Protein: HTH
Homeobox protein homothorax (Homeobox protein dorsotonals)

Gene: HTH
Organism: Drosophila melanogaster
Interactions: 91
UniProt ID: O46339

Gene Ontology (top 5):
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0000987 - cis-regulatory region sequence-specific DNA binding
GO:0001223 - transcription coactivator binding
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0001654 - eye development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

235199

EXD
Homeobox protein extradenticle

14

20

Small-scale

0.986

High

235194

ABDA
Homeobox protein abdominal-A

1

20

High-throughput

0.621

High

235202

UBX
Homeotic protein ultrabithorax

1

20

High-throughput

0.621

High

197553

PAX6
Paired box protein Pax-6

1

9

Small-scale

0.618

High

235186

ABDB
Homeobox protein abdominal-B

1

20

Small-scale

0.618

High

235249

Q9VTX7
Eyegone, isoform A

1

13

Small-scale

0.618

High

235208

Q7JY26
AT24188p

2

2

High-throughput

0.594

High

235191

TSH
Protein teashirt

2

3

Small-scale

0.584

High

121508

M9PFG6
Sox21a, isoform B

1

5

High-throughput

0.541

High

235190

CI
Transcriptional activator cubitus interruptus

1

3

High-throughput

0.541

High

235195

ETS3
DNA-binding protein D-ETS-3

1

1

High-throughput

0.541

High

235201

OVO
Transcriptional regulator ovo

1

3

High-throughput

0.541

High

235242

CHNMO
Zinc finger protein chinmo

1

7

High-throughput

0.541

High

235243

EXOC2
Exocyst complex component 2

1

1

High-throughput

0.541

High

235204

ESMD
Enhancer of split mdelta protein

1

0

High-throughput

0.518

High

235247

Q9VTE8
GEO08928p1

1

0

High-throughput

0.518

High

235256

TAMO
Protein tamozhennic

1

1

High-throughput

0.508

High

235181

HMEN
Segmentation polarity homeobox protein engrailed

1

20

High-throughput

0.492

High

235189

SXL
Protein sex-lethal

1

0

High-throughput

0.486

High

235226

Q9VBP2
GH01133p

1

0

High-throughput

0.486

High

120549

M9PDL4
Multiple wing hairs, isoform B

1

2

High-throughput

0.481

High

235180

O77284
Beadex, isoform A

1

8

High-throughput

0.481

High

235192

DSX
Protein doublesex

1

3

Small-scale

0.481

High

235221

Q9U8L5
Dorsocross1, isoform A

1

10

High-throughput

0.481

High

235223

Q9V9Q2
IP01335p

1

1

High-throughput

0.481

High

235206

YAP1
Transcriptional coactivator yorkie

1

3

Small-scale

0.479

High

235220

TIPT
Protein tiptop

1

3

Small-scale

0.479

High

235216

GOGA5
Golgin-84

1

1

High-throughput

0.464

High

235219

HRS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

3

High-throughput

0.464

High

235229

Q9VBY6
LD40504p

1

0

High-throughput

0.458

High

235237

Q9VK90
Heat shock factor-binding protein 1

1

0

High-throughput

0.458

High

235215

Q8SXJ5
RE19601p

1

1

High-throughput

0.457

High

94171

D5SHL1
RT07968p

1

1

High-throughput

0.451

High

235193

PSMD7
26S proteasome non-ATPase regulatory subunit 7

1

1

High-throughput

0.445

High

235203

H4
Histone H4

1

1

High-throughput

0.445

High

235205

Q2MGN0
FI01014p

1

3

High-throughput

0.445

High

235213

MMD4
Modifier of mdg4

1

5

High-throughput

0.445

High

235225

Q9VA36
CIN85 and CD2AP related, isoform C

1

1

High-throughput

0.445

High

235230

Q9VCM6
IP14385p

1

3

High-throughput

0.445

High

235235

RDX
Protein roadkill

1

1

High-throughput

0.445

High

235238

C2D1
Coiled-coil and C2 domain-containing protein 1-like

1

1

High-throughput

0.445

High

235240

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

3

High-throughput

0.445

High

235254

Q9VZT7
Girdin, isoform A

1

2

High-throughput

0.445

High

235212

Q7YU90
SD09829p

1

1

High-throughput

0.439

High

57456

A1ZB68
FI01423p

1

0

High-throughput

0.426

High

235182

RL32
Large ribosomal subunit protein eL32

1

0

High-throughput

0.426

High

235183

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

0

High-throughput

0.426

High

235184

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

High-throughput

0.426

High

235187

MODU
DNA-binding protein modulo

1

0

High-throughput

0.426

High

235197

PSB1
Proteasome subunit beta type-1

1

0

High-throughput

0.426

High

235198

SQH
Myosin regulatory light chain sqh

1

0

High-throughput

0.426

High

235200

CADF
Cofilin/actin-depolymerizing factor homolog

1

0

High-throughput

0.426

High

235209

MARS
Guanylate kinase-associated protein mars

1

0

High-throughput

0.426

High

235214

EXOS3
Exosome complex component RRP40

1

0

High-throughput

0.426

High

235217

RS23
Small ribosomal subunit protein uS12

1

0

High-throughput

0.426

High

235222

Q9V3E7
LD24793p

1

0

High-throughput

0.426

High

235227

NPL4
Nuclear protein localization protein 4 homolog

1

0

High-throughput

0.426

High

235234

Q9VFG4
pyruvate kinase

1

0

High-throughput

0.426

High

235250

Q9VUE8
Big bang, isoform C

1

0

High-throughput

0.426

High

235255

Q9W170
GH18016p

1

0

High-throughput

0.426

High

235260

CAPZA
F-actin-capping protein subunit alpha

1

0

High-throughput

0.426

High

235207

Q59DY1
IP21282p

1

1

High-throughput

0.407

High

235228

Q9VBT1
CHK kinase-like domain-containing protein

1

1

High-throughput

0.407

High

235248

Q9VTX5
ADP-ribosylation factor GTPase-activating protein 1

1

1

High-throughput

0.407

High

235251

Q9VW72
GH08353p

1

1

High-throughput

0.407

High

235252

NUP35
Nucleoporin Nup35

1

1

High-throughput

0.407

High

235257

Q9W205
Jitterbug, isoform F

1

1

High-throughput

0.407

High

235224

Q9VA32
Cuticular protein 100A

3

0

High-throughput

0.340

High

235211

Q7KVC9
FI04445p

2

0

High-throughput

0.310

High

235231

Q9VCX6
AT09144p

2

0

High-throughput

0.310

High

235232

Q9VEG8
RE59232p

2

0

High-throughput

0.310

High

235246

Q9VSF5
GH02649p

2

0

High-throughput

0.310

High

235258

Q9W218
GEO08374p1

2

0

High-throughput

0.310

High

235259

Q9W2A3
IP10558p

2

0

High-throughput

0.310

High

235188

KPC3
Protein kinase C

1

0

High-throughput

0.265

Low

235241

CH60B
60 kDa heat shock protein homolog 1, mitochondrial

1

0

High-throughput

0.265

Low

235244

Q9VRL7
Chitin-binding type-2 domain-containing protein

1

0

High-throughput

0.265

Low

235185

CO4A1
Collagen alpha-1(IV) chain

1

0

High-throughput

0.253

Low

235253

RT25
Small ribosomal subunit protein mS25

1

0

High-throughput

0.253

Low

117970

M9MRQ3
Uncharacterized protein

1

0

High-throughput

0.251

Low

54397

C19L1
CWF19-like protein 1 homolog

1

0

High-throughput

0.232

Low

54496

A1Z8N9
Ionotropic receptor 48b

1

0

High-throughput

0.232

Low

58325

A1ZBK1
FXNA-like protease

1

0

High-throughput

0.232

Low

84774

B7Z0I0
Gustatory receptor

1

0

High-throughput

0.232

Low

235196

FTN
Flightin

1

0

High-throughput

0.232

Low

235210

Q7KT77
Uncharacterized protein

1

0

High-throughput

0.232

Low

235218

Q95SH2
Charged multivesicular body protein 1, isoform A

1

0

High-throughput

0.232

Low

235233

Q9VES7
Fatty acyl-CoA reductase

1

0

High-throughput

0.232

Low

235236

Q9VHB8
2-oxoisovalerate dehydrogenase subunit alpha

1

0

High-throughput

0.232

Low

235239

Q9VMM4
LD40415p

1

0

High-throughput

0.232

Low

235245

RL18
Large ribosomal subunit protein eL18

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025