Protein: GNAO
Guanine nucleotide-binding protein G(o) subunit alpha

Gene: GNAO, GNAO1
Organism: Homo sapiens
Interactions: 96
UniProt ID: P09471

Gene Ontology (top 5):
GO:0003924 - GTPase activity
GO:0005525 - GTP binding
GO:0005737 - cytoplasm
GO:0005834 - heterotrimeric G-protein complex
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

391311

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

3

11

High-throughput

0.861

High

444650

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

3

11

High-throughput

0.861

High

451001

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

3

12

High-throughput

0.861

High

451041

RIC8A
Synembryn-A

2

13

Small-scale

0.808

High

450989

RGS4
Regulator of G-protein signaling 4

2

20

Small-scale

0.778

High

182443

RGS5
Regulator of G-protein signaling 5

2

20

Small-scale

0.768

High

451000

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

2

20

Small-scale

0.754

High

450988

RGS19
Regulator of G-protein signaling 19

2

20

Small-scale

0.754

High

450974

GNAT2
Guanine nucleotide-binding protein G(t) subunit alpha-2

1

12

High-throughput

0.691

High

451009

DMWD
Dystrophia myotonica WD repeat-containing protein

1

3

High-throughput

0.691

High

451044

KTU
Protein kintoun

3

1

High-throughput

0.667

High

451048

NUFP1
FMR1-interacting protein NUFIP1

3

3

High-throughput

0.667

High

180653

RGS16
Regulator of G-protein signaling 16

1

20

Small-scale

0.647

High

283160

RGS20
Regulator of G-protein signaling 20

1

20

Small-scale

0.647

High

445801

ADA2A
Alpha-2A adrenergic receptor

1

10

Small-scale

0.647

High

451047

GABR1
Gamma-aminobutyric acid type B receptor subunit 1

1

1

Small-scale

0.647

High

451002

GBG3

2

20

High-throughput

0.628

High

277782

RGS9
Regulator of G-protein signaling 9

1

20

Small-scale

0.618

High

450977

CXCR5
C-X-C chemokine receptor type 5

1

14

Small-scale

0.618

High

450978

CRFR1
Corticotropin-releasing factor receptor 1

1

5

Small-scale

0.618

High

450979

OPRM
Mu-type opioid receptor

1

17

Small-scale

0.618

High

450980

DRD3
D(3) dopamine receptor

1

10

Small-scale

0.618

High

450984

OPRD
Delta-type opioid receptor

1

17

Small-scale

0.618

High

451036

ECT2
Protein ECT2

1

15

High-throughput

0.618

High

451037

GPR35
G-protein coupled receptor 35

1

20

High-throughput

0.618

High

451019

DGUOK
Deoxyguanosine kinase, mitochondrial

2

1

High-throughput

0.611

High

450985

HD
Huntingtin

2

10

High-throughput

0.588

High

451045

ARMC1
Armadillo repeat-containing protein 1

2

0

High-throughput

0.585

High

451022

CXB7
Gap junction beta-7 protein

2

3

High-throughput

0.574

High

118173

HAX1
HCLS1-associated protein X-1

2

1

High-throughput

0.558

High

447218

HXB5
Homeobox protein Hox-B5

2

4

High-throughput

0.558

High

240336

SNX2
Sorting nexin-2

1

5

High-throughput

0.536

High

450973

TAU
Microtubule-associated protein tau

1

15

High-throughput

0.536

High

450990

GBG10

1

20

High-throughput

0.536

High

450991

GPM6A
Neuronal membrane glycoprotein M6-a

1

2

High-throughput

0.536

High

450995

GBG2
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

1

20

High-throughput

0.536

High

450996

ACTB
Actin, cytoplasmic 1

1

2

High-throughput

0.536

High

450999

ACTA
Actin, aortic smooth muscle

1

2

High-throughput

0.536

High

451008

CD69
Early activation antigen CD69

1

3

High-throughput

0.536

High

451013

SNX1
Sorting nexin-1

1

5

High-throughput

0.536

High

451025

MICA1
[F-actin]-monooxygenase MICAL1

1

2

High-throughput

0.536

High

451043

DUS22
Dual specificity protein phosphatase 22

1

14

High-throughput

0.536

High

451049

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

20

High-throughput

0.536

High

451051

MYH4
Myosin-4

1

2

High-throughput

0.536

High

451012

DCTN2
Dynactin subunit 2

1

0

High-throughput

0.518

High

450975

CALR
Calreticulin

1

1

High-throughput

0.515

High

450982

TGFR2
TGF-beta receptor type-2

1

2

High-throughput

0.515

High

450992

KS6A3
Ribosomal protein S6 kinase alpha-3

1

2

High-throughput

0.515

High

450994

TERA
Transitional endoplasmic reticulum ATPase

1

2

High-throughput

0.515

High

451024

NEK7
Serine/threonine-protein kinase Nek7

1

3

High-throughput

0.515

High

451034

P4K2A
Phosphatidylinositol 4-kinase type 2-alpha

1

0

High-throughput

0.513

High

451003

CAC1B
Voltage-dependent N-type calcium channel subunit alpha-1B

1

11

Small-scale

0.501

High

451006

ZBT16
Zinc finger and BTB domain-containing protein 16

1

1

Small-scale

0.501

High

451007

APLP2
Amyloid beta precursor like protein 2

1

6

Small-scale

0.501

High

451039

NGB
Neuroglobin

1

1

Small-scale

0.501

High

451031

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

12

High-throughput

0.500

High

451026

KIFA3
Kinesin-associated protein 3

1

1

High-throughput

0.489

High

451027

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

4

High-throughput

0.489

High

451028

CERS2
Ceramide synthase 2

1

2

High-throughput

0.489

High

451050

SNX5
Sorting nexin-5

1

5

High-throughput

0.489

High

324185

BAG3
BAG family molecular chaperone regulator 3

1

1

High-throughput

0.479

High

384139

NTRK1
High affinity nerve growth factor receptor

1

6

High-throughput

0.479

High

393978

A4
Amyloid-beta precursor protein

1

6

Small-scale

0.479

High

450987

YAP1
Transcriptional coactivator YAP1

1

9

High-throughput

0.479

High

450993

MOT1
Monocarboxylate transporter 1

1

4

High-throughput

0.479

High

450998

RB11A
Ras-related protein Rab-11A

1

3

High-throughput

0.479

High

451010

FOXO1
Forkhead box protein O1

1

1

High-throughput

0.479

High

451023

EMC5
ER membrane protein complex subunit 5

1

3

High-throughput

0.479

High

451035

CHM4B
Charged multivesicular body protein 4b

1

4

High-throughput

0.479

High

451046

HDAC6
Histone deacetylase 6

1

6

High-throughput

0.479

High

450976

ABCD3
ATP-binding cassette sub-family D member 3

1

1

High-throughput

0.470

High

157109

ZNT4
Probable proton-coupled zinc antiporter SLC30A4

1

0

High-throughput

0.458

High

450983

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

451018

PCM1
Pericentriolar material 1 protein

1

0

High-throughput

0.458

High

239725

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

7

High-throughput

0.445

High

451004

ANK2
Ankyrin-2

1

2

High-throughput

0.445

High

451005

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

3

High-throughput

0.445

High

451015

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

3

High-throughput

0.445

High

451016

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

11

High-throughput

0.445

High

451032

SCN2A
Sodium channel protein type 2 subunit alpha

1

11

High-throughput

0.445

High

451033

ZBT18
Zinc finger and BTB domain-containing protein 18

1

4

High-throughput

0.445

High

308343

KI20A
Kinesin-like protein KIF20A

1

19

High-throughput

0.437

High

451011

TFCP2
Alpha-globin transcription factor CP2

1

8

High-throughput

0.437

High

451017

KIF14
Kinesin-like protein KIF14

1

6

High-throughput

0.437

High

451038

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

8

High-throughput

0.437

High

451042

ANLN
Anillin

1

8

High-throughput

0.437

High

451014

CUL3
Cullin-3

1

0

High-throughput

0.426

High

451030

CEP63
Centrosomal protein of 63 kDa

1

7

High-throughput

0.407

High

451029

JSPR1
Junctional sarcoplasmic reticulum protein 1

3

0

High-throughput

0.347

High

270957

SPAG6
Sperm-associated antigen 6

1

0

High-throughput

0.279

Low

451020

GRAM4
GRAM domain-containing protein 4

1

0

High-throughput

0.279

Low

451021

FXL22
F-box and leucine-rich protein 22

1

0

High-throughput

0.279

Low

451040

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.279

Low

450981

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.268

Low

450986

CBX5
Chromobox protein homolog 5

1

0

High-throughput

0.268

Low

450997

SMS
Somatostatin

1

0

Small-scale

0.232

Low


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Last updated: 15 Jul 2024