Protein: MYPT1
Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit)

Gene: MYPT1, PPP1R12A
Organism: Homo sapiens
Interactions: 233
UniProt ID: O14974

Gene Ontology (top 5):
GO:0000278 - mitotic cell cycle
GO:0000776 - kinetochore
GO:0001725 - stress fiber
GO:0004857 - enzyme inhibitor activity
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

161449

NUAK2
NUAK family SNF1-like kinase 2

3

6

High-throughput

0.871

High

161333

CDK8
Cyclin-dependent kinase 8

3

10

High-throughput

0.861

High

161337

PLK1
Serine/threonine-protein kinase PLK1

2

10

Small-scale

0.819

High

161260

NUAK1
NUAK family SNF1-like kinase 1

2

7

Small-scale

0.789

High

161277

CHK2
Serine/threonine-protein kinase Chk2

1

8

Small-scale

0.747

High

161361

DMPK
Myotonin-protein kinase

2

4

Small-scale

0.738

High

161348

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

5

20

Small-scale

0.727

High

161275

LATS1
Serine/threonine-protein kinase LATS1

1

10

Small-scale

0.724

High

161258

MYPT2
Protein phosphatase 1 regulatory subunit 12B

1

18

High-throughput

0.715

High

161444

UACA
Uveal autoantigen with coiled-coil domains and ankyrin repeats

1

19

High-throughput

0.715

High

161445

PP12C
Protein phosphatase 1 regulatory subunit 12C

1

18

High-throughput

0.715

High

161466

RAI14
Ankycorbin

1

20

High-throughput

0.715

High

154096

CHK1
Serine/threonine-protein kinase Chk1

1

0

Small-scale

0.708

High

161263

CC14B
Dual specificity protein phosphatase CDC14B

1

17

High-throughput

0.691

High

161308

CDK2
Cyclin-dependent kinase 2

1

2

High-throughput

0.691

High

161327

CRK
Adapter molecule crk

1

10

High-throughput

0.691

High

161330

CAZA2
F-actin-capping protein subunit alpha-2

1

2

High-throughput

0.691

High

161331

CAPZB
F-actin-capping protein subunit beta

1

3

High-throughput

0.691

High

161342

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.691

High

161372

SRC8
Src substrate cortactin

1

20

High-throughput

0.691

High

161475

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

1

11

High-throughput

0.691

High

161254

DAPK3
Death-associated protein kinase 3

1

7

Small-scale

0.690

High

161265

FKBP6
Inactive peptidyl-prolyl cis-trans isomerase FKBP6

3

12

High-throughput

0.667

High

161442

PHF7
PHD finger protein 7

3

1

High-throughput

0.667

High

161461

ANLN
Anillin

3

4

High-throughput

0.656

High

161346

1433G
14-3-3 protein gamma

3

20

High-throughput

0.650

High

161359

1433F
14-3-3 protein eta

3

20

High-throughput

0.650

High

161289

CDK1
Cyclin-dependent kinase 1

1

2

Small-scale

0.647

High

161362

PTPRJ
Receptor-type tyrosine-protein phosphatase eta

1

9

High-throughput

0.647

High

161370

KGP1
cGMP-dependent protein kinase 1

1

14

Small-scale

0.647

High

161468

ATX10
Ataxin-10

3

0

Small-scale

0.636

High

161252

ZN263
Zinc finger protein 263

2

20

High-throughput

0.628

High

161268

TULP3
Tubby-related protein 3

2

3

High-throughput

0.628

High

161285

PAI2
Plasminogen activator inhibitor 2

2

6

High-throughput

0.628

High

161303

JUNB
Transcription factor JunB

2

7

High-throughput

0.628

High

161395

3BP5L
SH3 domain-binding protein 5-like

2

4

High-throughput

0.628

High

161418

ANR49
Ankyrin repeat domain-containing protein 49

1

20

High-throughput

0.618

High

161473

ANR50
Ankyrin repeat domain-containing protein 50

1

18

High-throughput

0.618

High

148138

CTRO
Citron Rho-interacting kinase

1

7

High-throughput

0.618

High

161270

RECQ4
ATP-dependent DNA helicase Q4

1

10

High-throughput

0.618

High

161282

P53
Cellular tumor antigen p53

1

7

Small-scale

0.618

High

161288

FYN
Tyrosine-protein kinase Fyn

1

10

High-throughput

0.618

High

161301

VAV
Proto-oncogene vav

1

7

High-throughput

0.618

High

161326

RECQ1
ATP-dependent DNA helicase Q1

1

8

High-throughput

0.618

High

161334

CDK9
Cyclin-dependent kinase 9

1

10

High-throughput

0.618

High

161336

NEK2
Serine/threonine-protein kinase Nek2

1

9

Small-scale

0.618

High

161350

RAN
GTP-binding nuclear protein Ran

1

13

Small-scale

0.618

High

161367

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

10

High-throughput

0.618

High

161369

DX39B
Spliceosome RNA helicase DDX39B

1

4

High-throughput

0.618

High

161376

MYLK
Myosin light chain kinase, smooth muscle

1

12

High-throughput

0.618

High

161380

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

6

Small-scale

0.618

High

161393

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

161421

TRIB2
Tribbles homolog 2

1

5

Small-scale

0.618

High

161431

AURKB
Aurora kinase B

1

6

Small-scale

0.618

High

161438

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

7

High-throughput

0.618

High

161443

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

7

High-throughput

0.618

High

161452

SIK2
Serine/threonine-protein kinase SIK2

1

4

Small-scale

0.618

High

161477

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

1

7

High-throughput

0.618

High

161278

FOS
Protein c-Fos

2

14

High-throughput

0.611

High

161459

SP110
Sp110 nuclear body protein

2

11

High-throughput

0.611

High

161297

CFTR
Cystic fibrosis transmembrane conductance regulator

2

1

High-throughput

0.601

High

161302

RFA2
Replication protein A 32 kDa subunit

2

2

High-throughput

0.584

High

161310

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

3

High-throughput

0.584

High

161318

RFA3
Replication protein A 14 kDa subunit

2

2

High-throughput

0.584

High

161322

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

2

20

Small-scale

0.584

High

161323

CCNF
Cyclin-F

2

7

High-throughput

0.584

High

161349

1433E
14-3-3 protein epsilon

2

6

Small-scale

0.584

High

161261

KDM1A
Lysine-specific histone demethylase 1A

1

4

Small-scale

0.578

High

161293

CALM3
Calmodulin-3

1

1

High-throughput

0.575

High

161345

RHOA
Transforming protein RhoA

1

20

Small-scale

0.575

High

161352

GRB2
Growth factor receptor-bound protein 2

1

14

High-throughput

0.575

High

161397

TLK2
Serine/threonine-protein kinase tousled-like 2

1

9

High-throughput

0.575

High

161371

IL16
Pro-interleukin-16 [Cleaved into: Interleukin-16

1

20

Small-scale

0.573

High

161280

ESR1
Estrogen receptor

2

18

High-throughput

0.571

High

161347

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

2

20

High-throughput

0.571

High

161353

1433Z
14-3-3 protein zeta/delta

2

20

Small-scale

0.571

High

161382

SYDE2
Rho GTPase-activating protein SYDE2

2

13

High-throughput

0.571

High

161385

FTM
Protein fantom

2

15

High-throughput

0.571

High

161391

MPRIP
Myosin phosphatase Rho-interacting protein

2

19

Small-scale

0.571

High

161453

TARA
TRIO and F-actin-binding protein

1

20

High-throughput

0.554

High

161253

SIAH2
E3 ubiquitin-protein ligase SIAH2

1

5

Small-scale

0.552

High

117511

MYO1C
Unconventional myosin-Ic

1

10

High-throughput

0.536

High

152817

TRDMT
tRNA

1

1

High-throughput

0.536

High

161256

ACTN4
Alpha-actinin-4

1

14

High-throughput

0.536

High

161266

TP4A3
Protein tyrosine phosphatase type IVA 3

1

15

High-throughput

0.536

High

161267

SH3L1
Adapter SH3BGRL

1

2

High-throughput

0.536

High

161269

TRPM2
Transient receptor potential cation channel subfamily M member 2

1

1

High-throughput

0.536

High

161274

BAG2
BAG family molecular chaperone regulator 2

1

4

High-throughput

0.536

High

161306

FLNA
Filamin-A

1

16

High-throughput

0.536

High

161314

ARRB2
Beta-arrestin-2

1

1

High-throughput

0.536

High

161319

MYH9
Myosin-9

1

5

High-throughput

0.536

High

161321

AHR
Aryl hydrocarbon receptor

1

2

High-throughput

0.536

High

161329

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

10

High-throughput

0.536

High

161338

CLH2
Clathrin heavy chain 2

1

3

High-throughput

0.536

High

161339

HAP1
Huntingtin-associated protein 1

1

7

High-throughput

0.536

High

161340

HSP72
Heat shock-related 70 kDa protein 2

1

12

High-throughput

0.536

High

161343

ARP2
Actin-related protein 2

1

7

High-throughput

0.536

High

161351

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

4

High-throughput

0.536

High

161354

DYL1
Dynein light chain 1, cytoplasmic

1

1

High-throughput

0.536

High

161360

CALD1
Caldesmon

1

20

High-throughput

0.536

High

161363

MALL
MAL-like protein

1

1

High-throughput

0.536

High

161366

SMAD4
Mothers against decapentaplegic homolog 4

1

5

High-throughput

0.536

High

161375

MARE1
Microtubule-associated protein RP/EB family member 1

1

3

High-throughput

0.536

High

161377

DREB
Drebrin

1

6

High-throughput

0.536

High

161387

CYTSA
Cytospin-A

1

16

High-throughput

0.536

High

161396

MILR1
Allergin-1

1

7

High-throughput

0.536

High

161401

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1

3

High-throughput

0.536

High

161402

SYNPO
Synaptopodin

1

10

High-throughput

0.536

High

161403

RYBP
RING1 and YY1-binding protein

1

4

High-throughput

0.536

High

161404

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

20

High-throughput

0.536

High

161406

POC1A
POC1 centriolar protein homolog A

1

6

High-throughput

0.536

High

161409

BBS1
Bardet-Biedl syndrome 1 protein

1

1

High-throughput

0.536

High

161419

PSPC1
Paraspeckle component 1

1

2

High-throughput

0.536

High

161420

JPH3
Junctophilin-3

1

5

High-throughput

0.536

High

161423

MY18A
Unconventional myosin-XVIIIa

1

11

High-throughput

0.536

High

161424

PGTA
Geranylgeranyl transferase type-2 subunit alpha

1

9

High-throughput

0.536

High

161425

THRSP
Thyroid hormone-inducible hepatic protein

1

1

High-throughput

0.536

High

161432

MYO19
Unconventional myosin-XIX

1

7

High-throughput

0.536

High

161462

MYO5C
Unconventional myosin-Vc

1

3

High-throughput

0.536

High

161470

GABR1
Gamma-aminobutyric acid type B receptor subunit 1

1

2

High-throughput

0.536

High

161478

WIF1
Wnt inhibitory factor 1

1

15

High-throughput

0.536

High

161464

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

19

Small-scale

0.516

High

161283

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

2

High-throughput

0.515

High

161300

ENPL
Endoplasmin

1

14

High-throughput

0.515

High

161299

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.513

High

161304

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.513

High

161320

DDIT3
DNA damage-inducible transcript 3 protein

1

0

High-throughput

0.513

High

161325

KPB2
Phosphorylase b kinase regulatory subunit alpha, liver isoform

1

0

High-throughput

0.513

High

161356

CXCL6
C-X-C motif chemokine 6

1

0

High-throughput

0.513

High

161413

HASP
Serine/threonine-protein kinase haspin

1

0

High-throughput

0.513

High

161456

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.513

High

161460

OSGEP
tRNA N6-adenosine threonylcarbamoyltransferase

1

0

High-throughput

0.513

High

161463

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.513

High

161479

RM42
Large ribosomal subunit protein mL42

1

0

High-throughput

0.513

High

161414

SETD7
Histone-lysine N-methyltransferase SETD7

1

5

Small-scale

0.501

High

161428

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

4

High-throughput

0.501

High

161390

CORO6
Coronin-6

1

9

High-throughput

0.489

High

161433

IMP1L
Mitochondrial inner membrane protease subunit 1

1

5

High-throughput

0.489

High

161435

IMP2L
Mitochondrial inner membrane protease subunit 2

1

5

High-throughput

0.489

High

161439

SOST
Sclerostin

1

2

High-throughput

0.489

High

161458

MAGF1
Melanoma-associated antigen F1

1

9

High-throughput

0.489

High

161378

CDKN3
Cyclin-dependent kinase inhibitor 3

1

0

Small-scale

0.480

High

161255

PRC1
Protein regulator of cytokinesis 1

1

7

High-throughput

0.479

High

161257

SPOP
Speckle-type POZ protein

1

3

Small-scale

0.479

High

161259

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.479

High

161271

KI20A
Kinesin-like protein KIF20A

1

14

High-throughput

0.479

High

161272

FMNL1
Formin-like protein 1

1

3

Small-scale

0.479

High

161273

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

5

High-throughput

0.479

High

161279

MYC
Myc proto-oncogene protein

1

8

High-throughput

0.479

High

161281

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.479

High

161286

ISG15
Ubiquitin-like protein ISG15

1

9

High-throughput

0.479

High

161290

ENOA
Alpha-enolase

1

3

High-throughput

0.479

High

161291

NFM
Neurofilament medium polypeptide

1

14

High-throughput

0.479

High

161292

F16P1
Fructose-1,6-bisphosphatase 1

1

1

High-throughput

0.479

High

161295

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

1

5

High-throughput

0.479

High

161296

HSP7C
Heat shock cognate 71 kDa protein

1

12

High-throughput

0.479

High

161298

EF2
Elongation factor 2

1

2

High-throughput

0.479

High

161305

BTF3
Transcription factor BTF3

1

3

High-throughput

0.479

High

161309

1433T
14-3-3 protein theta

1

20

High-throughput

0.479

High

161311

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

17

High-throughput

0.479

High

161312

1433B
14-3-3 protein beta/alpha

1

20

High-throughput

0.479

High

161313

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

161316

CTNB1
Catenin beta-1

1

10

High-throughput

0.479

High

161324

CASR
Extracellular calcium-sensing receptor

1

2

Small-scale

0.479

High

161328

YAP1
Transcriptional coactivator YAP1

1

11

High-throughput

0.479

High

161332

SOX2
Transcription factor SOX-2

1

4

High-throughput

0.479

High

161335

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

7

High-throughput

0.479

High

161341

ACTB
Actin, cytoplasmic 1

1

5

High-throughput

0.479

High

161355

UB2L3
Ubiquitin-conjugating enzyme E2 L3

1

5

High-throughput

0.479

High

161357

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

7

High-throughput

0.479

High

161358

KIF23
Kinesin-like protein KIF23

1

7

High-throughput

0.479

High

161373

TNIP1
TNFAIP3-interacting protein 1

1

20

High-throughput

0.479

High

161374

KIF14
Kinesin-like protein KIF14

1

10

High-throughput

0.479

High

161379

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

3

High-throughput

0.479

High

161384

A16L1
Autophagy-related protein 16-1

1

13

High-throughput

0.479

High

161386

VIR
Protein virilizer homolog

1

2

High-throughput

0.479

High

161389

RHGBA
Rho GTPase-activating protein 11A

1

13

High-throughput

0.479

High

161392

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

15

High-throughput

0.479

High

161394

PAXI1
PAX-interacting protein 1

1

7

High-throughput

0.479

High

161398

NAA40
N-alpha-acetyltransferase 40

1

3

High-throughput

0.479

High

161399

ARHGP
Rho guanine nucleotide exchange factor 25

1

8

High-throughput

0.479

High

161400

RHG24
Rho GTPase-activating protein 24

1

13

High-throughput

0.479

High

161408

FBX22
F-box only protein 22

1

3

High-throughput

0.479

High

161411

RBCC1
RB1-inducible coiled-coil protein 1

1

17

Small-scale

0.479

High

161415

HDAC7
Histone deacetylase 7

1

9

Small-scale

0.479

High

161416

RN138
E3 ubiquitin-protein ligase RNF138

1

13

High-throughput

0.479

High

161422

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

10

High-throughput

0.479

High

161429

CHM4C
Charged multivesicular body protein 4c

1

3

High-throughput

0.479

High

161447

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

8

High-throughput

0.479

High

161448

WWTR1
WW domain-containing transcription regulator protein 1

1

11

High-throughput

0.479

High

161450

TOLIP
Toll-interacting protein

1

1

High-throughput

0.479

High

161451

RNF38
E3 ubiquitin-protein ligase RNF38

1

4

Small-scale

0.479

High

161454

CHM4B
Charged multivesicular body protein 4b

1

3

High-throughput

0.479

High

161455

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

161457

ECT2
Protein ECT2

1

12

High-throughput

0.479

High

161465

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

161469

HDAC6
Histone deacetylase 6

1

9

High-throughput

0.479

High

161471

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.479

High

161472

SEPT9
Septin-9

1

4

Small-scale

0.479

High

161474

MED23
Mediator of RNA polymerase II transcription subunit 23

1

1

High-throughput

0.479

High

161262

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

161307

GCSP
Glycine dehydrogenase

1

0

High-throughput

0.458

High

161344

RL27
Large ribosomal subunit protein eL27

1

0

High-throughput

0.458

High

161368

NACA
Nascent polypeptide-associated complex subunit alpha

1

0

Small-scale

0.458

High

161410

FBX25
F-box only protein 25

1

0

High-throughput

0.458

High

161412

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

161417

NUDC2
NudC domain-containing protein 2

1

0

High-throughput

0.458

High

161427

TF3B
Transcription factor IIIB 90 kDa subunit

1

0

Small-scale

0.458

High

161467

LUZP4
Leucine zipper protein 4

1

0

Small-scale

0.458

High

161264

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

5

High-throughput

0.445

High

161287

JUN
Transcription factor Jun

1

9

High-throughput

0.445

High

161294

TAU
Microtubule-associated protein tau

1

19

High-throughput

0.445

High

161315

MCM7
DNA replication licensing factor MCM7

1

4

Small-scale

0.445

High

161317

BMI1
Polycomb complex protein BMI-1

1

4

High-throughput

0.445

High

161365

CTBP1
C-terminal-binding protein 1

1

2

High-throughput

0.445

High

161388

PKHA7
Pleckstrin homology domain-containing family A member 7

1

19

High-throughput

0.445

High

161407

MOT11
Monocarboxylate transporter 11

1

3

High-throughput

0.445

High

161426

CSN5
COP9 signalosome complex subunit 5

1

5

Small-scale

0.445

High

161434

CEP63
Centrosomal protein of 63 kDa

1

12

High-throughput

0.445

High

161436

PARK7
Parkinson disease protein 7

1

2

Small-scale

0.445

High

161437

ZBT18
Zinc finger and BTB domain-containing protein 18

1

20

High-throughput

0.445

High

161446

ZDHC5
Palmitoyltransferase ZDHHC5

1

4

High-throughput

0.445

High

161284

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.437

High

161405

EMC1
ER membrane protein complex subunit 1

1

1

High-throughput

0.437

High

161440

OVOL2
Transcription factor Ovo-like 2

1

20

Small-scale

0.437

High

161381

LITD1
LINE-1 type transposase domain-containing protein 1

1

2

High-throughput

0.407

High

135728

EST2
Cocaine esterase

1

0

High-throughput

0.279

Low

161276

CX001
Putative transmembrane protein CXorf1

1

0

High-throughput

0.279

Low

161364

GAGE5
G antigen 5

1

0

High-throughput

0.279

Low

161430

ERLEC
Endoplasmic reticulum lectin 1

1

0

High-throughput

0.279

Low

161441

MND1
Meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.279

Low

161476

RT18C
Small ribosomal subunit protein bS18m

1

0

High-throughput

0.279

Low

161383

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024