Protein: M4K1
Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1)

Gene: M4K1, MAP4K1
Organism: Homo sapiens
Interactions: 124
UniProt ID: Q92918

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0006468 - protein phosphorylation
GO:0007254 - JNK cascade

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

432128

HS90A
Heat shock protein HSP 90-alpha

4

20

High-throughput

0.881

High

438410

HS90B
Heat shock protein HSP 90-beta

4

20

High-throughput

0.881

High

1272882

M4K1
Mitogen-activated protein kinase kinase kinase kinase 1

3

15

Small-scale

0.861

High

338799

EGFR
Epidermal growth factor receptor

3

20

High-throughput

0.843

High

931780

CSK2B
Casein kinase II subunit beta

2

2

High-throughput

0.789

High

581035

PLCG1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1

1

3

High-throughput

0.770

High

1083518

M3K11
Mitogen-activated protein kinase kinase kinase 11

2

9

Small-scale

0.757

High

924745

GRB2
Growth factor receptor-bound protein 2

8

20

Small-scale

0.753

High

337520

ABL1
Tyrosine-protein kinase ABL1

2

20

Small-scale

0.743

High

734986

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

2

17

High-throughput

0.737

High

557762

NCK1
SH2/SH3 adapter protein NCK1

6

20

Small-scale

0.727

High

802687

CRK
Adapter molecule crk

5

20

Small-scale

0.717

High

802883

CRKL
Crk-like protein

4

20

Small-scale

0.702

High

803678

BAG6
Large proline-rich protein BAG6

1

10

High-throughput

0.691

High

1036779

SQSTM
Sequestosome-1

1

7

High-throughput

0.691

High

1082312

DDB1
DNA damage-binding protein 1

1

1

High-throughput

0.691

High

1272885

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

5

High-throughput

0.691

High

1272906

NUDC
Nuclear migration protein nudC

4

4

High-throughput

0.683

High

201385

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

12

Small-scale

0.665

High

1220447

DJC10
DnaJ homolog subfamily C member 10

1

0

High-throughput

0.656

High

1028411

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

17

Small-scale

0.647

High

275218

GRAP2
GRB2-related adapter protein 2

2

20

Small-scale

0.644

High

890991

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

2

20

Small-scale

0.624

High

412291

FYN
Tyrosine-protein kinase Fyn

1

20

High-throughput

0.618

High

523095

SRC
Proto-oncogene tyrosine-protein kinase Src

1

20

High-throughput

0.618

High

972562

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

10

High-throughput

0.618

High

979336

UBXN1
UBX domain-containing protein 1

1

1

High-throughput

0.618

High

1034951

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

10

High-throughput

0.618

High

1050246

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

20

Small-scale

0.618

High

1082906

CDC37
Hsp90 co-chaperone Cdc37

1

10

High-throughput

0.618

High

1105475

LRRK1
Leucine-rich repeat serine/threonine-protein kinase 1

1

10

High-throughput

0.618

High

1217332

VRK3
Serine/threonine-protein kinase VRK3

1

16

High-throughput

0.618

High

1272902

KBRS2
NF-kappa-B inhibitor-interacting Ras-like protein 2

1

18

High-throughput

0.618

High

1272903

TBK1
Serine/threonine-protein kinase TBK1

1

19

Small-scale

0.618

High

929017

SKP1
S-phase kinase-associated protein 1

2

3

Small-scale

0.584

High

1272896

CAR11
Caspase recruitment domain-containing protein 11

1

14

Small-scale

0.578

High

719039

PHB1
Prohibitin 1

2

3

High-throughput

0.571

High

719571

MERL
Merlin

2

13

High-throughput

0.571

High

892869

IF4A1
Eukaryotic initiation factor 4A-I

2

6

High-throughput

0.571

High

1261028

BLNK
B-cell linker protein

1

10

Small-scale

0.561

High

1272904

DBNL
Drebrin-like protein

1

16

Small-scale

0.561

High

588924

IF2B
Eukaryotic translation initiation factor 2 subunit 2

2

0

High-throughput

0.547

High

156043

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

1

High-throughput

0.536

High

229712

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

18

High-throughput

0.536

High

304277

UBR5
E3 ubiquitin-protein ligase UBR5

1

20

High-throughput

0.536

High

396969

HMGN1
Non-histone chromosomal protein HMG-14

1

1

High-throughput

0.536

High

573404

TCPA
T-complex protein 1 subunit alpha

1

17

High-throughput

0.536

High

653331

PYR1
Multifunctional protein CAD

1

5

High-throughput

0.536

High

676952

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

1

High-throughput

0.536

High

737427

LONM
Lon protease homolog, mitochondrial

1

5

High-throughput

0.536

High

770966

TCPZ
T-complex protein 1 subunit zeta

1

15

High-throughput

0.536

High

821345

TCPE
T-complex protein 1 subunit epsilon

1

19

High-throughput

0.536

High

826805

TCPG
T-complex protein 1 subunit gamma

1

19

High-throughput

0.536

High

842984

TCPQ
T-complex protein 1 subunit theta

1

20

High-throughput

0.536

High

843316

TCPD
T-complex protein 1 subunit delta

1

14

High-throughput

0.536

High

902986

DCAF7
DDB1- and CUL4-associated factor 7

1

3

High-throughput

0.536

High

943390

TCPB
T-complex protein 1 subunit beta

1

20

High-throughput

0.536

High

1040039

IQGA2
Ras GTPase-activating-like protein IQGAP2

1

15

High-throughput

0.536

High

1268212

GCN1
Stalled ribosome sensor GCN1

1

20

High-throughput

0.536

High

1272509

CSN5
COP9 signalosome complex subunit 5

1

10

High-throughput

0.536

High

1272891

TCPH
T-complex protein 1 subunit eta

1

20

High-throughput

0.536

High

1272898

WDR6
tRNA

1

17

High-throughput

0.536

High

1272901

BCLF1
Bcl-2-associated transcription factor 1

1

8

High-throughput

0.536

High

1272908

TR150
Thyroid hormone receptor-associated protein 3

1

9

High-throughput

0.536

High

1272886

TM101
Transmembrane protein 101

1

0

High-throughput

0.518

High

336569

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.513

High

1272250

GSLG1
Golgi apparatus protein 1

1

0

High-throughput

0.513

High

1272887

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.513

High

1272890

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

0

High-throughput

0.513

High

930942

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

20

High-throughput

0.501

High

1272899

STRN4
Striatin-4

1

20

High-throughput

0.501

High

118389

HAX1
HCLS1-associated protein X-1

1

1

High-throughput

0.489

High

151860

IRS4
Insulin receptor substrate 4

1

1

High-throughput

0.489

High

440647

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.489

High

678034

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

2

High-throughput

0.489

High

1030744

SLAF1
Signaling lymphocytic activation molecule

1

9

Small-scale

0.489

High

207471

LAT
Linker for activation of T-cells family member 1

1

1

Small-scale

0.479

High

209135

NCK2
Cytoplasmic protein NCK2

1

20

High-throughput

0.479

High

321919

RIGI
Antiviral innate immune response receptor RIG-I

1

9

Small-scale

0.479

High

506635

BCR
Breakpoint cluster region protein

1

9

High-throughput

0.479

High

536584

HCLS1
Hematopoietic lineage cell-specific protein

1

20

Small-scale

0.479

High

623758

PPAC
Low molecular weight phosphotyrosine protein phosphatase

1

1

High-throughput

0.479

High

655434

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

9

High-throughput

0.479

High

684251

1433S
14-3-3 protein sigma

1

20

High-throughput

0.479

High

858659

PPP5
Serine/threonine-protein phosphatase 5

1

20

High-throughput

0.479

High

893435

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

1

High-throughput

0.479

High

909881

1433E
14-3-3 protein epsilon

1

15

High-throughput

0.479

High

922878

RL32
Large ribosomal subunit protein eL32

1

3

High-throughput

0.479

High

978835

TF65
Transcription factor p65

1

3

Small-scale

0.479

High

1056443

IRF3
Interferon regulatory factor 3

1

1

Small-scale

0.479

High

1061537

CUL7
Cullin-7

1

3

Small-scale

0.479

High

1075619

TRBP2
RISC-loading complex subunit TARBP2

1

5

High-throughput

0.479

High

1117776

Q4LE69
1-phosphatidylinositol 4-kinase

1

5

High-throughput

0.479

High

1232680

FBXW8
F-box/WD repeat-containing protein 8

1

16

Small-scale

0.479

High

1272883

FBXW7
F-box/WD repeat-containing protein 7

1

15

Small-scale

0.479

High

1272888

PARK7
Parkinson disease protein 7

1

1

High-throughput

0.479

High

1272892

PYM1
Partner of Y14 and mago

1

1

High-throughput

0.479

High

1272900

PIHD1
PIH1 domain-containing protein 1

1

2

High-throughput

0.479

High

1272905

VPS4A
Vacuolar protein sorting-associated protein 4A

1

3

High-throughput

0.479

High

1272907

DTX4
E3 ubiquitin-protein ligase DTX4

1

4

Small-scale

0.479

High

1272912

NEMO
NF-kappa-B essential modulator

1

20

Small-scale

0.479

High

1087315

H2B2E
Histone H2B type 2-E

1

13

High-throughput

0.470

High

921372

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

Small-scale

0.458

High

1190354

HDDC2
5'-deoxynucleotidase HDDC2

1

0

High-throughput

0.458

High

1272910

CIA2B
Cytosolic iron-sulfur assembly component 2B

1

0

High-throughput

0.458

High

391827

H2A1B
Histone H2A type 1-B/E

1

1

Small-scale

0.457

High

787674

PI4KA
Phosphatidylinositol 4-kinase alpha

1

5

High-throughput

0.445

High

119836

SMAP
Small acidic protein

1

2

High-throughput

0.437

High

684934

STIP1
Stress-induced-phosphoprotein 1

1

10

High-throughput

0.437

High

1069458

TEBP
Prostaglandin E synthase 3

1

3

High-throughput

0.437

High

1190042

MAVS
Mitochondrial antiviral-signaling protein

1

8

Small-scale

0.437

High

1272897

RPAP3
RNA polymerase II-associated protein 3

1

12

High-throughput

0.437

High

1272909

SGT1
Protein SGT1 homolog

1

13

High-throughput

0.437

High

1272911

RT16
Small ribosomal subunit protein bS16m

1

2

High-throughput

0.437

High

858302

TXTP
Tricarboxylate transport protein, mitochondrial

2

0

High-throughput

0.298

High

1272895

RPAP1
RNA polymerase II-associated protein 1

1

0

High-throughput

0.279

Low

208389

SPY1
Protein sprouty homolog 1

1

0

Small-scale

0.249

Low

1022659

AF1Q
Protein AF1q

1

0

High-throughput

0.249

Low

1086449

NDUA5
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5

1

0

High-throughput

0.249

Low

1272884

MGN2
Protein mago nashi homolog 2

1

0

High-throughput

0.249

Low

1272889

METH
Methionine synthase

1

0

High-throughput

0.249

Low

1272893

HGH1
Protein HGH1 homolog

1

0

High-throughput

0.249

Low

1272894

THTPA
Thiamine-triphosphatase

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024