Protein: IDE
Insulin-degrading enzyme (EC 3.4.24.56) (Abeta-degrading protease) (Insulin protease) (Insulinase) (Insulysin)

Gene: IDE
Organism: Homo sapiens
Interactions: 139
UniProt ID: P14735

Gene Ontology (top 5):
GO:0001618 - virus receptor activity
GO:0004175 - endopeptidase activity
GO:0004222 - metalloendopeptidase activity
GO:0005524 - ATP binding
GO:0005615 - extracellular space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

539771

IDE
Insulin-degrading enzyme

2

8

Small-scale

0.778

High

351923

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

2

0

Small-scale

0.777

High

539786

NEST
Nestin

3

13

Small-scale

0.670

High

539780

HXC9
Homeobox protein Hox-C9

3

2

High-throughput

0.667

High

539871

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

3

8

Small-scale

0.650

High

352345

IGF2
Insulin-like growth factor II

1

2

Small-scale

0.647

High

392949

IGF1
Insulin-like growth factor I

1

1

Small-scale

0.647

High

394047

A4
Amyloid-beta precursor protein

2

2

Small-scale

0.646

High

539839

HYLS1
Centriolar and ciliogenesis-associated protein HYLS1

3

0

High-throughput

0.638

High

539845

DOHH
Deoxyhypusine hydroxylase

3

0

High-throughput

0.638

High

443298

VIME
Vimentin

2

11

High-throughput

0.628

High

539791

ISK7
Serine protease inhibitor Kazal-type 7

2

6

High-throughput

0.628

High

539832

RPGR
X-linked retinitis pigmentosa GTPase regulator

2

4

High-throughput

0.628

High

539836

VWCE
von Willebrand factor C and EGF domain-containing protein

2

4

High-throughput

0.628

High

539790

CCL23
C-C motif chemokine 23

2

4

High-throughput

0.612

High

362054

MBP
Myelin basic protein

2

0

High-throughput

0.602

High

382579

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

2

0

High-throughput

0.602

High

539810

TAFA3
Chemokine-like protein TAFA-3

2

0

High-throughput

0.602

High

539811

SAXO4
Stabilizer of axonemal microtubules 4

2

0

High-throughput

0.602

High

539837

ARSG
Arylsulfatase G

2

0

High-throughput

0.602

High

539847

PHF7
PHD finger protein 7

2

0

High-throughput

0.602

High

539864

TINAG
Tubulointerstitial nephritis antigen

2

0

High-throughput

0.602

High

539869

TSSC4
U5 small nuclear ribonucleoprotein TSSC4

2

0

High-throughput

0.602

High

377064

GCR
Glucocorticoid receptor

2

4

Small-scale

0.595

High

486219

CCL3
C-C motif chemokine 3

1

4

Small-scale

0.586

High

501599

IAPP
Islet amyloid polypeptide

1

1

Small-scale

0.586

High

539824

MTMRE
Myotubularin-related protein 14

2

0

High-throughput

0.585

High

539785

SOX2
Transcription factor SOX-2

2

2

High-throughput

0.584

High

539794

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

2

4

Small-scale

0.584

High

539800

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

3

High-throughput

0.584

High

539774

ISK2
Serine protease inhibitor Kazal-type 2

2

3

High-throughput

0.574

High

475299

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

6

Small-scale

0.568

High

351815

GLUC
Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide

1

0

Small-scale

0.561

High

539865

NSF1C
NSFL1 cofactor p47

2

0

Small-scale

0.559

High

126422

FOXE1
Forkhead box protein E1

1

2

High-throughput

0.536

High

410603

CD5
T-cell surface glycoprotein CD5

1

3

High-throughput

0.536

High

422141

NFL
Neurofilament light polypeptide

1

11

High-throughput

0.536

High

422339

NFM
Neurofilament medium polypeptide

1

12

High-throughput

0.536

High

535317

GFAP
Glial fibrillary acidic protein

1

11

High-throughput

0.536

High

539773

CL3L1
C-C motif chemokine 3-like 1

1

4

High-throughput

0.536

High

539779

HXC8
Homeobox protein Hox-C8

1

1

High-throughput

0.536

High

539793

DEFB1
Beta-defensin 1

1

2

High-throughput

0.536

High

539796

AMPD2
AMP deaminase 2

1

1

High-throughput

0.536

High

539799

AINX
Alpha-internexin

1

11

High-throughput

0.536

High

539801

KR132
Keratin-associated protein 13-2

1

3

High-throughput

0.536

High

539805

PRR27
Proline-rich protein 27

1

3

High-throughput

0.536

High

539812

YTHD3
YTH domain-containing family protein 3

1

1

High-throughput

0.536

High

539813

NEK8
Serine/threonine-protein kinase Nek8

1

1

High-throughput

0.536

High

539817

EGFL6
Epidermal growth factor-like protein 6

1

3

High-throughput

0.536

High

539819

CDKL3
Cyclin-dependent kinase-like 3

1

1

High-throughput

0.536

High

539826

G45IP
Large ribosomal subunit protein mL64

1

2

High-throughput

0.536

High

539827

BRSK1
Serine/threonine-protein kinase BRSK1

1

3

High-throughput

0.536

High

539848

IFIH1
Interferon-induced helicase C domain-containing protein 1

1

1

High-throughput

0.536

High

539859

DKK4
Dickkopf-related protein 4

1

1

High-throughput

0.536

High

539866

SCAF8
SR-related and CTD-associated factor 8

1

1

High-throughput

0.536

High

539872

RM42
Large ribosomal subunit protein mL42

1

2

High-throughput

0.536

High

539874

NEMO
NF-kappa-B essential modulator

1

1

High-throughput

0.536

High

124971

CACB4
Voltage-dependent L-type calcium channel subunit beta-4

1

0

High-throughput

0.513

High

278910

SPF30
Survival of motor neuron-related-splicing factor 30

1

0

High-throughput

0.513

High

427741

CO8A
Complement component C8 alpha chain

1

0

High-throughput

0.513

High

539775

SIAL
Integrin-binding sialoprotein

1

0

High-throughput

0.513

High

539778

AVR2A
Activin receptor type-2A

1

0

High-throughput

0.513

High

539782

CHKA
Choline kinase alpha

1

0

High-throughput

0.513

High

539784

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

539789

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

0

High-throughput

0.513

High

539814

ILDR1
Immunoglobulin-like domain-containing receptor 1

1

0

High-throughput

0.513

High

539828

ES8L1
Epidermal growth factor receptor kinase substrate 8-like protein 1

1

0

High-throughput

0.513

High

539829

DCNP1
Dendritic cell nuclear protein 1

1

0

High-throughput

0.513

High

539833

GATA6
Transcription factor GATA-6

1

0

High-throughput

0.513

High

539838

LURA1
Leucine rich adaptor protein 1

1

0

High-throughput

0.513

High

539846

ISCA1
Iron-sulfur cluster assembly 1 homolog, mitochondrial

1

0

High-throughput

0.513

High

539851

LIME1
Lck-interacting transmembrane adapter 1

1

0

High-throughput

0.513

High

539860

DUX4
Double homeobox protein 4

1

0

High-throughput

0.513

High

539863

MRM2
rRNA methyltransferase 2, mitochondrial

1

0

High-throughput

0.513

High

539870

TNR18
Tumor necrosis factor receptor superfamily member 18

1

0

High-throughput

0.513

High

539841

MIA2
Melanoma inhibitory activity protein 2

2

3

High-throughput

0.504

High

487095

ANDR
Androgen receptor

1

4

Small-scale

0.501

High

526554

CCL4
C-C motif chemokine 4

1

4

Small-scale

0.501

High

391530

H2A1B
Histone H2A type 1-B/E

1

0

High-throughput

0.493

High

539804

ISK14
Serine protease inhibitor Kazal-type 14

1

2

High-throughput

0.489

High

539861

CS025
UPF0449 protein C19orf25

1

1

High-throughput

0.489

High

539868

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

0

Small-scale

0.480

High

118533

EYA2
Eyes absent homolog 2

1

1

High-throughput

0.479

High

201635

LYRM1
LYR motif-containing protein 1

1

2

High-throughput

0.479

High

226421

PRKN
E3 ubiquitin-protein ligase parkin

1

9

High-throughput

0.479

High

258398

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

2

High-throughput

0.479

High

267371

ECI2
Enoyl-CoA delta isomerase 2

1

5

High-throughput

0.479

High

384201

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

386022

P53
Cellular tumor antigen p53

1

2

High-throughput

0.479

High

473371

CISD3
CDGSH iron-sulfur domain-containing protein 3, mitochondrial

1

4

High-throughput

0.479

High

539772

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

539776

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

7

High-throughput

0.479

High

539777

ATPA
ATP synthase subunit alpha, mitochondrial

1

8

High-throughput

0.479

High

539795

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

539797

BIRC3
Baculoviral IAP repeat-containing protein 3

1

6

High-throughput

0.479

High

539798

CUL4A
Cullin-4A

1

2

High-throughput

0.479

High

539803

TET5C
Terminal nucleotidyltransferase 5C

1

2

High-throughput

0.479

High

539807

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

539809

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

5

High-throughput

0.479

High

539815

NIT1
Deaminated glutathione amidase

1

3

High-throughput

0.479

High

539816

DCP2
m7GpppN-mRNA hydrolase

1

1

High-throughput

0.479

High

539822

PPM1K
Protein phosphatase Mn(2+)-dependent 1K

1

3

High-throughput

0.479

High

539830

SPRY4
SPRY domain-containing protein 4

1

3

High-throughput

0.479

High

539831

ESR2
Estrogen receptor beta

1

4

High-throughput

0.479

High

539834

CHCH1
Small ribosomal subunit protein mS37

1

2

High-throughput

0.479

High

539843

COQ7
5-demethoxyubiquinone hydroxylase, mitochondrial

1

5

High-throughput

0.479

High

539849

NMES1
Normal mucosa of esophagus-specific gene 1 protein

1

3

High-throughput

0.479

High

539852

OPA3
Optic atrophy 3 protein

1

1

High-throughput

0.479

High

539854

LYRM4
LYR motif-containing protein 4

1

4

High-throughput

0.479

High

539855

XPP3
Xaa-Pro aminopeptidase 3

1

2

High-throughput

0.479

High

539856

MTMRA
Myotubularin-related protein 10

1

1

High-throughput

0.479

High

539857

PAK5
Serine/threonine-protein kinase PAK 5

1

8

High-throughput

0.479

High

539862

ZRAN1
Ubiquitin thioesterase ZRANB1

1

5

High-throughput

0.479

High

539867

LOXL2
Lysyl oxidase homolog 2

1

3

High-throughput

0.479

High

539873

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

5

High-throughput

0.479

High

539806

DLK2
Protein delta homolog 2

1

2

High-throughput

0.470

High

503361

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

539783

FEN1
Flap endonuclease 1

1

0

High-throughput

0.458

High

539823

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

539835

F136A
Protein FAM136A

1

0

High-throughput

0.458

High

539844

TCPH
T-complex protein 1 subunit eta

1

0

High-throughput

0.458

High

401348

JUN
Transcription factor Jun

1

5

High-throughput

0.445

High

539788

NCBP2
Nuclear cap-binding protein subunit 2

1

3

High-throughput

0.445

High

539802

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

6

High-throughput

0.445

High

539850

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.445

High

539781

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

539842

ZBT18
Zinc finger and BTB domain-containing protein 18

1

0

High-throughput

0.426

High

539787

PEX5
Peroxisomal targeting signal 1 receptor

1

2

Small-scale

0.408

High

539818

P3H3
Prolyl 3-hydroxylase 3

2

0

High-throughput

0.328

High

539808

CC062
Uncharacterized protein C3orf62

1

0

High-throughput

0.289

High

472653

F163B
Protein FAM163B

1

0

High-throughput

0.279

Low

539792

PROK1
Prokineticin-1

1

0

High-throughput

0.279

Low

539820

D107A
Beta-defensin 107

1

0

High-throughput

0.279

Low

539821

H6ST3
Heparan-sulfate 6-O-sulfotransferase 3

1

0

High-throughput

0.279

Low

539825

LPD6B
Ly6/PLAUR domain-containing protein 6B

1

0

High-throughput

0.279

Low

539858

GALP
Galanin-like peptide

1

0

High-throughput

0.279

Low

539840

CF195
Uncharacterized protein encoded by LINC01600

1

0

High-throughput

0.269

Low

539853

GPAT1
Glycerol-3-phosphate acyltransferase 1, mitochondrial

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024