Protein: PFKAM
ATP-dependent 6-phosphofructokinase, muscle type (ATP-PFK) (PFK-M) (EC 2.7.1.11) (6-phosphofructokinase type A) (Phosphofructo-1-kinase isozyme A) (PFK-A) (Phosphohexokinase)

Gene: PFKAM, PFKM
Organism: Homo sapiens
Interactions: 131
UniProt ID: P08237

Gene Ontology (top 5):
GO:0003872 - 6-phosphofructokinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0005945 - 6-phosphofructokinase complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

437738

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

5

13

Small-scale

0.916

High

437706

PFKAM
ATP-dependent 6-phosphofructokinase, muscle type

2

13

Small-scale

0.793

High

437712

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

2

13

Small-scale

0.757

High

437733

SUMO2
Small ubiquitin-related modifier 2

2

4

High-throughput

0.602

High

226301

PRKN
E3 ubiquitin-protein ligase parkin

2

9

High-throughput

0.584

High

437709

HSP7C
Heat shock cognate 71 kDa protein

2

2

High-throughput

0.584

High

437768

TBA1A
Tubulin alpha-1A chain

2

2

High-throughput

0.571

High

437754

TEAD4
Transcriptional enhancer factor TEF-3

1

1

High-throughput

0.561

High

437708

TAU
Microtubule-associated protein tau

2

9

Small-scale

0.552

High

437774

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

0

High-throughput

0.549

High

437763

SFRP4
Secreted frizzled-related protein 4

1

1

High-throughput

0.541

High

437784

SFRP2
Secreted frizzled-related protein 2

1

1

High-throughput

0.541

High

437787

RHG07
Rho GTPase-activating protein 7

1

3

High-throughput

0.541

High

437802

VPP4
V-type proton ATPase 116 kDa subunit a 4

1

0

Small-scale

0.537

High

437745

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.536

High

437746

CUL3
Cullin-3

1

1

High-throughput

0.536

High

437759

RHG44
Rho GTPase-activating protein 44

1

2

High-throughput

0.536

High

437788

CDC5L
Cell division cycle 5-like protein

1

2

High-throughput

0.536

High

437793

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

2

High-throughput

0.536

High

437814

SC6A5
Sodium- and chloride-dependent glycine transporter 2

1

1

High-throughput

0.536

High

437812

LSM7
U6 snRNA-associated Sm-like protein LSm7

1

0

High-throughput

0.518

High

437726

CAZA2
F-actin-capping protein subunit alpha-2

1

0

High-throughput

0.513

High

437729

KIF11
Kinesin-like protein KIF11

1

0

High-throughput

0.513

High

437747

CKAP5
Cytoskeleton-associated protein 5

1

0

High-throughput

0.513

High

437807

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

0

High-throughput

0.513

High

437715

MK03
Mitogen-activated protein kinase 3

1

11

High-throughput

0.508

High

411276

INSR
Insulin receptor

1

16

High-throughput

0.500

High

437757

NTRK3
NT-3 growth factor receptor

1

14

High-throughput

0.500

High

437752

PGFRL
Platelet-derived growth factor receptor-like protein

1

5

High-throughput

0.494

High

159850

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

0

Small-scale

0.480

High

437710

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.480

High

437748

FHL2
Four and a half LIM domains protein 2

1

0

Small-scale

0.480

High

123465

PGRC1
Membrane-associated progesterone receptor component 1

1

2

Small-scale

0.479

High

148300

CTRO
Citron Rho-interacting kinase

1

5

High-throughput

0.479

High

209597

PRC1
Protein regulator of cytokinesis 1

1

1

High-throughput

0.479

High

312003

ZBT7A
Zinc finger and BTB domain-containing protein 7A

1

1

Small-scale

0.479

High

337798

EGFR
Epidermal growth factor receptor

1

7

High-throughput

0.479

High

345728

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.479

High

373548

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

378923

MYCN
N-myc proto-oncogene protein

1

4

High-throughput

0.479

High

384121

NTRK1
High affinity nerve growth factor receptor

1

14

High-throughput

0.479

High

411555

LCK
Tyrosine-protein kinase Lck

1

3

High-throughput

0.479

High

437707

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

8

Small-scale

0.479

High

437713

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

3

High-throughput

0.479

High

437714

CRCM
Colorectal mutant cancer protein

1

1

High-throughput

0.479

High

437716

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

437717

TEAD1
Transcriptional enhancer factor TEF-1

1

1

High-throughput

0.479

High

437718

UFO
Tyrosine-protein kinase receptor UFO

1

13

High-throughput

0.479

High

437721

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

10

High-throughput

0.479

High

437722

BRCA1
Breast cancer type 1 susceptibility protein

1

3

High-throughput

0.479

High

437723

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

437728

RND2
Rho-related GTP-binding protein RhoN

1

8

High-throughput

0.479

High

437730

CAV3
Caveolin-3

1

1

Small-scale

0.479

High

437732

CDC42
Cell division control protein 42 homolog

1

7

High-throughput

0.479

High

437735

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

437736

RAC1
Ras-related C3 botulinum toxin substrate 1

1

6

High-throughput

0.479

High

437737

RHOG
Rho-related GTP-binding protein RhoG

1

5

High-throughput

0.479

High

437739

KIF23
Kinesin-like protein KIF23

1

2

High-throughput

0.479

High

437740

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

6

Small-scale

0.479

High

437741

RFA4
Replication protein A 30 kDa subunit

1

2

High-throughput

0.479

High

437743

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

437744

SQSTM
Sequestosome-1

1

2

High-throughput

0.479

High

437751

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

437756

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.479

High

437758

DUS6
Dual specificity protein phosphatase 6

1

2

High-throughput

0.479

High

437762

VIR
Protein virilizer homolog

1

2

High-throughput

0.479

High

437765

ZN746
Zinc finger protein 746

1

1

High-throughput

0.479

High

437769

RHOU
Rho-related GTP-binding protein RhoU

1

9

High-throughput

0.479

High

437770

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

437771

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

437781

FBX32
F-box only protein 32

1

1

High-throughput

0.479

High

437782

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.479

High

437783

AURKB
Aurora kinase B

1

7

High-throughput

0.479

High

437785

RHOV
Rho-related GTP-binding protein RhoV

1

9

High-throughput

0.479

High

437786

LMTK3
Serine/threonine-protein kinase LMTK3

1

19

High-throughput

0.479

High

437789

DNJC7
DnaJ homolog subfamily C member 7

1

1

High-throughput

0.479

High

437790

LZTS2
Leucine zipper putative tumor suppressor 2

1

3

High-throughput

0.479

High

437791

ACE2
Angiotensin-converting enzyme 2

1

2

High-throughput

0.479

High

437795

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

2

High-throughput

0.479

High

437796

SPRTN
DNA-dependent metalloprotease SPRTN

1

2

High-throughput

0.479

High

437797

Q9H4D1
Protein kinase

1

1

High-throughput

0.479

High

437803

RHOF
Rho-related GTP-binding protein RhoF

1

8

High-throughput

0.479

High

437805

FBX6
F-box only protein 6

1

2

High-throughput

0.479

High

437806

TMPS4
Transmembrane protease serine 4

1

6

High-throughput

0.479

High

437809

HDAC6
Histone deacetylase 6

1

5

High-throughput

0.479

High

437810

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

437811

ANC2
Anaphase-promoting complex subunit 2

1

2

High-throughput

0.479

High

437813

AGO2
Protein argonaute-2

1

1

Small-scale

0.479

High

118169

HAX1
HCLS1-associated protein X-1

1

0

High-throughput

0.458

High

197192

SERA
D-3-phosphoglycerate dehydrogenase

1

0

Small-scale

0.458

High

351895

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.458

High

375852

ALDOA
Fructose-bisphosphate aldolase A

1

0

Small-scale

0.458

High

385945

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

437719

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

437724

PERI
Peripherin

1

0

High-throughput

0.458

High

437725

MAP1B
Microtubule-associated protein 1B

1

0

High-throughput

0.458

High

437742

HAP28
28 kDa heat- and acid-stable phosphoprotein

1

0

High-throughput

0.458

High

437749

FLOT2
Flotillin-2

1

0

High-throughput

0.458

High

437753

NONO
Non-POU domain-containing octamer-binding protein

1

0

Small-scale

0.458

High

437772

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.458

High

437773

DCP2
m7GpppN-mRNA hydrolase

1

0

High-throughput

0.458

High

437777

NIN
Ninein

1

0

High-throughput

0.458

High

437778

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.458

High

437780

JOS2
Josephin-2

1

0

Small-scale

0.458

High

437800

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

437804

DCP1A
mRNA-decapping enzyme 1A

1

0

High-throughput

0.458

High

437808

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

437711

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.445

High

437731

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

437734

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

1

High-throughput

0.445

High

437760

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

437776

RYBP
RING1 and YY1-binding protein

1

2

High-throughput

0.445

High

437794

ZDHC5
Palmitoyltransferase ZDHHC5

1

2

High-throughput

0.445

High

297571

RHBT1
Rho-related BTB domain-containing protein 1

1

9

High-throughput

0.437

High

437720

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

437755

RHOH
Rho-related GTP-binding protein RhoH

1

8

High-throughput

0.437

High

437767

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

437775

RHG24
Rho GTPase-activating protein 24

1

2

High-throughput

0.437

High

437779

KDF1
Keratinocyte differentiation factor 1

1

2

High-throughput

0.437

High

437792

RHBT2
Rho-related BTB domain-containing protein 2

1

9

High-throughput

0.437

High

437798

RHOJ
Rho-related GTP-binding protein RhoJ

1

7

High-throughput

0.437

High

437799

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.437

High

437727

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

306599

NDUB2
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial

1

0

High-throughput

0.282

High

437766

MDEAS
Mitotic deacetylase-associated SANT domain protein

1

0

High-throughput

0.279

Low

437801

UBTD1
Ubiquitin domain-containing protein 1

1

0

Small-scale

0.251

Low

437750

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.249

Low

437761

OTUD1
OTU domain-containing protein 1

1

0

High-throughput

0.249

Low

437764

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.249

Low

239722

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024