Protein: TPM2
Tropomyosin-2 (Tropomyosin I)

Gene: TPM2, Tm2
Organism: Drosophila melanogaster
Interactions: 116
UniProt ID: P09491

Gene Ontology (top 5):
GO:0005884 - actin filament
GO:0006936 - muscle contraction
GO:0007015 - actin filament organization
GO:0007507 - heart development
GO:0051015 - actin filament binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

432162

MYSA
Myosin heavy chain, muscle

2

7

High-throughput

0.737

High

482732

TNNI
Troponin I

2

6

High-throughput

0.737

High

482727

TNNT
Troponin T, skeletal muscle

2

0

High-throughput

0.699

High

387020

ACT4
Actin, larval muscle

2

15

High-throughput

0.659

High

482740

ACT6
Actin, indirect flight muscle

2

15

High-throughput

0.659

High

482760

Q8MSI2
GH15296p

2

0

High-throughput

0.617

High

446257

MLC1
Myosin light chain alkali

2

2

High-throughput

0.571

High

482725

ACTN
Alpha-actinin, sarcomeric

2

3

High-throughput

0.571

High

482726

MLR
Myosin regulatory light chain 2

2

1

High-throughput

0.521

High

482728

ATC1
Calcium-transporting ATPase sarcoplasmic/endoplasmic reticulum type

2

1

High-throughput

0.521

High

482730

MYSP2
Paramyosin, short form

2

8

High-throughput

0.521

High

482734

TNNC1
Troponin C, isoform 1

2

4

High-throughput

0.521

High

482752

Q7K569
Glycerol-3-phosphate dehydrogenase

2

5

High-throughput

0.521

High

482753

Q7K860
FI07231p

2

4

High-throughput

0.521

High

482766

VDAC
Voltage-dependent anion-selective channel

2

3

High-throughput

0.521

High

482784

Q9VEB1
Malate dehydrogenase, mitochondrial

2

1

High-throughput

0.521

High

482786

Q9VIE8
Aconitate hydratase, mitochondrial

2

1

High-throughput

0.521

High

482787

Q9VIQ8
Cytochrome c oxidase subunit 4

2

2

High-throughput

0.521

High

482798

Q9VSA9
CG7409

2

6

High-throughput

0.521

High

482721

ACT5
Actin-87E

1

15

High-throughput

0.514

High

482799

EXOC7
Exocyst complex component 7

1

3

High-throughput

0.494

High

362487

SRC64
Tyrosine-protein kinase Src64B

1

2

High-throughput

0.464

High

482746

PP2B2
Serine/threonine-protein phosphatase 2B catalytic subunit 2

1

9

High-throughput

0.464

High

482747

WGE
Protein winged eye

1

1

High-throughput

0.464

High

482748

Q59E05
Transcription factor Ouib

1

3

High-throughput

0.464

High

482769

Q9I7J8
FI01424p

1

1

High-throughput

0.464

High

482780

Q9VBH0
IP09281p

1

1

High-throughput

0.464

High

482782

Q9VCV4
Cytoplasmic aconitate hydratase

1

1

High-throughput

0.464

High

482783

Q9VCZ7
Uncharacterized protein

1

2

High-throughput

0.464

High

50262

A1A735
IP17475p

1

1

High-throughput

0.451

High

482723

MP20
Muscle-specific protein 20

1

9

High-throughput

0.445

High

482768

Q9I7J0
GH21596p

1

8

High-throughput

0.445

High

482816

X2J8I7
Sorting nexin 1, isoform B

1

2

High-throughput

0.439

High

84516

B7YZK8
Thin, isoform C

1

5

Small-scale

0.437

High

119507

M9NHC5
Uncharacterized protein, isoform C

1

6

High-throughput

0.437

High

482729

OSKA
Maternal effect protein oskar

1

1

Small-scale

0.437

High

482759

Q8IQQ0
2-oxoglutarate dehydrogenase, mitochondrial

1

3

High-throughput

0.437

High

482757

MSRB
Methionine-R-sulfoxide reductase B1

1

0

High-throughput

0.426

High

482737

PP1B
Serine/threonine-protein phosphatase beta isoform

1

8

High-throughput

0.417

High

482762

Q8MYW5
RE61749p

1

2

High-throughput

0.417

High

482795

Q9VQQ6
FI18122p1

1

2

High-throughput

0.417

High

54773

A1Z8Y3
Cuticular protein 49Ab

1

3

High-throughput

0.407

High

56338

ZASP
PDZ and LIM domain protein Zasp

1

9

High-throughput

0.407

High

68038

A8DRW0
Cuticular protein 49Aa

1

4

High-throughput

0.407

High

87080

Y5076
Uncharacterized protein CG45076

1

11

High-throughput

0.407

High

87144

FAU
Protein anoxia up-regulated

1

1

High-throughput

0.407

High

444166

VIT3
Vitellogenin-3

1

4

High-throughput

0.407

High

482735

TNNC2
Troponin C, isoform 2

1

4

High-throughput

0.407

High

482736

TNNC3
Troponin C, isoform 3

1

4

High-throughput

0.407

High

482751

Q7K2P1
Cuticular protein 50Cb

1

1

High-throughput

0.407

High

482754

Q7KQP6
Bent, isoform C

1

8

High-throughput

0.407

High

482761

Q8MYR8
RH74685p

1

2

High-throughput

0.407

High

482767

Q95RB2
Cuticular protein 49Ae

1

4

High-throughput

0.407

High

482770

Q9I7Q5
Cuticular protein 65Au, isoform A

1

3

High-throughput

0.407

High

482771

CP4G1
Cytochrome P450 4g1

1

1

High-throughput

0.407

High

482773

CP4C3
Cytochrome P450 4c3

1

1

High-throughput

0.407

High

482777

Q9VAN7
Phosphoglycerate mutase

1

1

High-throughput

0.407

High

482779

WDR20
WD repeat-containing protein 20 homolog

1

1

High-throughput

0.407

High

482788

Q9VKW1
LD41958p

1

1

High-throughput

0.407

High

482792

Q9VMT2
GEO07854p1

1

4

High-throughput

0.407

High

482805

Q9VVC5
2-oxoglutarate dehydrogenase, mitochondrial

1

3

High-throughput

0.407

High

482806

Q9VWG1
LD37169p

1

6

High-throughput

0.407

High

482811

Q9W077
Cuticular protein 62Bc, isoform A

1

1

High-throughput

0.407

High

482733

GSTS1
Glutathione S-transferase S1

3

0

High-throughput

0.322

High

57245

ICLN
Methylosome subunit pICln

2

0

High-throughput

0.298

High

358454

ADH
Alcohol dehydrogenase

2

0

High-throughput

0.298

High

459973

ALF
Fructose-bisphosphate aldolase

2

0

High-throughput

0.298

High

482722

GPDA
Glycerol-3-phosphate dehydrogenase [NAD(+)], cytoplasmic

2

0

High-throughput

0.298

High

482724

ENO
Enolase

2

0

High-throughput

0.298

High

482731

FTN
Flightin

2

0

High-throughput

0.298

High

482738

KARG
Arginine kinase 1

2

0

High-throughput

0.298

High

482739

DHE3
Glutamate dehydrogenase, mitochondrial

2

0

High-throughput

0.298

High

482741

CYC2
Cytochrome c-2

2

0

High-throughput

0.298

High

482744

ATP5J
ATP synthase-coupling factor 6, mitochondrial

2

0

High-throughput

0.298

High

482745

ATPO
ATP synthase subunit O, mitochondrial

2

0

High-throughput

0.298

High

482749

Q6IHY5
Cytochrome c oxidase subunit 7A-like 2, isoform A

2

0

High-throughput

0.298

High

482750

Q7JUS9
Phosphate carrier protein, mitochondrial

2

0

High-throughput

0.298

High

482755

Q8I062
GH23305p

2

0

High-throughput

0.298

High

482765

AT5F1
ATP synthase subunit b, mitochondrial

2

0

High-throughput

0.298

High

482785

Q9VED1
IP07781p

2

0

High-throughput

0.298

High

482789

Q9VM18
Trehalose 6-phosphate phosphatase

2

0

High-throughput

0.298

High

482793

Q9VP84
IP06402p

2

0

High-throughput

0.298

High

482797

Q9VRL0
Cytochrome c1, heme protein, mitochondrial

2

0

High-throughput

0.298

High

482802

NPLP2
Neuropeptide-like 2

2

0

High-throughput

0.298

High

482807

IDH3A
Probable isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

2

0

High-throughput

0.298

High

482812

ATPK
Putative ATP synthase subunit f, mitochondrial

2

0

High-throughput

0.298

High

482814

CISY
Probable citrate synthase, mitochondrial

2

0

High-throughput

0.298

High

56615

A1ZAC8
Uncharacterized protein, isoform B

1

0

High-throughput

0.265

Low

57155

PTRO
Patronin

1

0

High-throughput

0.265

Low

57992

A1ZBC3
Uncharacterized protein

1

0

High-throughput

0.265

Low

482781

Q9VBI1
DNA replication complex GINS protein SLD5

1

0

High-throughput

0.265

Low

482791

Q9VMJ2
RT07854p

1

0

High-throughput

0.265

Low

482801

Q9VT87
Uncharacterized protein, isoform B

1

0

High-throughput

0.265

Low

482809

Q9VXK9
Centrosomal protein 164, isoform A

1

0

High-throughput

0.265

Low

482815

TFP11
Septin-interacting protein 1

1

0

High-throughput

0.265

Low

482763

OB56D
General odorant-binding protein 56d

1

0

High-throughput

0.249

Low

482774

FRIL
Ferritin light chain

1

0

High-throughput

0.249

Low

482776

Q9VAC1
GM14349p

1

0

High-throughput

0.249

Low

482778

Q9VBA0
GH09623p

1

0

High-throughput

0.249

Low

482796

Q9VQR2
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10

1

0

High-throughput

0.249

Low

482803

PYRG
CTP synthase

1

0

High-throughput

0.249

Low

482808

NDUS4
NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial

1

0

High-throughput

0.249

Low

482813

Q9W2X6
ATP synthase F(1) complex subunit delta, mitochondrial

1

0

High-throughput

0.249

Low

360509

COX2
Cytochrome c oxidase subunit 2

1

0

High-throughput

0.232

Low

482742

ATP5H
ATP synthase subunit d, mitochondrial

1

0

High-throughput

0.232

Low

482743

RUXF
Small nuclear ribonucleoprotein F

1

0

High-throughput

0.232

Low

482756

Q8I0D4
RE20510p

1

0

High-throughput

0.232

Low

482758

Q8IQB4
Z band alternatively spliced PDZ-motif protein 66, isoform E

1

0

High-throughput

0.232

Low

482764

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

0

High-throughput

0.232

Low

482772

Q9V9U0
RE35358p

1

0

High-throughput

0.232

Low

482775

Q9VA92
RH14937p

1

0

High-throughput

0.232

Low

482790

Q9VMB9
Cytochrome c oxidase subunit 5B, isoform A

1

0

High-throughput

0.232

Low

482794

Q9VP98
Uncharacterized protein

1

0

High-throughput

0.232

Low

482800

Q9VSY0
Cuticular protein 67B

1

0

High-throughput

0.232

Low

482804

SMN
Survival motor neuron protein

1

0

High-throughput

0.232

Low

482810

SUN
Protein stunted

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025