Protein: KDM6A
Lysine-specific demethylase 6A (EC 1.14.11.68) (Histone demethylase UTX) (Ubiquitously-transcribed TPR protein on the X chromosome) (Ubiquitously-transcribed X chromosome tetratricopeptide repeat protein) ([histone H3]-trimethyl-L-lysine(27) demethylase 6A)

Gene: KDM6A
Organism: Homo sapiens
Interactions: 150
UniProt ID: O15550

Gene Ontology (top 5):
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0006338 - chromatin remodeling
GO:0007507 - heart development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

183095

WDR5
WD repeat-containing protein 5

9

12

Small-scale

0.970

High

183118

RBBP5
Retinoblastoma-binding protein 5

9

18

Small-scale

0.969

High

152556

KMT2D
Histone-lysine N-methyltransferase 2D

6

20

Small-scale

0.935

High

183137

KMT2C
Histone-lysine N-methyltransferase 2C

3

20

Small-scale

0.847

High

183125

WDR82
WD repeat-containing protein 82

2

16

Small-scale

0.754

High

183146

FBXW7
F-box/WD repeat-containing protein 7

2

14

Small-scale

0.754

High

183170

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

11

7

Small-scale

0.754

High

183115

NCOA6
Nuclear receptor coactivator 6

6

13

Small-scale

0.730

High

183126

PAXI1
PAX-interacting protein 1

6

10

Small-scale

0.729

High

183154

PAGR1
PAXIP1-associated glutamate-rich protein 1

5

1

Small-scale

0.709

High

183054

ANDR
Androgen receptor

4

20

Small-scale

0.686

High

183156

DPY30
Protein dpy-30 homolog

3

2

Small-scale

0.650

High

183080

SOX2
Transcription factor SOX-2

3

14

Small-scale

0.640

High

183106

TLE1
Transducin-like enhancer protein 1

1

14

Small-scale

0.621

High

174456

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

14

Small-scale

0.618

High

183044

BUB3
Mitotic checkpoint protein BUB3

1

15

High-throughput

0.618

High

183105

KMT2A
Histone-lysine N-methyltransferase 2A

1

20

High-throughput

0.618

High

183162

CSR2B
Cysteine-rich protein 2-binding protein

1

6

High-throughput

0.618

High

183167

CXXC1
CXXC-type zinc finger protein 1

1

11

High-throughput

0.618

High

183176

KMT2B
Histone-lysine N-methyltransferase 2B

1

20

High-throughput

0.618

High

183131

RHG22
Rho GTPase-activating protein 22

2

6

High-throughput

0.611

High

180961

GSC2
Homeobox protein goosecoid-2

2

6

High-throughput

0.606

High

183098

H31
Histone H3.1

2

9

Small-scale

0.602

High

183043

KLF4
Krueppel-like factor 4

2

13

Small-scale

0.584

High

183094

KLF3
Krueppel-like factor 3

2

14

High-throughput

0.584

High

183088

NKX25
Homeobox protein Nkx-2.5

1

5

Small-scale

0.552

High

183151

TBX5
T-box transcription factor TBX5

1

3

Small-scale

0.552

High

183141

RSPH1
Radial spoke head 1 homolog

1

3

High-throughput

0.541

High

183052

TRY1
Serine protease 1

1

1

High-throughput

0.536

High

183148

DYL2
Dynein light chain 2, cytoplasmic

1

2

High-throughput

0.536

High

183058

SRF
Serum response factor

1

0

Small-scale

0.529

High

183124

Q6FHY5
MEOX2 protein

1

3

High-throughput

0.515

High

171344

SMAD9
Mothers against decapentaplegic homolog 9

1

9

High-throughput

0.508

High

183122

H31T
Histone H3.1t

1

9

Small-scale

0.501

High

183127

H32
Histone H3.2

1

9

Small-scale

0.501

High

183093

HUNK
Hormonally up-regulated neu tumor-associated kinase

1

3

High-throughput

0.494

High

183069

S10A2
Protein S100-A2

1

3

High-throughput

0.489

High

183097

TBA1B
Tubulin alpha-1B chain

1

7

High-throughput

0.489

High

183084

MEOX2
Homeobox protein MOX-2

1

4

High-throughput

0.481

High

183144

CBP
CREB-binding protein

1

15

Small-scale

0.481

High

118516

EYA2
Eyes absent homolog 2

1

7

High-throughput

0.479

High

122375

MEN1
Menin

1

2

High-throughput

0.479

High

135052

NFIB
Nuclear factor 1 B-type

1

4

High-throughput

0.479

High

165600

SET1A
Histone-lysine N-methyltransferase SETD1A

1

20

High-throughput

0.479

High

170994

TBXT
T-box transcription factor T

1

3

High-throughput

0.479

High

183041

SERA
D-3-phosphoglycerate dehydrogenase

1

4

Small-scale

0.479

High

183042

CRX
Cone-rod homeobox protein

1

9

High-throughput

0.479

High

183045

TLX3
T-cell leukemia homeobox protein 3

1

4

High-throughput

0.479

High

183046

SOX15
Transcription factor SOX-15

1

13

High-throughput

0.479

High

183047

BRD4
Bromodomain-containing protein 4

1

10

High-throughput

0.479

High

183049

FOS
Protein c-Fos

1

2

High-throughput

0.479

High

183050

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

183051

P53
Cellular tumor antigen p53

1

6

Small-scale

0.479

High

183053

NFIC
Nuclear factor 1 C-type

1

9

High-throughput

0.479

High

183056

EGR2
E3 SUMO-protein ligase EGR2

1

5

High-throughput

0.479

High

183057

ERG
Transcriptional regulator ERG

1

7

High-throughput

0.479

High

183059

ETS1
Protein C-ets-1

1

7

High-throughput

0.479

High

183060

MYOD1
Myoblast determination protein 1

1

3

High-throughput

0.479

High

183061

GATA1
Erythroid transcription factor

1

7

High-throughput

0.479

High

183062

TFE3
Transcription factor E3

1

2

Small-scale

0.479

High

183063

HNF1A
Hepatocyte nuclear factor 1-alpha

1

5

High-throughput

0.479

High

183064

PAX7
Paired box protein Pax-7

1

10

High-throughput

0.479

High

183065

GATA2
Endothelial transcription factor GATA-2

1

7

High-throughput

0.479

High

183066

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

7

High-throughput

0.479

High

183067

PAX6
Paired box protein Pax-6

1

8

High-throughput

0.479

High

183068

TEAD1
Transcriptional enhancer factor TEF-1

1

1

High-throughput

0.479

High

183070

TLX1
T-cell leukemia homeobox protein 1

1

7

High-throughput

0.479

High

183071

HNF1B
Hepatocyte nuclear factor 1-beta

1

10

High-throughput

0.479

High

183072

PPARG
Peroxisome proliferator-activated receptor gamma

1

20

High-throughput

0.479

High

183073

ETV5
ETS translocation variant 5

1

8

High-throughput

0.479

High

183074

HNF4A
Hepatocyte nuclear factor 4-alpha

1

19

High-throughput

0.479

High

183075

ELK3
ETS domain-containing protein Elk-3

1

8

High-throughput

0.479

High

183077

ETV4
ETS translocation variant 4

1

8

High-throughput

0.479

High

183078

GATA4
Transcription factor GATA-4

1

7

Small-scale

0.479

High

183079

YAP1
Transcriptional coactivator YAP1

1

15

High-throughput

0.479

High

183081

SOX9
Transcription factor SOX-9

1

14

High-throughput

0.479

High

183082

LHX1
LIM/homeobox protein Lhx1

1

5

High-throughput

0.479

High

183083

CEBPA
CCAAT/enhancer-binding protein alpha

1

7

High-throughput

0.479

High

183085

LHX2
LIM/homeobox protein Lhx2

1

7

High-throughput

0.479

High

183086

SMCA4
Transcription activator BRG1

1

9

Small-scale

0.479

High

183087

HCFC1
Host cell factor 1

1

4

High-throughput

0.479

High

183089

FOXA1
Hepatocyte nuclear factor 3-alpha

1

7

High-throughput

0.479

High

183090

PAX9
Paired box protein Pax-9

1

8

High-throughput

0.479

High

183091

SOX10
Transcription factor SOX-10

1

16

High-throughput

0.479

High

183092

GSC
Homeobox protein goosecoid

1

4

High-throughput

0.479

High

183096

H4
Histone H4

1

4

High-throughput

0.479

High

183099

FOXK1
Forkhead box protein K1

1

6

Small-scale

0.479

High

183100

FOXK2
Forkhead box protein K2

1

9

Small-scale

0.479

High

183101

PO5F1
POU domain, class 5, transcription factor 1

1

7

Small-scale

0.479

High

183102

IRF8
Interferon regulatory factor 8

1

4

High-throughput

0.479

High

183103

HEN1
Helix-loop-helix protein 1

1

4

High-throughput

0.479

High

183104

PAX2
Paired box protein Pax-2

1

8

High-throughput

0.479

High

183107

HME1
Homeobox protein engrailed-1

1

3

High-throughput

0.479

High

183108

PAX8
Paired box protein Pax-8

1

8

High-throughput

0.479

High

183110

NFIA
Nuclear factor 1 A-type

1

9

High-throughput

0.479

High

183111

FOXI1
Forkhead box protein I1

1

6

High-throughput

0.479

High

183112

FOXL1
Forkhead box protein L1

1

6

High-throughput

0.479

High

183113

CUL3
Cullin-3

1

5

High-throughput

0.479

High

183114

KLF5
Krueppel-like factor 5

1

12

High-throughput

0.479

High

183116

NFIX
Nuclear factor 1 X-type

1

9

High-throughput

0.479

High

183117

SUZ12
Polycomb protein SUZ12

1

1

High-throughput

0.479

High

183119

IRF4
Interferon regulatory factor 4

1

4

High-throughput

0.479

High

183120

EZH2
Histone-lysine N-methyltransferase EZH2

1

15

High-throughput

0.479

High

183121

TBR1
T-box brain protein 1

1

3

High-throughput

0.479

High

183123

PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

1

4

Small-scale

0.479

High

183128

ASXL2
Putative Polycomb group protein ASXL2

1

11

Small-scale

0.479

High

183129

KANL1
KAT8 regulatory NSL complex subunit 1

1

1

High-throughput

0.479

High

183130

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

4

High-throughput

0.479

High

183134

ASXL1
Polycomb group protein ASXL1

1

5

Small-scale

0.479

High

183138

BD1L1
Biorientation of chromosomes in cell division protein 1-like 1

1

1

High-throughput

0.479

High

183139

MAFA
Transcription factor MafA

1

3

Small-scale

0.479

High

183140

SP7
Transcription factor Sp7

1

8

High-throughput

0.479

High

183142

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

Small-scale

0.479

High

183143

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

183145

LHX4
LIM/homeobox protein Lhx4

1

5

High-throughput

0.479

High

183147

MCRS1
Microspherule protein 1

1

1

High-throughput

0.479

High

183149

RING2
E3 ubiquitin-protein ligase RING2

1

14

Small-scale

0.479

High

183150

FEV
Protein FEV

1

7

High-throughput

0.479

High

183152

ELF4
ETS-related transcription factor Elf-4

1

8

High-throughput

0.479

High

183153

SOX7
Transcription factor SOX-7

1

13

High-throughput

0.479

High

183155

KLF16
Krueppel-like factor 16

1

10

High-throughput

0.479

High

183157

ASXL3
Putative Polycomb group protein ASXL3

1

9

Small-scale

0.479

High

183158

WWTR1
WW domain-containing transcription regulator protein 1

1

12

High-throughput

0.479

High

183160

SOX17
Transcription factor SOX-17

1

14

High-throughput

0.479

High

183161

KAT8
Histone acetyltransferase KAT8

1

3

High-throughput

0.479

High

183163

KANL2
KAT8 regulatory NSL complex subunit 2

1

1

High-throughput

0.479

High

183165

MBIP1
MAP3K12-binding inhibitory protein 1

1

1

High-throughput

0.479

High

183168

KANL3
KAT8 regulatory NSL complex subunit 3

1

1

High-throughput

0.479

High

183169

RERE
Arginine-glutamic acid dipeptide repeats protein

1

7

High-throughput

0.479

High

183171

LHX3
LIM/homeobox protein Lhx3

1

4

High-throughput

0.479

High

183172

KLF15
Krueppel-like factor 15

1

10

High-throughput

0.479

High

183173

SIX4
Homeobox protein SIX4

1

2

Small-scale

0.479

High

183174

ELF5
ETS-related transcription factor Elf-5

1

7

High-throughput

0.479

High

183175

YETS2
YEATS domain-containing protein 2

1

3

High-throughput

0.479

High

183177

SET1B
Histone-lysine N-methyltransferase SETD1B

1

20

High-throughput

0.479

High

183178

ZN281
Zinc finger protein 281

1

3

Small-scale

0.479

High

183179

RN114
E3 ubiquitin-protein ligase RNF114

1

6

Small-scale

0.479

High

183180

MAFB
Transcription factor MafB

1

3

Small-scale

0.479

High

183181

HCFC2
Host cell factor 2

1

9

High-throughput

0.479

High

183132

N4BP2
NEDD4-binding protein 2

1

0

Small-scale

0.458

High

183135

ZZZ3
ZZ-type zinc finger-containing protein 3

1

0

High-throughput

0.458

High

183164

GCM1
Chorion-specific transcription factor GCMa

1

0

High-throughput

0.458

High

183055

TAU
Microtubule-associated protein tau

1

10

High-throughput

0.445

High

183076

MATR3
Matrin-3

1

5

Small-scale

0.445

High

183166

GRHL1
Grainyhead-like protein 1 homolog

1

2

High-throughput

0.445

High

183109

GOGA2
Golgin subfamily A member 2

1

2

High-throughput

0.437

High

183133

PRSR1
Proline and serine-rich protein 1

1

13

Small-scale

0.437

High

183159

PKHA4
Pleckstrin homology domain-containing family A member 4

1

13

High-throughput

0.437

High

183048

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.279

Low

183136

CF107
Cilia- and flagella-associated protein 107

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024