Protein: KMT2D
Histone-lysine N-methyltransferase 2D (Lysine N-methyltransferase 2D) (EC 2.1.1.364) (ALL1-related protein) (Myeloid/lymphoid or mixed-lineage leukemia protein 2)

Gene: KMT2D
Organism: Homo sapiens
Interactions: 158
UniProt ID: O14686

Gene Ontology (top 5):
GO:0000976 - transcription cis-regulatory region binding
GO:0001555 - oocyte growth
GO:0003677 - DNA binding
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

152622

WDR5
WD repeat-containing protein 5

24

20

Small-scale

0.990

High

152695

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

16

20

Small-scale

0.985

High

152650

RBBP5
Retinoblastoma-binding protein 5

16

20

Small-scale

0.983

High

152556

KDM6A
Lysine-specific demethylase 6A

6

20

Small-scale

0.935

High

152623

H4
Histone H4

4

13

Small-scale

0.888

High

152678

FBXW7
F-box/WD repeat-containing protein 7

2

20

Small-scale

0.806

High

152553

SET1A
Histone-lysine N-methyltransferase SETD1A

2

20

High-throughput

0.754

High

152694

CXXC1
CXXC-type zinc finger protein 1

2

20

Small-scale

0.754

High

152675

CBP
CREB-binding protein

1

20

Small-scale

0.724

High

152579

ANDR
Androgen receptor

5

20

Small-scale

0.709

High

152685

PAGR1
PAXIP1-associated glutamate-rich protein 1

5

2

Small-scale

0.703

High

150088

UTY
Histone demethylase UTY

1

20

High-throughput

0.691

High

152664

RBM45
RNA-binding protein 45

1

8

High-throughput

0.691

High

152683

PYGO2
Pygopus homolog 2

1

0

Small-scale

0.687

High

152660

PAXI1
PAX-interacting protein 1

4

20

Small-scale

0.678

High

152645

NCOA6
Nuclear receptor coactivator 6

4

20

Small-scale

0.666

High

152575

H2A1B
Histone H2A type 1-B/E

1

19

Small-scale

0.647

High

152598

H2B1B
Histone H2B type 1-B

1

20

Small-scale

0.647

High

152625

H31
Histone H3.1

1

20

Small-scale

0.647

High

152661

H32
Histone H3.2

1

20

Small-scale

0.647

High

152574

GCR
Glucocorticoid receptor

3

20

Small-scale

0.640

High

152573

ESR1
Estrogen receptor

2

20

Small-scale

0.629

High

152559

BUB3
Mitotic checkpoint protein BUB3

1

20

High-throughput

0.618

High

152567

KDM4B
Lysine-specific demethylase 4B

1

9

Small-scale

0.618

High

152630

KMT2A
Histone-lysine N-methyltransferase 2A

1

20

High-throughput

0.618

High

152632

TLE3
Transducin-like enhancer protein 3

1

20

High-throughput

0.618

High

152649

SUZ12
Polycomb protein SUZ12

1

11

High-throughput

0.618

High

152654

EZH2
Histone-lysine N-methyltransferase EZH2

1

18

High-throughput

0.618

High

152658

WDR82
WD repeat-containing protein 82

1

20

Small-scale

0.618

High

152667

KMT2C
Histone-lysine N-methyltransferase 2C

1

20

High-throughput

0.618

High

152669

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.618

High

152679

PF21A
PHD finger protein 21A

1

20

High-throughput

0.618

High

152682

GRWD1
Glutamate-rich WD repeat-containing protein 1

1

20

Small-scale

0.618

High

152700

KMT2B
Histone-lysine N-methyltransferase 2B

1

20

High-throughput

0.618

High

152701

SET1B
Histone-lysine N-methyltransferase SETD1B

1

20

High-throughput

0.618

High

152599

CTNB1
Catenin beta-1

2

14

Small-scale

0.602

High

122360

MEN1
Menin

2

8

Small-scale

0.584

High

152610

SOX2
Transcription factor SOX-2

2

20

Small-scale

0.584

High

152621

KLF3
Krueppel-like factor 3

2

20

High-throughput

0.584

High

152663

WDR5B
WD repeat-containing protein 5B

1

20

Small-scale

0.575

High

152642

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

2

11

High-throughput

0.571

High

152687

DPY30
Protein dpy-30 homolog

2

7

Small-scale

0.571

High

152597

AKT1
RAC-alpha serine/threonine-protein kinase

1

3

Small-scale

0.561

High

152631

TF65
Transcription factor p65

1

11

Small-scale

0.561

High

152624

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

8

High-throughput

0.536

High

152608

KI67
Proliferation marker protein Ki-67

1

20

High-throughput

0.536

High

152635

GOGA2
Golgin subfamily A member 2

2

6

High-throughput

0.533

High

152655

SEPT7
Septin-7

1

6

High-throughput

0.515

High

152555

SMAD9
Mothers against decapentaplegic homolog 9

1

14

High-throughput

0.508

High

152653

SMAD1
Mothers against decapentaplegic homolog 1

1

14

High-throughput

0.508

High

152571

ABL1
Tyrosine-protein kinase ABL1

1

16

High-throughput

0.501

High

152577

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

11

High-throughput

0.501

High

152591

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

15

Small-scale

0.501

High

152676

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

12

High-throughput

0.501

High

152617

MANF
Mesencephalic astrocyte-derived neurotrophic factor

1

0

High-throughput

0.493

High

152595

S10A2
Protein S100-A2

1

8

High-throughput

0.489

High

118512

EYA2
Eyes absent homolog 2

1

17

High-throughput

0.479

High

123781

SPT5H
Transcription elongation factor SPT5

1

20

High-throughput

0.479

High

135048

NFIB
Nuclear factor 1 B-type

1

18

High-throughput

0.479

High

135183

E2F3
Transcription factor E2F3

1

12

Small-scale

0.479

High

152554

TBXT
T-box transcription factor T

1

7

High-throughput

0.479

High

152557

CRX
Cone-rod homeobox protein

1

20

High-throughput

0.479

High

152558

KLF4
Krueppel-like factor 4

1

20

High-throughput

0.479

High

152560

TLX3
T-cell leukemia homeobox protein 3

1

20

High-throughput

0.479

High

152561

TLX2
T-cell leukemia homeobox protein 2

1

20

High-throughput

0.479

High

152562

SOX15
Transcription factor SOX-15

1

20

High-throughput

0.479

High

152564

KDM1A
Lysine-specific histone demethylase 1A

1

18

High-throughput

0.479

High

152565

E2F6
Transcription factor E2F6

1

12

Small-scale

0.479

High

152568

TRI37
E3 ubiquitin-protein ligase TRIM37

1

14

High-throughput

0.479

High

152569

KLF8
Krueppel-like factor 8

1

20

High-throughput

0.479

High

152570

HERC2
E3 ubiquitin-protein ligase HERC2

1

10

High-throughput

0.479

High

152572

FOS
Protein c-Fos

1

9

High-throughput

0.479

High

152576

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

152578

MYB
Transcriptional activator Myb

1

9

High-throughput

0.479

High

152580

EGR2
E3 SUMO-protein ligase EGR2

1

10

High-throughput

0.479

High

152581

ERG
Transcriptional regulator ERG

1

20

High-throughput

0.479

High

152582

HXB2
Homeobox protein Hox-B2

1

20

High-throughput

0.479

High

152583

ETS1
Protein C-ets-1

1

20

High-throughput

0.479

High

152584

MYOD1
Myoblast determination protein 1

1

15

High-throughput

0.479

High

152585

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.479

High

152586

GATA1
Erythroid transcription factor

1

16

High-throughput

0.479

High

152587

HNF1A
Hepatocyte nuclear factor 1-alpha

1

19

High-throughput

0.479

High

152588

PAX7
Paired box protein Pax-7

1

20

High-throughput

0.479

High

152589

GATA2
Endothelial transcription factor GATA-2

1

16

High-throughput

0.479

High

152590

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

16

High-throughput

0.479

High

152592

PAX6
Paired box protein Pax-6

1

20

High-throughput

0.479

High

152593

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

9

High-throughput

0.479

High

152594

TEAD1
Transcriptional enhancer factor TEF-1

1

4

High-throughput

0.479

High

152596

TLX1
T-cell leukemia homeobox protein 1

1

20

High-throughput

0.479

High

152600

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.479

High

152601

HNF1B
Hepatocyte nuclear factor 1-beta

1

20

High-throughput

0.479

High

152602

SOX5
Transcription factor SOX-5

1

20

High-throughput

0.479

High

152603

PPARG
Peroxisome proliferator-activated receptor gamma

1

20

High-throughput

0.479

High

152604

ETV5
ETS translocation variant 5

1

20

High-throughput

0.479

High

152605

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

High-throughput

0.479

High

152607

ETV4
ETS translocation variant 4

1

20

High-throughput

0.479

High

152609

YAP1
Transcriptional coactivator YAP1

1

20

High-throughput

0.479

High

152611

SOX9
Transcription factor SOX-9

1

20

High-throughput

0.479

High

152612

LHX1
LIM/homeobox protein Lhx1

1

20

High-throughput

0.479

High

152613

CEBPA
CCAAT/enhancer-binding protein alpha

1

14

High-throughput

0.479

High

152615

LHX2
LIM/homeobox protein Lhx2

1

20

High-throughput

0.479

High

152616

HCFC1
Host cell factor 1

1

20

High-throughput

0.479

High

152618

PAX9
Paired box protein Pax-9

1

20

High-throughput

0.479

High

152619

SOX10
Transcription factor SOX-10

1

20

High-throughput

0.479

High

152620

GSC
Homeobox protein goosecoid

1

17

High-throughput

0.479

High

152626

FOXK2
Forkhead box protein K2

1

10

High-throughput

0.479

High

152627

IRF8
Interferon regulatory factor 8

1

7

High-throughput

0.479

High

152628

HEN1
Helix-loop-helix protein 1

1

11

High-throughput

0.479

High

152629

PAX2
Paired box protein Pax-2

1

20

High-throughput

0.479

High

152633

HME1
Homeobox protein engrailed-1

1

12

High-throughput

0.479

High

152634

PAX8
Paired box protein Pax-8

1

20

High-throughput

0.479

High

152636

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

152637

FOXI1
Forkhead box protein I1

1

9

High-throughput

0.479

High

152638

FOXL1
Forkhead box protein L1

1

9

High-throughput

0.479

High

152639

HDAC1
Histone deacetylase 1

1

20

High-throughput

0.479

High

152641

CUL3
Cullin-3

1

12

High-throughput

0.479

High

152643

KLF5
Krueppel-like factor 5

1

20

High-throughput

0.479

High

152644

E2F2
Transcription factor E2F2

1

12

Small-scale

0.479

High

152646

STAT4
Signal transducer and activator of transcription 4

1

2

High-throughput

0.479

High

152647

MEF2D
Myocyte-specific enhancer factor 2D

1

2

Small-scale

0.479

High

152648

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

152651

IRF4
Interferon regulatory factor 4

1

7

High-throughput

0.479

High

152652

E2F5
Transcription factor E2F5

1

12

Small-scale

0.479

High

152656

TBR1
T-box brain protein 1

1

7

High-throughput

0.479

High

152657

LHX8
LIM/homeobox protein Lhx8

1

20

High-throughput

0.479

High

152662

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

12

High-throughput

0.479

High

152665

SRRM1
Serine/arginine repetitive matrix protein 1

1

20

High-throughput

0.479

High

152668

BD1L1
Biorientation of chromosomes in cell division protein 1-like 1

1

19

High-throughput

0.479

High

152670

NUP35
Nucleoporin NUP35

1

2

High-throughput

0.479

High

152671

SP7
Transcription factor Sp7

1

20

High-throughput

0.479

High

152674

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

152677

LHX4
LIM/homeobox protein Lhx4

1

20

High-throughput

0.479

High

152680

FEV
Protein FEV

1

20

High-throughput

0.479

High

152681

ELF4
ETS-related transcription factor Elf-4

1

20

High-throughput

0.479

High

152684

SOX7
Transcription factor SOX-7

1

20

High-throughput

0.479

High

152686

KLF16
Krueppel-like factor 16

1

20

High-throughput

0.479

High

152688

WWTR1
WW domain-containing transcription regulator protein 1

1

19

High-throughput

0.479

High

152689

SENP3
Sentrin-specific protease 3

1

4

Small-scale

0.479

High

152690

SOX17
Transcription factor SOX-17

1

20

High-throughput

0.479

High

152691

GCM1
Chorion-specific transcription factor GCMa

1

2

High-throughput

0.479

High

152696

LHX3
LIM/homeobox protein Lhx3

1

20

High-throughput

0.479

High

152697

KLF15
Krueppel-like factor 15

1

20

High-throughput

0.479

High

152698

RCOR1
REST corepressor 1

1

20

High-throughput

0.479

High

152699

ELF5
ETS-related transcription factor Elf-5

1

20

High-throughput

0.479

High

152703

ASF1A
Histone chaperone ASF1A

1

6

High-throughput

0.479

High

152704

HCFC2
Host cell factor 2

1

20

High-throughput

0.479

High

152614

NDUV1
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

1

0

High-throughput

0.458

High

152672

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

0

High-throughput

0.458

High

152673

TOPB1
DNA topoisomerase 2-binding protein 1

1

15

Small-scale

0.457

High

152606

MATR3
Matrin-3

1

6

Small-scale

0.445

High

152640

SNW1
SNW domain-containing protein 1

1

3

High-throughput

0.445

High

152693

GRHL1
Grainyhead-like protein 1 homolog

1

4

High-throughput

0.445

High

152566

NU155
Nuclear pore complex protein Nup155

1

1

High-throughput

0.437

High

152692

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

11

High-throughput

0.437

High

152702

ITM2B
Integral membrane protein 2B

1

3

High-throughput

0.407

High

152659

PPR21
Protein phosphatase 1 regulatory subunit 21

1

0

High-throughput

0.279

Low

152666

UBAC2
Ubiquitin-associated domain-containing protein 2

1

0

High-throughput

0.279

Low

152563

KATIP
Katanin-interacting protein

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024