Protein: NCOR2
Nuclear receptor corepressor 2 (N-CoR2) (CTG repeat protein 26) (SMAP270) (Silencing mediator of retinoic acid and thyroid hormone receptor) (SMRT) (T3 receptor-associating factor) (TRAC) (Thyroid-, retinoic-acid-receptor-associated corepressor)

Gene: NCOR2
Organism: Homo sapiens
Interactions: 230
UniProt ID: Q9Y618

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0003677 - DNA binding
GO:0003682 - chromatin binding
GO:0003714 - transcription corepressor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

177416

HDAC3
Histone deacetylase 3

22

20

Small-scale

0.992

High

1028223

GPS2
G protein pathway suppressor 2

5

2

Small-scale

0.937

High

880872

HDAC4
Histone deacetylase 4

5

20

Small-scale

0.924

High

1038852

HDAC1
Histone deacetylase 1

3

20

Small-scale

0.855

High

1260208

HDAC7
Histone deacetylase 7

3

20

Small-scale

0.847

High

1270546

HDAC2
Histone deacetylase 2

3

20

Small-scale

0.847

High

1357907

HDAC5
Histone deacetylase 5

2

20

Small-scale

0.783

High

1282247

HDA10
Polyamine deacetylase HDAC10

2

20

Small-scale

0.776

High

781496

BCL6
B-cell lymphoma 6 protein

12

7

Small-scale

0.759

High

261618

NCOR1
Nuclear receptor corepressor 1

2

16

Small-scale

0.757

High

487879

ANDR
Androgen receptor

10

20

Small-scale

0.756

High

488042

RARA
Retinoic acid receptor alpha

10

20

Small-scale

0.754

High

740633

PPARG
Peroxisome proliferator-activated receptor gamma

11

20

Small-scale

0.750

High

500510

THB
Thyroid hormone receptor beta

8

20

Small-scale

0.747

High

984049

ZBT16
Zinc finger and BTB domain-containing protein 16

7

5

Small-scale

0.746

High

245652

TBL1X
F-box-like/WD repeat-containing protein TBL1X

5

20

Small-scale

0.726

High

370824

ESR1
Estrogen receptor

5

20

Small-scale

0.710

High

987024

SUH
Recombining binding protein suppressor of hairless

5

5

Small-scale

0.707

High

587211

RXRA
Retinoic acid receptor RXR-alpha

5

20

Small-scale

0.702

High

1039976

SNW1
SNW domain-containing protein 1

4

5

Small-scale

0.684

High

1302939

MINT
Msx2-interacting protein

3

12

Small-scale

0.682

High

728974

AHR
Aryl hydrocarbon receptor

3

11

Small-scale

0.680

High

978950

TF65
Transcription factor p65

3

12

Small-scale

0.678

High

987492

MTG8
Protein CBFA2T1

3

12

Small-scale

0.672

High

918222

H4
Histone H4

3

9

Small-scale

0.667

High

540885

PO2F1
POU domain, class 2, transcription factor 1

3

19

Small-scale

0.664

High

265885

NR1I2
Nuclear receptor subfamily 1 group I member 2

3

20

Small-scale

0.658

High

414534

PRGR
Progesterone receptor

3

20

Small-scale

0.653

High

500454

THA
Thyroid hormone receptor alpha

3

20

Small-scale

0.651

High

669111

PML
Protein PML

3

18

Small-scale

0.646

High

312107

ZBT7A
Zinc finger and BTB domain-containing protein 7A

3

19

Small-scale

0.642

High

377839

GCR
Glucocorticoid receptor

3

20

Small-scale

0.642

High

387814

P53
Cellular tumor antigen p53

2

8

Small-scale

0.641

High

818668

SOX2
Transcription factor SOX-2

3

20

Small-scale

0.640

High

1270043

ESR2
Estrogen receptor beta

3

20

Small-scale

0.640

High

348379

MYC
Myc proto-oncogene protein

3

18

High-throughput

0.633

High

992457

PPARA
Peroxisome proliferator-activated receptor alpha

2

20

Small-scale

0.633

High

473582

ATX1L
Ataxin-1-like

2

10

Small-scale

0.631

High

611536

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

2

20

Small-scale

0.631

High

964295

FOXK2
Forkhead box protein K2

2

20

Small-scale

0.628

High

1309170

TBL1Y
F-box-like/WD repeat-containing protein TBL1Y

2

20

High-throughput

0.628

High

1312862

ZSA5A
Zinc finger and SCAN domain-containing protein 5A

2

9

High-throughput

0.628

High

975486

PPARD
Peroxisome proliferator-activated receptor delta

2

20

Small-scale

0.625

High

1046778

KLF5
Krueppel-like factor 5

2

20

Small-scale

0.620

High

134987

IMA3
Importin subunit alpha-3

2

5

Small-scale

0.619

High

1038098

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

2

3

Small-scale

0.619

High

999262

EP300
Histone acetyltransferase p300

1

20

Small-scale

0.618

High

1270850

CBP
CREB-binding protein

1

16

Small-scale

0.618

High

639833

IKBA
NF-kappa-B inhibitor alpha

2

20

Small-scale

0.612

High

345592

FOS
Protein c-Fos

2

13

Small-scale

0.606

High

167641

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

2

6

Small-scale

0.602

High

782706

HNF4A
Hepatocyte nuclear factor 4-alpha

2

20

Small-scale

0.595

High

1302485

SIN3A
Paired amphipathic helix protein Sin3a

2

8

Small-scale

0.595

High

509999

VDR
Vitamin D3 receptor

2

20

Small-scale

0.594

High

874405

NR1H2
Oxysterols receptor LXR-beta

2

20

Small-scale

0.594

High

1356427

TNIK
TRAF2 and NCK-interacting protein kinase

2

12

High-throughput

0.590

High

868830

ATX1
Ataxin-1

2

10

Small-scale

0.586

High

245142

BRD4
Bromodomain-containing protein 4

2

14

High-throughput

0.584

High

1032718

CTBP1
C-terminal-binding protein 1

2

11

Small-scale

0.584

High

1327648

UBP44
Ubiquitin carboxyl-terminal hydrolase 44

2

5

Small-scale

0.584

High

963713

E2F1
Transcription factor E2F1

1

7

High-throughput

0.578

High

1038954

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

1

2

Small-scale

0.578

High

166193

ZBTB5
Zinc finger and BTB domain-containing protein 5

1

20

Small-scale

0.573

High

435196

SP1
Transcription factor Sp1

1

20

Small-scale

0.573

High

521413

SKIL
Ski-like protein

1

4

Small-scale

0.573

High

649178

ARNT
Aryl hydrocarbon receptor nuclear translocator

1

7

Small-scale

0.569

High

570236

CEBPB
CCAAT/enhancer-binding protein beta

1

19

Small-scale

0.561

High

625662

CDK2
Cyclin-dependent kinase 2

1

5

Small-scale

0.561

High

1039480

IRF5
Interferon regulatory factor 5

1

6

Small-scale

0.561

High

1081269

NF2L2
Nuclear factor erythroid 2-related factor 2

1

11

Small-scale

0.561

High

1329978

FOXP1
Forkhead box protein P1

1

20

Small-scale

0.561

High

1378167

NCOA3
Nuclear receptor coactivator 3

1

9

Small-scale

0.561

High

429161

ADRB2
Beta-2 adrenergic receptor

1

2

High-throughput

0.541

High

245763

B4GT2
Beta-1,4-galactosyltransferase 2

1

2

High-throughput

0.536

High

265283

SAP30
Histone deacetylase complex subunit SAP30

1

4

Small-scale

0.536

High

316221

CBX6
Chromobox protein homolog 6

1

8

High-throughput

0.536

High

829626

DGKG
Diacylglycerol kinase gamma

1

1

High-throughput

0.536

High

1050855

FHL2
Four and a half LIM domains protein 2

1

20

High-throughput

0.536

High

1306187

NPAS1
Neuronal PAS domain-containing protein 1

1

8

High-throughput

0.536

High

1317574

BACH2
Transcription regulator protein BACH2

1

20

High-throughput

0.536

High

1332835

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.536

High

995337

GOGA2
Golgin subfamily A member 2

2

9

High-throughput

0.533

High

402682

JUN
Transcription factor Jun

1

18

Small-scale

0.527

High

515629

SRF
Serum response factor

1

2

Small-scale

0.527

High

1298120

CEP63
Centrosomal protein of 63 kDa

2

13

High-throughput

0.526

High

682094

AKT1
RAC-alpha serine/threonine-protein kinase

1

0

Small-scale

0.513

High

121607

IKBE
NF-kappa-B inhibitor epsilon

1

20

Small-scale

0.501

High

130339

NR5A2
Nuclear receptor subfamily 5 group A member 2

1

20

Small-scale

0.501

High

476650

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

13

High-throughput

0.501

High

592827

NR1D1
Nuclear receptor subfamily 1 group D member 1

1

20

Small-scale

0.501

High

928238

SUMO1
Small ubiquitin-related modifier 1

1

8

Small-scale

0.501

High

930475

UBC9
SUMO-conjugating enzyme UBC9

1

5

Small-scale

0.501

High

1025275

NR1H3
Oxysterols receptor LXR-alpha

1

20

Small-scale

0.501

High

1047046

C1D
Nuclear nucleic acid-binding protein C1D

1

1

Small-scale

0.501

High

1076399

IKBB
NF-kappa-B inhibitor beta

1

19

Small-scale

0.501

High

1300897

NR1H4
Bile acid receptor

1

20

Small-scale

0.501

High

1070107

NADC
Nicotinate-nucleotide pyrophosphorylase [carboxylating]

1

4

High-throughput

0.489

High

1102676

INSY1
Inhibitory synaptic factor 1

1

2

High-throughput

0.489

High

1162317

WDR59
GATOR2 complex protein WDR59

1

20

High-throughput

0.489

High

1309725

SGIP1
SH3-containing GRB2-like protein 3-interacting protein 1

1

6

High-throughput

0.489

High

500380

RARB
Retinoic acid receptor beta

1

20

High-throughput

0.481

High

530817

RARG
Retinoic acid receptor gamma

1

20

High-throughput

0.481

High

818890

RXRG
Retinoic acid receptor RXR-gamma

1

20

High-throughput

0.481

High

1057810

NCOA6
Nuclear receptor coactivator 6

1

16

Small-scale

0.481

High

1245250

TNIP2
TNFAIP3-interacting protein 2

1

1

High-throughput

0.481

High

1301846

RANB9
Ran-binding protein 9

1

12

High-throughput

0.481

High

1311821

INP5K
Inositol polyphosphate 5-phosphatase K

1

3

Small-scale

0.481

High

1349356

CNOT2
CCR4-NOT transcription complex subunit 2

1

6

Small-scale

0.481

High

118625

EYA2
Eyes absent homolog 2

1

20

High-throughput

0.479

High

124137

SPT5H
Transcription elongation factor SPT5

1

12

High-throughput

0.479

High

135181

NFIB
Nuclear factor 1 B-type

1

17

High-throughput

0.479

High

160879

AURKA
Aurora kinase A

1

11

High-throughput

0.479

High

171100

TBXT
T-box transcription factor T

1

14

High-throughput

0.479

High

197863

CRX
Cone-rod homeobox protein

1

20

High-throughput

0.479

High

212006

TLX3
T-cell leukemia homeobox protein 3

1

20

High-throughput

0.479

High

213412

TLX2
T-cell leukemia homeobox protein 2

1

20

High-throughput

0.479

High

225812

SOX15
Transcription factor SOX-15

1

20

High-throughput

0.479

High

271814

PRDM1
PR domain zinc finger protein 1

1

7

High-throughput

0.479

High

302066

TRI37
E3 ubiquitin-protein ligase TRIM37

1

18

High-throughput

0.479

High

314705

PARN
Poly(A)-specific ribonuclease PARN

1

1

High-throughput

0.479

High

317047

KLF8
Krueppel-like factor 8

1

20

High-throughput

0.479

High

318762

EYA4
Eyes absent homolog 4

1

20

High-throughput

0.479

High

319398

BRD1
Bromodomain-containing protein 1

1

14

High-throughput

0.479

High

419251

ITAV
Integrin alpha-V

1

3

Small-scale

0.479

High

443276

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

502734

BIP
Endoplasmic reticulum chaperone BiP

1

14

High-throughput

0.479

High

505320

EGR2
E3 SUMO-protein ligase EGR2

1

6

High-throughput

0.479

High

507534

ERG
Transcriptional regulator ERG

1

15

High-throughput

0.479

High

546063

MYOD1
Myoblast determination protein 1

1

10

High-throughput

0.479

High

554174

RFA2
Replication protein A 32 kDa subunit

1

9

High-throughput

0.479

High

554535

GATA1
Erythroid transcription factor

1

18

High-throughput

0.479

High

565080

HMGA1
High mobility group protein HMG-I/HMG-Y

1

5

Small-scale

0.479

High

620230

PAX7
Paired box protein Pax-7

1

20

High-throughput

0.479

High

620449

GATA2
Endothelial transcription factor GATA-2

1

18

High-throughput

0.479

High

620599

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

18

High-throughput

0.479

High

641615

PAX6
Paired box protein Pax-6

1

20

High-throughput

0.479

High

652734

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

8

High-throughput

0.479

High

658583

TEAD1
Transcriptional enhancer factor TEF-1

1

4

High-throughput

0.479

High

679200

TLX1
T-cell leukemia homeobox protein 1

1

20

High-throughput

0.479

High

721904

RFA3
Replication protein A 14 kDa subunit

1

8

High-throughput

0.479

High

727620

HNF1B
Hepatocyte nuclear factor 1-beta

1

20

High-throughput

0.479

High

727832

SOX5
Transcription factor SOX-5

1

20

High-throughput

0.479

High

727951

SOX6
Transcription factor SOX-6

1

20

High-throughput

0.479

High

785430

ELK3
ETS domain-containing protein Elk-3

1

17

High-throughput

0.479

High

794577

ETV4
ETS translocation variant 4

1

16

High-throughput

0.479

High

795610

NR4A2
Nuclear receptor subfamily 4 group A member 2

1

20

Small-scale

0.479

High

799053

GATA4
Transcription factor GATA-4

1

19

High-throughput

0.479

High

822702

LHX1
LIM/homeobox protein Lhx1

1

18

High-throughput

0.479

High

831855

CEBPA
CCAAT/enhancer-binding protein alpha

1

20

High-throughput

0.479

High

839855

LHX2
LIM/homeobox protein Lhx2

1

19

High-throughput

0.479

High

874360

GEM
GTP-binding protein GEM

1

1

Small-scale

0.479

High

878483

PAX9
Paired box protein Pax-9

1

20

High-throughput

0.479

High

881837

SOX10
Transcription factor SOX-10

1

20

High-throughput

0.479

High

882174

GSC
Homeobox protein goosecoid

1

20

High-throughput

0.479

High

884274

KLF3
Krueppel-like factor 3

1

20

High-throughput

0.479

High

890917

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

1

Small-scale

0.479

High

941630

RNF4
E3 ubiquitin-protein ligase RNF4

1

5

High-throughput

0.479

High

968023

PO5F1
POU domain, class 5, transcription factor 1

1

13

High-throughput

0.479

High

973897

PAX2
Paired box protein Pax-2

1

20

High-throughput

0.479

High

980923

TLE3
Transducin-like enhancer protein 3

1

20

High-throughput

0.479

High

985274

HME1
Homeobox protein engrailed-1

1

12

High-throughput

0.479

High

988821

PAX8
Paired box protein Pax-8

1

20

High-throughput

0.479

High

1018287

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

1021272

FOXI1
Forkhead box protein I1

1

20

High-throughput

0.479

High

1021390

FOXL1
Forkhead box protein L1

1

20

High-throughput

0.479

High

1024614

CAF1B
Chromatin assembly factor 1 subunit B

1

18

Small-scale

0.479

High

1033769

IKZF1
DNA-binding protein Ikaros

1

4

Small-scale

0.479

High

1036256

BIRC3
Baculoviral IAP repeat-containing protein 3

1

6

Small-scale

0.479

High

1044317

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

17

High-throughput

0.479

High

1060396

NFIX
Nuclear factor 1 X-type

1

20

High-throughput

0.479

High

1069095

Q15156
PML-RAR protein

1

20

Small-scale

0.479

High

1071085

IRF4
Interferon regulatory factor 4

1

6

High-throughput

0.479

High

1075783

SF01
Splicing factor 1

1

7

Small-scale

0.479

High

1080652

ZBTB6
Zinc finger and BTB domain-containing protein 6

1

15

Small-scale

0.479

High

1081463

E2F4
Transcription factor E2F4

1

7

Small-scale

0.479

High

1083443

RBBP7
Histone-binding protein RBBP7

1

18

High-throughput

0.479

High

1085198

TBR1
T-box brain protein 1

1

14

High-throughput

0.479

High

1134093

DCA12
DDB1- and CUL4-associated factor 12

1

3

High-throughput

0.479

High

1148908

VIR
Protein virilizer homolog

1

3

High-throughput

0.479

High

1164188

BRWD3
Bromodomain and WD repeat-containing protein 3

1

20

High-throughput

0.479

High

1167351

BCOR
BCL-6 corepressor

1

20

Small-scale

0.479

High

1168763

SYNE3
Nesprin-3

1

8

High-throughput

0.479

High

1189126

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

8

High-throughput

0.479

High

1191156

I2BP2
Interferon regulatory factor 2-binding protein 2

1

3

Small-scale

0.479

High

1200384

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

8

High-throughput

0.479

High

1221882

SMC5
Structural maintenance of chromosomes protein 5

1

7

High-throughput

0.479

High

1244024

FBX22
F-box only protein 22

1

5

High-throughput

0.479

High

1244604

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.479

High

1244776

NUP35
Nucleoporin NUP35

1

4

High-throughput

0.479

High

1246211

COP1
E3 ubiquitin-protein ligase COP1

1

20

High-throughput

0.479

High

1254974

SP7
Transcription factor Sp7

1

20

High-throughput

0.479

High

1260976

DCAF4
DDB1- and CUL4-associated factor 4

1

2

High-throughput

0.479

High

1262850

PHIP
PH-interacting protein

1

20

High-throughput

0.479

High

1266733

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

3

High-throughput

0.479

High

1281213

LHX4
LIM/homeobox protein Lhx4

1

19

High-throughput

0.479

High

1288413

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

20

High-throughput

0.479

High

1304732

FEV
Protein FEV

1

14

High-throughput

0.479

High

1311943

SOX7
Transcription factor SOX-7

1

20

High-throughput

0.479

High

1318670

FOXQ1
Forkhead box protein Q1

1

20

High-throughput

0.479

High

1332335

SOX17
Transcription factor SOX-17

1

20

High-throughput

0.479

High

1334458

NANOG
Homeobox protein NANOG

1

20

High-throughput

0.479

High

1342315

GCM1
Chorion-specific transcription factor GCMa

1

4

High-throughput

0.479

High

1346974

NLE1
Notchless protein homolog 1

1

17

High-throughput

0.479

High

1348409

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

5

High-throughput

0.479

High

1354255

LHX3
LIM/homeobox protein Lhx3

1

19

High-throughput

0.479

High

1355815

KLF15
Krueppel-like factor 15

1

20

High-throughput

0.479

High

1356704

BAG5
BAG family molecular chaperone regulator 5

1

5

High-throughput

0.479

High

1377134

ASF1A
Histone chaperone ASF1A

1

7

High-throughput

0.479

High

1377170

FBW1A
F-box/WD repeat-containing protein 1A

1

20

Small-scale

0.479

High

1377813

TRRAP
Transformation/transcription domain-associated protein

1

4

High-throughput

0.479

High

1204211

CIR1
Corepressor interacting with RBPJ 1

1

0

Small-scale

0.460

High

1161857

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

521320

SKI
Ski oncogene

1

4

Small-scale

0.445

High

879166

SUMO3
Small ubiquitin-related modifier 3

1

8

Small-scale

0.445

High

964472

RUNX1
Runt-related transcription factor 1

1

5

Small-scale

0.445

High

1307233

BAG1
BAG family molecular chaperone regulator 1

1

1

Small-scale

0.445

High

1287552

AP2M1
AP-2 complex subunit mu

1

2

High-throughput

0.439

High

129864

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

6

High-throughput

0.437

High

165118

SC16A
Protein transport protein Sec16A

1

20

High-throughput

0.437

High

216117

NRDC
Nardilysin

1

3

Small-scale

0.437

High

782839

CSK
Tyrosine-protein kinase CSK

1

6

High-throughput

0.437

High

1060087

LASP1
LIM and SH3 domain protein 1

1

18

Small-scale

0.437

High

1159481

FBX42
F-box only protein 42

1

9

High-throughput

0.437

High

1223428

ZDH23
Palmitoyltransferase ZDHHC23

1

1

Small-scale

0.437

High

1285144

RGMA
Repulsive guidance molecule A

1

1

High-throughput

0.437

High

1342415

ALG13
UDP-N-acetylglucosamine transferase subunit ALG13

1

10

High-throughput

0.437

High

825284

RL34
Large ribosomal subunit protein eL34

1

0

High-throughput

0.279

Low

1288739

RM38
Large ribosomal subunit protein mL38

1

0

High-throughput

0.279

Low

486211

IL8
Interleukin-8

1

0

Small-scale

0.249

Low

1345920

ZDH18
Palmitoyltransferase ZDHHC18

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024