HitPredict

Interactor 1: MYO1C (O00159)
Unconventional myosin-Ic (Myosin I beta) (MMI-beta) (MMIb)
Gene: MYO1C

Interactor 2: DEST (P60981)
Destrin (Actin-depolymerizing factor) (ADF)
Gene: DSTN

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	26496610
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005737 - cytoplasm GO:0015629 - actin cytoskeleton GO:0051015 - actin filament binding GO:0070062 - extracellular exosome
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1063 Hs			1 165
+	Hs
		117589 MYO1C_HUMAN (1-1063): 0: 1215: 100.00		COF1_HUMAN (1-165): 5.13e-70: 210: 71.08
+	Hs
		117865 MYO1C_HUMAN (1-1063): 0: 1215: 100.00		COF2_HUMAN (1-165): 4.17e-70: 210: 68.68
+	Hs
		117679 MYO1C_HUMAN (1-1063): 0: 1215: 100.00		TWF1_HUMAN (3-152): 1.54e-37: 133: 20.26
+	Hs
		117729 MYO1C_HUMAN (1-1063): 0: 1215: 100.00		TWF2_HUMAN (3-152): 3.92e-31: 116: 18.30
+	Hs
		724739 MYH9_HUMAN (5-974): 0: 994: 29.37		DEST_HUMAN (1-165): 6.05e-74: 220: 100.00
+	Hs
		618006 MYH9_HUMAN (5-974): 0: 994: 29.37		COF1_HUMAN (1-165): 5.13e-70: 210: 71.08
+	Hs
		725077 MYH9_HUMAN (5-974): 0: 994: 29.37		COF2_HUMAN (1-165): 4.17e-70: 210: 68.68
+	Hs
		724797 MYH9_HUMAN (5-974): 0: 994: 29.37		TWF1_HUMAN (3-152): 1.54e-37: 133: 20.26
+	Hs
		724875 MYH9_HUMAN (5-974): 0: 994: 29.37		TWF2_HUMAN (3-152): 3.92e-31: 116: 18.30