

0

High-throughput

0.458

High

132200

POP1
Ribonucleases P/MRP protein subunit POP1

1

0

Small-scale

0.458

High

132202

MBB1A
Myb-binding protein 1A

1

0

Small-scale

0.458

High

132205

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

Small-scale

0.458

High

132210

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

132214

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

0

High-throughput

0.458

High

132225

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

0

High-throughput

0.458

High

132228

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

132232

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.458

High

132235

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

132237

MKRN1
E3 ubiquitin-protein ligase makorin-1

1

0

High-throughput

0.458

High

132244

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

132082

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

132080

H2A1B
Histone H2A type 1-B/E

1

1

High-throughput

0.437

High

132169

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

132171

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.437

High

132247

MAFB
Transcription factor MafB

1

1

High-throughput

0.437

High

132164

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

132120

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

132179

KLH23
Kelch-like protein 23

2

0

High-throughput

0.328

High

132190

ARK2N
Protein ARK2N

2

0

High-throughput

0.328

High

132215

MYLK2
Myosin light chain kinase 2, skeletal/cardiac muscle

2

0

High-throughput

0.298

High

132191

HDA11
Histone deacetylase 11

1

0

High-throughput

0.279

Low

132243

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

0

High-throughput

0.279

Low

132208

KLF16
Krueppel-like factor 16

1

0

High-throughput

0.261

Low

132078

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

132096

EPHA1
Ephrin type-A receptor 1

1

0

High-throughput

0.249

Low

132107

TRI23
E3 ubiquitin-protein ligase TRIM23

1

0

Small-scale

0.249

Low

132168

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

132217

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

132224

TLR9
Toll-like receptor 9

1

0

Small-scale

0.249

Low

132092

VCAM1
Vascular cell adhesion protein 1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024