Protein: DPTOR
DEP domain-containing mTOR-interacting protein (hDEPTOR) (DEP domain-containing protein 6)

Gene: DPTOR, DEPTOR
Organism: Homo sapiens
Interactions: 79
UniProt ID: Q8TB45

Gene Ontology (top 5):
GO:0004860 - protein kinase inhibitor activity
GO:0005765 - lysosomal membrane
GO:0006469 - negative regulation of protein kinase activity
GO:0010508 - positive regulation of autophagy
GO:0030291 - protein serine/threonine kinase inhibitor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

787530

MTOR
Serine/threonine-protein kinase mTOR

5

2

Small-scale

0.935

High

1252053

FBW1A
F-box/WD repeat-containing protein 1A

6

4

Small-scale

0.858

High

1229994

RPTOR
Regulatory-associated protein of mTOR

2

4

Small-scale

0.802

High

1252047

FBW1B
F-box/WD repeat-containing protein 11

4

4

Small-scale

0.781

High

1252041

LST8
Target of rapamycin complex subunit LST8

2

1

Small-scale

0.737

High

1023730

TRAF1
TNF receptor-associated factor 1

1

1

High-throughput

0.573

High

1135815

DCAF8
DDB1- and CUL4-associated factor 8

1

3

Small-scale

0.553

High

1252036

FBXW7
F-box/WD repeat-containing protein 7

1

4

Small-scale

0.553

High

599693

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

1

Small-scale

0.523

High

1163755

RICTR
Rapamycin-insensitive companion of mTOR

1

1

Small-scale

0.506

High

1073452

KS6A1
Ribosomal protein S6 kinase alpha-1

1

3

Small-scale

0.501

High

647633

MK03
Mitogen-activated protein kinase 3

1

0

Small-scale

0.480

High

533853

KAP2
cAMP-dependent protein kinase type II-alpha regulatory subunit

1

1

Small-scale

0.479

High

568739

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

4

Small-scale

0.479

High

983191

UBE3A
Ubiquitin-protein ligase E3A

1

1

Small-scale

0.479

High

1218227

MAPK5
MAP kinase-activated protein kinase 5

1

1

Small-scale

0.479

High

1252034

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

1

Small-scale

0.479

High

1252056

X5D778
Ankyrin repeat domain 11 isoform A

1

4

High-throughput

0.470

High

898974

PSME3
Proteasome activator complex subunit 3

1

1

High-throughput

0.464

High

231128

OPA1
Dynamin-like GTPase OPA1, mitochondrial

1

0

Small-scale

0.458

High

364367

TFR1
Transferrin receptor protein 1

1

0

Small-scale

0.458

High

383890

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

0

Small-scale

0.458

High

1036747

SQSTM
Sequestosome-1

1

0

Small-scale

0.458

High

1252044

PIM2
Serine/threonine-protein kinase pim-2

1

0

Small-scale

0.458

High

1252046

AKA11
A-kinase anchor protein 11

1

0

Small-scale

0.458

High

395277

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.457

High

616720

KS6B1
Ribosomal protein S6 kinase beta-1

1

5

Small-scale

0.457

High

1252035

CUL5
Cullin-5

1

2

Small-scale

0.457

High

1164764

ANR11
Ankyrin repeat domain-containing protein 11

1

4

High-throughput

0.439

High

117186

DX39A
ATP-dependent RNA helicase DDX39A

1

1

Small-scale

0.437

High

163030

XPO1
Exportin-1

1

2

High-throughput

0.437

High

304256

UBR5
E3 ubiquitin-protein ligase UBR5

1

2

Small-scale

0.437

High

311865

TRI16
Tripartite motif-containing protein 16

1

1

Small-scale

0.437

High

348812

RASN
GTPase NRas

1

3

High-throughput

0.437

High

509690

UBL4A
Ubiquitin-like protein 4A

1

2

Small-scale

0.437

High

803658

BAG6
Large proline-rich protein BAG6

1

2

Small-scale

0.437

High

832024

PSB3
Proteasome subunit beta type-3

1

2

Small-scale

0.437

High

833628

NUMB
Protein numb homolog

1

1

Small-scale

0.437

High

912241

LSM6
U6 snRNA-associated Sm-like protein LSm6

1

2

Small-scale

0.437

High

915243

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

2

Small-scale

0.437

High

986822

PSME1
Proteasome activator complex subunit 1

1

1

Small-scale

0.437

High

1041104

CUL1
Cullin-1

1

2

Small-scale

0.437

High

1081107

CCDC6
Coiled-coil domain-containing protein 6

1

2

Small-scale

0.437

High

1187678

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

2

Small-scale

0.437

High

1252037

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

1

Small-scale

0.437

High

1252039

ATX2
Ataxin-2

1

2

Small-scale

0.437

High

1252051

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

1

Small-scale

0.437

High

1252052

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

1

1

Small-scale

0.437

High

1252054

COPG1
Coatomer subunit gamma-1

1

1

Small-scale

0.437

High

1252031

CC110
Coiled-coil domain-containing protein 110

1

0

High-throughput

0.299

High

728576

CHKA
Choline kinase alpha

1

0

Small-scale

0.261

Low

1252030

LNX1
E3 ubiquitin-protein ligase LNX

1

0

Small-scale

0.261

Low

1252032

FBX25
F-box only protein 25

1

0

Small-scale

0.261

Low

1252033

TRI41
E3 ubiquitin-protein ligase TRIM41

1

0

High-throughput

0.251

Low

116878

KIF2A
Kinesin-like protein KIF2A

1

0

Small-scale

0.249

Low

117770

MYO1C
Unconventional myosin-Ic

1

0

Small-scale

0.249

Low

136192

SCD
Stearoyl-CoA desaturase

1

0

Small-scale

0.249

Low

270680

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

0

Small-scale

0.249

Low

306473

NDUB4
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4

1

0

Small-scale

0.249

Low

451933

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

0

Small-scale

0.249

Low

574715

ARF4
ADP-ribosylation factor 4

1

0

Small-scale

0.249

Low

682373

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

0

Small-scale

0.249

Low

782809

CSK
Tyrosine-protein kinase CSK

1

0

Small-scale

0.249

Low

814999

LEG7
Galectin-7

1

0

Small-scale

0.249

Low

957812

RHG04
Rho GTPase-activating protein 4

1

0

Small-scale

0.249

Low

1017180

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

Small-scale

0.249

Low

1045088

LAMB3
Laminin subunit beta-3

1

0

Small-scale

0.249

Low

1049276

KEAP1
Kelch-like ECH-associated protein 1

1

0

Small-scale

0.249

Low

1088569

MIC60
MICOS complex subunit MIC60

1

0

Small-scale

0.249

Low

1139845

OBI1
ORC ubiquitin ligase 1

1

0

Small-scale

0.249

Low

1252038

OTUB1
Ubiquitin thioesterase OTUB1

1

0

Small-scale

0.249

Low

1252040

RN126
E3 ubiquitin-protein ligase RNF126

1

0

Small-scale

0.249

Low

1252042

EI2BG
Translation initiation factor eIF2B subunit gamma

1

0

Small-scale

0.249

Low

1252043

ERAP1
Endoplasmic reticulum aminopeptidase 1

1

0

Small-scale

0.249

Low

1252045

EIF3K
Eukaryotic translation initiation factor 3 subunit K

1

0

Small-scale

0.249

Low

1252048

AGO2
Protein argonaute-2

1

0

Small-scale

0.249

Low

1252049

SYNRG
Synergin gamma

1

0

Small-scale

0.249

Low

1252050

MAGD2
Melanoma-associated antigen D2

1

0

Small-scale

0.249

Low

1252055

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024