Protein: DUS4
Dual specificity protein phosphatase 4 (EC 3.1.3.16) (EC 3.1.3.48) (Dual specificity protein phosphatase hVH2) (Mitogen-activated protein kinase phosphatase 2) (MAP kinase phosphatase 2) (MKP-2)

Gene: DUS4, DUSP4
Organism: Homo sapiens
Interactions: 112
UniProt ID: Q13115

Gene Ontology (top 5):
GO:0001706 - endoderm formation
GO:0004725 - protein tyrosine phosphatase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

658919

MK01
Mitogen-activated protein kinase 1

9

20

Small-scale

0.966

High

647563

MK03
Mitogen-activated protein kinase 3

4

20

Small-scale

0.882

High

800767

MK08
Mitogen-activated protein kinase 8

4

20

Small-scale

0.878

High

1024807

MK14
Mitogen-activated protein kinase 14

4

20

Small-scale

0.878

High

800878

MK09
Mitogen-activated protein kinase 9

3

20

High-throughput

0.843

High

1024799

DUS4
Dual specificity protein phosphatase 4

2

15

High-throughput

0.754

High

518645

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

2

1

High-throughput

0.737

High

1024822

DC2I2
Cytoplasmic dynein 2 intermediate chain 2

3

1

High-throughput

0.656

High

121745

PSD11
26S proteasome non-ATPase regulatory subunit 11

3

1

High-throughput

0.633

High

572940

PRS6A
26S proteasome regulatory subunit 6A

3

8

High-throughput

0.633

High

907007

PRS8
26S proteasome regulatory subunit 8

3

6

High-throughput

0.633

High

913253

PRS10
26S proteasome regulatory subunit 10B

3

6

High-throughput

0.633

High

854724

MP2K6
Dual specificity mitogen-activated protein kinase kinase 6

1

8

High-throughput

0.618

High

1024845

DS13B
Dual specificity protein phosphatase 13B

1

15

High-throughput

0.618

High

1024850

DUS12
Dual specificity protein phosphatase 12

1

15

High-throughput

0.618

High

1023646

TRAF1
TNF receptor-associated factor 1

2

3

High-throughput

0.606

High

1024816

ZN655
Zinc finger protein 655

2

1

High-throughput

0.606

High

1024827

LYSM1
LysM and putative peptidoglycan-binding domain-containing protein 1

2

1

High-throughput

0.606

High

1024833

ZN426
Zinc finger protein 426

2

1

High-throughput

0.606

High

1024847

NUP50
Nuclear pore complex protein Nup50

2

2

High-throughput

0.584

High

1024851

TNPO3
Transportin-3

2

9

High-throughput

0.584

High

1024825

AP4AT
AP-4 complex accessory subunit Tepsin

2

0

High-throughput

0.580

High

117683

MYO1C
Unconventional myosin-Ic

2

14

High-throughput

0.571

High

130870

PSDE
26S proteasome non-ATPase regulatory subunit 14

2

3

High-throughput

0.571

High

198612

PSMD3
26S proteasome non-ATPase regulatory subunit 3

2

1

High-throughput

0.571

High

214566

MYO1B
Unconventional myosin-Ib

2

15

High-throughput

0.571

High

388408

HSPB1
Heat shock protein beta-1

2

6

High-throughput

0.571

High

391386

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

2

16

High-throughput

0.571

High

433737

LYN
Tyrosine-protein kinase Lyn

2

7

High-throughput

0.571

High

502039

BIP
Endoplasmic reticulum chaperone BiP

2

6

High-throughput

0.571

High

542302

PLAK
Junction plakoglobin

2

4

High-throughput

0.571

High

551686

DESP
Desmoplakin

2

7

High-throughput

0.571

High

653239

PYR1
Multifunctional protein CAD

2

2

High-throughput

0.571

High

657598

ITPI2
Protein ITPRID2

2

1

High-throughput

0.571

High

730245

PRS7
26S proteasome regulatory subunit 7

2

5

High-throughput

0.571

High

798647

PRS6B
26S proteasome regulatory subunit 6B

2

4

High-throughput

0.571

High

849191

PSMD7
26S proteasome non-ATPase regulatory subunit 7

2

1

High-throughput

0.571

High

896881

ARP2
Actin-related protein 2

2

14

High-throughput

0.571

High

921545

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

2

2

High-throughput

0.571

High

983477

PTN12
Tyrosine-protein phosphatase non-receptor type 12

2

7

High-throughput

0.571

High

1024800

SRSF6
Serine/arginine-rich splicing factor 6

2

8

High-throughput

0.571

High

1024804

PLEC
Plectin

2

3

High-throughput

0.571

High

1024805

SF3A1
Splicing factor 3A subunit 1

2

1

High-throughput

0.571

High

1024808

DREB
Drebrin

2

4

High-throughput

0.571

High

1024815

CCAR2
Cell cycle and apoptosis regulator protein 2

2

2

High-throughput

0.571

High

1024819

HS105
Heat shock protein 105 kDa

2

9

High-throughput

0.571

High

1024831

PKP2
Plakophilin-2

2

2

High-throughput

0.571

High

1024837

GBB4
Guanine nucleotide-binding protein subunit beta-4

2

2

High-throughput

0.571

High

1024838

GID8
Glucose-induced degradation protein 8 homolog

2

4

High-throughput

0.571

High

1024841

TECR
Very-long-chain enoyl-CoA reductase

2

2

High-throughput

0.571

High

1024842

SYLC
Leucine--tRNA ligase, cytoplasmic

2

3

High-throughput

0.571

High

1024849

G3BP2
Ras GTPase-activating protein-binding protein 2

2

2

High-throughput

0.571

High

1024813

LYSM2
LysM and putative peptidoglycan-binding domain-containing protein 2

2

1

High-throughput

0.553

High

1024832

LZTS2
Leucine zipper putative tumor suppressor 2

2

8

High-throughput

0.553

High

1024835

PKHF2
Pleckstrin homology domain-containing family F member 2

2

1

High-throughput

0.553

High

1024836

GORS2
Golgi reassembly-stacking protein 2

2

2

High-throughput

0.553

High

1024801

DX39B
Spliceosome RNA helicase DDX39B

2

0

High-throughput

0.547

High

1024806

ADRM1
Proteasomal ubiquitin receptor ADRM1

2

0

High-throughput

0.547

High

1024839

LYAR
Cell growth-regulating nucleolar protein

2

0

High-throughput

0.547

High

1024820

EFMT3
EEF1A lysine methyltransferase 3

1

1

High-throughput

0.536

High

1024846

HSPB8
Heat shock protein beta-8

1

6

High-throughput

0.536

High

388026

AMYP
Pancreatic alpha-amylase

2

6

High-throughput

0.521

High

588390

AMY2B
Alpha-amylase 2B

2

2

High-throughput

0.521

High

643855

SYVC
Valine--tRNA ligase

2

3

High-throughput

0.521

High

716669

CTNA1
Catenin alpha-1

2

2

High-throughput

0.521

High

1024802

DSG2
Desmoglein-2

2

3

High-throughput

0.521

High

1024840

TMOD3
Tropomodulin-3

2

3

High-throughput

0.521

High

1024843

GBG12

2

1

High-throughput

0.521

High

1024848

COR1C
Coronin-1C

2

4

High-throughput

0.521

High

394638

A4
Amyloid-beta precursor protein

1

5

High-throughput

0.501

High

117395

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

2

High-throughput

0.479

High

499723

CH60
60 kDa heat shock protein, mitochondrial

1

6

High-throughput

0.479

High

637403

PSA1
Proteasome subunit alpha type-1

1

1

High-throughput

0.479

High

637677

PSA2
Proteasome subunit alpha type-2

1

2

High-throughput

0.479

High

656453

PSB4
Proteasome subunit beta type-4

1

2

High-throughput

0.479

High

656706

PSB5
Proteasome subunit beta type-5

1

1

High-throughput

0.479

High

670697

PRDX6
Peroxiredoxin-6

1

3

High-throughput

0.479

High

670828

PRDX5
Peroxiredoxin-5, mitochondrial

1

3

High-throughput

0.479

High

785533

ACTY
Beta-centractin

1

17

High-throughput

0.479

High

789770

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

10

High-throughput

0.479

High

850024

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

7

High-throughput

0.479

High

868467

ATX1
Ataxin-1

1

5

Small-scale

0.479

High

923662

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

3

High-throughput

0.479

High

932507

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

2

High-throughput

0.479

High

1024809

RN187
E3 ubiquitin-protein ligase RNF187

1

2

High-throughput

0.479

High

1024817

NUD10
Diphosphoinositol polyphosphate phosphohydrolase 3-alpha

1

2

High-throughput

0.479

High

1024821

COA7
Cytochrome c oxidase assembly factor 7

1

1

High-throughput

0.479

High

1024823

ABHEB
Putative protein-lysine deacylase ABHD14B

1

2

High-throughput

0.479

High

1024824

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

1

8

High-throughput

0.479

High

1024826

QKI
KH domain-containing RNA-binding protein QKI

1

3

High-throughput

0.479

High

1024828

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

5

High-throughput

0.479

High

1024829

PARK7
Parkinson disease protein 7

1

5

High-throughput

0.479

High

1024834

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

2

High-throughput

0.479

High

1024852

MTCH2
Mitochondrial carrier homolog 2

1

5

High-throughput

0.479

High

1024803

DPYL1
Dihydropyrimidinase-related protein 1

1

2

High-throughput

0.464

High

637868

PSA3
Proteasome subunit alpha type-3

1

0

High-throughput

0.458

High

737085

8ODP
Oxidized purine nucleoside triphosphate hydrolase

1

0

High-throughput

0.458

High

1024811

NXN
Nucleoredoxin

1

0

High-throughput

0.458

High

1024810

H37
Histone H3-7

1

1

High-throughput

0.445

High

585962

SPEE
Spermidine synthase

1

5

High-throughput

0.437

High

677950

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

1

High-throughput

0.437

High

849097

DHB4
Peroxisomal multifunctional enzyme type 2

1

3

High-throughput

0.437

High

1024818

AP3S1
AP-3 complex subunit sigma-1

1

7

High-throughput

0.437

High

1024844

VPS29
Vacuolar protein sorting-associated protein 29

1

1

High-throughput

0.437

High

484819

AMY1B
Alpha-amylase 1B

1

2

High-throughput

0.407

High

1024812

NOXA1
NADPH oxidase activator 1

2

0

High-throughput

0.316

High

363514

FETUA
Alpha-2-HS-glycoprotein

2

0

High-throughput

0.298

High

534184

CD59
CD59 glycoprotein

2

0

High-throughput

0.298

High

560130

EPCAM
Epithelial cell adhesion molecule

2

0

High-throughput

0.298

High

1024814

MISP
Mitotic interactor and substrate of PLK1

2

0

High-throughput

0.298

High

1024830

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024