Protein: SPTN2
Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein)

Gene: SPTN2, SPTBN2
Organism: Homo sapiens
Interactions: 151
UniProt ID: O15020

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0005200 - structural constituent of cytoskeleton
GO:0005543 - phospholipid binding
GO:0005615 - extracellular space
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

164614

SPTN1
Spectrin alpha chain, non-erythrocytic 1

3

17

Small-scale

0.829

High

164592

ACTZ
Alpha-centractin

2

20

Small-scale

0.804

High

164588

ACTB
Actin, cytoplasmic 1

2

20

Small-scale

0.778

High

117513

MYO1C
Unconventional myosin-Ic

1

12

High-throughput

0.691

High

164566

FLNA
Filamin-A

1

18

High-throughput

0.691

High

164575

MYH9
Myosin-9

1

8

High-throughput

0.691

High

164580

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

10

High-throughput

0.691

High

164647

MY18A
Unconventional myosin-XVIIIa

1

18

High-throughput

0.691

High

164655

MYO19
Unconventional myosin-XIX

1

13

High-throughput

0.691

High

164548

RASK
GTPase KRas

3

20

High-throughput

0.640

High

164551

LCK
Tyrosine-protein kinase Lck

1

17

High-throughput

0.618

High

164555

LYN
Tyrosine-protein kinase Lyn

1

17

High-throughput

0.618

High

164603

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

18

High-throughput

0.618

High

164611

ANK3
Ankyrin-3

1

20

High-throughput

0.618

High

164539

OBSL1
Obscurin-like protein 1

2

18

High-throughput

0.584

High

164547

RASN
GTPase NRas

2

20

High-throughput

0.584

High

164579

YAP1
Transcriptional coactivator YAP1

2

11

High-throughput

0.584

High

164598

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.584

High

164668

ANLN
Anillin

2

10

High-throughput

0.584

High

164604

ANK2
Ankyrin-2

1

20

High-throughput

0.575

High

164613

TBB3
Tubulin beta-3 chain

1

1

High-throughput

0.575

High

164632

TBA1A
Tubulin alpha-1A chain

1

4

High-throughput

0.575

High

164558

TAU
Microtubule-associated protein tau

2

14

High-throughput

0.571

High

164630

TRI67
Tripartite motif-containing protein 67

1

12

High-throughput

0.553

High

164543

PCNT
Pericentrin

1

20

High-throughput

0.541

High

164552

ADRB2
Beta-2 adrenergic receptor

1

2

High-throughput

0.541

High

164568

APC
Adenomatous polyposis coli protein

1

13

High-throughput

0.541

High

164572

CCR1
C-C chemokine receptor type 1

1

3

High-throughput

0.536

High

164581

CAZA2
F-actin-capping protein subunit alpha-2

1

7

High-throughput

0.536

High

164586

DAPK1
Death-associated protein kinase 1

1

20

High-throughput

0.536

High

164596

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

11

High-throughput

0.536

High

164608

CALD1
Caldesmon

1

20

High-throughput

0.536

High

164615

SCRB2
Lysosome membrane protein 2

1

3

High-throughput

0.536

High

164638

SYNPO
Synaptopodin

1

11

High-throughput

0.536

High

164642

TBCK
TBC domain-containing protein kinase-like protein

1

15

High-throughput

0.536

High

164650

KIFA3
Kinesin-associated protein 3

1

10

High-throughput

0.536

High

164679

NEMO
NF-kappa-B essential modulator

1

20

High-throughput

0.536

High

155776

UN13B
Protein unc-13 homolog B

1

1

Small-scale

0.527

High

164553

CATL1
Procathepsin L

1

6

High-throughput

0.515

High

164554

CATB
Cathepsin B

1

10

High-throughput

0.515

High

164561

IFM1
Interferon-induced transmembrane protein 1

1

7

High-throughput

0.515

High

164569

DPP4
Dipeptidyl peptidase 4

1

4

High-throughput

0.515

High

164605

IFM3
Interferon-induced transmembrane protein 3

1

7

High-throughput

0.515

High

164645

CLC4D
C-type lectin domain family 4 member D

1

9

High-throughput

0.515

High

164675

CLC4E
C-type lectin domain family 4 member E

1

9

High-throughput

0.515

High

164610

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

High-throughput

0.513

High

164636

ABRA
Actin-binding Rho-activating protein

1

0

High-throughput

0.513

High

164658

SORT
Sortilin

1

0

High-throughput

0.513

High

164669

MBNL1
Muscleblind-like protein 1

1

0

High-throughput

0.513

High

164546

CHK2
Serine/threonine-protein kinase Chk2

1

3

High-throughput

0.489

High

164576

MLH1
DNA mismatch repair protein Mlh1

1

5

High-throughput

0.489

High

164617

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

2

High-throughput

0.489

High

164640

BHE23
Class E basic helix-loop-helix protein 23

1

3

High-throughput

0.489

High

164643

HASP
Serine/threonine-protein kinase haspin

1

3

High-throughput

0.489

High

164654

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

5

High-throughput

0.489

High

120207

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.479

High

148142

CTRO
Citron Rho-interacting kinase

1

10

High-throughput

0.479

High

164535

TMPS2
Transmembrane protease serine 2

1

6

High-throughput

0.479

High

164536

PRC1
Protein regulator of cytokinesis 1

1

17

High-throughput

0.479

High

164537

PRKN
E3 ubiquitin-protein ligase parkin

1

7

High-throughput

0.479

High

164540

FLOT1
Flotillin-1

1

6

High-throughput

0.479

High

164541

ZFPL1
Zinc finger protein-like 1

1

4

High-throughput

0.479

High

164544

DIRA3
GTP-binding protein Di-Ras3

1

8

High-throughput

0.479

High

164549

TFR1
Transferrin receptor protein 1

1

3

High-throughput

0.479

High

164550

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

6

High-throughput

0.479

High

164556

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

164559

LAMP1
Lysosome-associated membrane glycoprotein 1

1

9

High-throughput

0.479

High

164560

CADH1
Cadherin-1

1

9

High-throughput

0.479

High

164562

LAMP2
Lysosome-associated membrane glycoprotein 2

1

9

High-throughput

0.479

High

164564

RHOQ
Rho-related GTP-binding protein RhoQ

1

20

High-throughput

0.479

High

164567

GCSP
Glycine dehydrogenase

1

5

High-throughput

0.479

High

164571

MARCS
Myristoylated alanine-rich C-kinase substrate

1

7

High-throughput

0.479

High

164578

RS10
Small ribosomal subunit protein eS10

1

5

High-throughput

0.479

High

164582

SOX2
Transcription factor SOX-2

1

8

High-throughput

0.479

High

164584

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

2

High-throughput

0.479

High

164585

RAB5C
Ras-related protein Rab-5C

1

9

High-throughput

0.479

High

164587

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

6

High-throughput

0.479

High

164589

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.479

High

164590

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.479

High

164591

RAB2A
Ras-related protein Rab-2A

1

6

High-throughput

0.479

High

164593

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

164594

RND3
Rho-related GTP-binding protein RhoE

1

20

High-throughput

0.479

High

164597

ARF6
ADP-ribosylation factor 6

1

3

High-throughput

0.479

High

164599

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

164602

RHOG
Rho-related GTP-binding protein RhoG

1

20

High-throughput

0.479

High

164606

CAV1
Caveolin-1

1

14

High-throughput

0.479

High

164607

K1C17
Keratin, type I cytoskeletal 17

1

10

High-throughput

0.479

High

164609

TFCP2
Alpha-globin transcription factor CP2

1

4

High-throughput

0.479

High

164612

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

20

Small-scale

0.479

High

164618

TNIP1
TNFAIP3-interacting protein 1

1

20

High-throughput

0.479

High

164619

KIF14
Kinesin-like protein KIF14

1

10

High-throughput

0.479

High

164620

RAB35
Ras-related protein Rab-35

1

8

High-throughput

0.479

High

164622

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.479

High

164624

OCLN
Occludin

1

5

High-throughput

0.479

High

164626

MIDN
Midnolin

1

3

High-throughput

0.479

High

164627

RN123
E3 ubiquitin-protein ligase RNF123

1

4

High-throughput

0.479

High

164628

LTOR1
Ragulator complex protein LAMTOR1

1

3

High-throughput

0.479

High

164633

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

164637

CXD3
Gap junction delta-3 protein

1

12

High-throughput

0.479

High

164641

FBX22
F-box only protein 22

1

1

High-throughput

0.479

High

164644

NUDC2
NudC domain-containing protein 2

1

6

High-throughput

0.479

High

164646

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

7

High-throughput

0.479

High

164648

RND1
Rho-related GTP-binding protein Rho6

1

20

High-throughput

0.479

High

164653

CHM4C
Charged multivesicular body protein 4c

1

14

High-throughput

0.479

High

164659

ANM1
Protein arginine N-methyltransferase 1

1

6

High-throughput

0.479

High

164660

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

16

High-throughput

0.479

High

164662

CCDC8
Coiled-coil domain-containing protein 8

1

5

High-throughput

0.479

High

164663

DNJC5
DnaJ homolog subfamily C member 5

1

3

High-throughput

0.479

High

164664

CHM4B
Charged multivesicular body protein 4b

1

14

High-throughput

0.479

High

164665

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

164666

ECT2
Protein ECT2

1

17

High-throughput

0.479

High

164667

RHOF
Rho-related GTP-binding protein RhoF

1

20

High-throughput

0.479

High

164674

HDAC6
Histone deacetylase 6

1

18

High-throughput

0.479

High

164676

LAMP3
Lysosome-associated membrane glycoprotein 3

1

9

High-throughput

0.479

High

164629

ATAD2
ATPase family AAA domain-containing protein 2

1

5

High-throughput

0.470

High

145998

CLD4
Claudin-4

1

0

Small-scale

0.458

High

164621

LRC41
Leucine-rich repeat-containing protein 41

1

0

High-throughput

0.458

High

164651

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

0

High-throughput

0.458

High

164673

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.458

High

164595

STXB1
Syntaxin-binding protein 1

1

3

High-throughput

0.457

High

164671

DISC1
Disrupted in schizophrenia 1 protein

1

7

High-throughput

0.457

High

164672

CELR3
Cadherin EGF LAG seven-pass G-type receptor 3

1

2

Small-scale

0.457

High

164538

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

8

High-throughput

0.445

High

164573

BMI1
Polycomb complex protein BMI-1

1

16

High-throughput

0.445

High

164577

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

9

High-throughput

0.445

High

164623

NF2L2
Nuclear factor erythroid 2-related factor 2

1

6

High-throughput

0.445

High

164649

ESR2
Estrogen receptor beta

1

19

High-throughput

0.445

High

164656

CEP63
Centrosomal protein of 63 kDa

1

20

High-throughput

0.445

High

164657

CK5P2
CDK5 regulatory subunit-associated protein 2

1

20

High-throughput

0.445

High

164542

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.437

High

164545

TOP3B
DNA topoisomerase 3-beta-1

1

4

High-throughput

0.437

High

164557

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

2

High-throughput

0.437

High

164563

RFA2
Replication protein A 32 kDa subunit

1

10

High-throughput

0.437

High

164565

CEBPB
CCAAT/enhancer-binding protein beta

1

8

High-throughput

0.437

High

164570

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

7

High-throughput

0.437

High

164574

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.437

High

164583

LMAN1
Protein ERGIC-53

1

2

High-throughput

0.437

High

164600

DYLT1
Dynein light chain Tctex-type 1

1

3

High-throughput

0.437

High

164616

BOP1
Ribosome biogenesis protein BOP1

1

4

High-throughput

0.437

High

164631

UBP53
Inactive ubiquitin carboxyl-terminal hydrolase 53

1

6

Small-scale

0.437

High

164634

ZCH18
Zinc finger CCCH domain-containing protein 18

1

9

High-throughput

0.437

High

164652

CK052
Uncharacterized protein C11orf52

1

5

High-throughput

0.437

High

164670

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

10

High-throughput

0.437

High

164639

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.426

High

164601

KGD4
Alpha-ketoglutarate dehydrogenase component 4

1

0

High-throughput

0.279

Low

164625

CR021
UPF0711 protein C18orf21

1

0

High-throughput

0.279

Low

164635

ZC3C1
Zinc finger C3HC-type protein 1

1

0

High-throughput

0.279

Low

164661

CF263
Cilia- and flagella-associated protein 263

1

0

High-throughput

0.279

Low

164677

ASF1A
Histone chaperone ASF1A

1

0

High-throughput

0.279

Low

164678

SSUH2
Protein SSUH2 homolog

1

0

High-throughput

0.279

Low

164534

CTDSL
CTD small phosphatase-like protein

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024