Protein: G6PI
Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) (Autocrine motility factor) (AMF) (Neuroleukin) (NLK) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI) (Sperm antigen 36) (SA-36)

Gene: G6PI, GPI
Organism: Homo sapiens
Interactions: 141
UniProt ID: P06744

Gene Ontology (top 5):
GO:0001701 - in utero embryonic development
GO:0001707 - mesoderm formation
GO:0002639 - positive regulation of immunoglobulin production
GO:0004347 - glucose-6-phosphate isomerase activity
GO:0005125 - cytokine activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

226270

PRKN
E3 ubiquitin-protein ligase parkin

3

2

High-throughput

0.640

High

417672

TAU
Microtubule-associated protein tau

2

1

High-throughput

0.628

High

397720

ISG15
Ubiquitin-like protein ISG15

2

2

High-throughput

0.584

High

329242

AGR2
Anterior gradient protein 2 homolog

2

0

Small-scale

0.576

High

417775

AMFR
E3 ubiquitin-protein ligase AMFR

1

1

Small-scale

0.561

High

417688

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

2

High-throughput

0.536

High

417760

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

1

High-throughput

0.536

High

118528

EYA2
Eyes absent homolog 2

1

0

High-throughput

0.513

High

175365

PPM1D
Protein phosphatase 1D

1

0

High-throughput

0.513

High

417676

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.513

High

417692

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

417712

KPCZ
Protein kinase C zeta type

1

0

High-throughput

0.513

High

417722

ITPR3
Inositol 1,4,5-trisphosphate receptor type 3

1

0

High-throughput

0.513

High

417730

DUS7
Dual specificity protein phosphatase 7

1

0

High-throughput

0.513

High

417747

PHOP1
Phosphoethanolamine/phosphocholine phosphatase

1

0

High-throughput

0.513

High

417674

PCNA
Proliferating cell nuclear antigen

1

1

Small-scale

0.501

High

417711

TIE2
Angiopoietin-1 receptor

1

2

High-throughput

0.500

High

146581

SOCS2
Suppressor of cytokine signaling 2

1

0

High-throughput

0.493

High

417714

MERTK
Tyrosine-protein kinase Mer

1

3

High-throughput

0.489

High

417748

NEK7
Serine/threonine-protein kinase Nek7

1

1

High-throughput

0.489

High

417758

LMTK3
Serine/threonine-protein kinase LMTK3

1

3

High-throughput

0.489

High

177788

TMPS2
Transmembrane protease serine 2

1

1

High-throughput

0.479

High

260715

H2AY
Core histone macro-H2A.1

1

3

High-throughput

0.479

High

373527

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

417670

MET
Hepatocyte growth factor receptor

1

2

High-throughput

0.479

High

417675

IFM1
Interferon-induced transmembrane protein 1

1

1

High-throughput

0.479

High

417678

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

417684

PDIA3
Protein disulfide-isomerase A3

1

1

High-throughput

0.479

High

417691

YAP1
Transcriptional coactivator YAP1

1

2

High-throughput

0.479

High

417696

GSK3B
Glycogen synthase kinase-3 beta

1

2

High-throughput

0.479

High

417703

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

1

High-throughput

0.479

High

417705

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

417715

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

2

High-throughput

0.479

High

417719

CUL3
Cullin-3

1

1

High-throughput

0.479

High

417731

PAR14
Protein mono-ADP-ribosyltransferase PARP14

1

2

Small-scale

0.479

High

417732

DCAF6
DDB1- and CUL4-associated factor 6

1

1

High-throughput

0.479

High

417737

ADCK2
Uncharacterized aarF domain-containing protein kinase 2

1

1

High-throughput

0.479

High

417738

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.479

High

417742

RPTOR
Regulatory-associated protein of mTOR

1

2

High-throughput

0.479

High

417764

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

2

High-throughput

0.479

High

417770

TMPS4
Transmembrane protease serine 4

1

1

High-throughput

0.479

High

417771

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

1

High-throughput

0.479

High

417776

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.479

High

160331

AURKA
Aurora kinase A

1

0

High-throughput

0.458

High

165910

PER2
Period circadian protein homolog 2

1

0

Small-scale

0.458

High

200473

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

Small-scale

0.458

High

242651

IF2P
Eukaryotic translation initiation factor 5B

1

0

High-throughput

0.458

High

254860

CPNE3
Copine-3

1

0

High-throughput

0.458

High

255434

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.458

High

262675

CISY
Citrate synthase, mitochondrial

1

0

High-throughput

0.458

High

324169

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

337048

HPRT
Hypoxanthine-guanine phosphoribosyltransferase

1

0

High-throughput

0.458

High

384099

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

392980

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

0

High-throughput

0.458

High

417668

CATL1
Procathepsin L

1

0

High-throughput

0.458

High

417671

ANXA5
Annexin A5

1

0

High-throughput

0.458

High

417673

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

417677

PLST
Plastin-3

1

0

High-throughput

0.458

High

417679

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

417680

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.458

High

417682

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.458

High

417689

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

417690

RS27
Small ribosomal subunit protein eS27

1

0

High-throughput

0.458

High

417694

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

417695

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

0

High-throughput

0.458

High

417699

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.458

High

417702

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

417704

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.458

High

417707

ARF5
ADP-ribosylation factor 5

1

0

High-throughput

0.458

High

417713

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.458

High

417716

TRAF3
TNF receptor-associated factor 3

1

0

Small-scale

0.458

High

417718

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

417723

CUL7
Cullin-7

1

0

High-throughput

0.458

High

417724

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

417726

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

417728

IPYR
Inorganic pyrophosphatase

1

0

High-throughput

0.458

High

417729

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

417733

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

417736

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

High-throughput

0.458

High

417739

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

417744

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.458

High

417745

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

417751

ASB15
Ankyrin repeat and SOCS box protein 15

1

0

High-throughput

0.458

High

417752

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

417754

CHM4C
Charged multivesicular body protein 4c

1

0

High-throughput

0.458

High

417761

NECD
Necdin

1

0

High-throughput

0.458

High

417762

ACON
Aconitate hydratase, mitochondrial

1

0

High-throughput

0.458

High

417763

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

417768

NGB
Neuroglobin

1

0

High-throughput

0.458

High

417769

SIAS
Sialic acid synthase

1

0

High-throughput

0.458

High

417772

CRNN
Cornulin

1

0

High-throughput

0.458

High

417773

HDAC6
Histone deacetylase 6

1

0

High-throughput

0.458

High

417774

TES
Testin

1

0

High-throughput

0.458

High

417778

PA2G4
Proliferation-associated protein 2G4

1

0

High-throughput

0.458

High

417780

SBDS
Ribosome maturation protein SBDS

1

0

High-throughput

0.458

High

417781

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.458

High

401266

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

417700

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

417701

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

1

High-throughput

0.445

High

417765

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

1

High-throughput

0.445

High

417756

SPTCS
Spatacsin

1

0

Small-scale

0.438

High

243802

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.437

High

417669

RU2B
U2 small nuclear ribonucleoprotein B''

1

1

High-throughput

0.437

High

417681

U2AF2
Splicing factor U2AF 65 kDa subunit

1

2

High-throughput

0.437

High

417683

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

417698

EPHA4
Ephrin type-A receptor 4

1

2

High-throughput

0.437

High

417710

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.437

High

417717

RFA4
Replication protein A 30 kDa subunit

1

1

High-throughput

0.437

High

417727

BRD3
Bromodomain-containing protein 3

1

1

High-throughput

0.437

High

417750

CLC4D
C-type lectin domain family 4 member D

1

1

High-throughput

0.437

High

417766

Q9H4D1
Protein kinase

1

1

High-throughput

0.437

High

417767

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

417685

BMI1
Polycomb complex protein BMI-1

1

0

High-throughput

0.426

High

417740

MYLK4
Myosin light chain kinase family member 4

1

0

High-throughput

0.279

Low

417746

PPTC7
Protein phosphatase PTC7 homolog

1

0

High-throughput

0.279

Low

210437

ZN207
BUB3-interacting and GLEBS motif-containing protein ZNF207

1

0

High-throughput

0.249

Low

225468

PCDH7
Protocadherin-7

1

0

High-throughput

0.249

Low

328701

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.249

Low

345701

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

417686

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

417687

FUS
RNA-binding protein FUS

1

0

High-throughput

0.249

Low

417693

TISD
mRNA decay activator protein ZFP36L2

1

0

High-throughput

0.249

Low

417697

RM12
Large ribosomal subunit protein bL12m

1

0

High-throughput

0.249

Low

417706

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

417708

VIGLN
Vigilin

1

0

High-throughput

0.249

Low

417720

FA50A
Protein FAM50A

1

0

High-throughput

0.249

Low

417721

RBM39
RNA-binding protein 39

1

0

High-throughput

0.249

Low

417725

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.249

Low

417734

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

417735

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.249

Low

417741

SPICE
Spindle and centriole-associated protein 1

1

0

High-throughput

0.249

Low

417743

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.249

Low

417749

SPRY4
SPRY domain-containing protein 4

1

0

High-throughput

0.249

Low

417753

TAM41
Phosphatidate cytidylyltransferase, mitochondrial

1

0

High-throughput

0.249

Low

417755

MMAB
Corrinoid adenosyltransferase MMAB

1

0

High-throughput

0.249

Low

417757

NEUL4
Neuralized-like protein 4

1

0

Small-scale

0.249

Low

417759

ATAD5
ATPase family AAA domain-containing protein 5

1

0

High-throughput

0.249

Low

417777

TRI33
E3 ubiquitin-protein ligase TRIM33

1

0

High-throughput

0.249

Low

417779

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

417782

PPME1
Protein phosphatase methylesterase 1

1

0

Small-scale

0.249

Low

417709

E2F1
Transcription factor E2F1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024