Protein: GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2 (Adenylate cyclase-inhibiting G alpha protein)

Gene: GNAI2
Organism: Homo sapiens
Interactions: 218
UniProt ID: P04899

Gene Ontology (top 5):
GO:0001664 - G protein-coupled receptor binding
GO:0001973 - G protein-coupled adenosine receptor signaling pathway
GO:0003924 - GTPase activity
GO:0005525 - GTP binding
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

391469

RIC8A
Synembryn-A

4

13

Small-scale

0.902

High

391465

GBB4
Guanine nucleotide-binding protein subunit beta-4

4

20

Small-scale

0.899

High

391373

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

4

20

Small-scale

0.886

High

391352

MTR1A
Melatonin receptor type 1A

3

20

Small-scale

0.866

High

391309

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

3

11

High-throughput

0.861

High

391311

GNAO

3

11

High-throughput

0.861

High

391321

GBB3
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3

3

20

High-throughput

0.861

High

391380

GPSM2
G-protein-signaling modulator 2

3

14

Small-scale

0.857

High

391338

CXCR5
C-X-C chemokine receptor type 5

2

13

Small-scale

0.806

High

391374

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

2

20

Small-scale

0.799

High

391355

MTR1B
Melatonin receptor type 1B

2

19

Small-scale

0.789

High

391475

RIC8B
Synembryn-B

2

13

High-throughput

0.789

High

182439

RGS5
Regulator of G-protein signaling 5

2

20

Small-scale

0.768

High

391333

CXCR1
C-X-C chemokine receptor type 1

2

19

Small-scale

0.754

High

391356

RGS19
Regulator of G-protein signaling 19

2

20

Small-scale

0.743

High

283156

RGS20
Regulator of G-protein signaling 20

1

20

High-throughput

0.740

High

391488

GPSM3
G-protein-signaling modulator 3

1

3

High-throughput

0.740

High

391427

PCP2
Purkinje cell protein 2 homolog

2

11

High-throughput

0.700

High

391403

LT4R1
Leukotriene B4 receptor 1

1

16

Small-scale

0.692

High

229233

GBG7

3

20

High-throughput

0.667

High

391359

GBG4

3

20

High-throughput

0.667

High

391360

GBG10

3

20

High-throughput

0.667

High

391378

GBG5

3

20

High-throughput

0.667

High

391441

PAQR1
Adiponectin receptor protein 1

3

1

High-throughput

0.667

High

391477

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

3

1

High-throughput

0.667

High

180650

RGS16
Regulator of G-protein signaling 16

1

20

Small-scale

0.647

High

391305

ADRB2
Beta-2 adrenergic receptor

1

10

Small-scale

0.647

High

391310

ADA2A
Alpha-2A adrenergic receptor

1

12

Small-scale

0.647

High

391330

TA2R
Thromboxane A2 receptor

1

20

Small-scale

0.647

High

391358

RGS4
Regulator of G-protein signaling 4

1

20

Small-scale

0.647

High

391446

MRGX1
Mas-related G-protein coupled receptor member X1

1

19

Small-scale

0.647

High

391473

RGS18
Regulator of G-protein signaling 18

1

20

Small-scale

0.647

High

391317

CFTR
Cystic fibrosis transmembrane conductance regulator

3

4

High-throughput

0.643

High

391414

LMBD2
G-protein coupled receptor-associated protein LMBRD2

3

0

High-throughput

0.638

High

391468

ABCB6
ATP-binding cassette sub-family B member 6

3

0

High-throughput

0.638

High

391452

MDFI
MyoD family inhibitor

2

0

High-throughput

0.629

High

391377

GBG3

2

20

High-throughput

0.628

High

158597

RGS12
Regulator of G-protein signaling 12

1

20

Small-scale

0.621

High

207505

RGS14
Regulator of G-protein signaling 14

1

20

Small-scale

0.621

High

158580

RGS13
Regulator of G-protein signaling 13

1

20

Small-scale

0.618

High

391327

CNR1
Cannabinoid receptor 1

1

20

Small-scale

0.618

High

391334

PAR1
Proteinase-activated receptor 1

1

19

Small-scale

0.618

High

391337

AA1R
Adenosine receptor A1

1

12

Small-scale

0.618

High

391340

CRFR1
Corticotropin-releasing factor receptor 1

1

9

Small-scale

0.618

High

391347

OPRD
Delta-type opioid receptor

1

17

Small-scale

0.618

High

391348

MUC18
Cell surface glycoprotein MUC18

1

2

High-throughput

0.618

High

391357

RGS3
Regulator of G-protein signaling 3

1

20

Small-scale

0.618

High

391370

WDR5
WD repeat-containing protein 5

1

1

High-throughput

0.618

High

391376

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

1

11

High-throughput

0.618

High

391464

ECT2
Protein ECT2

1

12

High-throughput

0.618

High

391365

CD81
CD81 antigen

2

7

Small-scale

0.612

High

391391

IQGA2
Ras GTPase-activating-like protein IQGAP2

2

11

High-throughput

0.611

High

391407

GRDN
Girdin

2

7

High-throughput

0.611

High

391442

ARL8A
ADP-ribosylation factor-like protein 8A

2

2

High-throughput

0.611

High

391434

MCU
Calcium uniporter protein, mitochondrial

3

1

High-throughput

0.609

High

226243

PRKN
E3 ubiquitin-protein ligase parkin

2

4

High-throughput

0.584

High

345669

MYC
Myc proto-oncogene protein

2

4

High-throughput

0.584

High

349793

RASK
GTPase KRas

2

12

High-throughput

0.584

High

391390

SQSTM
Sequestosome-1

2

3

High-throughput

0.584

High

391470

ANLN
Anillin

2

8

High-throughput

0.584

High

391329

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

15

Small-scale

0.575

High

391400

K1H1
Keratin, type I cuticular Ha1

1

1

High-throughput

0.573

High

391401

TRIP6
Thyroid receptor-interacting protein 6

1

1

High-throughput

0.573

High

391416

K1C40
Keratin, type I cytoskeletal 40

1

1

High-throughput

0.573

High

391386

DUS4
Dual specificity protein phosphatase 4

2

16

High-throughput

0.571

High

391399

KPCD1
Serine/threonine-protein kinase D1

2

5

High-throughput

0.571

High

391410

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

4

Small-scale

0.571

High

391396

RASA3
Ras GTPase-activating protein 3

1

15

Small-scale

0.561

High

391322

NCF2
Neutrophil cytosol factor 2

1

2

Small-scale

0.554

High

391366

KR108
Keratin-associated protein 10-8

1

0

High-throughput

0.549

High

391423

NT2NA
Notch homolog 2 N-terminal-like protein A

1

0

High-throughput

0.549

High

161491

S27A2
Long-chain fatty acid transport protein 2

1

1

High-throughput

0.536

High

316547

ACSL3
Fatty acid CoA ligase Acsl3

1

2

High-throughput

0.536

High

391308

HS90B
Heat shock protein HSP 90-beta

1

3

Small-scale

0.536

High

391314

TAU
Microtubule-associated protein tau

1

16

High-throughput

0.536

High

391343

MYH9
Myosin-9

1

3

High-throughput

0.536

High

391387

STK3
Serine/threonine-protein kinase 3

1

4

High-throughput

0.536

High

391419

S27A4
Long-chain fatty acid transport protein 4

1

1

High-throughput

0.536

High

391426

PIM3
Serine/threonine-protein kinase pim-3

1

5

High-throughput

0.536

High

391429

SYNPO
Synaptopodin

1

2

High-throughput

0.536

High

391436

TBCK
TBC domain-containing protein kinase-like protein

1

4

High-throughput

0.536

High

391438

HASP
Serine/threonine-protein kinase haspin

1

4

High-throughput

0.536

High

391471

PDLI7
PDZ and LIM domain protein 7

1

1

High-throughput

0.536

High

391478

PAK5
Serine/threonine-protein kinase PAK 5

1

10

High-throughput

0.536

High

391482

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

20

High-throughput

0.536

High

118526

EYA2
Eyes absent homolog 2

1

5

Small-scale

0.527

High

170023

PLS1
Phospholipid scramblase 1

1

0

High-throughput

0.518

High

391304

NPM
Nucleophosmin

1

0

High-throughput

0.518

High

391451

TTC1
Tetratricopeptide repeat protein 1

1

7

Small-scale

0.515

High

391325

LMNB1
Lamin-B1

1

0

High-throughput

0.513

High

391339

ERD22
ER lumen protein-retaining receptor 2

1

0

High-throughput

0.513

High

391349

AL3B1
Aldehyde dehydrogenase family 3 member B1

1

0

High-throughput

0.513

High

391351

CAZA2
F-actin-capping protein subunit alpha-2

1

0

High-throughput

0.513

High

391402

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

High-throughput

0.513

High

391367

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

3

Small-scale

0.501

High

391445

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

1

Small-scale

0.501

High

157278

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

3

High-throughput

0.489

High

391328

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

5

Small-scale

0.481

High

391383

NUCB1
Nucleobindin-1

1

7

Small-scale

0.481

High

358700

CRYAA
Alpha-crystallin A chain

1

0

High-throughput

0.480

High

128958

PLK4
Serine/threonine-protein kinase PLK4

1

2

Small-scale

0.479

High

155240

NRP1
Neuropilin-1

1

5

High-throughput

0.479

High

167799

NPC1
NPC intracellular cholesterol transporter 1

1

2

High-throughput

0.479

High

177782

TMPS2
Transmembrane protease serine 2

1

4

High-throughput

0.479

High

204918

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.479

High

209581

PRC1
Protein regulator of cytokinesis 1

1

2

High-throughput

0.479

High

214746

PM34
Peroxisomal membrane protein PMP34

1

5

High-throughput

0.479

High

233140

NUPR1
Nuclear protein 1

1

3

High-throughput

0.479

High

308309

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

318556

EYA4
Eyes absent homolog 4

1

5

High-throughput

0.479

High

373499

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

8

High-throughput

0.479

High

378897

MYCN
N-myc proto-oncogene protein

1

4

High-throughput

0.479

High

391306

HS90A
Heat shock protein HSP 90-alpha

1

3

Small-scale

0.479

High

391307

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.479

High

391312

FURIN
Furin

1

2

High-throughput

0.479

High

391313

IL8
Interleukin-8

1

1

Small-scale

0.479

High

391315

BIP
Endoplasmic reticulum chaperone BiP

1

9

High-throughput

0.479

High

391316

HSP7C
Heat shock cognate 71 kDa protein

1

5

High-throughput

0.479

High

391318

NCF1
Neutrophil cytosol factor 1

1

1

Small-scale

0.479

High

391319

BRAF
Serine/threonine-protein kinase B-raf

1

12

High-throughput

0.479

High

391320

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.479

High

391323

BTF3
Transcription factor BTF3

1

1

High-throughput

0.479

High

391324

ATP4A
Potassium-transporting ATPase alpha chain 1

1

6

Small-scale

0.479

High

391331

CBL
E3 ubiquitin-protein ligase CBL

1

3

Small-scale

0.479

High

391335

U2AF2
Splicing factor U2AF 65 kDa subunit

1

1

High-throughput

0.479

High

391336

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

3

High-throughput

0.479

High

391342

RFA3
Replication protein A 14 kDa subunit

1

5

High-throughput

0.479

High

391344

BASI
Basigin

1

3

High-throughput

0.479

High

391345

BMR1A
Bone morphogenetic protein receptor type-1A

1

2

High-throughput

0.479

High

391346

CCNF
Cyclin-F

1

4

High-throughput

0.479

High

391350

YAP1
Transcriptional coactivator YAP1

1

10

High-throughput

0.479

High

391353

SOX2
Transcription factor SOX-2

1

3

High-throughput

0.479

High

391354

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.479

High

391361

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

5

High-throughput

0.479

High

391362

RND2
Rho-related GTP-binding protein RhoN

1

20

High-throughput

0.479

High

391364

GBG2
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

1

20

Small-scale

0.479

High

391368

RAB2A
Ras-related protein Rab-2A

1

5

High-throughput

0.479

High

391369

RHOA
Transforming protein RhoA

1

20

High-throughput

0.479

High

391372

RHOB
Rho-related GTP-binding protein RhoB

1

20

High-throughput

0.479

High

391375

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.479

High

391382

KIF23
Kinesin-like protein KIF23

1

14

High-throughput

0.479

High

391384

VAC14
Protein VAC14 homolog

1

1

High-throughput

0.479

High

391385

TFCP2
Alpha-globin transcription factor CP2

1

8

High-throughput

0.479

High

391393

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

3

High-throughput

0.479

High

391394

DX39B
Spliceosome RNA helicase DDX39B

1

1

High-throughput

0.479

High

391397

KIF14
Kinesin-like protein KIF14

1

7

High-throughput

0.479

High

391404

EZH2
Histone-lysine N-methyltransferase EZH2

1

2

High-throughput

0.479

High

391406

DUS6
Dual specificity protein phosphatase 6

1

16

High-throughput

0.479

High

391408

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

3

High-throughput

0.479

High

391409

MIDN
Midnolin

1

3

High-throughput

0.479

High

391413

ECM29
Proteasome adapter and scaffold protein ECM29

1

1

High-throughput

0.479

High

391421

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

391422

RHOU
Rho-related GTP-binding protein RhoU

1

20

High-throughput

0.479

High

391428

MILK2
MICAL-like protein 2

1

1

High-throughput

0.479

High

391430

EMC5
ER membrane protein complex subunit 5

1

3

High-throughput

0.479

High

391437

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

1

High-throughput

0.479

High

391439

RN138
E3 ubiquitin-protein ligase RNF138

1

4

High-throughput

0.479

High

391440

ESR2
Estrogen receptor beta

1

10

High-throughput

0.479

High

391443

DCPS
m7GpppX diphosphatase

1

1

High-throughput

0.479

High

391444

OPTN
Optineurin

1

10

High-throughput

0.479

High

391449

RING2
E3 ubiquitin-protein ligase RING2

1

3

High-throughput

0.479

High

391453

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

6

High-throughput

0.479

High

391454

DUS9
Dual specificity protein phosphatase 9

1

16

High-throughput

0.479

High

391455

FACD2
Fanconi anemia group D2 protein

1

7

High-throughput

0.479

High

391456

ACE2
Angiotensin-converting enzyme 2

1

3

High-throughput

0.479

High

391458

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

2

High-throughput

0.479

High

391459

TOLIP
Toll-interacting protein

1

1

High-throughput

0.479

High

391460

CCDC8
Coiled-coil domain-containing protein 8

1

2

High-throughput

0.479

High

391461

CHM4B
Charged multivesicular body protein 4b

1

5

High-throughput

0.479

High

391462

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.479

High

391463

PKHA4
Pleckstrin homology domain-containing family A member 4

1

12

High-throughput

0.479

High

391466

NMRL1
NmrA-like family domain-containing protein 1

1

3

High-throughput

0.479

High

391467

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

8

High-throughput

0.479

High

391472

DUS22
Dual specificity protein phosphatase 22

1

15

High-throughput

0.479

High

391474

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.479

High

391479

SYLC
Leucine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

391480

HDAC6
Histone deacetylase 6

1

7

High-throughput

0.479

High

391481

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

391484

RNF6
E3 ubiquitin-protein ligase RNF6

1

3

High-throughput

0.479

High

391486

CRYL1
Lambda-crystallin homolog

1

1

High-throughput

0.479

High

391487

TRRAP
Transformation/transcription domain-associated protein

1

1

High-throughput

0.479

High

353229

CD4
T-cell surface glycoprotein CD4

1

0

Small-scale

0.458

High

390651

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

391332

GCSP
Glycine dehydrogenase

1

0

High-throughput

0.458

High

391389

S39A6
Zinc transporter ZIP6

1

0

High-throughput

0.458

High

391415

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

391418

RINT1
RAD50-interacting protein 1

1

0

High-throughput

0.458

High

391420

BRAT1
BRCA1-associated ATM activator 1

1

0

High-throughput

0.458

High

391425

NLRX1
NLR family member X1

1

0

High-throughput

0.458

High

391433

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

391435

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

1

0

High-throughput

0.458

High

391476

MED9
Mediator of RNA polymerase II transcription subunit 9

1

0

High-throughput

0.458

High

391483

MTMR7
Myotubularin-related protein 7

1

0

High-throughput

0.458

High

391489

SCC4
MAU2 chromatid cohesion factor homolog

1

0

High-throughput

0.458

High

391379

TBA4A
Tubulin alpha-4A chain

1

2

High-throughput

0.457

High

239698

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

8

High-throughput

0.445

High

391341

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.445

High

391363

MOT1
Monocarboxylate transporter 1

1

4

High-throughput

0.445

High

391371

RB11A
Ras-related protein Rab-11A

1

3

High-throughput

0.445

High

391381

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

3

High-throughput

0.445

High

391392

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

3

High-throughput

0.445

High

391395

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

11

High-throughput

0.445

High

391417

PKHA7
Pleckstrin homology domain-containing family A member 7

1

14

High-throughput

0.445

High

391431

CD177
CD177 antigen

1

4

Small-scale

0.445

High

391447

CEP63
Centrosomal protein of 63 kDa

1

9

High-throughput

0.445

High

391448

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

14

High-throughput

0.445

High

391450

ZBT18
Zinc finger and BTB domain-containing protein 18

1

5

High-throughput

0.445

High

391457

ZDHC5
Palmitoyltransferase ZDHHC5

1

3

High-throughput

0.445

High

391485

ITM2B
Integral membrane protein 2B

1

8

High-throughput

0.445

High

328697

TOP3B
DNA topoisomerase 3-beta-1

1

3

High-throughput

0.437

High

391405

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

2

High-throughput

0.437

High

391326

CD3Z
T-cell surface glycoprotein CD3 zeta chain

1

0

High-throughput

0.426

High

391388

CTBP1
C-terminal-binding protein 1

1

0

High-throughput

0.426

High

391432

POC5
Centrosomal protein POC5

1

0

High-throughput

0.426

High

391412

MFS4B
Sodium-dependent glucose transporter 1

3

0

High-throughput

0.347

High

391424

ADCK1
AarF domain-containing protein kinase 1

2

0

High-throughput

0.318

High

391398

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

1

0

High-throughput

0.269

Low

391411

LITD1
LINE-1 type transposase domain-containing protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024