Protein: BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase (BCKDH kinase) (BCKDHKIN) (BDK) (EC 2.7.11.1) ([3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial) (EC 2.7.11.4)

Gene: BCKD, BCKDK
Organism: Homo sapiens
Interactions: 139
UniProt ID: O14874

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0004722 - protein serine/threonine phosphatase activity
GO:0004740 - pyruvate dehydrogenase (acetyl-transferring) kinase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

157282

HS90A
Heat shock protein HSP 90-alpha

1

9

High-throughput

0.691

High

157283

HS90B
Heat shock protein HSP 90-beta

1

9

High-throughput

0.691

High

157261

CETN3
Centrin-3

4

2

High-throughput

0.638

High

157301

CETN2
Centrin-2

4

2

High-throughput

0.638

High

157307

RM12
Large ribosomal subunit protein bL12m

2

2

High-throughput

0.628

High

157330

TEBP
Prostaglandin E synthase 3

1

1

High-throughput

0.618

High

157355

WDTC1
WD and tetratricopeptide repeats protein 1

3

3

High-throughput

0.609

High

157349

NIT1
Deaminated glutathione amidase

2

0

High-throughput

0.602

High

157263

PRKN
E3 ubiquitin-protein ligase parkin

2

5

High-throughput

0.584

High

157319

LG3BP
Galectin-3-binding protein

2

1

High-throughput

0.574

High

157320

CETN1
Centrin-1

2

2

High-throughput

0.574

High

157300

STAT3
Signal transducer and activator of transcription 3

1

2

High-throughput

0.573

High

157293

DNJB1
DnaJ homolog subfamily B member 1

2

1

High-throughput

0.558

High

157262

TIM8A
Mitochondrial import inner membrane translocase subunit Tim8 A

1

3

High-throughput

0.536

High

157266

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

1

3

High-throughput

0.536

High

157267

KBL
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial

1

3

High-throughput

0.536

High

157287

CH60
60 kDa heat shock protein, mitochondrial

1

4

High-throughput

0.536

High

157294

KAD4
Adenylate kinase 4, mitochondrial

1

4

High-throughput

0.536

High

157298

BASI
Basigin

1

2

High-throughput

0.536

High

157304

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

3

High-throughput

0.536

High

157309

KAD2
Adenylate kinase 2, mitochondrial

1

4

High-throughput

0.536

High

157326

KCC2D
Calcium/calmodulin-dependent protein kinase type II subunit delta

1

1

High-throughput

0.536

High

157328

KCC1A
Calcium/calmodulin-dependent protein kinase type 1

1

1

High-throughput

0.536

High

157334

MK06
Mitogen-activated protein kinase 6

1

2

High-throughput

0.536

High

157348

ADCK1
AarF domain-containing protein kinase 1

1

1

High-throughput

0.536

High

157354

CBR4
3-oxoacyl-[acyl-carrier-protein] reductase

1

2

High-throughput

0.536

High

157365

MYL10
Myosin regulatory light chain 10

1

1

High-throughput

0.536

High

157366

SCOT2
Succinyl-CoA:3-ketoacid coenzyme A transferase 2, mitochondrial

1

2

High-throughput

0.536

High

157367

GATA
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

1

1

High-throughput

0.536

High

157370

MTG2
Mitochondrial ribosome-associated GTPase 2

1

1

High-throughput

0.536

High

157380

NPS3A
Protein NipSnap homolog 3A

1

3

High-throughput

0.536

High

157387

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

1

High-throughput

0.536

High

157391

TIM13
Mitochondrial import inner membrane translocase subunit Tim13

1

3

High-throughput

0.536

High

157276

ESR1
Estrogen receptor

2

3

High-throughput

0.521

High

157289

ODBA
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

1

9

High-throughput

0.515

High

130346

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.513

High

157268

MTU1
Mitochondrial tRNA-specific 2-thiouridylase 1

1

0

High-throughput

0.513

High

157299

PPM1A
Protein phosphatase 1A

1

0

High-throughput

0.513

High

157308

TXTP
Tricarboxylate transport protein, mitochondrial

1

0

High-throughput

0.513

High

157333

TAZ
Tafazzin

1

0

High-throughput

0.513

High

157343

ACSM5
Acyl-coenzyme A synthetase ACSM5, mitochondrial

1

0

High-throughput

0.513

High

157344

FAHD1
Oxaloacetate decarboxylase, mitochondrial

1

0

High-throughput

0.513

High

157347

RM52
Large ribosomal subunit protein mL52

1

0

High-throughput

0.513

High

157352

MIRO2
Mitochondrial Rho GTPase 2

1

0

High-throughput

0.513

High

157378

DIC
Mitochondrial dicarboxylate carrier

1

0

High-throughput

0.513

High

157382

AMACR
Alpha-methylacyl-CoA racemase

1

0

High-throughput

0.513

High

157383

MRM2
rRNA methyltransferase 2, mitochondrial

1

0

High-throughput

0.513

High

157305

FXR1
RNA-binding protein FXR1

1

1

High-throughput

0.494

High

157306

FXR2
RNA-binding protein FXR2

1

1

High-throughput

0.494

High

128685

RTCA
RNA 3'-terminal phosphate cyclase

1

0

High-throughput

0.493

High

118644

AIP
AH receptor-interacting protein

1

6

High-throughput

0.489

High

157278

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

3

High-throughput

0.489

High

157285

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

3

High-throughput

0.489

High

157288

MLRV
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform

1

1

High-throughput

0.489

High

157295

MAP4
Microtubule-associated protein 4

1

3

High-throughput

0.489

High

157296

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

2

High-throughput

0.489

High

157297

STIP1
Stress-induced-phosphoprotein 1

1

3

High-throughput

0.489

High

157313

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

1

3

High-throughput

0.489

High

157315

IF5A1
Eukaryotic translation initiation factor 5A-1

1

1

High-throughput

0.489

High

157316

BASP1
Brain acid soluble protein 1

1

1

High-throughput

0.489

High

157317

SHC2
SHC-transforming protein 2

1

2

High-throughput

0.489

High

157321

TP53B
TP53-binding protein 1

1

1

High-throughput

0.489

High

157324

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

7

High-throughput

0.489

High

157332

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

1

High-throughput

0.489

High

157357

SRB4D
Scavenger receptor cysteine-rich domain-containing group B protein

1

1

High-throughput

0.489

High

157361

TRI43
Tripartite motif-containing protein 43

1

1

High-throughput

0.489

High

157364

PFD5
Prefoldin subunit 5

1

1

High-throughput

0.489

High

157377

HCST
Hematopoietic cell signal transducer

1

1

High-throughput

0.489

High

157379

ZO2
Tight junction protein ZO-2

1

1

High-throughput

0.489

High

157390

TIM8B
Mitochondrial import inner membrane translocase subunit Tim8 B

1

3

High-throughput

0.489

High

157389

FBX7
F-box only protein 7

1

0

High-throughput

0.480

High

157277

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

2

High-throughput

0.479

High

157284

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

9

High-throughput

0.479

High

157303

IF2M
Translation initiation factor IF-2, mitochondrial

1

4

High-throughput

0.479

High

157310

TERA
Transitional endoplasmic reticulum ATPase

1

2

High-throughput

0.479

High

157318

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

2

High-throughput

0.479

High

157353

PPM1K
Protein phosphatase Mn(2+)-dependent 1K

1

2

High-throughput

0.479

High

157359

ESR2
Estrogen receptor beta

1

3

High-throughput

0.479

High

157374

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

1

High-throughput

0.479

High

157269

SRBS2
Sorbin and SH3 domain-containing protein 2

1

1

High-throughput

0.470

High

157371

CB39L
Calcium-binding protein 39-like

1

1

High-throughput

0.470

High

157388

CAB39
Calcium-binding protein 39

1

1

High-throughput

0.470

High

157270

NDUAA
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

1

0

High-throughput

0.458

High

157325

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

157360

FBXW7
F-box/WD repeat-containing protein 7

1

0

High-throughput

0.458

High

157279

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.457

High

128360

DNM1L
Dynamin-1-like protein

1

1

Small-scale

0.445

High

157337

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

130307

NR5A2
Nuclear receptor subfamily 5 group A member 2

1

2

High-throughput

0.439

High

157272

LSM8
U6 snRNA-associated Sm-like protein LSm8

1

2

High-throughput

0.439

High

157291

CREB1
Cyclic AMP-responsive element-binding protein 1

1

1

High-throughput

0.437

High

157312

GNAS2
Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

1

4

High-throughput

0.437

High

157327

CUL3
Cullin-3

1

2

High-throughput

0.437

High

157340

TENS2
Tensin-2

1

2

High-throughput

0.437

High

157342

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.437

High

157345

TRI72
Tripartite motif-containing protein 72

1

1

Small-scale

0.437

High

157346

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

157368

ZBP1
Z-DNA-binding protein 1

1

1

High-throughput

0.437

High

157384

HECD1
E3 ubiquitin-protein ligase HECTD1

1

1

High-throughput

0.437

High

157274

IGHM
Immunoglobulin heavy constant mu

1

2

High-throughput

0.407

High

157336

GNAS1
Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas

1

4

High-throughput

0.407

High

157341

CP135
Centrosomal protein of 135 kDa

1

1

High-throughput

0.407

High

146301

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

3

0

High-throughput

0.347

High

157338

MT21C
Protein-lysine methyltransferase METTL21C

3

0

High-throughput

0.345

High

157271

GCNT3
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase 3

2

0

High-throughput

0.328

High

157275

SPTA1
Spectrin alpha chain, erythrocytic 1

2

0

High-throughput

0.316

High

153404

PDCD5
Programmed cell death protein 5

1

0

High-throughput

0.279

Low

157264

DPM1
Dolichol-phosphate mannosyltransferase subunit 1

1

0

High-throughput

0.279

Low

157265

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.279

Low

157273

BPNT1
3'(2'),5'-bisphosphate nucleotidase 1

1

0

High-throughput

0.279

Low

157280

MYL1
Myosin light chain 1/3, skeletal muscle isoform

1

0

High-throughput

0.279

Low

157281

TPM3
Tropomyosin alpha-3 chain

1

0

High-throughput

0.279

Low

157292

EGLN
Endoglin

1

0

High-throughput

0.279

Low

157302

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.279

Low

157311

TMM33
Transmembrane protein 33

1

0

High-throughput

0.279

Low

157329

RBM39
RNA-binding protein 39

1

0

High-throughput

0.279

Low

157350

ARMC8
Armadillo repeat-containing protein 8

1

0

High-throughput

0.279

Low

157351

FXRD2
FAD-dependent oxidoreductase domain-containing protein 2

1

0

High-throughput

0.279

Low

157356

F174A
Membrane protein FAM174A

1

0

High-throughput

0.279

Low

157362

NUD16
U8 snoRNA-decapping enzyme

1

0

High-throughput

0.279

Low

157363

RSLAB
Ras-like protein family member 10B

1

0

High-throughput

0.279

Low

157369

TRABD
TraB domain-containing protein

1

0

High-throughput

0.279

Low

157372

SDF2L
Stromal cell-derived factor 2-like protein 1

1

0

High-throughput

0.279

Low

157373

CT096
Uncharacterized protein C20orf96

1

0

High-throughput

0.279

Low

157375

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.279

Low

157376

GBG12

1

0

High-throughput

0.279

Low

157385

SSRG
Translocon-associated protein subunit gamma

1

0

High-throughput

0.279

Low

157386

CLC11
C-type lectin domain family 11 member A

1

0

High-throughput

0.279

Low

157392

SNX9
Sorting nexin-9

1

0

High-throughput

0.279

Low

157335

FA98B
Protein FAM98B

1

0

High-throughput

0.269

Low

157358

BRK1
Protein BRICK1

1

0

High-throughput

0.268

Low

157286

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.261

Low

157322

EPS8
Epidermal growth factor receptor kinase substrate 8

1

0

High-throughput

0.251

Low

157290

LYL1
Protein lyl-1

1

0

High-throughput

0.249

Low

157323

DC1I2
Cytoplasmic dynein 1 intermediate chain 2

1

0

High-throughput

0.249

Low

157331

TERF2
Telomeric repeat-binding factor 2

1

0

High-throughput

0.249

Low

157339

OBI1
ORC ubiquitin ligase 1

1

0

High-throughput

0.249

Low

157381

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

157314

SUMO1
Small ubiquitin-related modifier 1

1

0

Small-scale

0.232

Low


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Last updated: 15 Jul 2024